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dimethyl sulfoxide and Brain Swelling

dimethyl sulfoxide has been researched along with Brain Swelling in 26 studies

Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.

Research Excerpts

ExcerptRelevanceReference
"The results of a prospective study on the effects of dimethyl sulfoxide (DMSO) in patients with severe closed head injuries causing brain edema and increase in intracranial pressure (ICP) are presented."7.68Dimethyl sulfoxide in the management of patient with brain swelling and increased intracranial pressure after severe closed head injury. ( Akar, M; Baykut, L; Kulah, A, 1990)
"Albino rabbits with experimental brain edema produced by a combined cryogenic left hemisphere lesion and metabolic 6-aminonicotinamide lesion were administered a 3-hour intravenous infusion of dimethyl sulfoxide (DMSO)."7.66Acute dimethyl sulfoxide therapy in brain edema. Part 3: effect of a 3-hour infusion. ( Camp, PE; Del Bigio, M; James, HE; Marshall, LF; Tung, H; Werner, R, 1982)
"Albino rabbits with experimental brain edema produced by a combined cryogenic and metabolic 6-aminonicotinamide lesion were administered intravenous dimethyl sulfoxide in varying concentrations and doses in the following manner: Subgroup A (concentration response) received a 1."7.66Acute dimethyl sulfoxide therapy in experimental brain edema: part 2. Effect of dose and concentration on intracranial pressure, blood pressure, and central venous pressure. ( Camp, PE; James, HE; Tsuruda, J; Werner, R, 1982)
"Albino rabbits with experimental brain edema produced by a cryogenic lesion or by a cryogenic lesion combined with a metabolic blocker, 6-aminonicotinamide, were given 1 g of a 10% solution of dimethyl sulfoxide (DMSO) per kg by intravenous bolus."7.66Acute dimethyl sulfoxide therapy in experimental brain edema: Part I. Effects on intracranial pressure, blood pressure, central venous pressure, and brain water and electrolyte content. ( Camp, PE; James, HE; Werner, R, 1981)
"The safety and tolerability of a free radical scavenger with Na+ channel blocking activity (dimethyl sulfoxide (DMSO)) combined with a glycolytic intermediate and high energy substrate (fructose 1,6-disphosphate (FDP)) were assessed in a mostly elderly patient group presenting with acute and subacute ischemic stroke."5.10Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial. ( de la Torre, JC; Demir, S; Karaça, M; Kiliç, E; Yazici, B, 2002)
"The results of a prospective study on the effects of dimethyl sulfoxide (DMSO) in patients with severe closed head injuries causing brain edema and increase in intracranial pressure (ICP) are presented."3.68Dimethyl sulfoxide in the management of patient with brain swelling and increased intracranial pressure after severe closed head injury. ( Akar, M; Baykut, L; Kulah, A, 1990)
"To ascertain the clinical significance of dimethyl sulfoxide-induced pigmenturia, we evaluated renal function and indicators of systemic hemolysis in stable quadriplegic patients receiving the drug intravenously (IV) for spinal cord injury."3.66Effects of dimethyl sulfoxide on renal function in man. ( Bennett, WM; Muther, RS, 1980)
"Albino rabbits with experimental brain edema produced by a combined cryogenic left hemisphere lesion and metabolic 6-aminonicotinamide lesion were administered a 3-hour intravenous infusion of dimethyl sulfoxide (DMSO)."3.66Acute dimethyl sulfoxide therapy in brain edema. Part 3: effect of a 3-hour infusion. ( Camp, PE; Del Bigio, M; James, HE; Marshall, LF; Tung, H; Werner, R, 1982)
"Albino rabbits with experimental brain edema produced by a combined cryogenic and metabolic 6-aminonicotinamide lesion were administered intravenous dimethyl sulfoxide in varying concentrations and doses in the following manner: Subgroup A (concentration response) received a 1."3.66Acute dimethyl sulfoxide therapy in experimental brain edema: part 2. Effect of dose and concentration on intracranial pressure, blood pressure, and central venous pressure. ( Camp, PE; James, HE; Tsuruda, J; Werner, R, 1982)
"Albino rabbits with experimental brain edema produced by a cryogenic lesion or by a cryogenic lesion combined with a metabolic blocker, 6-aminonicotinamide, were given 1 g of a 10% solution of dimethyl sulfoxide (DMSO) per kg by intravenous bolus."3.66Acute dimethyl sulfoxide therapy in experimental brain edema: Part I. Effects on intracranial pressure, blood pressure, central venous pressure, and brain water and electrolyte content. ( Camp, PE; James, HE; Werner, R, 1981)
"Onyx embolization of cerebral arteriovenous malformations (AVM) has become increasingly common."1.37Seizures after Onyx embolization for the treatment of cerebral arteriovenous malformation. ( Bederson, JB; de Los Reyes, K; Doshi, A; Egorova, N; Frontera, JA; Panov, F; Patel, A, 2011)
"The toxic effects of onyx, its solvent dimethyl sulphoxide (DMSO), and n-butyl 2-cyanoacrylate (NBCA) were evaluated after infusion into the subaracnoid space of a rabbit model."1.36Evaluation of the toxicity of onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model: an experimental research. ( Atilla, P; Bakar, B; Hazer, BD; Kilic, K; Muftuoglu, SF; Oruckaptan, HH; Saatci, I, 2010)
"Taurine release was most affected, exhibiting a greater than 9-fold increase during the hyposmotic stimulus."1.30Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases. ( Estevez, AY; O'Regan, MH; Phillis, JW; Song, D, 1999)
"With indomethacin there was an initial decrease immediately following the drug, and at 60 minutes there was a rise in the insulted left hemisphere, more than the right one."1.27An experimental study on the effects of DMSO and indomethacin on cerebral circulation and intracranial pressure. ( Drummond, JC; James, HE; Moore, S; Tung, H, 1986)
"Thus, ischemic cerebral edema appears to contribute heavily to morbidity and mortality in stroke."1.26Cerebral edema in stroke: a common, often fatal complication. ( Easton, JD; Sherman, DG, 1980)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199011 (42.31)18.7374
1990's5 (19.23)18.2507
2000's5 (19.23)29.6817
2010's4 (15.38)24.3611
2020's1 (3.85)2.80

