dimethyl sulfoxide has been researched along with Chemical and Drug Induced Liver Injury in 46 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the preventive effects of dimethyl sulfoxide (DMSO) on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats." | 7.71 | Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. ( Enjoji, M; Kato, M; Kotoh, K; Nakamuta, M; Nakashima, Y; Nawata, H; Ohta, S; Sugimoto, R; Tada, S; Tsuruta, S, 2001) |
| "We studied the preventive effects of dimethyl sulfoxide (DMSO) on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats." | 3.71 | Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats. ( Enjoji, M; Kato, M; Kotoh, K; Nakamuta, M; Nakashima, Y; Nawata, H; Ohta, S; Sugimoto, R; Tada, S; Tsuruta, S, 2001) |
| "Dimethyl sulfoxide (DMSO) is a very simple compound that has stimulated much controversy in the scientific and popular literature." | 2.37 | Dimethyl sulfoxide (DMSO): a review. ( Brayton, CF, 1986) |
| "The resorufin level was significantly (P < 0." | 1.36 | The effect of TCDD dioxin on the rat liver in biochemical and histological assessment. ( Biesiada, G; Czepiel, J; Dabrowski, Z; Gajda, M; Mach, T; Szczepański, W; Szypuła, K, 2010) |
| "Dimethyl sulfoxide (DMSO) has previously been shown to have the ability to attenuate chloroform (CHCl(3))-induced liver injury in the naive rat even when administered 24 h after the toxicant." | 1.31 | Hepatoprotection by dimethyl sulfoxide. III. Role of inhibition of the bioactivation and covalent bonding of chloroform. ( Begay, CK; Gandolfi, AJ; Lind, RC, 2000) |
| "The chloroform-treated rats also developed renal tubular necrosis with large increases in plasma creatinine and urea nitrogen, which were completely ameliorated by DMSO." | 1.30 | Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney. ( Gandolfi, AJ; Lind, RC, 1997) |
| "Dimethyl sulfoxide (DMSO) has previously been shown to attenuate chloroform (CHCl3) and bromobenzene (BB) induced hepatotoxicity in the rat when a dose of 2." | 1.30 | Hepatoprotection by dimethyl sulfoxide. II. Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury. ( Gandolfi, AJ; Lind, RC, 1999) |
| " Although dimethyl sulfoxide is not highly flammable, normal safety precautions used with any flammable solvent are the minimal requirements for safe use of this drug." | 1.25 | The safe use of dimethyl sulfoxide in the laboratory. ( Cotter, DA, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (41.30) | 18.7374 |
| 1990's | 5 (10.87) | 18.2507 |
| 2000's | 7 (15.22) | 29.6817 |
| 2010's | 12 (26.09) | 24.3611 |
| 2020's | 3 (6.52) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Liu, Y | 1 |
| Acosta-Cota, SJ | 1 |
| Castillo-Romero, DJ | 1 |
| Montes-Ávila, J | 1 |
| Delgado-Vargas, F | 1 |
| Báez-Flores, ME | 1 |
| Noguera-Corona, E | 1 |
| Osuna-Martínez, U | 1 |
| Pereira, CMC | 1 |
| Júnior, GJD | 1 |
| Lima, JVDN | 1 |
