dimethyl sulfoxide has been researched along with Brain Edema in 26 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of a prospective study on the effects of dimethyl sulfoxide (DMSO) in patients with severe closed head injuries causing brain edema and increase in intracranial pressure (ICP) are presented." | 7.68 | Dimethyl sulfoxide in the management of patient with brain swelling and increased intracranial pressure after severe closed head injury. ( Akar, M; Baykut, L; Kulah, A, 1990) |
| "Albino rabbits with experimental brain edema produced by a combined cryogenic left hemisphere lesion and metabolic 6-aminonicotinamide lesion were administered a 3-hour intravenous infusion of dimethyl sulfoxide (DMSO)." | 7.66 | Acute dimethyl sulfoxide therapy in brain edema. Part 3: effect of a 3-hour infusion. ( Camp, PE; Del Bigio, M; James, HE; Marshall, LF; Tung, H; Werner, R, 1982) |
| "Albino rabbits with experimental brain edema produced by a combined cryogenic and metabolic 6-aminonicotinamide lesion were administered intravenous dimethyl sulfoxide in varying concentrations and doses in the following manner: Subgroup A (concentration response) received a 1." | 7.66 | Acute dimethyl sulfoxide therapy in experimental brain edema: part 2. Effect of dose and concentration on intracranial pressure, blood pressure, and central venous pressure. ( Camp, PE; James, HE; Tsuruda, J; Werner, R, 1982) |
| "Albino rabbits with experimental brain edema produced by a cryogenic lesion or by a cryogenic lesion combined with a metabolic blocker, 6-aminonicotinamide, were given 1 g of a 10% solution of dimethyl sulfoxide (DMSO) per kg by intravenous bolus." | 7.66 | Acute dimethyl sulfoxide therapy in experimental brain edema: Part I. Effects on intracranial pressure, blood pressure, central venous pressure, and brain water and electrolyte content. ( Camp, PE; James, HE; Werner, R, 1981) |
| "The safety and tolerability of a free radical scavenger with Na+ channel blocking activity (dimethyl sulfoxide (DMSO)) combined with a glycolytic intermediate and high energy substrate (fructose 1,6-disphosphate (FDP)) were assessed in a mostly elderly patient group presenting with acute and subacute ischemic stroke." | 5.10 | Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial. ( de la Torre, JC; Demir, S; Karaça, M; Kiliç, E; Yazici, B, 2002) |
| "The results of a prospective study on the effects of dimethyl sulfoxide (DMSO) in patients with severe closed head injuries causing brain edema and increase in intracranial pressure (ICP) are presented." | 3.68 | Dimethyl sulfoxide in the management of patient with brain swelling and increased intracranial pressure after severe closed head injury. ( Akar, M; Baykut, L; Kulah, A, 1990) |
| "To ascertain the clinical significance of dimethyl sulfoxide-induced pigmenturia, we evaluated renal function and indicators of systemic hemolysis in stable quadriplegic patients receiving the drug intravenously (IV) for spinal cord injury." | 3.66 | Effects of dimethyl sulfoxide on renal function in man. ( Bennett, WM; Muther, RS, 1980) |
| "Albino rabbits with experimental brain edema produced by a combined cryogenic left hemisphere lesion and metabolic 6-aminonicotinamide lesion were administered a 3-hour intravenous infusion of dimethyl sulfoxide (DMSO)." | 3.66 | Acute dimethyl sulfoxide therapy in brain edema. Part 3: effect of a 3-hour infusion. ( Camp, PE; Del Bigio, M; James, HE; Marshall, LF; Tung, H; Werner, R, 1982) |