Authors

AuthorsStudies
Mirabet, V1
García, D1
Roca, A1
Quiroz, AR1
Antón, J1
Rodríguez-Cadarso, M1
Ocete, D1
Aranda, L1
Melero, A1
Guillot, AJ1
Yagüe, N1
Guillén, I1
Botella, C1
Trivelato, FP1
Manzato, LB1
Rezende, MT1
Ulhôa, AC1
Soltani, Z1
Khaksari, M1
Jafari, E1
Iranpour, M1
Shahrokhi, N1
Rossitti, S1
Bakar, B1
Oruckaptan, HH1
Hazer, BD1
Saatci, I1
Atilla, P1
Kilic, K1
Muftuoglu, SF1
de Los Reyes, K1
Patel, A1
Doshi, A1
Egorova, N1
Panov, F1
Bederson, JB1
Frontera, JA1
Ginsberg, MD1
Becker, DA1
Busto, R1
Belayev, A1
Zhang, Y1
Khoutorova, L1
Ley, JJ1
Zhao, W1
Belayev, L1
Kleindienst, A1
Dunbar, JG1
Glisson, R1
Okuno, K1
Marmarou, A1
Goodnough, J1
Allen, N1
Nesham, ME1
Clendenon, NR1
James, HE7
Cornell, W1
del Bigio, M2
Werner, R6
Tsuruda, J2
Camp, PE5
Rasmussen, G1
Sherman, DG1
Easton, JD1
Chan, PH1
Yurko, M1
Fishman, RA1
Muther, RS1
Bennett, WM1
Marshall, LF2
Tung, H2
Harbaugh, RD1
McConnel, JR1
Ong, CS1
McAllister, JL1
Gross, TG1
Banks, P1
Roussel, AJ1
Mealey, RH1
Estevez, AY1
O'Regan, MH1
Song, D1
Phillis, JW1
Kumon, Y1
Kim, SC1
Tompkins, P1
Stevens, A1
Sakaki, S1
Loftus, CM1
Karaça, M1
Kiliç, E1
Yazici, B1
Demir, S1
de la Torre, JC1
Ikeda, Y1
Long, DM1
Kulah, A1
Akar, M1
Baykut, L1
Drummond, JC1
Moore, S1

