dimethyl sulfoxide has been researched along with Hemorrhage in 22 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Hemorrhage: Bleeding or escape of blood from a vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dimethyl sulfoxide (DMSO) was given intraperitoneally to the rats in the III." | 5.40 | The effect of hesperetin on ischemia-reperfusion injury in rat ovary. ( Cakir Gungor, AN; Cosar, E; Demirtas, S; Gencer, M; Hacivelioglu, S; Karaca, T; Korkmaz, F; Uysal, A, 2014) |
| "The use of 40% DMSO with lidocaine instilled into the rectal vault for 10 minutes avoids any need for injection and is capable of decreasing the discomfort or pain experienced during probe insertion and prostate biopsy comparable to the perianal and periprostatic protocols." | 5.11 | Comparison of different local anesthesia techniques during TRUS-guided biopsies: a prospective pilot study. ( Ben-Dor, D; Cytron, S; Dorfman, D; Kesari, D; Kravchick, S; Peled, R, 2005) |
| "The role of oxygen-derived free radicals in the pathogenesis of acute pancreatitis was studied by evaluating the effects of catalase, allopurinol, and dimethylsulfoxide on diet-induced acute hemorrhagic pancreatic necrosis in mice." | 3.67 | Role of oxygen-derived free radicals in diet-induced hemorrhagic pancreatitis in mice. ( Powers, RE; Rutledge, PL; Saluja, AK; Steer, ML, 1987) |
| " Patients were monitored for adverse events (AEs), coagulation markers, PLT responses, and hemostatic efficacy." | 2.87 | Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia. ( Cancelas, JA; Dumont, LJ; Dunbar, NM; Gernsheimer, TB; Hmel, P; Housler, G; Jones, M; Kinne, B; Macdonald, VW; Medlin, S; Prakash, G; Ransom, JH; Rugg, N; Slichter, SJ; Szczepiorkowski, ZM; Valiyaveettil, M, 2018) |
| "The bleeding was oropharyngeal in 66." | 1.42 | Transarterial embolization of intractable nasal and oropharyngeal hemorrhage using liquid embolic agents. ( Aziz-Sultan, MA; Elhammady, MS; Hayes, SB; Johnson, JN; Most, Z; Yavagal, D, 2015) |
| "Dimethyl sulfoxide (DMSO) was given intraperitoneally to the rats in the III." | 1.40 | The effect of hesperetin on ischemia-reperfusion injury in rat ovary. ( Cakir Gungor, AN; Cosar, E; Demirtas, S; Gencer, M; Hacivelioglu, S; Karaca, T; Korkmaz, F; Uysal, A, 2014) |
| "A 50-year-old man with neurofibromatosis type 1 presented to the emergency department after a spontaneous hemorrhage into a facial plexiform neurofibroma." | 1.39 | Spontaneous hemorrhage of a facial neurofibroma: endovascular embolization before surgical intervention. ( Gandhi, CD; Gupta, V; Prestigiacomo, CJ; Tomei, KL, 2013) |
| "Bleeding was located in the pelvis (5 patients), kidney (3 patients), mesenteric region (2 patients), retroperitoneal space (2 patients), neck (1 patient), and thigh (1 patient)." | 1.38 | Endovascular treatment of acute arterial hemorrhage in trauma patients using ethylene vinyl alcohol copolymer (Onyx). ( Hamer, OW; Heiss, P; Herold, T; Hoffstetter, P; Jung, EM; Müller-Wille, R; Rennert, J; Schreyer, AG; Stroszczynski, C; Zorger, N, 2012) |
| "Bleeding was caused by iatrogenic vessel injury (6 patients), malignancy/inflammation (5 patients) and trauma (3 patients)." | 1.35 | [Onyx (ethylene-vinyl-alcohol-copolymer)--a novel approach to the endovascular treatment of acute bleeding]. ( Feuerbach, S; Heiss, P; Herold, T; Jung, EM; Lenhart, M; Müller-Wille, R; Paetzel, C; Rennert, J; Zorger, N, 2009) |
