dimethyl sulfoxide has been researched along with Arthritis, Degenerative in 35 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The search strategy combined terms: osteoarthritis, degenerative joint disorder, dimethyl sulfoxide, DMSO, methylsulfonylmethane, MSM, clinical trial; double-blind, single blind, RCT, placebo, randomized, comparative study, evaluation study, control." | 8.84 | Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. ( Bashir, N; Brien, S; Lewith, G; Lewith, H; Prescott, P, 2008) |
| "5% dimethyl sulfoxide (TDiclo) for the treatment of knee or hand osteoarthritis in persons aged 75 years or older." | 7.78 | Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older. ( Fuller, P; Roth, SH, 2012) |
| " However, serious gastrointestinal and cardiovascular systemic adverse events (AEs) are associated with oral NSAIDs and can be treatment limiting." | 6.47 | Diclofenac sodium topical solution 1.5% w/w with dimethyl sulfoxide compared with placebo for the treatment of osteoarthritis: pooled safety results. ( Fuller, P; Roth, SH, 2011) |
| "The effect of the free radical scavengers allopurinol (50 milligrams) and dimethyl sulfoxide (DMSO) (500 milligrams), taken orally four times a day, on the clinical outcome of hematemesis resulting from nonsteroidal anti-inflammatory drugs (NSAID) induced erosive gastritis was examined in a prospective randomized double-blinded controlled trial." | 5.07 | A new approach to the treatment of nonsteroidal anti-inflammatory drugs induced gastric bleeding by free radical scavengers. ( Salim, AS, 1993) |
| " The search strategy combined terms: osteoarthritis, degenerative joint disorder, dimethyl sulfoxide, DMSO, methylsulfonylmethane, MSM, clinical trial; double-blind, single blind, RCT, placebo, randomized, comparative study, evaluation study, control." | 4.84 | Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. ( Bashir, N; Brien, S; Lewith, G; Lewith, H; Prescott, P, 2008) |
| "5% dimethyl sulfoxide (TDiclo) for the treatment of knee or hand osteoarthritis in persons aged 75 years or older." | 3.78 | Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older. ( Fuller, P; Roth, SH, 2012) |
| " Adverse events were monitored weekly." | 3.01 | Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study. ( Deveza, LA; Eyles, J; Fedorova, T; Hunter, DJ; Liu, X; McLachlan, AJ; Robbins, S; Virk, S, 2021) |
| "To ensure that 16 weeks of methylsulfonylmethane (MSM) does not cause adverse effects in patients with the musculoskeletal disorders of osteoarthritis and back pain." | 2.90 | Methylsulfonylmethane for treatment of low back pain: A safety analysis of a randomized, controlled trial. ( Crawford, A; Crawford, P; Lystrup, R; Nielson, F, 2019) |
| "Dimethyl sulfoxide (DMSO) is a molecule with a long history in pharmaceutics and is now well established as a penetration enhancer in topical pharmaceutical formulations." | 2.47 | Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs. ( Marren, K, 2011) |
| " However, serious gastrointestinal and cardiovascular systemic adverse events (AEs) are associated with oral NSAIDs and can be treatment limiting." | 2.47 | Diclofenac sodium topical solution 1.5% w/w with dimethyl sulfoxide compared with placebo for the treatment of osteoarthritis: pooled safety results. ( Fuller, P; Roth, SH, 2011) |