Trials

1 trial available for dimethyl sulfoxide and Brain Swelling

ArticleYear
Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial.
    Neurological research, 2002, Volume: 24, Issue:1

    Topics: Adult; Aged; Aging; Brain; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Drug Combin

2002

Other Studies

25 other studies available for dimethyl sulfoxide and Brain Swelling

ArticleYear
Cranioplasty with Autologous Bone Flaps Cryopreserved with Dimethylsulphoxide: Does Tissue Processing Matter.
    World neurosurgery, 2021, Volume: 149

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Autografts; Bone Resorption; Brain Edema; Brain Injuries,

2021
Transitory brain stem edema following successfully transvenous embolization of a posterior fossa arteriovenous malformation.
    Clinical neuroradiology, 2014, Volume: 24, Issue:2

    Topics: Brain Edema; Dimethyl Sulfoxide; Embolization, Therapeutic; Humans; Intracranial Arteriovenous Malfo

2014
Is genistein neuroprotective in traumatic brain injury?
    Physiology & behavior, 2015, Dec-01, Volume: 152, Issue:Pt A

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Capillary Permeability; Dimethyl S

2015
Transarterial embolization of intracranial dural arteriovenous fistulas with direct cortical venous drainage using ethylene vinyl alcohol copolymer (Onyx).
    Klinische Neuroradiologie, 2009, Volume: 19, Issue:2

    Topics: Aged; Brain Edema; Central Nervous System Vascular Malformations; Cerebral Angiography; Cerebral Art

2009
Evaluation of the toxicity of onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model: an experimental research.
    Neuroradiology, 2010, Volume: 52, Issue:2

    Topics: Animals; Brain; Brain Edema; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enbucrilate; Lipi

2010
Seizures after Onyx embolization for the treatment of cerebral arteriovenous malformation.
    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2011, Volume: 17, Issue:3

    Topics: Adult; Brain Edema; Dimethyl Sulfoxide; Embolization, Therapeutic; Epilepsy; Female; Humans; Intracr

2011
Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia.
    Annals of neurology, 2003, Volume: 54, Issue:3

    Topics: Animals; Antioxidants; Behavior, Animal; Brain; Brain Edema; Dimethyl Sulfoxide; Disease Models, Ani

2003
Effect of dimethyl sulfoxide on blood-brain barrier integrity following middle cerebral artery occlusion in the rat.
    Acta neurochirurgica. Supplement, 2006, Volume: 96

    Topics: Animals; Blood-Brain Barrier; Brain Edema; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Inf

2006
The effect of dimethyl sulfoxide on gray matter injury in experimental spinal cord trauma.
    Surgical neurology, 1980, Volume: 13, Issue:4

    Topics: Animals; Brain Edema; Culture Techniques; Dimethyl Sulfoxide; Dogs; Electron Transport Complex IV; F

1980
Dimethyl sulfoxide in brain edema and intracranial pressure.
    Annals of the New York Academy of Sciences, 1983, Volume: 411

    Topics: Animals; Blood Pressure; Brain Edema; Dimethyl Sulfoxide; Intracranial Pressure; Pentobarbital; Rabb

1983
Acute dimethyl sulphoxide therapy in experimental brain oedema, effect of dose and concentration on brain water and electrolyte content.
    Acta neurochirurgica, 1983, Volume: 69, Issue:1-2