| "Inflammation could play a role in cerebral vasospasm after subarachnoid hemorrhage (SAH)." | 1.33 | Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage. ( Calvert, JW; Yamaguchi, M; Yatsushige, H; Zhang, JH; Zhou, C, 2005) |
| "Lentinan was also denatured by NaOH and the transition of [alpha]D values and optical rotatory dispersion curves were seen in the manner of two concentration-dependent phases." | 1.27 | Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses. ( Chihara, C; Maeda, YY; Rokutanda, M; Watanabe, ST, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (36.36) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Qiu, H | 1 |
| Li, J | 1 |
| Huang, Y | 1 |
| Shen, C | 1 |
| Dai, L | 1 |
| Su, Q | 1 |
| Zhi, Y | 1 |
| Fang, Q | 1 |
| Shi, C | 1 |
| Li, W | 1 |
| Slichter, SJ | 1 |
| Dumont, LJ | 1 |
| Cancelas, JA | 1 |
| Jones, M | 1 |
| Gernsheimer, TB | 1 |
| Szczepiorkowski, ZM | 1 |
| Dunbar, NM | 1 |
| Prakash, G | 1 |
| Medlin, S | 1 |
| Rugg, N | 1 |
| Kinne, B | 1 |
| Macdonald, VW | 1 |
| Housler, G | 1 |
| Valiyaveettil, M | 1 |
| Hmel, P | 1 |
| Ransom, JH | 1 |
| Tomei, KL | 1 |
| Gupta, V | 1 |
| Prestigiacomo, CJ | 1 |
| Gandhi, CD | 1 |
| Cakir Gungor, AN | 1 |
| Gencer, M | 1 |
| Karaca, T | 1 |
| Hacivelioglu, S | 1 |
| Uysal, A | 1 |
| Korkmaz, F | 1 |
| Demirtas, S | 1 |
| Cosar, E | 1 |
| Hayes, SB | 1 |
| Johnson, JN | 1 |
| Most, Z | 1 |
| Elhammady, MS | 1 |
| Yavagal, D | 1 |
| Aziz-Sultan, MA | 1 |
| Kolber, MK | 1 |
| Shukla, PA | 1 |
| Kumar, A | 1 |
| Silberzweig, JE | 1 |
| Müller-Wille, R | 2 |
| Herold, T | 3 |
| Jung, EM | 3 |
| Rennert, J | 3 |
| Heiss, P | 2 |
| Lenhart, M | 2 |
| Paetzel, C | 1 |
| Feuerbach, S | 2 |
| Zorger, N | 3 |
| Schreyer, AG | 2 |
| Banas, B | 1 |
| Mueller-Wille, R | 1 |
| Hamer, OW | 1 |
| Hoffstetter, P | 1 |
| Stroszczynski, C | 1 |
| Kravchick, S | 1 |
| Peled, R | 1 |
| Ben-Dor, D | 1 |
| Dorfman, D | 1 |
| Kesari, D | 1 |
| Cytron, S | 1 |
| Yatsushige, H | 1 |
| Yamaguchi, M | 1 |
| Zhou, C | 1 |
| Calvert, JW | 1 |
| Zhang, JH | 1 |
| Ebanks, SC | 1 |
| Grosell, M | 1 |
| Corso, S | 1 |
| Vukelja, SJ | 1 |
| Wiener, D | 1 |
| Baker, WJ | 1 |
| Fefelova, IV | 1 |
| Mkheidze, DM | 1 |
| Selidovkin, GD | 1 |
| Baranov, AE | 1 |
| Buachidze, LN | 1 |
| Rutledge, PL | 1 |
| Saluja, AK | 1 |
| Powers, RE | 1 |
| Steer, ML | 1 |
| Maeda, YY | 1 |
| Watanabe, ST | 1 |
| Chihara, C | 1 |
| Rokutanda, M | 1 |
| Wisner, JR | 1 |
| Renner, IG | 1 |
| Mulder, PO | 1 |
| Maas, A | 1 |
| de Vries, EG | 1 |
| Orie, JL | 1 |
| Sleijfer, DT | 1 |
| Smit Sibinga, CT | 1 |
| Willemse, PH | 1 |
| Mulder, NH | 1 |
| Görög, P | 1 |
| Kovács, IB | 1 |
| Schwarzenberg, L | 1 |
| Ward, JR | 1 |
| Miller, ML | 1 |
| Marcus, S | 1 |
| Alexandre, P | 1 |
| Stoltz, JF | 1 |
| Genetet, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dose Escalation Study Evaluating the Safety of Dimethyl Sulfoxide Cryopreserved Platelets Compared With Liquid Stored Platelets in Patients With Uncontrolled Bleeding[NCT02078284] | Phase 1 | 28 participants (Actual) | Interventional | 2014-11-05 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Subjects with any signs or symptoms of thrombotic events. (NCT02078284)
Timeframe: 6 days after transfusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Cohort 1 With 0.5 Units of CPP | 0 |
| Cohort 2 With 1 Unit of CPP | 0 |
| Cohort 3 With 2 Units of CPP | 0 |
| Cohort 4 With 3 Units of CPP | 0 |
| 1 Unit of LSP | 0 |
