dimethyl sulfoxide has been researched along with Bladder Pain Syndrome in 60 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The primary aim of this study was to compare the effect of bladder instillations using dimethyl sulfoxide (DMSO) with triamcinolone versus bupivacaine, triamcinolone, and heparin (BTH) in women with newly diagnosed interstitial cystitis/painful bladder syndrome." | 9.69 | A prospective, randomized trial comparing intravesical dimethyl sulfoxide (DMSO) to bupivacaine, triamcinolone, and heparin (BTH), for newly diagnosed interstitial cystitis/painful bladder syndrome (IC/PBS). ( Chang, C; Chill, HH; Gafni-Kane, A; Goldberg, RP; Moss, NP; Sand, PK, 2023) |
| "To evaluate the efficacy and safety of intravesical KRP-116D, 50% dimethyl sulfoxide solution compared with placebo, in interstitial cystitis/bladder pain syndrome patients." | 9.41 | Efficacy and safety of intravesical instillation of KRP-116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double-blind, placebo-controlled, clinical study. ( Akiyama, Y; Ameda, K; Homma, Y; Kageyama, S; Kajiwara, M; Kitta, T; Kobayashi, S; Kokura, K; Masumori, N; Mitsui, T; Muraki, O; Namima, T; Nanri, M; Niimi, A; Ohashi, Y; Ohinata, A; Okazoe, H; Otsuka, A; Sakamoto, S; Sekiguchi, Y; Shishido, T; Takei, M; Tomoe, H; Ueda, T; Uno, T; Watanabe, T; Yamaguchi, A; Yamanishi, T; Yoshimura, N, 2021) |
| "For decades, intravesical dimethyl sulfoxide (DMSO) cocktail therapy has been used for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS), but little is known about its long-term efficacy." | 7.85 | Long-term outcomes of intravesical dimethyl sulfoxide/heparin/hydrocortisone therapy for interstitial cystitis/bladder pain syndrome. ( Dwyer, P; Karmakar, D; Lim, YN; Murray, C; Rosamilia, A; Thomas, E, 2017) |
| "The purpose of this study was to investigate change in bladder capacity as a measure of response to combined intravesical dimethyl sulfoxide (DMSO) and triamcinolone instillations for the treatment of newly diagnosed bladder pain syndrome/interstitial cystitis (BPS/IC)." | 7.79 | Measuring the success of combined intravesical dimethyl sulfoxide and triamcinolone for treatment of bladder pain syndrome/interstitial cystitis. ( Botros, SM; Du, H; Gafni-Kane, A; Sand, PK; Sand, RI, 2013) |
| " At least one adverse event was reported in 14." | 6.84 | A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. ( Cervigni, M; Ciani, O; Frangione, V; Giammò, A; Ostardo, E; Pappagallo, GL; Porru, D; Sommariva, M; Tarricone, R; Tenaglia, R; Trevisan, S, 2017) |
| "The primary aim of this study was to compare the effect of bladder instillations using dimethyl sulfoxide (DMSO) with triamcinolone versus bupivacaine, triamcinolone, and heparin (BTH) in women with newly diagnosed interstitial cystitis/painful bladder syndrome." | 5.69 | A prospective, randomized trial comparing intravesical dimethyl sulfoxide (DMSO) to bupivacaine, triamcinolone, and heparin (BTH), for newly diagnosed interstitial cystitis/painful bladder syndrome (IC/PBS). ( Chang, C; Chill, HH; Gafni-Kane, A; Goldberg, RP; Moss, NP; Sand, PK, 2023) |
| "To evaluate the efficacy of intravesical KRP-116D, 50% dimethyl sulfoxide solution, in interstitial cystitis/bladder pain syndrome patients with Hunner lesions (Hunner-type interstitial cystitis), and to evaluate the correlations between efficacy variables and global response assessment to determine what constitutes a minimal clinically important change." | 5.51 | The O'Leary-Sant Interstitial Cystitis Symptom Index is a clinically useful indicator of treatment outcome in patients with interstitial cystitis/bladder pain syndrome with Hunner lesions: A post hoc analysis of the Japanese phase III trial of KRP-116D, 5 ( Nawata, S; Ohinata, A; Sasaki, M; Ueda, T; Uno, T; Yoshimura, N, 2022) |