    Topics: Animals; Body Water; Brain; Brain Edema; Dimethyl Sulfoxide; Potassium; Rabbits; Sodium

1983
Cerebral edema in stroke: a common, often fatal complication.
    Postgraduate medicine, 1980, Volume: 68, Issue:1

    Topics: Adrenal Cortex Hormones; Antioxidants; Barbiturates; Brain Edema; Cerebral Infarction; Cerebrovascul

1980
Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices.
    Journal of neurochemistry, 1982, Volume: 38, Issue:2

    Topics: Animals; Brain Edema; Cerebral Cortex; Dimethyl Sulfoxide; Free Radicals; Lactates; Lactic Acid; Lip

1982
Effects of dimethyl sulfoxide on renal function in man.
    JAMA, 1980, Nov-07, Volume: 244, Issue:18

    Topics: Adolescent; Adult; Brain Edema; Dimethyl Sulfoxide; Female; Hemoglobinuria; Hemolysis; Humans; Kidne

1980
Acute dimethyl sulfoxide therapy in brain edema. Part 3: effect of a 3-hour infusion.
    Neurosurgery, 1982, Volume: 10, Issue:1

    Topics: Animals; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Dimethyl Sulfoxide; Female; Intra

1982
Acute dimethyl sulfoxide therapy in experimental brain edema: part 2. Effect of dose and concentration on intracranial pressure, blood pressure, and central venous pressure.
    Neurosurgery, 1982, Volume: 10, Issue:3

    Topics: 6-Aminonicotinamide; Animals; Blood Pressure; Brain Edema; Central Venous Pressure; Dimethyl Sulfoxi

1982
Comparison of the effects of DMSO and pentobarbitone on experimental brain oedema.
    Acta neurochirurgica, 1982, Volume: 60, Issue:3-4

    Topics: Animals; Blood Pressure; Brain Chemistry; Brain Edema; Central Venous Pressure; Dimethyl Sulfoxide;

1982
Acute dimethyl sulfoxide therapy in experimental brain edema: Part I. Effects on intracranial pressure, blood pressure, central venous pressure, and brain water and electrolyte content.
    Neurosurgery, 1981, Volume: 9, Issue:1

    Topics: Animals; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Central Venous Pressure; Dimethyl

1981
Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema.
    Neurosurgery, 1996, Volume: 38, Issue:1

    Topics: Acidosis, Lactic; Brain; Brain Edema; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug The

1996
High-sodium crystalloid solution for treatment of hypernatremia in a Vietnamese pot-bellied pig.
    Journal of the American Veterinary Medical Association, 1996, Oct-01, Volume: 209, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Dehydration; Dexamethasone; Dimethyl Sulfoxide; Drug

1996
Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases.
    Brain research, 1999, Oct-09, Volume: 844, Issue:1-2

    Topics: Acetophenones; Alanine; Amino Acids; Animals; Arachidonic Acids; Aspartic Acid; Brain Edema; Cerebra

1999
Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia.
    Journal of neurosurgery, 2000, Volume: 92, Issue:5

    Topics: Analysis of Variance; Animals; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Follow-

2000
Comparative effects of direct and indirect hydroxyl radical scavengers on traumatic brain oedema.
    Acta neurochirurgica. Supplementum, 1990, Volume: 51

    Topics: Animals; Body Water; Brain; Brain Edema; Brain Injuries; Cats; Deferoxamine; Dimethyl Sulfoxide; Fre

1990
Dimethyl sulfoxide in the management of patient with brain swelling and increased intracranial pressure after severe closed head injury.
    Neurochirurgia, 1990, Volume: 33, Issue:6

    Topics: Adolescent; Adult; Brain Concussion; Brain Edema; Child; Dimethyl Sulfoxide; Female; Glasgow Coma Sc

1990
An experimental study on the effects of DMSO and indomethacin on cerebral circulation and intracranial pressure.
    Brain research bulletin, 1986, Volume: 17, Issue:3

    Topics: Animals; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Indomethacin; Intracranial Pr

1986