| "Albino rabbits with experimental brain edema produced by a combined cryogenic and metabolic 6-aminonicotinamide lesion were administered intravenous dimethyl sulfoxide in varying concentrations and doses in the following manner: Subgroup A (concentration response) received a 1." | 3.66 | Acute dimethyl sulfoxide therapy in experimental brain edema: part 2. Effect of dose and concentration on intracranial pressure, blood pressure, and central venous pressure. ( Camp, PE; James, HE; Tsuruda, J; Werner, R, 1982) |
| "Albino rabbits with experimental brain edema produced by a cryogenic lesion or by a cryogenic lesion combined with a metabolic blocker, 6-aminonicotinamide, were given 1 g of a 10% solution of dimethyl sulfoxide (DMSO) per kg by intravenous bolus." | 3.66 | Acute dimethyl sulfoxide therapy in experimental brain edema: Part I. Effects on intracranial pressure, blood pressure, central venous pressure, and brain water and electrolyte content. ( Camp, PE; James, HE; Werner, R, 1981) |
| "Onyx embolization of cerebral arteriovenous malformations (AVM) has become increasingly common." | 1.37 | Seizures after Onyx embolization for the treatment of cerebral arteriovenous malformation. ( Bederson, JB; de Los Reyes, K; Doshi, A; Egorova, N; Frontera, JA; Panov, F; Patel, A, 2011) |
| "The toxic effects of onyx, its solvent dimethyl sulphoxide (DMSO), and n-butyl 2-cyanoacrylate (NBCA) were evaluated after infusion into the subaracnoid space of a rabbit model." | 1.36 | Evaluation of the toxicity of onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model: an experimental research. ( Atilla, P; Bakar, B; Hazer, BD; Kilic, K; Muftuoglu, SF; Oruckaptan, HH; Saatci, I, 2010) |
| "Taurine release was most affected, exhibiting a greater than 9-fold increase during the hyposmotic stimulus." | 1.30 | Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases. ( Estevez, AY; O'Regan, MH; Phillis, JW; Song, D, 1999) |
| "With indomethacin there was an initial decrease immediately following the drug, and at 60 minutes there was a rise in the insulted left hemisphere, more than the right one." | 1.27 | An experimental study on the effects of DMSO and indomethacin on cerebral circulation and intracranial pressure. ( Drummond, JC; James, HE; Moore, S; Tung, H, 1986) |
| "Thus, ischemic cerebral edema appears to contribute heavily to morbidity and mortality in stroke." | 1.26 | Cerebral edema in stroke: a common, often fatal complication. ( Easton, JD; Sherman, DG, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (42.31) | 18.7374 |
| 1990's | 5 (19.23) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 4 (15.38) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Mirabet, V | 1 |
| García, D | 1 |
| Roca, A | 1 |
| Quiroz, AR | 1 |
| Antón, J | 1 |
| Rodríguez-Cadarso, M | 1 |
| Ocete, D | 1 |
| Aranda, L | 1 |
| Melero, A | 1 |
| Guillot, AJ | 1 |
| Yagüe, N | 1 |
| Guillén, I | 1 |
| Botella, C | 1 |
| Trivelato, FP | 1 |
| Manzato, LB | 1 |
| Rezende, MT | 1 |
| Ulhôa, AC | 1 |
| Soltani, Z | 1 |
| Khaksari, M | 1 |
| Jafari, E | 1 |
| Iranpour, M | 1 |
| Shahrokhi, N | 1 |
| Rossitti, S | 1 |
| Bakar, B | 1 |
| Oruckaptan, HH | 1 |
| Hazer, BD | 1 |
| Saatci, I | 1 |
| Atilla, P | 1 |
| Kilic, K | 1 |
| Muftuoglu, SF | 1 |
| de Los Reyes, K | 1 |
| Patel, A | 1 |