| "To evaluate the efficacy and safety of intravesical KRP-116D, 50% dimethyl sulfoxide solution compared with placebo, in interstitial cystitis/bladder pain syndrome patients." | 5.41 | Efficacy and safety of intravesical instillation of KRP-116D (50% dimethyl sulfoxide solution) for interstitial cystitis/bladder pain syndrome in Japanese patients: A multicenter, randomized, double-blind, placebo-controlled, clinical study. ( Akiyama, Y; Ameda, K; Homma, Y; Kageyama, S; Kajiwara, M; Kitta, T; Kobayashi, S; Kokura, K; Masumori, N; Mitsui, T; Muraki, O; Namima, T; Nanri, M; Niimi, A; Ohashi, Y; Ohinata, A; Okazoe, H; Otsuka, A; Sakamoto, S; Sekiguchi, Y; Shishido, T; Takei, M; Tomoe, H; Ueda, T; Uno, T; Watanabe, T; Yamaguchi, A; Yamanishi, T; Yoshimura, N, 2021) |
| "For decades, intravesical dimethyl sulfoxide (DMSO) cocktail therapy has been used for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS), but little is known about its long-term efficacy." | 3.85 | Long-term outcomes of intravesical dimethyl sulfoxide/heparin/hydrocortisone therapy for interstitial cystitis/bladder pain syndrome. ( Dwyer, P; Karmakar, D; Lim, YN; Murray, C; Rosamilia, A; Thomas, E, 2017) |
| "The purpose of this study was to investigate change in bladder capacity as a measure of response to combined intravesical dimethyl sulfoxide (DMSO) and triamcinolone instillations for the treatment of newly diagnosed bladder pain syndrome/interstitial cystitis (BPS/IC)." | 3.79 | Measuring the success of combined intravesical dimethyl sulfoxide and triamcinolone for treatment of bladder pain syndrome/interstitial cystitis. ( Botros, SM; Du, H; Gafni-Kane, A; Sand, PK; Sand, RI, 2013) |
| " Carbon monoxide-oximetry may falsely identify sulfhemoglobin as methemoglobin; sulfhemoglobinemia should be considered in cases of methemoglobinemia refractory to methylene blue therapy." | 3.70 | Sulfhemoglobinemia after dermal application of DMSO. ( Burgess, JL; Hamner, AP; Robertson, WO, 1998) |
| " At least one adverse event was reported in 14." | 2.84 | A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. ( Cervigni, M; Ciani, O; Frangione, V; Giammò, A; Ostardo, E; Pappagallo, GL; Porru, D; Sommariva, M; Tarricone, R; Tenaglia, R; Trevisan, S, 2017) |
| "Interstitial cystitis (IC)/painful bladder syndrome (PBS) is a difficult disease to manage and creates critical limitations in patients' daily lives." | 2.78 | Maintenance of the response to dimethyl sulfoxide treatment using hyperbaric oxygen in interstitial cystitis/painful bladder syndrome: a prospective, randomized, comparative study. ( Gallego-Gomez, J; Gallego-Vilar, D; García-Fadrique, G; Povo-Martin, I; Salvador-Marin, M, 2013) |
| "Painful bladder syndrome/interstitial cystitis (PBS/IC) is an inflammatory bladder disease of unknown origin." | 2.74 | Evaluation of health-related quality of life in patients with painful bladder syndrome/interstitial cystitis and the impact of four treatments on it. ( Aaltomaa, S; Leppilahti, M; Paananen, I; Ruutu, M; Sairanen, J; Taari, K; Tammela, TL, 2009) |
| "Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic symptom complex that may cause bothersome storage symptoms and pain or discomfort of the bladder, adversely affecting a patient's quality of life." | 2.58 | Advances in intravesical therapy for bladder pain syndrome (BPS)/interstitial cystitis (IC). ( Chuang, YC; Hsu, YC; Meng, E, 2018) |
| "Interstitial cystitis/painful bladder syndrome is a chronic condition that causes debilitating bladder pain which can be associated with urgency, frequency and nocturia." | 2.48 | Interstitial cystitis: diagnosis and management. ( Cardozo, L; Srikrishna, S; Vij, M, 2012) |
| "Bladder pain syndrome/interstitial cystitis (BPS/IC) is a disabling chronic condition that affects up to 7% of women in the USA." | 2.48 | Intravesical treatments of bladder pain syndrome/interstitial cystitis. ( Neuhaus, J; Schwalenberg, T, 2012) |
