dimethyl sulfoxide has been researched along with Brain Ischemia in 25 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously reported that the combined administration of mannitol and perfluorochemical blood substitutes is evidently effective in protecting the brain from cerebral ischemia." | 7.67 | [Experimental study of cerebral protective effect on cerebral ischemia of various antioxidants and other agents. With special reference to the combined treatment of mannitol, vitamin E, dexamethasone and perfluorochemicals]. ( Fujimoto, S; Mizoi, K; Oba, M; Suzuki, J, 1984) |
| "Diphenyleneiodonium (DPI) is an inhibitor of the free radical producing NAD(P)H-oxidase." | 5.34 | Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat. ( Gardner, H; Genius, J; Heiland, S; Horstmann, S; Nagel, S; Wagner, S, 2007) |
| "To explore the effect of extracellular signal-regulated kinase (ERK) inhibitor PD98059 on calpain-related proteins in the brain, and to understand the pathophysiological changes of calpain in cerebral ischemia/reperfusion injury (CIRI)." | 4.12 | [Effect of extracellular signal-regulated kinase inhibitor on calpain in rat cerebral cortex after cardiopulmonary resuscitation]. ( Dai, C; Wang, W; Yang, Y; Zhong, R, 2022) |
| "Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia." | 3.73 | Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. ( Bari, F; Domoki, F; Farkas, E; Luiten, PG; Mihály, A; Timmer, NM, 2005) |
| "We have previously reported that the combined administration of mannitol and perfluorochemical blood substitutes is evidently effective in protecting the brain from cerebral ischemia." | 3.67 | [Experimental study of cerebral protective effect on cerebral ischemia of various antioxidants and other agents. With special reference to the combined treatment of mannitol, vitamin E, dexamethasone and perfluorochemicals]. ( Fujimoto, S; Mizoi, K; Oba, M; Suzuki, J, 1984) |
| "A beneficial effect of dimethyl sulfoxide (DMSO) in the treatment of acute focal cerebral ischemia has not been proven." | 3.66 | Ineffectiveness of DMSO in treating experimental brain ischemia. ( Lesser, RP; Little, JR; Roski, RA; Selman, WR; Spetzler, RF; Zabramski, J, 1983) |
| "Aiming whether intraperitoneal administration of disulfiram (tetraethyl thiuram disulfide, DS) achieves potentially therapeutic drug concentrations in brain tissue, the behaviour of blood-brain barrier (BBB) to 14C-labelled DS in cerebral ischemia with and without simultaneous administration of dimethylsulfoxide (DMSO) was studied in Mongolian gerbils subjected to left common carotid artery (CCA) occlusion." | 3.66 | Distribution of disulfiram in brain after carotid ligation in gerbils. ( Anderson, G; Chvapil, M; Gunasekaran, S; Misiorowski, RL; Parker, D; Weinstein, P, 1983) |
| "However, the effects of ASD in chronic cerebral ischemia and its underlying mechanisms still remain unclear." | 1.62 | Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK-mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats. ( Cheng, CY; Huang, HC; Kao, ST; Lee, YC, 2021) |
| "Diphenyleneiodonium (DPI) is an inhibitor of the free radical producing NAD(P)H-oxidase." | 1.34 | Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat. ( Gardner, H; Genius, J; Heiland, S; Horstmann, S; Nagel, S; Wagner, S, 2007) |