| Doshi, A | 1 |
| Egorova, N | 1 |
| Panov, F | 1 |
| Bederson, JB | 1 |
| Frontera, JA | 1 |
| Ginsberg, MD | 1 |
| Becker, DA | 1 |
| Busto, R | 1 |
| Belayev, A | 1 |
| Zhang, Y | 1 |
| Khoutorova, L | 1 |
| Ley, JJ | 1 |
| Zhao, W | 1 |
| Belayev, L | 1 |
| Kleindienst, A | 1 |
| Dunbar, JG | 1 |
| Glisson, R | 1 |
| Okuno, K | 1 |
| Marmarou, A | 1 |
| Goodnough, J | 1 |
| Allen, N | 1 |
| Nesham, ME | 1 |
| Clendenon, NR | 1 |
| James, HE | 7 |
| Cornell, W | 1 |
| del Bigio, M | 2 |
| Werner, R | 6 |
| Tsuruda, J | 2 |
| Camp, PE | 5 |
| Rasmussen, G | 1 |
| Sherman, DG | 1 |
| Easton, JD | 1 |
| Chan, PH | 1 |
| Yurko, M | 1 |
| Fishman, RA | 1 |
| Muther, RS | 1 |
| Bennett, WM | 1 |
| Marshall, LF | 2 |
| Tung, H | 2 |
| Harbaugh, RD | 1 |
| McConnel, JR | 1 |
| Ong, CS | 1 |
| McAllister, JL | 1 |
| Gross, TG | 1 |
| Banks, P | 1 |
| Roussel, AJ | 1 |
| Mealey, RH | 1 |
| Estevez, AY | 1 |
| O'Regan, MH | 1 |
| Song, D | 1 |
| Phillis, JW | 1 |
| Kumon, Y | 1 |
| Kim, SC | 1 |
| Tompkins, P | 1 |
| Stevens, A | 1 |
| Sakaki, S | 1 |
| Loftus, CM | 1 |
| Karaça, M | 1 |
| Kiliç, E | 1 |
| Yazici, B | 1 |
| Demir, S | 1 |
| de la Torre, JC | 1 |
| Ikeda, Y | 1 |
| Long, DM | 1 |
| Kulah, A | 1 |
| Akar, M | 1 |
| Baykut, L | 1 |
| Drummond, JC | 1 |
| Moore, S | 1 |
1 trial available for dimethyl sulfoxide and Brain Edema
| Article | Year |
|---|---|
Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial.
Topics: Adult; Aged; Aging; Brain; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Drug Combin | 2002 |
25 other studies available for dimethyl sulfoxide and Brain Edema
| Article | Year |
|---|---|
Cranioplasty with Autologous Bone Flaps Cryopreserved with Dimethylsulphoxide: Does Tissue Processing Matter.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Autografts; Bone Resorption; Brain Edema; Brain Injuries, | 2021 |
Transitory brain stem edema following successfully transvenous embolization of a posterior fossa arteriovenous malformation.
Topics: Brain Edema; Dimethyl Sulfoxide; Embolization, Therapeutic; Humans; Intracranial Arteriovenous Malfo | 2014 |
Is genistein neuroprotective in traumatic brain injury?
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Brain Injuries; Capillary Permeability; Dimethyl S | 2015 |
Transarterial embolization of intracranial dural arteriovenous fistulas with direct cortical venous drainage using ethylene vinyl alcohol copolymer (Onyx).
Topics: Aged; Brain Edema; Central Nervous System Vascular Malformations; Cerebral Angiography; Cerebral Art | 2009 |
Evaluation of the toxicity of onyx compared with n-butyl 2-cyanoacrylate in the subarachnoid space of a rabbit model: an experimental research.
Topics: Animals; Brain; Brain Edema; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enbucrilate; Lipi | 2010 |
Seizures after Onyx embolization for the treatment of cerebral arteriovenous malformation.
Topics: Adult; Brain Edema; Dimethyl Sulfoxide; Embolization, Therapeutic; Epilepsy; Female; Humans; Intracr | 2011 |
Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Brain Edema; Dimethyl Sulfoxide; Disease Models, Ani | 2003 |
Effect of dimethyl sulfoxide on blood-brain barrier integrity following middle cerebral artery occlusion in the rat.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Inf | 2006 |
The effect of dimethyl sulfoxide on gray matter injury in experimental spinal cord trauma.