| "The evaluation was measured by Interstitial Cystitis Symptomatic Index (ICSI) and Interstitial Cystitis Problem Index (ICPI) both validated evaluation instruments, 82% of the patients had a significative improvement of symptomatology and quality of live The ICSI pre and post treatment was of 17." | 2.47 | [Experience in the treatment of interstitial cystitis: review of 17 cases]. ( Flores-Carreras, O; González-Ruiz, MI; Martínez-Espinoza, CJ, 2011) |
| "The typical patient with interstitial cystitis (IC) is symptomatic for many years and consults multiple physicians before IC is diagnosed." | 2.44 | [Interstitial cystitis in 2008]. ( Mouracade, P; Saussine, C, 2008) |
| "The so-called interstitial cystitis is a chronic pain syndrome rather than a purely end organ disease of the urinary bladder." | 2.44 | [The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 2: Treatment]. ( Binder, I; Rossbach, G; van Ophoven, A, 2008) |
| "Symptoms of interstitial cystitis can usually be successfully managed with heparinoid therapy to theoretically alter bladder urothelial abnormalities, and with oral medications to inhibit neural upregulation or to control mast cell dysfunction." | 2.44 | Rational approaches to the treatment of patients with interstitial cystitis. ( Evans, RJ; Moldwin, RM; Rosenberg, MT; Stanford, EJ, 2007) |
| "Interstitial cystitis/painful bladder syndrome is a chronic disease characterized by pain, frequency, urgency, and nocturia and diagnosed primarily in women." | 2.44 | Interstitial cystitis/painful bladder syndrome. ( Warren, JW, 2007) |
| "Resiniferatoxin was not associated with sustained differences in the review outcomes reported but pain during instillation and withdrawal from treatment was significantly more common." | 2.44 | Intravesical treatments for painful bladder syndrome/ interstitial cystitis. ( Dawson, TE; Jamison, J, 2007) |
| "Interstitial cystitis is a relatively common disorder that can be treated successfully in the majority of cases." | 2.42 | Current strategies for managing interstitial cystitis. ( Parsons, CL, 2004) |
| "Interstitial cystitis is a chronic, severely debilitating disease of the urinary bladder." | 2.41 | Interstitial cystitis: urgency and frequency syndrome. ( Metts, JF, 2001) |
| "The therapeutic effects of DMSO on interstitial cystitis are presumed to involve anti-inflammatory and analgesic effects." | 1.91 | Dimethyl Sulfoxide Enhances Acetylcholine-Induced Contractions in Rat Urinary Bladder Smooth Muscle by Inhibiting Acetylcholinesterase Activities. ( Abe, Y; Fujii, A; Ikegami, Y; Iwata, N; Matsuoka, Y; Obara, K; Tanaka, Y; Yoshioka, K, 2023) |
| "The management of bladder pain syndrome (BPS) in our center is standardized although there is no real consensus and recommendations." | 1.72 | [Bladder pain syndrome: Long-term results (15 years) of a single-center experience]. ( De Cian, M; Saussine, C; Tricard, T, 2022) |
| "Dimethyl sulfoxide (DMSO) is a highly reactive by-product of paper production in the form of an odorless, colorless liquid that has been studied since the 1860s." | 1.62 | DMSO: an aid to combat pain and pruritus. ( Anzelc, M; Burkhart, CG, 2021) |
| "Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic and debilitating condition." | 1.46 | Which bladder instillations are more effective? DMSO vs. bupivacaine/heparin/triamcinolone: a retrospective study. ( Botros, C; Botros, S; Gafni-Kane, A; Goldberg, R; Iyer, S; Lotsof, E; Sand, P; Tomezsko, J; Tran, A; Zhou, Y, 2017) |
| "DMSO is used as a treatment for interstitial cystitis and this study examined the effects of luminal DMSO treatment on bladder function and histology." | 1.40 | Luminal DMSO: effects on detrusor and urothelial/lamina propria function. ( Chess-Williams, R; McDermott, C; Smith, KJ, 2014) |
| "Interstitial cystitis/painful bladder syndrome affects more than 1 million persons in the United States, but the cause remains unknown." | 1.37 | Interstitial cystitis/painful bladder syndrome. ( Bhambore, N; French, LM, 2011) |