| "Dimethyl sulfoxide (DMSO) is a highly reactive by-product of paper production in the form of an odorless, colorless liquid that has been studied since the 1860s." | 1.62 | DMSO: an aid to combat pain and pruritus. ( Anzelc, M; Burkhart, CG, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (31.43) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 5 (14.29) | 29.6817 |
| 2010's | 11 (31.43) | 24.3611 |
| 2020's | 4 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Anzelc, M | 1 |
| Burkhart, CG | 1 |
| Lu, W | 1 |
| Ding, Z | 1 |
| Liu, F | 1 |
| Shan, W | 1 |
| Cheng, C | 1 |
| Xu, J | 1 |
| He, W | 1 |
| Huang, W | 1 |
| Ma, J | 1 |
| Yin, Z | 1 |
| Liu, X | 2 |
| Robbins, S | 2 |
| Eyles, J | 2 |
| Fedorova, T | 2 |
| Virk, S | 2 |
| Deveza, LA | 2 |
| McLachlan, A | 1 |
| Hunter, D | 1 |
| McLachlan, AJ | 1 |
| Hunter, DJ | 1 |
| Cömert Kılıç, S | 1 |
| Gasparini, S | 1 |
| Villa, F | 1 |
| Molfetta, L | 1 |
| Repaci, E | 1 |
| Castagnola, P | 1 |
| Quarto, R | 1 |
| Giannoni, P | 1 |
| Henrotin, Y | 1 |
| Mobasheri, A | 1 |
| Cheleschi, S | 1 |
| Fioravanti, A | 1 |
| De Palma, A | 1 |
| Corallo, C | 1 |
| Franci, D | 1 |
| Volpi, N | 1 |
| Bedogni, G | 1 |
| Giannotti, S | 1 |
| Giordano, N | 1 |
| Fujisawa, R | 1 |
| Mizuno, M | 1 |
| Katano, H | 1 |
| Otabe, K | 1 |
| Ozeki, N | 1 |
| Tsuji, K | 1 |
| Koga, H | 1 |
| Sekiya, I | 1 |
| Crawford, P | 1 |
| Crawford, A | 1 |
| Nielson, F | 1 |
| Lystrup, R | 1 |
| Ucuncu, Y | 1 |
| Celik, N | 1 |
| Ozturk, C | 1 |
| Turkoglu, M | 1 |
| Cetin, N | 1 |
| Kockara, N | 1 |
| Sener, E | 1 |
| Dundar, C | 1 |
| Arslan, A | 1 |
| Dogan, H | 1 |
| Kurt, N | 1 |
| Suleyman, H | 1 |
| Dillemans, M | 1 |
| Appelboom, T | 1 |
| Van Nedervelde, L | 1 |
| Xie, Q | 1 |
| Shi, R | 1 |
| Xu, G | 1 |
| Cheng, L | 1 |
| Shao, L | 1 |
| Rao, J | 1 |
| Marren, K | 1 |
| Roth, SH | 2 |
| Fuller, P | 2 |
| Tsui, T | 1 |
| Boon, H | 1 |
| Boecker, A | 1 |
| Kachan, N | 1 |
| Krahn, M | 1 |
| ROSENBAUM, EE | 2 |
| JACOB, SW | 2 |
| HERSCHLER, RJ | 1 |
| Garner, ST | 1 |
| Israel, BJ | 1 |
| Achmed, H | 1 |
| Capomacchia, AC | 1 |
| Abney, T | 1 |
| Azadi, P | 1 |
| Gregory, PJ | 1 |
| Sperry, M | 1 |
| Wilson, AF | 1 |
| Brien, S | 1 |
| Prescott, P | 1 |
| Bashir, N | 1 |
| Lewith, H | 1 |
| Lewith, G | 1 |
| Salim, AS | 1 |
| Eberhardt, R | 1 |
| Zwingers, T | 1 |
| Hofmann, R | 1 |
| Baum, J | 1 |
| Aliab'eva, AP | 1 |
| Akimova, TF | 1 |
| Trusova, TM | 1 |
| Kantor, TG | 1 |
| Owaki, H | 1 |
| Yukawa, K | 1 |
| Ochi, T | 1 |
| Shimaoka, Y | 1 |
| Ono, K | 1 |
| Zborovskii, AB | 1 |
| Chernov, AS | 1 |
| Lempert, BA | 1 |
| Fofanova, NA | 1 |
| Panavene, DP | 1 |
| Bandzhiulene, SIu | 1 |
| Iokimaĭtis, KG | 1 |
| Dadonene, IG | 1 |
| Murav'ev, IuV | 1 |
| Sigidin, IaA | 1 |
| Alab'eva, AP | 1 |
| Ivanova, ED | 1 |
| Mitrofanov, VA | 1 |
| Trice, JM | 1 |
| Pinals, RS | 1 |
| Steinberg, A | 1 |
| Mondragón Kalb, M | 1 |
| Matsumoto, J | 1 |
6 reviews available for dimethyl sulfoxide and Arthritis, Degenerative
| Article | Year |
|---|---|
Natural Products for Promoting Joint Health and Managing Osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Products; Boswellia; Chondroitin; Curcumin; Diet | 2018 |
Dimethyl sulfoxide: an effective penetration enhancer for topical administration of NSAIDs.
