Page last updated: 2024-10-18

dimethyl sulfoxide and Huntington Disease

dimethyl sulfoxide has been researched along with Huntington Disease in 2 studies

Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Paul, S1
Nagao, Y1
Ishiguro, H1
Nukina, N1

Reviews

1 review available for dimethyl sulfoxide and Huntington Disease

ArticleYear
Polyglutamine-mediated neurodegeneration: use of chaperones as prevention strategy.
    Biochemistry. Biokhimiia, 2007, Volume: 72, Issue:4

    Topics: Animals; Dimethyl Sulfoxide; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Huntingto

2007

Other Studies

1 other study available for dimethyl sulfoxide and Huntington Disease

ArticleYear
DMSO and glycerol reduce bacterial death induced by expression of truncated N-terminal huntingtin with expanded polyglutamine tracts.
    Biochimica et biophysica acta, 2000, Oct-18, Volume: 1502, Issue:2

    Topics: Animals; Cell Line; COS Cells; Dimethyl Sulfoxide; Escherichia coli; Exons; Gene Expression; Glycero

2000