Page last updated: 2024-08-25

dimethyl itaconate and Inflammation

dimethyl itaconate has been researched along with Inflammation in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (27.27)24.3611
2020's8 (72.73)2.80

Authors

AuthorsStudies
Abd El-Aty, AM; Hacimuftuoglu, A; Jeong, JH; Jung, TW; Lee, HJ; Park, SY; Ramadan, A; Shin, YK; Song, JH1
Cui, Z; Huang, B; Li, L; Wang, H; Yang, Y1
Fan, Y; Gu, L; Li, C; Lin, H; Lin, J; Lu, C; Niu, Y; Peng, X; Wang, Q; Zhao, G; Zhu, G1
Brown, DA; Kuo, PC; Paraiso, HC; Scofield, BA; Wang, PY; Weng, WT; Yen, JH; Yu, IC1
Jia, H; Jiao, Y; Li, C; Liang, X; Nie, Z; Zhang, S; Zhang, Y1
Duan, Y; Gao, C; Lu, L; Mao, Z; Nakkala, JR; Yao, Y; Zhai, Z; Zhang, D1
Kang, YY; Lan, JQ; Peng, Y; Tang, JS; Wu, L; Zhang, Y; Zhou, YJ1
Chen, X; Huang, L; Lin, X; Yang, S; Zhang, H; Zhang, X; Zhang, Y; Zhuge, Q1
Akira, S; Amarasinghe, GK; Apte, RS; Artyomov, MN; Auclair, K; Bambouskova, M; Biller, SA; Bregman, H; de Guzman Strong, C; Duncan, D; Gorvel, L; Hai, T; Huang, LH; Johnson, B; Johnson, K; Jovanovic, M; Keskin, A; Kim, H; Klechevsky, E; Korenfeld, D; Lampropoulou, V; Loginicheva, E; Mathyer, ME; Randolph, GJ; Roddy, TP; Santeford, A; Satoh, T; Sehgal, R; Sergushichev, A; Soares, MP; Stewart, KM1
Cao, Y; Fu, Y; Guo, J; He, Z; Hu, X; Jiang, P; Li, Y; Yuan, X; Zhang, N; Zhao, C1
Burant, CF; ElAzzouny, M; Evans, CR; Gallagher, KA; Martin, BR; Olson, LL; Tanga, MJ; Tom, CT1

Trials

1 trial(s) available for dimethyl itaconate and Inflammation

ArticleYear
Protective effects of dietary dimethyl itaconate supplementation on oxidative stress, inflammation, and apoptosis in broilers under chronic heat stress.
    Journal of animal science, 2023, Jan-03, Volume: 101

    Topics: Animal Feed; Animals; Antioxidants; Apoptosis; Chickens; Diet; Dietary Supplements; Heat-Shock Response; Inflammation; Male; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger

2023

Other Studies

10 other study(ies) available for dimethyl itaconate and Inflammation

ArticleYear
Dimethyl itaconate attenuates palmitate-induced insulin resistance in skeletal muscle cells through the AMPK/FGF21/PPARδ-mediated suppression of inflammation.
    Life sciences, 2021, Dec-15, Volume: 287

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Cell Line; Dose-Response Relationship, Drug; Fibroblast Growth Factors; Inflammation; Insulin Resistance; Mice; Muscle Fibers, Skeletal; Palmitates; PPAR delta; Succinates

2021
Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO-1 signaling pathway.
    Immunology and cell biology, 2020, Volume: 98, Issue:3

    Topics: Animals; Aspergillosis; Aspergillus fumigatus; Chemokine CXCL1; Cornea; Epithelial Cells; Epithelium, Corneal; Heme Oxygenase-1; Humans; Inflammation; Interleukin-6; Interleukin-8; Keratitis; Mice; NF-E2-Related Factor 2; Signal Transduction; Succinates

2020
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
    Journal of neuroinflammation, 2020, Apr-29, Volume: 17, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Encephalomyelitis, Autoimmune, Experimental; Inflammation; Mice; Mice, Inbred C57BL; Microglia; Spinal Cord; Succinates

2020
Dimethyl Itaconate Alleviates the Inflammatory Responses of Macrophages in Sepsis.
    Inflammation, 2021, Volume: 44, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Blotting, Western; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Sepsis; Succinates

2021
Dimethyl Itaconate-Loaded Nanofibers Rewrite Macrophage Polarization, Reduce Inflammation, and Enhance Repair of Myocardic Infarction.
    Small (Weinheim an der Bergstrasse, Germany), 2021, Volume: 17, Issue:17

    Topics: Animals; Infarction; Inflammation; Macrophages; Mice; Nanofibers; Succinates

2021
A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation
    Journal of Asian natural products research, 2022, Volume: 24, Issue:6

    Topics: Anti-Inflammatory Agents; Dimethyl Fumarate; Humans; Inflammation; Molecular Structure; NF-E2-Related Factor 2; Succinates

2022
Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway.
    Molecular medicine reports, 2021, Volume: 24, Issue:3

    Topics: Animals; Autophagy; Cell Line; Cell Survival; Heme Oxygenase-1; Inflammasomes; Inflammation; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Microglia; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphate-Binding Proteins; Primary Cell Culture; Protective Agents; Pyroptosis; Reactive Oxygen Species; Signal Transduction; Succinates

2021
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.
    Nature, 2018, Volume: 556, Issue:7702

    Topics: Activating Transcription Factor 3; Animals; Cells, Cultured; Cytokines; Female; Gene Expression Regulation; Glutathione; Humans; I-kappa B Proteins; Inflammation; Interleukin-6; Keratinocytes; Macrophages; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Psoriasis; Stress, Physiological; Succinates; Toll-Like Receptors

2018
Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathways.
    Microbial pathogenesis, 2019, Volume: 133

    Topics: Animals; Cytokines; Disease Models, Animal; Down-Regulation; Female; Heme Oxygenase-1; Humans; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Mammary Glands, Human; MAP Kinase Signaling System; Mastitis; Membrane Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; NF-E2-Related Factor 2; NF-kappa B; Phosphorylation; Protective Agents; Signal Transduction; Succinates; Toll-Like Receptor 4; Transcription Factor RelA; Up-Regulation

2019
Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly.
    The Journal of biological chemistry, 2017, 03-24, Volume: 292, Issue:12

    Topics: Animals; Cells, Cultured; Inflammation; Lipopolysaccharides; Macrophages; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Succinates; Succinic Acid

2017