| "To provide an overview of interstitial cystitis (IC), including the presentation of patients with the disorder, and to explore diagnostic and treatment options." | 1.35 | Evolving trends in the successful management of interstitial cystitis/painful bladder syndrome. ( Dell, J; Mishell, DR; Sand, PK, 2008) |
| "Over a 4-year period, 12 patients with interstitial cystitis who had one course of intravesical dimethyl sulphoxide (DMSO) therapy for interstitial cystitis were studied." | 1.32 | Pregnancy outcomes following the diagnosis of interstitial cystitis. ( Onwude, JL; Selo-Ojeme, DO, 2003) |
| "It is important to always include interstitial cystitis in the differential diagnosis of urinary symptoms associated with pelvic pain." | 1.31 | Interstitial cystitis coexisting with vulvar vestibulitis in a 4-year-old girl. ( Onwude, JL; Paranjothy, S; Selo-Ojeme, DO, 2002) |
| "Interstitial cystitis is a disease characterized by pain occurring as the urinary bladder is gradually filling up." | 1.31 | [Interstitial cystitis]. ( Amarenco, G; Haab, F; Hermieu, JF, 2002) |
| "Interstitial cystitis is a particular type of cystitis with clear urine, essentially observed in women." | 1.30 | [Interstitial cystitis]. ( Lépinard, V, 1998) |
| "Interstitial cystitis is the most therapeutically frustrating condition of the urinary tract." | 1.29 | Treatment of refractory interstitial cystitis. ( Emerson, L; Morales, A; Nickel, JC, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (10.00) | 18.2507 |
| 2000's | 29 (48.33) | 29.6817 |
| 2010's | 18 (30.00) | 24.3611 |
| 2020's | 7 (11.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yoshimura, N | 3 |
| Uno, T | 2 |
| Sasaki, M | 1 |
| Ohinata, A | 2 |
| Nawata, S | 1 |
| Ueda, T | 2 |
| Anzelc, M | 1 |
| Burkhart, CG | 1 |
| Abelleyra Lastoria, DA | 1 |
| Raison, N | 1 |
| Aydin, A | 1 |
| Khan, S | 1 |
| Dasgupta, P | 1 |
| Ahmed, K | 1 |
| De Cian, M | 1 |
| Tricard, T | 2 |
| Saussine, C | 3 |
| Obara, K | 1 |
| Matsuoka, Y | 1 |
| Iwata, N | 1 |
| Abe, Y | 1 |
| Ikegami, Y | 1 |
| Fujii, A | 1 |
| Yoshioka, K | 1 |
| Tanaka, Y | 1 |
| Moss, NP | 1 |
| Chill, HH | 1 |
| Sand, PK | 3 |
| Chang, C | 1 |
| Goldberg, RP | 1 |
| Gafni-Kane, A | 3 |
| Kollerup Madsen, B | 2 |
| Hilscher, M | 2 |
| Zetner, D | 2 |
| Rosenberg, J | 2 |
| Homma, Y | 1 |
| Tomoe, H | 1 |
| Otsuka, A | 1 |
| Kitta, T | 1 |
| Masumori, N | 1 |
| Akiyama, Y | 1 |
| Niimi, A | 1 |
| Mitsui, T | 1 |
| Nanri, M | 1 |
| Namima, T | 1 |
| Takei, M | 1 |
| Yamaguchi, A | 1 |
| Sekiguchi, Y | 1 |
| Kajiwara, M | 1 |
| Kobayashi, S | 1 |
| Ameda, K | 1 |
| Ohashi, Y | 1 |
| Sakamoto, S | 1 |
| Muraki, O | 1 |
| Shishido, T | 1 |
| Kageyama, S | 1 |
| Kokura, K | 1 |
| Okazoe, H | 1 |
| Yamanishi, T | 1 |
| Watanabe, T | 1 |
| Meng, E | 1 |
| Hsu, YC | 1 |
| Chuang, YC | 1 |
| Gaullier, M | 1 |
| Mouracade, P | 2 |
| Wein, AJ | 1 |
| Almeida, FG | 1 |
| Batezini, NSDS | 1 |
| Simões, RS | 1 |
| Bernardo, WM | 1 |
| Gallego-Vilar, D | 1 |
| García-Fadrique, G | 1 |
| Povo-Martin, I | 1 |
| Salvador-Marin, M | 1 |
| Gallego-Gomez, J | 1 |
| Smith, KJ | 1 |
| Chess-Williams, R | 1 |
| McDermott, C | 1 |
| Cervigni, M | 1 |
| Sommariva, M | 1 |
| Tenaglia, R | 1 |
| Porru, D | 1 |
| Ostardo, E | 1 |
| Giammò, A | 1 |
| Trevisan, S | 1 |
| Frangione, V | 1 |
| Ciani, O | 1 |
| Tarricone, R | 1 |
| Pappagallo, GL | 1 |
| Lim, YN | 1 |
| Dwyer, P | 1 |
| Murray, C | 1 |
| Karmakar, D | 1 |
| Rosamilia, A | 1 |
| Thomas, E | 1 |
| Iyer, S | 1 |
| Lotsof, E | 1 |
| Zhou, Y | 1 |
| Tran, A | 1 |
| Botros, C | 1 |
| Sand, P | 1 |
| Goldberg, R | 1 |
| Tomezsko, J | 1 |
| Botros, S | 1 |
| Rawls, WF | 1 |
| Cox, L | 1 |
| Rovner, ES | 1 |
| Binder, I | 1 |
| Rossbach, G | 1 |
| van Ophoven, A | 1 |
| Mishell, DR | 1 |
| Dell, J | 1 |
| Sairanen, J | 1 |
