dimethyl sulfoxide has been researched along with Adverse Drug Event in 14 studies
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5% dimethyl sulfoxide (TDiclo) for the treatment of knee or hand osteoarthritis in persons aged 75 years or older." | 7.78 | Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older. ( Fuller, P; Roth, SH, 2012) |
| "5% dimethyl sulfoxide (TDiclo) for the treatment of knee or hand osteoarthritis in persons aged 75 years or older." | 3.78 | Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older. ( Fuller, P; Roth, SH, 2012) |
| " The concentration in the residual DMSO solution was multiplied by the solution volume and divided by the dosage to calculate the recovery rate of DMSO." | 2.94 | Phase I study of KRP-116D, a 50% w/w dimethyl sulfoxide aqueous solution, on the systemic absorption from bladder by intravesical instillation in healthy Japanese subjects. ( Hamamura, Y; Hojo, Y; Ootsuki, A; Shimada, H; Yono, M, 2020) |
| " The commonest adverse event associated with TDiclo was dry skin (18." | 2.74 | Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis. ( Bookman, AAM; Grierson, LM; Naseer, Z; Shainhouse, ZJ; Simon, LS, 2009) |
| " Whether long-term use of oral contraceptives would produce ocular complications was queried by Cogan." | 2.35 | Effects of drugs on the lens. ( Paterson, CA, 1971) |
| " Evidence of systemic toxicity was observed in animals dosed chronically with pyrimethamine or amiloride, but no skin papillomas were observed in mice treated with amiloride, dipyridamole, or pyrimethamine for 26 weeks." | 1.32 | Evaluation of the Tg.AC assay: specificity testing with three noncarcinogenic pharmaceuticals that induce selected stress gene promoters in vitro and the inhibitory effects of solvent components. ( Lin, KK; Rosenzweig, BA; Sistare, FD; Thompson, KL; Weaver, JL; Zhang, J, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Ma, Y | 1 |
| Zheng, M | 1 |
| Shimada, H | 1 |
| Yono, M | 1 |
| Hojo, Y | 1 |
| Hamamura, Y | 1 |
| Ootsuki, A | 1 |
| Simon, LS | 1 |
| Grierson, LM | 1 |
| Naseer, Z | 1 |
| Bookman, AAM | 1 |
| Shainhouse, ZJ | 1 |
| Roth, SH | 1 |
| Fuller, P | 1 |
| Thompson, KL | 1 |
| Rosenzweig, BA | 1 |
| Weaver, JL | 1 |
| Zhang, J | 1 |
| Lin, KK | 1 |
| Sistare, FD | 1 |
| DeWitte, RS | 1 |
| Robins, RH | 1 |
| Rubin, LF | 1 |
| Maier, P | 1 |
| Hayes, MA | 1 |
| Pickering, DB | 1 |
| Koch, HR | 1 |
| Hockwin, O | 1 |
| Paterson, CA | 1 |
| Grübner, I | 1 |
| Klinger, W | 1 |
| Ankermann, H | 1 |
| Weston, JK | 1 |
2 reviews available for dimethyl sulfoxide and Adverse Drug Event
| Article | Year |
|---|---|
Toxicity of dimethyl sulfoxide, alone and in combination.
Topics: Animals; Cataract; Dimethyl Sulfoxide; Drug Combinations; Drug-Related Side Effects and Adverse Reac | 1975 |
Effects of drugs on the lens.
Topics: Adolescent; Adrenal Cortex Hormones; Animals; Antineoplastic Agents; Carbohydrates; Cataract; Contra | 1971 |
2 trials available for dimethyl sulfoxide and Adverse Drug Event
| Article | Year |
|---|---|
Phase I study of KRP-116D, a 50% w/w dimethyl sulfoxide aqueous solution, on the systemic absorption from bladder by intravesical instillation in healthy Japanese subjects.
Topics: Absorption, Physiological; Administration, Intravesical; Adult; Dimethyl Sulfoxide; Drug Monitoring; | 2020 |
Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis.
Topics: Activities of Daily Living; Administration, Oral; Administration, Topical; Aged; Anti-Inflammatory A | 2009 |
10 other studies available for dimethyl sulfoxide and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Improved PCR by the Use of Disruptors, a New Class of Oligonucleotide Reagents.
Topics: Betaine; Dimethyl Sulfoxide; Drug-Related Side Effects and Adverse Reactions; Humans; Oligonucleotid | 2023 |
Pooled safety analysis of diclofenac sodium topical solution 1.5% (w/w) in the treatment of osteoarthritis in patients aged 75 years or older.
Topics: Administration, Topical; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, No | 2012 |
Evaluation of the Tg.AC assay: specificity testing with three noncarcinogenic pharmaceuticals that induce selected stress gene promoters in vitro and the inhibitory effects of solvent components.
Topics: Acetone; Administration, Topical; Amiloride; Animal Testing Alternatives; Animals; Carcinogenicity T | 2003 |
A hierarchical screening methodology for physicochemical/ADME/Tox profiling.
Topics: Automation; Chemistry, Pharmaceutical; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 | 2006 |
Development of in vitro toxicity tests with cultures of freshly isolated rat hepatocytes.
Topics: Animals; Cells, Cultured; Dimethyl Sulfoxide; DNA; Drug-Related Side Effects and Adverse Reactions; | 1988 |
Comparative cytopathology of primary rat hepatocyte cultures exposed to aflatoxin B1, acetaminophen, and other hepatotoxins.
Topics: Acetaminophen; Aflatoxin B1; Aflatoxins; Animals; Cells, Cultured; Dimethyl Sulfoxide; Drug-Related | 1985 |
[Iatrogenic cataracts].
Topics: Aged; Anesthetics, Local; Anthelmintics; Azathioprine; Cataract; Chloroquine; Chlorpromazine; Dimeth | 1974 |
[Different substances and classes of substances with inducer properties. II].
Topics: Alcohols; Aminopyrine; Animals; Anisoles; Ascorbic Acid; Barbiturates; Dealkylation; Dimethyl Sulfox | 1972 |
The development of drugs and the responsibilities involved.
Topics: Dimethyl Sulfoxide; Drug Compounding; Drug Industry; Drug Therapy; Drug-Related Side Effects and Adv | 1967 |