| Alves Lemos, SI | 1 |
| da Rocha Rodrigues, L | 1 |
| Dos Santos Ferreira, J | 1 |
| Araújo, ASML | 1 |
| de Oliveira, JC | 1 |
| Monteiro, CE | 1 |
| Franco, ÁX | 1 |
| Pereira Alves, EH | 1 |
| Oliveira Silva, FG | 1 |
| de Carvalho Filgueiras, M | 1 |
| Soares, PMG | 1 |
| Pereira Vasconcelos, DF | 1 |
| de Oliveira, JS | 1 |
| de Brito, TV | 1 |
| Barbosa, ALR | 1 |
| Algfeley, SG | 1 |
| Al-Rejaie, SS | 1 |
| Nagi, MN | 1 |
| Kamel, R | 1 |
| El Morsy, EM | 1 |
| Du, K | 1 |
| Williams, CD | 2 |
| McGill, MR | 1 |
| Xie, Y | 1 |
| Farhood, A | 2 |
| Vinken, M | 1 |
| Jaeschke, H | 4 |
| Masson, MJ | 1 |
| Carpenter, LD | 1 |
| Graf, ML | 1 |
| Pohl, LR | 1 |
| Shirin, H | 1 |
| Aeed, H | 1 |
| Alin, A | 1 |
| Matas, Z | 1 |
| Kirchner, M | 1 |
| Brazowski, E | 1 |
| Goldiner, I | 1 |
| Bruck, R | 1 |
| Shin, MO | 1 |
| Yoon, S | 1 |
| Moon, JO | 1 |
| Khan, SA | 1 |
| McLean, MK | 1 |
| Gwaltney-Brant, S | 1 |
| Czepiel, J | 1 |
| Biesiada, G | 1 |
| Gajda, M | 1 |
| Szczepański, W | 1 |
| Szypuła, K | 1 |
| Dabrowski, Z | 1 |
| Mach, T | 1 |
| Mishra, A | 1 |
| Paul, S | 1 |
| Swarnakar, S | 1 |
| Anthérieu, S | 1 |
| Chesné, C | 1 |
| Li, R | 1 |
| Guguen-Guillouzo, C | 1 |
| Guillouzo, A | 1 |
| WILLSON, JE | 1 |
| BROWN, DE | 1 |
| TIMMENS, EK | 1 |
| Túnez, I | 1 |
| Muñoz, MC | 1 |
| Villavicencio, MA | 1 |
| Medina, FJ | 1 |
| de Prado, EP | 1 |
| Espejo, I | 1 |
| Barcos, M | 1 |
| Salcedo, M | 1 |
| Feijóo, M | 1 |
| Montilla, P | 1 |
| Cover, C | 1 |
| Bajt, ML | 1 |
| Zhang, M | 1 |
| Deng, Y | 1 |
| Zhang, HB | 1 |
| Su, XL | 1 |
| Chen, HL | 1 |
| Yu, T | 1 |
| Guo, P | 1 |
| Freston, JW | 1 |
| Bouchier, IA | 1 |
| Younes, M | 1 |
| Siegers, CP | 1 |
| El-Hage, AN | 1 |
| Herman, EH | 1 |
| Ferrans, VJ | 1 |
| Ishiyama, H | 1 |
| Ogino, K | 1 |
| Hobara, T | 1 |
| Edwards, MJ | 1 |
| Taylor, MF | 1 |
| Christian, JA | 1 |
| Rebar, AH | 1 |
| Boon, GD | 1 |
| Low, PS | 1 |
| Lind, RC | 3 |
| Gandolfi, AJ | 3 |
| Begay, CK | 1 |
| Nakamuta, M | 1 |
| Ohta, S | 1 |
| Tada, S | 1 |
| Tsuruta, S | 1 |
| Sugimoto, R | 1 |
| Kotoh, K | 1 |
| Kato, M | 1 |
| Nakashima, Y | 1 |
| Enjoji, M | 1 |
| Nawata, H | 1 |
| Willson, RA | 1 |
| Hart, FE | 1 |
| Cotter, DA | 1 |
| Arndt, K | 2 |
| Haschek, WM | 2 |
| Jeffery, EH | 2 |
| Brayton, CF | 1 |
| Feuer, G | 1 |
| Golberg, L | 1 |
| Le Pelley, JR | 1 |
| Gaaz, JW | 1 |
| Poser, W | 1 |
| Erdmann, WD | 1 |
| Rauen, HM | 1 |
| Schriewer, H | 1 |
| Mancini, RE | 1 |
| Kocsis, JJ | 1 |
| Smith, ER | 1 |
| Hadidian, Z | 1 |
| Mason, MM | 1 |
| Peterson, JE | 1 |
| Samuel, A | 1 |
| Jago, MV | 1 |
| Wogan, GN | 1 |
| Edwards, GS | 1 |
| Newberne, PM | 2 |
| Rogers, AE | 1 |
| Shilkin, KB | 1 |
| Papadimitriou, JM | 1 |
| Walters, MN | 1 |
3 reviews available for dimethyl sulfoxide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Optimization of the HepaRG cell model for drug metabolism and toxicity studies.