| Leppilahti, M | 1 |
| Tammela, TL | 1 |
| Paananen, I | 1 |
| Aaltomaa, S | 1 |
| Taari, K | 1 |
| Ruutu, M | 1 |
| Sea, J | 1 |
| Teichman, JM | 1 |
| Tyagi, P | 1 |
| Hsieh, VC | 1 |
| Kaufman, J | 1 |
| Chancellor, MB | 1 |
| French, LM | 1 |
| Bhambore, N | 1 |
| Flores-Carreras, O | 1 |
| Martínez-Espinoza, CJ | 1 |
| González-Ruiz, MI | 1 |
| Vij, M | 1 |
| Srikrishna, S | 1 |
| Cardozo, L | 1 |
| Hung, MJ | 1 |
| Chen, YT | 1 |
| Shen, PS | 1 |
| Hsu, ST | 1 |
| Chen, GD | 1 |
| Ho, ES | 1 |
| Botros, SM | 1 |
| Du, H | 1 |
| Sand, RI | 1 |
| Stav, K | 1 |
| Beberashvili, I | 1 |
| Lindner, A | 1 |
| Leibovici, D | 1 |
| Neuhaus, J | 1 |
| Schwalenberg, T | 1 |
| Sun, Y | 1 |
| Chai, TC | 1 |
| Selo-Ojeme, DO | 2 |
| Paranjothy, S | 1 |
| Onwude, JL | 2 |
| Parsons, CL | 3 |
| Dell, JR | 2 |
| Tincello, DG | 1 |
| Walker, AC | 1 |
| Rössberger, J | 1 |
| Fall, M | 2 |
| Peeker, R | 2 |
| Butrick, CW | 1 |
| Panzera, AK | 1 |
| Moldwin, RM | 2 |
| Evans, RJ | 1 |
| Stanford, EJ | 1 |
| Rosenberg, MT | 1 |
| Warren, JW | 1 |
| Dawson, TE | 1 |
| Jamison, J | 1 |
| Hill, JR | 1 |
| Isom-Batz, G | 1 |
| Panagopoulos, G | 1 |
| Zakariasen, K | 1 |
| Kavaler, E | 1 |
| Stout, L | 1 |
| Gerspach, JM | 1 |
| Levy, SM | 1 |
| Yun, SK | 1 |
| Lad, PM | 1 |
| Leach, GE | 1 |
| Zimmern, PE | 1 |
| Ger, DS | 1 |
| Parkin, J | 1 |
| Shea, C | 1 |
| Sant, GR | 2 |
| Burgess, JL | 1 |
| Hamner, AP | 1 |
| Robertson, WO | 1 |
| Lépinard, V | 1 |
| Morales, A | 1 |
| Emerson, L | 1 |
| Nickel, JC | 1 |
| Haghsheno, MA | 1 |
| Holmäng, S | 1 |
| von Heyden, B | 1 |
| Schmid, HP | 1 |
| Forrest, JB | 1 |
| Vo, Q | 1 |
| Rowley, S | 1 |
| Baer, R | 1 |
| Metts, JF | 1 |
| Yamada, T | 1 |
| Murayama, T | 1 |
| Haab, F | 1 |
| Hermieu, JF | 1 |
| Amarenco, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravesical Injection of Dextrose to Improve Lower Urinary Tract Symptoms Caused by Chronic Cystitis[NCT04821882] | 29 participants (Actual) | Interventional | 2019-05-01 | Completed | |||
| An Investigative, Randomized, Open, Pilot Study to Assess the Tolerability, Safety and Efficacy of HAcid/CS Intravesical Instillations Plus an Oral Combination of Curcumin,Quercetin, HA and CS in Prevention of Radiation Induced Cystitis[NCT03493997] | Phase 2 | 100 participants (Actual) | Interventional | 2017-04-04 | Completed | ||
| A Randomized Trial of Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain Syndrome[NCT04401176] | Phase 2 | 58 participants (Actual) | Interventional | 2020-09-15 | Completed | ||
| Intravesical Botulinum Toxin A Injection in Treatment of Interstitial Cystitis Refractory to Conventional Treatment - A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial[NCT01969773] | Phase 2 | 60 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Randomized Controlled Trial Comparing Two Different Bladder Instillation Treatments for Interstitial Cystitis/Bladder Pain Syndrome[NCT03463915] | Phase 3 | 90 participants (Actual) | Interventional | 2019-01-25 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total scores range: 0-36 (0= no symptoms to 36= the most severe symptoms) (NCT03463915)
Timeframe: Assessed at baseline, 3 and 6 weeks; change from baseline to week 6 reported
| Intervention | scores on a scale (Mean) |
|---|---|
| Bladder Instillation WITH Triamcinolone Acetonide | -6.7 |
| Bladder Instillation WITHOUT Triamcinolone Acetonide | -5.8 |
VAS is measured on marking on a 10-centimeter (cm) ruler (measured in cm, 0= no pain and 10= most severe pain possible) (NCT03463915)
Timeframe: Assessed at baseline, 3 and 6 weeks; change from baseline to week 6 reported
| Intervention | score on a scale (Mean) |
|---|---|
| Bladder Instillation WITH Triamcinolone Acetonide | -1.9 |
| Bladder Instillation WITHOUT Triamcinolone Acetonide | -1.8 |
Adverse events will only be those determined to be related to the study drug (NCT03463915)