| "A causal link between cerebral ischemia and WM damage has been demonstrated in rats; however, few attempts appear to have been made to test potential drugs for the alleviation of ischemia-related WM injury." | 1.33 | Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain. ( Annaházi, A; Bari, F; Farkas, E; Institóris, A; Luiten, PG; Mihály, A, 2005) |
| "Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest efficacy as a neuroprotectant." | 1.33 | Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model. ( Bardutzky, J; Bouley, J; Duong, TQ; Fisher, M; Meng, X; Ratan, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (36.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 10 (40.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, C | 1 |
| Wang, W | 1 |
| Yang, Y | 1 |
| Zhong, R | 1 |
| Cheng, CY | 1 |
| Huang, HC | 1 |
| Kao, ST | 1 |
| Lee, YC | 1 |
| Johnson, JN | 1 |
| Elhammady, M | 1 |
| Post, J | 1 |
| Pasol, J | 1 |
| Ebersole, K | 1 |
| Aziz-Sultan, MA | 1 |
| Farkas, E | 2 |
| Annaházi, A | 1 |
| Institóris, A | 1 |
| Mihály, A | 2 |
| Luiten, PG | 2 |
| Bari, F | 2 |
| Bardutzky, J | 1 |
| Meng, X | 1 |
| Bouley, J | 1 |
| Duong, TQ | 1 |
| Ratan, R | 1 |
| Fisher, M | 1 |
| Yin, XH | 1 |
| Zhang, QG | 1 |
| Miao, B | 1 |
| Zhang, GY | 1 |
| Timmer, NM | 1 |
| Domoki, F | 1 |
| Nagel, S | 1 |
| Genius, J | 1 |
| Heiland, S | 1 |
| Horstmann, S | 1 |
| Gardner, H | 1 |
| Wagner, S | 1 |
| Schaller, B | 1 |
| Filis, A | 1 |
| Buchfelder, M | 1 |
| Fujimoto, S | 1 |
| Mizoi, K | 1 |
| Oba, M | 1 |
| Suzuki, J | 1 |
| de la Torre, JC | 3 |
| Albin, MS | 1 |
| Bunegin, L | 1 |
| Helsel, P | 1 |
| Little, JR | 1 |
| Spetzler, RF | 1 |
| Roski, RA | 1 |
| Selman, WR | 1 |
| Zabramski, J | 1 |
| Lesser, RP | 1 |
| Gunasekaran, S | 1 |
| Weinstein, P | 1 |
| Anderson, G | 1 |
| Parker, D | 1 |
| Misiorowski, RL | 1 |
| Chvapil, M | 1 |
| Jiang, N | 1 |
| Chopp, M | 1 |
| Stein, D | 1 |
| Feit, H | 1 |
| Shimizu, S | 1 |
| Simon, RP | 1 |
| Graham, SH | 1 |
| Greiner, C | 1 |
| Schmidinger, A | 1 |
| Hülsmann, S | 1 |
| Moskopp, D | 1 |
| Wölfer, J | 1 |
| Köhling, R | 1 |
| Speckmann, EJ | 1 |
| Wassmann, H | 1 |
| Jahan, R | 1 |
| Murayama, Y | 1 |
| Gobin, YP | 1 |
| Duckwiler, GR | 1 |
| Vinters, HV | 1 |
| Viñuela, F | 1 |
| Hiraide, T | 1 |
| Katsura, K | 1 |
| Muramatsu, H | 1 |
| Asano, G | 1 |
| Katayama, Y | 1 |
| Nakamura, M | 1 |
| Nakakimura, K | 1 |
| Matsumoto, M | 1 |
| Sakabe, T | 1 |
| Brown, FD | 1 |
| Johns, LM | 1 |
| Mullan, JF | 1 |
| Birkle, DL | 1 |
| Kurian, P | 1 |
| Braquet, P | 1 |
| Bazan, NG | 1 |
| Gisvold, SE | 1 |
| Steen, PA | 1 |
2 reviews available for dimethyl sulfoxide and Brain Ischemia
| Article | Year |
|---|---|
Role of dimethyl sulfoxide in prostaglandin-thromboxane and platelet systems after cerebral ischemia.
Topics: Animals; Blood Platelets; Brain Ischemia; Calcium; Cell Membrane; Cerebrovascular Circulation; Dimet | 1983 |
Drug therapy in brain ischaemia.
Topics: Adrenal Cortex Hormones; Anesthetics; Animals; Anticonvulsants; Brain Ischemia; Calcium Channel Bloc | 1985 |
23 other studies available for dimethyl sulfoxide and Brain Ischemia
| Article | Year |
|---|---|
[Effect of extracellular signal-regulated kinase inhibitor on calpain in rat cerebral cortex after cardiopulmonary resuscitation].
Topics: Animals; Brain Ischemia; Calpain; Cardiopulmonary Resuscitation; Cerebral Cortex; Dimethyl Sulfoxide | 2022 |
Angelica sinensis extract promotes neuronal survival by enhancing p38 MAPK-mediated hippocampal neurogenesis and dendritic growth in the chronic phase of transient global cerebral ischemia in rats.