Clinical laboratory [chemistry (serum creatinine, lactate dehydrogenase (LDH), and troponin, and hematology (hemoglobin and hematocrit)] parameters, physical examination findings, electrocardiogram (ECG)] and vital sign AEs summarized by severity. (NCT02078284)
Timeframe: day of thru 6 days after transfusion
| Intervention | adverse events (Number) | ||||
|---|---|---|---|---|---|
| Total number of AEs | Total mild AEs | Total moderate AEs | Total Severe AEs | Total Life-threatening or Fatal AEs | |
| 1 Unit of LSP | 5 | 5 | 0 | 0 | 0 |
| Cohort 1 With 0.5 Units of CPP | 8 | 6 | 1 | 0 | 1 |
| Cohort 2 With 1 Unit of CPP | 18 | 11 | 3 | 1 | 3 |
| Cohort 3 With 2 Units of CPP | 6 | 1 | 5 | 0 | 0 |
| Cohort 4 With 3 Units of CPP | 21 | 9 | 5 | 1 | 6 |
Corrected Count Increments Expressed in units of mm^2/(µL*10¹¹ platelets) (CCI) in the 6 hour period after the study platelet transfusion and on Day 2 (approximately 24 hours after the study platelet transfusion) (NCT02078284)
Timeframe: Day 1 up to 6 hrs after transfusion and Day 2 approx 24 hrs after transfusion
| Intervention | mm^2/(μL*1011 platelets) (Mean) | |
|---|---|---|
| CII: Day 1 up to 6 hrs after | CII: Day 2 | |
| 1 Unit of LSP | 14.8 | 4.13 |
| Cohort 1 With 0.5 Units of CPP | 2.40 | 5.19 |
| Cohort 2 With 1 Unit of CPP | 3.10 | -2.05 |
| Cohort 3 With 2 Units of CPP | 2.73 | 5.63 |
| Cohort 4 With 3 Units of CPP | 3.70 | 2.35 |
Count Increment expressed in units of platelets (x10^3 µL) (CI) (NCT02078284)
Timeframe: On Day 1 up to 6 hours after transfusion and on Day 2 approximately 24 hours after transfusion
| Intervention | platelets*10^3 µL (Mean) | |
|---|---|---|
| Day 1 Up to 6 Hours After | Day 2 | |
| 1 Unit of LSP | 30.5 | 8.75 |
| Cohort 1 With 0.5 Units of CPP | 1.20 | 2.80 |
| Cohort 2 With 1 Unit of CPP | 3.67 | -2.57 |
| Cohort 3 With 2 Units of CPP | 6.50 | 12.5 |
| Cohort 4 With 3 Units of CPP | 13.2 | 10.7 |
Number of subjects who experienced AEs at specific levels of severity. Clinical laboratory [chemistry (serum creatinine, lactate dehydrogenase (LDH), and troponin, and hematology (hemoglobin and hematocrit)] parameters, physical examination findings, electrocardiogram (ECG)] and vital signs were evaluated. (NCT02078284)
Timeframe: day of thru 6 days after transfusion
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| Total Patients with Any AE | Total Patients with Mild AEs | Total Patients with Moderate AEs | Total Patients with Severe AEss | Total Patients with Life-threatening or Fatal AEs | Related to Investigational Product | ||
| 1 Unit of LSP | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| Cohort 1 With 0.5 Units of CPP | 4 | 4 | 4 | 1 | 0 | 1 | 1 |
| Cohort 2 With 1 Unit of CPP | 6 | 6 | 4 | 1 | 1 | 1 | 2 |
| Cohort 3 With 2 Units of CPP | 3 | 3 | 1 | 3 | 0 | 2 | 2 |
| Cohort 4 With 3 Units of CPP | 5 | 5 | 5 | 1 | 1 | 2 | 2 |
1 review available for dimethyl sulfoxide and Hemorrhage
| Article | Year |
|---|---|
Ethylene vinyl alcohol copolymer (onyx) embolization for acute hemorrhage: a systematic review of peripheral applications.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Dimethyl Sulfoxide; Embolization, Therapeutic; Endova | 2015 |
2 trials available for dimethyl sulfoxide and Hemorrhage
| Article | Year |
|---|---|
Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia.
Topics: Adult; Aged; Blood Preservation; Cell-Derived Microparticles; Cryopreservation; Cryoprotective Agent | 2018 |
Comparison of different local anesthesia techniques during TRUS-guided biopsies: a prospective pilot study.