Timeframe: End of study (6 weeks)
| Intervention | Participants (Count of Participants) |
|---|---|
| Bladder Instillation WITH Triamcinolone Acetonide | 1 |
| Bladder Instillation WITHOUT Triamcinolone Acetonide | 5 |
Total scores range: 0-100 (higher scores on the symptom-severity scale suggestive of greater severity of symptoms and higher scores on the quality-of-life scale suggestive of better quality of life) (NCT03463915)
Timeframe: Assessed at baseline, 3 and 6 weeks; change from baseline to week 6 reported
| Intervention | score on a scale (Mean) |
|---|---|
| Bladder Instillation WITH Triamcinolone Acetonide | -24.2 |
| Bladder Instillation WITHOUT Triamcinolone Acetonide | -18.8 |
20 question self-administered questionnaire on the presence and absence of pelvic floor symptoms. Score ranges from 0 (least distress) to 300 (most distress). (NCT03463915)
Timeframe: Assessed at baseline, 3 and 6 weeks; change from baseline to week 6 reported
| Intervention | score on a scale (Mean) |
|---|---|
| Bladder Instillation WITH Triamcinolone Acetonide | -5.3 |
| Bladder Instillation WITHOUT Triamcinolone Acetonide | -6.4 |
Total scores range: 0-35 (0= no symptoms to 35= the most severe symptoms) (NCT03463915)
Timeframe: Assessed at baseline, 3 and 6 weeks; change from baseline to week 6 reported
| Intervention | score on a scale (Mean) |
|---|---|
| Bladder Instillation WITH Triamcinolone Acetonide | -5.3 |
| Bladder Instillation WITHOUT Triamcinolone Acetonide | -2.7 |
Measures sexual function in women with pelvic floor disorders. Queries about arousal, orgasm, partner-related issues, sexual quality, and desire. The tool also takes into account those who are not sexually active. The questionnaire was used in the study solely to determine if patients had improved dyspareunia (as a categorical variable). (NCT03463915)
Timeframe: Assessed at baseline, 3 and 6 weeks; change from baseline to week 6 reported
| Intervention | participants (Number) |
|---|---|
| Bladder Instillation WITH Triamcinolone Acetonide | 4 |
| Bladder Instillation WITHOUT Triamcinolone Acetonide | 4 |
23 reviews available for dimethyl sulfoxide and Bladder Pain Syndrome
| Article | Year |
|---|---|
Comparing surgical interventions for interstitial cystitis: A systematic review.
Topics: Botulinum Toxins, Type A; Cystitis, Interstitial; Dimethyl Sulfoxide; Humans; Hyaluronic Acid; Triam | 2022 |
Adverse reactions of dimethyl sulfoxide in humans: a systematic review.
Topics: Cryopreservation; Cystitis, Interstitial; Dimethyl Sulfoxide; Humans; Stem Cells | 2018 |
Adverse reactions of dimethyl sulfoxide in humans: a systematic review.
Topics: Cryopreservation; Cystitis, Interstitial; Dimethyl Sulfoxide; Humans; Stem Cells | 2018 |
Adverse reactions of dimethyl sulfoxide in humans: a systematic review.
Topics: Cryopreservation; Cystitis, Interstitial; Dimethyl Sulfoxide; Humans; Stem Cells | 2018 |
Adverse reactions of dimethyl sulfoxide in humans: a systematic review.
Topics: Cryopreservation; Cystitis, Interstitial; Dimethyl Sulfoxide; Humans; Stem Cells | 2018 |
Advances in intravesical therapy for bladder pain syndrome (BPS)/interstitial cystitis (IC).
Topics: Acetylcholine Release Inhibitors; Administration, Intravesical; Anesthetics, Local; Anticoagulants; | 2018 |
Interstitial cystitis - intravesical treatment.
Topics: Administration, Intravesical; Botulinum Toxins, Type A; Brazil; Chondroitin Sulfates; Clinical Decis | 2019 |
Dimethyl sulfoxide (DMSO) as intravesical therapy for interstitial cystitis/bladder pain syndrome: A review.
Topics: Administration, Intravesical; Analgesics; Cystitis, Interstitial; Dimethyl Sulfoxide; Humans; Pain; | 2017 |
[Interstitial cystitis in 2008].
Topics: Adolescent; Adult; Algorithms; Anti-Ulcer Agents; Biopsy; Cimetidine; Cyclosporins; Cystectomy; Cyst | 2008 |
[The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 2: Treatment].