Topics: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Dimethyl Sulfoxide; Drug Delivery | 2011 |
Diclofenac sodium topical solution 1.5% w/w with dimethyl sulfoxide compared with placebo for the treatment of osteoarthritis: pooled safety results.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2011 |
Dietary supplements for osteoarthritis.
Topics: Anti-Inflammatory Agents; Chondroitin Sulfates; Curcuma; Dietary Supplements; Dimethyl Sulfoxide; Gl | 2008 |
Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis.
Topics: Anti-Inflammatory Agents; Dietary Supplements; Dimethyl Sulfoxide; Free Radical Scavengers; Humans; | 2008 |
Dimethyl sulfoxide: a review of its use in the rheumatic disorders.
Topics: Amyloidosis; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cell Division; Chemical Phenomena; Che | 1985 |
8 trials available for dimethyl sulfoxide and Arthritis, Degenerative
| Article | Year |
|---|---|
Efficacy and safety of a supplement combination for hand osteoarthritis pain: protocol for an internet-based randomised placebo-controlled trial (The RADIANT study).
Topics: Australia; Curcumin; Dimethyl Sulfoxide; Double-Blind Method; Hand; Humans; Internet; Osteoarthritis | 2020 |
Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study.
Topics: Aged; Anti-Inflammatory Agents; Boswellia; Curcumin; Dimethyl Sulfoxide; Double-Blind Method; Drug T | 2021 |
Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial.
Topics: Adolescent; Adult; Arthrocentesis; Chondroitin Sulfates; Dietary Supplements; Dimethyl Sulfoxide; Gl | 2021 |
Methylsulfonylmethane for treatment of low back pain: A safety analysis of a randomized, controlled trial.
Topics: Adult; Blood; Blood Pressure; Dimethyl Sulfoxide; Double-Blind Method; Female; Humans; Kidney; Liver | 2019 |
Effects of AR7 Joint Complex on arthralgia for patients with osteoarthritis: results of a three-month study in Shanghai, China.
Topics: Anti-Inflammatory Agents; Arthralgia; Arthrography; China; Collagen Type II; Dietary Supplements; Di | 2008 |
A new approach to the treatment of nonsteroidal anti-inflammatory drugs induced gastric bleeding by free radical scavengers.
Topics: Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dimethyl Sulfoxide; Dou | 1993 |
[DMSO in patients with active gonarthrosis. A double-blind placebo controlled phase III study].
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Dimethyl Sulfoxide; Double-Blin | 1995 |
Clinical trials of dimethyl sulfoxide in rheumatoid arthritis patients in Japan.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Dimethyl Sulfoxide; Edema; Female; Fever; Humans; I | 1967 |
21 other studies available for dimethyl sulfoxide and Arthritis, Degenerative
| Article | Year |
|---|---|
DMSO: an aid to combat pain and pruritus.
Topics: Animals; Chronic Pain; Cystitis, Interstitial; Dermatologic Agents; Dimethyl Sulfoxide; Humans; Off- | 2021 |
Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-κB and JAK2/STAT3 signaling pathways.
Topics: Animals; Cartilage, Articular; Cell Survival; Chondrocytes; Collagen Type II; Cyclooxygenase 2; Dime | 2019 |
Exposure to reversine affects the chondrocyte morphology and phenotype in vitro.
Topics: Aged; Aged, 80 and over; Cartilage, Articular; Cell Cycle Checkpoints; Cell Proliferation; Cell Shap | 2018 |
Methylsulfonylmethane and mobilee prevent negative effect of IL-1β in human chondrocyte cultures via NF-κB signaling pathway.
Topics: Aged; Cell Survival; Chondrocytes; Dimethyl Sulfoxide; Gene Expression Regulation; Humans; Hyaluroni | 2018 |
Cryopreservation in 95% serum with 5% DMSO maintains colony formation and chondrogenic abilities in human synovial mesenchymal stem cells.
