dimethyl-fumarate and Amyotrophic-Lateral-Sclerosis

Hybrid compounds containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids were designed with the aid of docking and molecular mechanics studies. Following the synthesis of the compounds using a peptide-coupling methodology, they were characterized for their ROCK2 inhibition, radical scavenging, effects on cell viability (MTT assay), and NRF2 induction (luciferase assay). One of the compounds (

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amyotrophic Lateral Sclerosis; Cell Line, Tumor; Cell Survival; Coumaric Acids; Female; Free Radical Scavengers; HEK293 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Lymphocytes; Male; Middle Aged; NF-E2-Related Factor 2; Protein Kinase Inhibitors; rho-Associated Kinases