Topics: Angelica sinensis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cell Survival; | 2021 |
Optic pathway infarct after Onyx HD 500 aneurysm embolization: visual pathway ischemia from superior hypophyseal artery occlusion.
Topics: Brain Ischemia; Cerebral Arterial Diseases; Cerebral Infarction; Dimethyl Sulfoxide; Embolization, T | 2014 |
Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain.
Topics: Animals; Astrocytes; Brain Ischemia; Corpus Callosum; Diazoxide; Dimethyl Sulfoxide; Male; Rats; Rat | 2005 |
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model.
Topics: Animals; Behavior, Animal; Blood Pressure; Body Temperature; Brain; Brain Ischemia; Cerebrovascular | 2005 |
Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation.
Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Cell Death; Chromones; Dimethyl Sulfoxide; Diseas | 2005 |
Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion.
Topics: Animals; Brain Infarction; Brain Ischemia; Carotid Stenosis; CD11 Antigens; Cerebrovascular Circulat | 2005 |
Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Ischemia; Cerebral Infarction; Dimethyl Sulfoxide; Diseas | 2007 |
Trigeminocardiac reflex in embolization of intracranial dural arteriovenous fistula.
Topics: Brain Ischemia; Central Nervous System Vascular Malformations; Dimethyl Sulfoxide; Dura Mater; Embol | 2008 |
[Experimental study of cerebral protective effect on cerebral ischemia of various antioxidants and other agents. With special reference to the combined treatment of mannitol, vitamin E, dexamethasone and perfluorochemicals].
Topics: Animals; Blood Substitutes; Brain Ischemia; Cerebrovascular Circulation; Dexamethasone; Dimethyl Sul | 1984 |
Dimethyl sulfoxide and other therapies in experimental pressure-induced cerebral focal ischemia.
Topics: Animals; Behavior, Animal; Brain Ischemia; Dimethyl Sulfoxide; Dogs; Furosemide; Mannitol; Pressure | 1983 |
Ineffectiveness of DMSO in treating experimental brain ischemia.
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebrovascular Circulation; Dimethyl Sulfoxide; Male; Papio; | 1983 |
Distribution of disulfiram in brain after carotid ligation in gerbils.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Dimethyl Sulfoxide; Disulfiram; Gerbillinae; Ligat | 1983 |
Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Body Weight; Brain Ischemia; Carbon Dioxide; C | 1996 |
Dimethylsulfoxide (DMSO) treatment reduces infarction volume after permanent focal cerebral ischemia in rats.
Topics: Animals; Blood Gas Analysis; Blood Glucose; Blood Pressure; Brain Ischemia; Cerebral Infarction; Dim | 1997 |
Acute protective effect of nimodipine and dimethyl sulfoxide against hypoxic and ischemic damage in brain slices.
Topics: Animals; Brain; Brain Ischemia; Dimethyl Sulfoxide; Evoked Potentials; Guinea Pigs; Hypoxia-Ischemia | 2000 |
Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients.
Topics: Adult; Aged; Brain Ischemia; Cerebral Angiography; Dimethyl Sulfoxide; Diplopia; Embolization, Thera | 2001 |
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil.
Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Free Radical Scavengers; Gerbillinae; Hippocampus; Isch | 2001 |
Rapid tolerance to focal cerebral ischemia in rats is attenuated by adenosine A1 receptor antagonist.
Topics: Adaptation, Physiological; Animals; Brain Ischemia; Cerebral Infarction; Cryoprotective Agents; Dime | 2002 |
DMSO treatment in an experimental cerebral missile injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Dimethyl Sulfoxide; Haplorhini; Hypotension; Macaca mulatta | 1979 |
Synergic activity of combined prostacyclin: dimethyl sulfoxide in experimental brain ischemia.
Topics: Animals; Body Temperature; Brain Ischemia; Carbon Dioxide; Cats; Cerebrovascular Circulation; Dimeth | 1991 |
Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock.
Topics: Animals; Brain; Brain Ischemia; Chromatography; Diglycerides; Dimethyl Sulfoxide; Diterpenes; Electr | 1988 |
Hyperbaric oxygen or DMSO for cerebral ischemia.
Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Gerbillinae; Haplorhini; Hyperbaric Oxygenation | 1987 |