Topics: Administration, Intravesical; Administration, Oral; Amitriptyline; Arginine; Botulinum Toxins, Type | 2008 |
Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment.
Topics: Administration, Intravesical; Amitriptyline; Child; Cimetidine; Cystitis, Interstitial; Diet Therapy | 2009 |
[Experience in the treatment of interstitial cystitis: review of 17 cases].
Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Cystitis, Interstitial; Dexamethasone; | 2011 |
Interstitial cystitis: diagnosis and management.
Topics: Administration, Intravesical; Analgesics; Antidepressive Agents, Tricyclic; Botulinum Toxins; Cystit | 2012 |
Intravesical treatments of bladder pain syndrome/interstitial cystitis.
Topics: Administration, Intravesical; Botulinum Toxins, Type A; Cystitis, Interstitial; Dimethyl Sulfoxide; | 2012 |
Methylsulfonylmethane (MSM). Monograph.
Topics: Analgesics; Animals; Autoimmune Diseases; Chemoprevention; Cystitis, Interstitial; Dimethyl Sulfoxid | 2003 |
Current strategies for managing interstitial cystitis.
Topics: Administration, Intravesical; Administration, Oral; Cystitis, Interstitial; Dimethyl Sulfoxide; Hepa | 2004 |
Multimodal therapy for interstitial cystitis.
Topics: Administration, Intravesical; Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agen | 2004 |
Advances in the treatment of interstitial cystitis.
Topics: Administration, Intravesical; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents | 2006 |
Multimodal therapy for painful bladder syndrome/interstitial cystitis.
Topics: Administration, Intravesical; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cli | 2006 |
Interstitial cystitis/painful bladder syndrome.
Topics: Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Antidepressiv | 2007 |
Rational approaches to the treatment of patients with interstitial cystitis.
Topics: Administration, Intravesical; Administration, Oral; Amitriptyline; Anesthetics, Local; Combined Moda | 2007 |
Interstitial cystitis/painful bladder syndrome.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; C | 2007 |
Intravesical treatments for painful bladder syndrome/ interstitial cystitis.
Topics: Administration, Intravesical; BCG Vaccine; Cystitis, Interstitial; Dimethyl Sulfoxide; Diterpenes; H | 2007 |
[Intravesical therapy of interstitial cystitis].
Topics: Administration, Intravesical; Cystitis, Interstitial; Dimethyl Sulfoxide; Heparin; Humans; Pentosan | 2000 |
Interstitial cystitis: urgency and frequency syndrome.
Topics: Administration, Intravesical; Administration, Oral; Analgesics, Non-Narcotic; Anti-Inflammatory Agen | 2001 |
Interstitial cystitis: a pathophysiology and treatment update.
Topics: Administration, Intravesical; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive | 2002 |
8 trials available for dimethyl sulfoxide and Bladder Pain Syndrome
29 other studies available for dimethyl sulfoxide and Bladder Pain Syndrome
| Article | Year |
|---|---|
DMSO: an aid to combat pain and pruritus.
Topics: Animals; Chronic Pain; Cystitis, Interstitial; Dermatologic Agents; Dimethyl Sulfoxide; Humans; Off- | 2021 |
[Bladder pain syndrome: Long-term results (15 years) of a single-center experience].
Topics: Administration, Intravesical; Cystitis, Interstitial; Dimethyl Sulfoxide; Female; Humans; Male; Pain | 2022 |
Dimethyl Sulfoxide Enhances Acetylcholine-Induced Contractions in Rat Urinary Bladder Smooth Muscle by Inhibiting Acetylcholinesterase Activities.
Topics: Acetone; Acetylcholine; Acetylcholinesterase; Animals; Cystitis, Interstitial; Dimethyl Sulfoxide; H | 2023 |
[The dimethyl sulfoxide under general anesthesia: An alternative after failure without anesthesia in the painful bladder syndrome/interstitial cystitis?]
Topics: Administration, Intravesical; Adult; Anesthesia, General; Cryoprotective Agents; Cystitis, Interstit | 2018 |
Re: Long-Term Outcomes of Intravesical Dimethyl Sulfoxide/Heparin/Hydrocortisone Therapy for Interstitial Cystitis/Bladder Pain Syndrome.
Topics: Cystitis, Interstitial; Dimethyl Sulfoxide; Heparin; Humans; Hydrocortisone; Pain | 2018 |
Luminal DMSO: effects on detrusor and urothelial/lamina propria function.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Cystitis, Interstitial; Dimethyl Sulfoxide; Humans; | 2014 |
Long-term outcomes of intravesical dimethyl sulfoxide/heparin/hydrocortisone therapy for interstitial cystitis/bladder pain syndrome.
Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anticoagulan | 2017 |
Which bladder instillations are more effective? DMSO vs. bupivacaine/heparin/triamcinolone: a retrospective study.