Topics: Cell Differentiation; Cell Line; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sys | 2012 |
Mechanism of dimethylsulfoxide protection against acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Humans | 1989 |
Dimethyl sulfoxide (DMSO): a review.
Topics: Absorption; Administration, Topical; Analgesia; Animals; Blood Coagulation; Chemical and Drug Induce | 1986 |
43 other studies available for dimethyl sulfoxide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Dimethyl Sulfoxide; Hepatocytes; Hum | 2022 |
Effect of 4-hydroxychalcone as preventive and curative treatment in Wistar rats with liver injury.
Topics: Animals; Carbon Tetrachloride; Chalcones; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide | 2022 |
Phosphatidylinositol 3-kinase gamma participates in nimesulide-induced hepatic damage.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Free | 2021 |
Can acetaminophen/dimethyl sulfoxide formulation prevent accidental and intentional acetaminophen hepatotoxicity?
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Dose-Response Re | 2019 |
Hepatoprotective effect of methylsulfonylmethane against carbon tetrachloride-induced acute liver injury in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Biomarke | 2013 |
The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
Topics: Acetaminophen; Animals; Boron Compounds; Chemical and Drug Induced Liver Injury; Connexins; Cytochro | 2013 |
Pathogenic role of natural killer T and natural killer cells in acetaminophen-induced liver injury in mice is dependent on the presence of dimethyl sulfoxide.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Culture Techniques; Chemical and D | 2008 |
Innate immunity and acetaminophen-induced liver injury: why so many controversies?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; | 2008 |
Inhibition of immune-mediated concanavalin a-induced liver damage by free-radical scavengers.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Concanavalin A; Dimethyl Sulfoxide; D | 2010 |
The proanthocyanidins inhibit dimethylnitrosamine-induced liver damage in rats.
Topics: Actins; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Fibrosis; | 2010 |
Accidental overdosage of joint supplements in dogs.
Topics: Animals; Chemical and Drug Induced Liver Injury; Creatine; Dietary Supplements; Dimethyl Sulfoxide; | 2010 |
The effect of TCDD dioxin on the rat liver in biochemical and histological assessment.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Dimethyl Sulfoxide; Dose-R | 2010 |
No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity.
Topics: Acetaminophen; Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; Cytochrome P-45 | 2011 |
Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical a | 2011 |
A TOXICOLOGIC STUDY OF DIMETHYL SULFOXIDE.
Topics: Anemia; Blood Cell Count; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Dogs; Dyspnea; | 1965 |
Hepato- and neurotoxicity induced by thioacetamide: protective effects of melatonin and dimethylsulfoxide.
Topics: Alanine Transaminase; Ammonia; Animals; Blood Urea Nitrogen; Brain; Catalase; Chemical and Drug Indu | 2005 |
Role of caspases in acetaminophen-induced liver injury.
Topics: Acetaminophen; Amino Acid Chloromethyl Ketones; Analgesics, Non-Narcotic; Animals; Caspase Inhibitor | 2006 |
Two new coumarins from Herpetospermum caudigerum.
Topics: Acetates; Animals; Carbon Tetrachloride Poisoning; Cell Survival; Cells, Cultured; Chemical and Drug | 2008 |
Potentiation of carbon tetrachloride toxicity by dimethyl sulphoxide.
Topics: Animals; Aspartate Aminotransferases; Carbon Isotopes; Carbon Tetrachloride; Chemical and Drug Induc | 1967 |
Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein.
