dimethyl sulfoxide has been researched along with Infarction, Middle Cerebral Artery in 6 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenyleneiodonium (DPI) is an inhibitor of the free radical producing NAD(P)H-oxidase." | 5.34 | Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat. ( Gardner, H; Genius, J; Heiland, S; Horstmann, S; Nagel, S; Wagner, S, 2007) |
| "The safety and tolerability of a free radical scavenger with Na+ channel blocking activity (dimethyl sulfoxide (DMSO)) combined with a glycolytic intermediate and high energy substrate (fructose 1,6-disphosphate (FDP)) were assessed in a mostly elderly patient group presenting with acute and subacute ischemic stroke." | 5.10 | Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial. ( de la Torre, JC; Demir, S; Karaça, M; Kiliç, E; Yazici, B, 2002) |
| "Diphenyleneiodonium (DPI) is an inhibitor of the free radical producing NAD(P)H-oxidase." | 1.34 | Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat. ( Gardner, H; Genius, J; Heiland, S; Horstmann, S; Nagel, S; Wagner, S, 2007) |
| "Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant." | 1.33 | Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model. ( Bardutzky, J; Bouley, J; Duong, TQ; Fisher, M; Meng, X; Ratan, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ginsberg, MD | 1 |
| Becker, DA | 1 |
| Busto, R | 1 |
| Belayev, A | 1 |
| Zhang, Y | 1 |
| Khoutorova, L | 1 |
| Ley, JJ | 1 |
| Zhao, W | 1 |
| Belayev, L | 1 |
| Bardutzky, J | 1 |
| Meng, X | 1 |
| Bouley, J | 1 |
| Duong, TQ | 1 |
| Ratan, R | 1 |
| Fisher, M | 1 |
| Kleindienst, A | 1 |
| Dunbar, JG | 1 |
| Glisson, R | 1 |
| Okuno, K | 1 |
| Marmarou, A | 1 |
| Nagel, S | 1 |
| Genius, J | 1 |
| Heiland, S | 1 |
| Horstmann, S | 1 |
| Gardner, H | 1 |
| Wagner, S | 1 |
| Kumon, Y | 1 |
| Kim, SC | 1 |
| Tompkins, P | 1 |
| Stevens, A | 1 |
| Sakaki, S | 1 |
| Loftus, CM | 1 |
| Karaça, M | 1 |
| Kiliç, E | 1 |
| Yazici, B | 1 |
| Demir, S | 1 |
| de la Torre, JC | 1 |
1 trial available for dimethyl sulfoxide and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial.
Topics: Adult; Aged; Aging; Brain; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Drug Combin | 2002 |
5 other studies available for dimethyl sulfoxide and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Brain Edema; Dimethyl Sulfoxide; Disease Models, Ani | 2003 |
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model.
Topics: Animals; Behavior, Animal; Blood Pressure; Body Temperature; Brain; Brain Ischemia; Cerebrovascular | 2005 |
Effect of dimethyl sulfoxide on blood-brain barrier integrity following middle cerebral artery occlusion in the rat.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Inf | 2006 |
Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Cerebral Infarction; Dimethyl Sulfoxide; Diseas | 2007 |
Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia.
Topics: Analysis of Variance; Animals; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Follow- | 2000 |