Topics: Administration, Intravesical; Adult; Anti-Inflammatory Agents; Bupivacaine; Cystitis, Interstitial; | 2017 |
Evolving trends in the successful management of interstitial cystitis/painful bladder syndrome.
Topics: Administration, Intravesical; Administration, Oral; Analgesics; Combined Modality Therapy; Cystitis, | 2008 |
Instillation of liposomes vs dimethyl sulphoxide or pentosan polysulphate for reducing bladder hyperactivity.
Topics: Administration, Intravesical; Animals; Cystitis, Interstitial; Dimethyl Sulfoxide; Drug Carriers; Fe | 2009 |
Interstitial cystitis/painful bladder syndrome.
Topics: Administration, Intravesical; Administration, Oral; Antidepressive Agents, Tricyclic; Clinical Trial | 2011 |
Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail.
Topics: Administration, Intravesical; Adult; Cystitis, Interstitial; Dimethyl Sulfoxide; Female; Free Radica | 2012 |
Measuring the success of combined intravesical dimethyl sulfoxide and triamcinolone for treatment of bladder pain syndrome/interstitial cystitis.
Topics: Administration, Intravesical; Adult; Anti-Inflammatory Agents; Cystitis, Interstitial; Dimethyl Sulf | 2013 |
Predictors of response to intravesical dimethyl-sulfoxide cocktail in patients with interstitial cystitis.
Topics: Administration, Intravesical; Adult; Cystitis, Interstitial; Dimethyl Sulfoxide; Drug Combinations; | 2012 |
Effects of dimethyl sulphoxide and heparin on stretch-activated ATP release by bladder urothelial cells from patients with interstitial cystitis.
Topics: Adenosine Triphosphate; Cystitis, Interstitial; Dimethyl Sulfoxide; Dose-Response Relationship, Drug | 2002 |
Interstitial cystitis coexisting with vulvar vestibulitis in a 4-year-old girl.
Topics: Analgesics, Non-Narcotic; Child, Preschool; Comorbidity; Cystitis, Interstitial; Dimethyl Sulfoxide; | 2002 |
Pregnancy outcomes following the diagnosis of interstitial cystitis.
Topics: Adult; Cystitis, Interstitial; Dimethyl Sulfoxide; Female; Fertilization; Humans; Pain; Pregnancy; P | 2003 |
Interstitial cystitis in the UK: results of a questionnaire survey of members of the Interstitial Cystitis Support Group.
Topics: Anticonvulsants; Cimetidine; Cystitis, Interstitial; Depression; Dimethyl Sulfoxide; Female; Histami | 2005 |
Critical appraisal of dimethyl sulfoxide treatment for interstitial cystitis: discomfort, side-effects and treatment outcome.
Topics: Administration, Intravesical; Cystitis, Interstitial; Dimethyl Sulfoxide; Drug Administration Schedu | 2005 |
Patient perceived outcomes of treatments used for interstitial cystitis.
Topics: Administration, Intravesical; Adult; Combined Modality Therapy; Cystitis, Interstitial; Dilatation; | 2008 |
Interstitial cystitis: what it is and how to treat it.
Topics: Administration, Intravesical; Administration, Topical; Adult; Anti-Inflammatory Agents; Anti-Inflamm | 1997 |
Intravesical dimethyl sulfoxide (DMSO) for interstitial cystitis--a practical approach.
Topics: Administration, Intravesical; Administration, Topical; Anti-Inflammatory Agents; Cystitis, Interstit | 1997 |
Sulfhemoglobinemia after dermal application of DMSO.
Topics: Administration, Topical; Adult; Anti-Infective Agents, Urinary; Anti-Inflammatory Agents; Carbon Mon | 1998 |
[Interstitial cystitis].
Topics: Administration, Topical; Amitriptyline; Anti-Inflammatory Agents; Anticoagulants; Antidepressive Age | 1998 |
Treatment of refractory interstitial cystitis.
Topics: Adjuvants, Immunologic; Algorithms; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroida | 1996 |
Observations on the presentation, diagnosis, and treatment of interstitial cystitis in men.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Cystitis, Interstitial; Dimethyl Sulfoxide | 2001 |
Lens deposits associated with RIMSO-50 (dimethylsulphoxide).
Topics: Analgesics, Non-Narcotic; Cystitis, Interstitial; Dimethyl Sulfoxide; Female; Humans; Lens Diseases; | 2001 |
Prognosis of conservative therapy of advanced interstitial cystitis: experience of five cases.
Topics: Administration, Intravesical; Aged; Algorithms; Cystitis, Interstitial; Dimethyl Sulfoxide; Female; | 2001 |
[Interstitial cystitis].
Topics: Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cystitis, Interstitial; Cy | 2002 |