Topics: Adenocarcinoma; Adjuvants, Anesthesia; Administration, Rectal; Aged; Anesthesia, Local; Anesthetics, | 2005 |
19 other studies available for dimethyl sulfoxide and Hemorrhage
| Article | Year |
|---|---|
Sulfhydryl functionalized hyaluronic acid hydrogels attenuate cyclophosphamide-induced bladder injury.
Topics: Animals; Cyclophosphamide; Cystitis; Dimethyl Sulfoxide; Hemorrhage; Hyaluronic Acid; Hydrogels; Inf | 2022 |
Spontaneous hemorrhage of a facial neurofibroma: endovascular embolization before surgical intervention.
Topics: Dimethyl Sulfoxide; Embolization, Therapeutic; Facial Neoplasms; Hemorrhage; Humans; Male; Middle Ag | 2013 |
The effect of hesperetin on ischemia-reperfusion injury in rat ovary.
Topics: Animals; Apoptosis; Caspase 3; Dimethyl Sulfoxide; Edema; Female; Hemorrhage; Hesperidin; Immunohist | 2014 |
Transarterial embolization of intractable nasal and oropharyngeal hemorrhage using liquid embolic agents.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Dimethyl Sulfoxide; Embolization, Therapeutic; En | 2015 |
[Onyx (ethylene-vinyl-alcohol-copolymer)--a novel approach to the endovascular treatment of acute bleeding].
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Arteries; Cause of Death; Dimethyl Sulfoxide; Emboliz | 2009 |
[Evaluation of a liquid embolization agent (Onyx) for transcatheter embolization for renal vascular lesions].
Topics: Adult; Aged; Aneurysm; Aneurysm, False; Angiography, Digital Subtraction; Arteriovenous Fistula; Dim | 2009 |
Endovascular treatment of acute arterial hemorrhage in trauma patients using ethylene vinyl alcohol copolymer (Onyx).
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arteries; Dimethyl Sulfoxide; Embolization, Therapeutic; | 2012 |
Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage.
Topics: Angiography; Animals; Anthracenes; Blotting, Western; Cytokines; Dimethyl Sulfoxide; Dogs; Dose-Resp | 2005 |
Fluid and osmolyte recovery in the common pond snail Lymnaea stagnalis following full-body withdrawal.
Topics: Amiloride; Animals; Bicarbonates; Biological Transport; Chlorides; Colchicine; Copper; Dimethyl Sulf | 2008 |
Diffuse alveolar hemorrhage following autologous bone marrow infusion.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Thera | 1993 |
[Cryopreservation of thrombocytes using dimethyl sulfoxide].
Topics: Blood Platelets; Blood Preservation; Blood Transfusion; Cryopreservation; Cryoprotective Agents; Dim | 1991 |
Role of oxygen-derived free radicals in diet-induced hemorrhagic pancreatitis in mice.
Topics: Acute Disease; Allopurinol; Amylases; Animals; Catalase; Choline Deficiency; Diet; Dimethyl Sulfoxid | 1987 |
Denaturation and renaturation of a beta-1,6;1,3-glucan, lentinan, associated with expression of T-cell-mediated responses.
Topics: Acute-Phase Proteins; Animals; Dimethyl Sulfoxide; Female; Hemorrhage; Immunity, Cellular; Immunothe | 1988 |
Asperlicin, a nonpeptidal cholecystokinin receptor antagonist, attenuates sodium taurocholate-induced acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Benzodiazepinones; Cholecystokinin; Dimethyl Sulfoxide; Hemorrhage | 1988 |
Bleeding prophylaxis in autologous bone marrow transplantation for solid tumors. Comparison of cryopreserved autologous and fresh allogeneic single-donor platelets.
Topics: Adult; Aged; Blood Preservation; Blood Transfusion, Autologous; Bone Marrow Transplantation; Dimethy | 1989 |
Effect of dimethyl sulfoxide (DMSO) on various experimental cutaneous reactions.
Topics: Animals; Arsenicals; Calcinosis; Dermatitis, Contact; Dihydrotachysterol; Dimethyl Sulfoxide; Dinitr | 1969 |
[The effectiveness of platelet transfusions].
Topics: Blood Platelets; Blood Preservation; Blood Transfusion; Dimethyl Sulfoxide; Hemorrhage; Humans; Leuk | 1967 |
The effect of dimethyl sulfoxide on the local Shwartzman phenomenon.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Dimethyl Sulfoxide; Hemorrhage; Lipopolys | 1967 |
[Preservation and transfusion of platelets frozen at -80 degrees in D.M.S.O. Technical, biologial and clinical study].
Topics: Blood Cell Count; Blood Coagulation Tests; Blood Platelets; Blood Preservation; Blood Transfusion; D | 1970 |