Topics: Animals; Brain Edema; Culture Techniques; Dimethyl Sulfoxide; Dogs; Electron Transport Complex IV; F | 1980 |
Dimethyl sulfoxide in brain edema and intracranial pressure.
Topics: Animals; Blood Pressure; Brain Edema; Dimethyl Sulfoxide; Intracranial Pressure; Pentobarbital; Rabb | 1983 |
Acute dimethyl sulphoxide therapy in experimental brain oedema, effect of dose and concentration on brain water and electrolyte content.
Topics: Animals; Body Water; Brain; Brain Edema; Dimethyl Sulfoxide; Potassium; Rabbits; Sodium | 1983 |
Cerebral edema in stroke: a common, often fatal complication.
Topics: Adrenal Cortex Hormones; Antioxidants; Barbiturates; Brain Edema; Cerebral Infarction; Cerebrovascul | 1980 |
Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices.
Topics: Animals; Brain Edema; Cerebral Cortex; Dimethyl Sulfoxide; Free Radicals; Lactates; Lactic Acid; Lip | 1982 |
Effects of dimethyl sulfoxide on renal function in man.
Topics: Adolescent; Adult; Brain Edema; Dimethyl Sulfoxide; Female; Hemoglobinuria; Hemolysis; Humans; Kidne | 1980 |
Acute dimethyl sulfoxide therapy in brain edema. Part 3: effect of a 3-hour infusion.
Topics: Animals; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Dimethyl Sulfoxide; Female; Intra | 1982 |
Acute dimethyl sulfoxide therapy in experimental brain edema: part 2. Effect of dose and concentration on intracranial pressure, blood pressure, and central venous pressure.
Topics: 6-Aminonicotinamide; Animals; Blood Pressure; Brain Edema; Central Venous Pressure; Dimethyl Sulfoxi | 1982 |
Comparison of the effects of DMSO and pentobarbitone on experimental brain oedema.
Topics: Animals; Blood Pressure; Brain Chemistry; Brain Edema; Central Venous Pressure; Dimethyl Sulfoxide; | 1982 |
Acute dimethyl sulfoxide therapy in experimental brain edema: Part I. Effects on intracranial pressure, blood pressure, central venous pressure, and brain water and electrolyte content.
Topics: Animals; Blood Pressure; Body Water; Brain Chemistry; Brain Edema; Central Venous Pressure; Dimethyl | 1981 |
Propylene glycol toxicity following continuous etomidate infusion for the control of refractory cerebral edema.
Topics: Acidosis, Lactic; Brain; Brain Edema; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Drug The | 1996 |
High-sodium crystalloid solution for treatment of hypernatremia in a Vietnamese pot-bellied pig.
Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Dehydration; Dexamethasone; Dimethyl Sulfoxide; Drug | 1996 |
Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases.
Topics: Acetophenones; Alanine; Amino Acids; Animals; Arachidonic Acids; Aspartic Acid; Brain Edema; Cerebra | 1999 |
Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia.
Topics: Analysis of Variance; Animals; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Follow- | 2000 |
Comparative effects of direct and indirect hydroxyl radical scavengers on traumatic brain oedema.
Topics: Animals; Body Water; Brain; Brain Edema; Brain Injuries; Cats; Deferoxamine; Dimethyl Sulfoxide; Fre | 1990 |
Dimethyl sulfoxide in the management of patient with brain swelling and increased intracranial pressure after severe closed head injury.
Topics: Adolescent; Adult; Brain Concussion; Brain Edema; Child; Dimethyl Sulfoxide; Female; Glasgow Coma Sc | 1990 |
An experimental study on the effects of DMSO and indomethacin on cerebral circulation and intracranial pressure.
Topics: Animals; Brain Edema; Cerebrovascular Circulation; Dimethyl Sulfoxide; Indomethacin; Intracranial Pr | 1986 |