dimethyl sulfoxide has been researched along with Epilepsy in 8 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Literature indicated that the highly efficient solvent dimethyl sulfoxide (DMSO) may have a confounding influence in epilepsy research, reporting both pro- and antiepileptic effects." | 8.31 | Dimethyl sulfoxide's impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy. ( Lieb, A; Mutti, A; Schwarzer, C; Widmann, M, 2023) |
| "9% saline, n = 5), the EP groups (lithium-pilocarpine was used to induce epilepsy, and tissues were harvested at 6 and 24 h, every time point, n = 5), the EP + Compound C group (the specific inhibitor of PGC-1α, 15 mg/kg in 2% DMSO, n = 5), and the EP + DMSO group (0." | 4.31 | PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats. ( Li, D; Liu, X; Luo, Z; Qiu, X; Tai, Z; Tuo, J; Wang, J; Xu, Z; Yang, J; Zhang, F; Zhang, H; Zhang, L, 2023) |
| " Literature indicated that the highly efficient solvent dimethyl sulfoxide (DMSO) may have a confounding influence in epilepsy research, reporting both pro- and antiepileptic effects." | 4.31 | Dimethyl sulfoxide's impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy. ( Lieb, A; Mutti, A; Schwarzer, C; Widmann, M, 2023) |
| "Onyx embolization of cerebral arteriovenous malformations (AVM) has become increasingly common." | 1.37 | Seizures after Onyx embolization for the treatment of cerebral arteriovenous malformation. ( Bederson, JB; de Los Reyes, K; Doshi, A; Egorova, N; Frontera, JA; Panov, F; Patel, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, Q | 1 |
| Zheng, S | 1 |
| Chen, Q | 1 |
| Chen, L | 1 |
| Yang, Y | 1 |
| Wang, Y | 1 |
| Zhang, H | 4 |
| Chen, J | 1 |
| Li, D | 3 |
| Zhang, L | 3 |
| Tuo, J | 3 |
| Zhang, F | 3 |
| Tai, Z | 3 |
| Liu, X | 3 |
| Qiu, X | 3 |
| Yang, J | 3 |
| Wang, J | 3 |
| Luo, Z | 3 |
| Xu, Z | 3 |
| Widmann, M | 1 |
| Lieb, A | 1 |
| Mutti, A | 1 |
| Schwarzer, C | 1 |
| Zhang, B | 1 |
| Feng, X | 1 |
| Peng, F | 1 |
| Wang, L | 1 |
| Guo, EK | 1 |
| Zhang, Y | 1 |
| Liu, P | 1 |
| Wu, Z | 1 |
| Liu, A | 1 |
| Rubi, L | 1 |
| Schandl, U | 1 |
| Lagler, M | 1 |
| Geier, P | 1 |
| Spies, D | 1 |
| Gupta, KD | 1 |
| Boehm, S | 1 |
| Kubista, H | 1 |
| de Los Reyes, K | 1 |
| Patel, A | 1 |
| Doshi, A | 1 |
| Egorova, N | 1 |
| Panov, F | 1 |
| Bederson, JB | 1 |
| Frontera, JA | 1 |
| Kaelin, AC | 1 |
| Cummings, AJ | 1 |
| Kubova, H | 1 |
| Lanstiakova, M | 1 |
| Mockova, M | 1 |
| Mares, P | 1 |
| Vorlicek, J | 1 |
8 other studies available for dimethyl sulfoxide and Epilepsy
| Article | Year |
|---|---|
The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway.
Topics: Animals; Brain Injuries; Caspase 3; Dimethyl Sulfoxide; Epilepsy; Hippocampus; Kindling, Neurologic; | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Dimethyl Sulfoxide; Epilepsy; Lithium; Male; Mitochondrial D | 2023 |
Dimethyl sulfoxide's impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; Hipp | 2023 |
Seizure predictors and outcome after Onyx embolization in patients with brain arteriovenous malformations.
Topics: Adolescent; Adult; Angiography, Digital Subtraction; Cerebral Angiography; Child; Child, Preschool; | 2019 |
Raised activity of L-type calcium channels renders neurons prone to form paroxysmal depolarization shifts.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2013 |
Seizures after Onyx embolization for the treatment of cerebral arteriovenous malformation.
Topics: Adult; Brain Edema; Dimethyl Sulfoxide; Embolization, Therapeutic; Epilepsy; Female; Humans; Intracr | 2011 |
Differential inhibition of human placental monooxygenase activity: evidence for multiple forms of 7-ethoxycoumarin O-deethylase.
Topics: 7-Alkoxycoumarin O-Dealkylase; Benzoflavones; Dimethyl Sulfoxide; Epilepsy; Female; Humans; Metyrapo | 1984 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal | 1996 |