Topics: Acetaminophen; Animals; Catechin; Chemical and Drug Induced Liver Injury; Deanol; Dimethyl Sulfoxide | 1980 |
Examination of the protective effect of ICRF-187 and dimethyl sulfoxide against acetaminophen-induced hepatotoxicity in Syrian golden hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Blood Proteins; Chemical and Drug Induced Liver Injury | 1983 |
Role of Kupffer cells in rat liver injury induced by diethyldithiocarbamate.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Dexamethasone | 1995 |
Substitution of DMSO for DMF as a solvent for X-gal.
Topics: Bacteriophages; beta-Galactosidase; Chemical and Drug Induced Liver Injury; Chromogenic Compounds; D | 1993 |
Methodologic considerations for the use of canine in vivo aged biotinylated erythrocytes to study RBC senescence.
Topics: Acetamides; Animals; Biotin; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Dimethyl | 1996 |
Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney.
Topics: Administration, Inhalation; Administration, Oral; Alanine Transaminase; Allyl Compounds; Animals; Bi | 1997 |
Hepatoprotection by dimethyl sulfoxide. II. Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury.
Topics: Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Chloroform; Dimethyl Sulfoxide; Dose | 1999 |
Hepatoprotection by dimethyl sulfoxide. III. Role of inhibition of the bioactivation and covalent bonding of chloroform.
Topics: Alanine Transaminase; Allyl Compounds; Animals; Binding Sites; Chemical and Drug Induced Liver Injur | 2000 |
Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Body Weight; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Collagen T | 2001 |
In vitro spectral alteration of hepatic cytochrome P-450 by experimental drug injury.
Topics: Acetaminophen; Animals; Buffers; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Cytoc | 1977 |
The safe use of dimethyl sulfoxide in the laboratory.
Topics: Accident Prevention; Bacteria; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry | 1975 |
Mechanism of inhibition of hepatic bioactivation of paracetamol by dimethyl sulfoxide.
Topics: Acetaminophen; Animals; Bile; Biotransformation; Chemical and Drug Induced Liver Injury; Dimethyl Su | 1988 |
Liver response tests. I. Exploratory studies on glucose 6-phosphatase and other liver enzymes.
Topics: Acid Phosphatase; Animals; Carbon Tetrachloride; Cathepsins; Chemical and Drug Induced Liver Injury; | 1965 |
[Research on liver toxicity of nitrostigmine (Parathion, E 605) in the perfused rat liver].
Topics: Acetoacetates; Acetylcholinesterase; Animals; Aspartate Aminotransferases; Bile; Chemical and Drug I | 1974 |
[The anti-hepatotoxic effect of parenterally administered silymarin in CCl4-induced liver damage of the rat].
Topics: Alcohols; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethyl | 1973 |
Dimethylsulfoxide increases the lethality of CCl4 in rats but decreases its hepatotoxicity.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1974 |
The single--and repeated--dose toxicity of dimethyl sulfoxide.
Topics: Animals; Cats; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Dogs; Eye Diseases; Femal | 1967 |
Dimethylsulphoxide: a fallen idol.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Culture Techniques; Dimethyl Sulfoxide; | 1968 |
Pathological effects of dehydroheliotridine, a metabolite of heliotridine-based pyrrolizidine alkaloids, in the young rat.
Topics: Alopecia; Animals; Atrophy; Bone Marrow; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; | 1972 |
Acute and chronic toxicity of rubratoxin B.
Topics: Administration, Oral; Aflatoxins; Animals; Chemical and Drug Induced Liver Injury; Chickens; Dimethy | 1971 |
Carcinoma, thymidine uptake, and mitosis in the livers of rats exposed to aflatoxin.
Topics: Aflatoxins; Animals; Autoradiography; Carcinogens; Chemical and Drug Induced Liver Injury; Dimethyl | 1968 |
The effect of dimethyl sulphoxide on hepatic cells of rats.
Topics: Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Dimethyl Sulfoxide; Liver; Mitochond | 1966 |