Topics: Aged; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Chondrogenesis; Cryopreservation | 2019 |
Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation.
Topics: Animals; Bromelains; Cartilage; Chondroitin Sulfates; Dimethyl Sulfoxide; Disease Models, Animal; Dr | 2015 |
Yeast as a model system for identification of metabolic targets of a 'glucosamine complex' used as a therapeutic agent of osteoarthritis.
Topics: Carbon Dioxide; Cell Proliferation; Culture Media; Dimethyl Sulfoxide; Ethanol; Glucosamine; Heat-Sh | 2008 |
Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older.
Topics: Administration, Topical; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, No | 2012 |
Understanding the role of scientific evidence in consumer evaluation of natural health products for osteoarthritis an application of the means end chain approach.
Topics: Adult; Aged; Biological Products; Bromelains; Chondroitin; Comprehension; Consumer Behavior; Decisio | 2012 |
DIMETHYL SULFOXIDE (DMSO) IN MUSCULOSKELETAL INJURIES AND INFLAMMATIONS. II. DIMETHYL SULFOXIDE IN RHEUMATOID ARTHRITIS, DEGENERATIVE ARTHRITIS AND GOUTY ARTHRITIS.
Topics: Arthritis; Arthritis, Gouty; Arthritis, Rheumatoid; Dimethyl Sulfoxide; Gout; Humans; Inflammation; | 1964 |
DIMETHYL SULFOXIDE IN MUSCULOSKELETAL DISORDERS.
Topics: Arthritis; Arthritis, Rheumatoid; Bursitis; Dimethyl Sulfoxide; Drug Therapy; Dupuytren Contracture; | 1965 |
Transdermal permeability of N-acetyl-D-glucosamine.
Topics: Acetylglucosamine; Adjuvants, Pharmaceutic; Administration, Cutaneous; Animals; Buffers; Dietary Sup | 2007 |
The present and potential role of dimethyl sulfoxide in connective tissue disorders.
Topics: Analgesics; Connective Tissue; Dimethyl Sulfoxide; Humans; Joint Diseases; Myositis; Osteoarthritis; | 1975 |
[Treatment of joint diseases with dimethyl sulfoxide (DMSO) applications].
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Dimethyl Sulfoxide; Female; Humans; Male; Middle Aged; Ost | 1979 |
Design of therapeutic trials for dimethyl sulfoxide.
Topics: Administration, Topical; Arthritis, Rheumatoid; Dimethyl Sulfoxide; Drug Evaluation; Gout; Humans; O | 1975 |
Facs analysis of myeloid differentiation stages in epiphyseal bone marrow, adjacent to joints affected with rheumatoid arthritis.
Topics: Adult; Aged; Antibodies, Monoclonal; Antigens, Differentiation; Arthritis, Rheumatoid; Bone Marrow; | 1991 |
[Laser reflexotherapy in osteoarthrosis deformans and rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Combined Modality Therapy; Dimethyl Sulfoxide; Humans; Laser Therapy; Osteoar | 1991 |
[The effect of intra-articular treatment with corticosteroids, polyvinylpyrrolidone and dimethyl sulfoxide on the composition of the synovial fluid in patients with rheumatoid arthritis].
Topics: Adrenal Cortex Hormones; Adult; Arthritis, Rheumatoid; Chronic Disease; Dimethyl Sulfoxide; Drug Eva | 1989 |
[Multicenter study of the efficacy of dimethyl sulfoxide in rheumatoid arthritis and osteoarthritis deformans].
Topics: Arthritis, Rheumatoid; Dimethyl Sulfoxide; Drug Therapy, Combination; Humans; Osteoarthritis | 1987 |
The employment of dimethyl sulfoxide as an antiinflammatory agent and steroid-transporter in diversified clinical diseases.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Breast Neoplasms; Dimethyl Sulfoxide; Drug Synergism | 1967 |
[Dimethyl sulfoxide in the treatment of diseases of the locomotor apparatus].
Topics: Adult; Arthritis, Rheumatoid; Dimethyl Sulfoxide; Female; Gout; Humans; Male; Osteoarthritis; Rheuma | 1965 |