dimethadione has been researched along with Pregnancy in 24 studies
Dimethadione: An anticonvulsant that is the active metabolite of TRIMETHADIONE.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is evidence that drug-induced embryonic arrhythmia initiates phenytoin (PHT) teratogenicity." | 3.71 | Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? ( Azarbayjani, F; Danielsson, BR, 2002) |
| " Instead, single dosing on specific days is proposed to be a better way to characterize the teratogenic potential of Ikr blocking drugs." | 2.44 | Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. ( Danielsson, BR; Danielsson, C; Nilsson, MF, 2007) |
| " Dosing pregnant rats with 300mg/kg DMO every 12h from the evening of gestational day (GD) 8 until the morning of GD 11 (six total doses) produces a mean 74% incidence of CHD with inter litter variability ranging from 40 to 100%." | 1.40 | Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung. ( Lam, I; Ozolinš, TR; Purssell, E; Rodger, I; Rutter, A; Thompson, M, 2014) |
| "The broadest dosing regimen yielded the highest incidence and the most severe heart and axioskeletal findings with a decrease in mean fetal body weight." | 1.37 | Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione. ( Brown, NA; Ozolinš, TR; Weston, AD, 2011) |
| "Dimethadione was given similarly on Days 11 and 12, or 12 and 13, in a dose (900 mg/kg ip) that was equimolar to 1000 mg/kg of trimethadione." | 1.28 | Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. ( Greco, GS; Nagai, MK; Wells, PG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 6 (25.00) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Lyu, G | 1 |
| He, S | 1 |
| Yang, H | 1 |
| Li, S | 1 |
| Aasa, KL | 2 |
| Purssell, E | 3 |
| Adams, MA | 2 |
| Ozolinš, TR | 6 |
| Rodger, I | 1 |
| Lam, I | 1 |
| Thompson, M | 1 |
| Rutter, A | 1 |
| Maciver, RD | 1 |
| Ramchandani, S | 1 |
| Weston, AD | 3 |
| Perretta, A | 1 |
| Thomson, JJ | 2 |
| Brown, NA | 3 |
| Zander-Fox, DL | 1 |
| Mitchell, M | 1 |
| Thompson, JG | 1 |
| Lane, M | 2 |
| Swanson, TA | 1 |
| Ocon, OM | 1 |
| Hansen, PJ | 1 |
| Danielsson, BR | 3 |
| Danielsson, C | 2 |
| Nilsson, MF | 1 |
| Azarbayjani, F | 2 |
| Sköld, AC | 1 |
| Sjögren, N | 1 |
| Schreiner, CM | 1 |
| Scott, WJ | 5 |
| Collins, MD | 5 |
| Colvin, J | 1 |
| McCandless, D | 1 |
| Hendrickx, AG | 1 |
| Peterson, PE | 1 |
| Nau, H | 2 |
| Squirrell, JM | 1 |
| Bavister, BD | 1 |
| Seeds, AE | 1 |
| Eichhorst, BC | 1 |
| Stolee, A | 1 |
| Midha, KK | 1 |
| Buttar, HS | 2 |
| Rowe, M | 1 |
| Dupuis, I | 2 |
| Khera, KS | 1 |
| Anderson, RC | 1 |
| O'Flaherty, EJ | 1 |
| Scott, W | 1 |
| Schreiner, C | 1 |
| Beliles, RP | 1 |
| Walling, KM | 1 |
| Resnick, E | 1 |
| Srivastava, M | 1 |
| Wittfoht, W | 1 |
| Fradkin, R | 1 |
| Wells, PG | 1 |
| Nagai, MK | 1 |
| Greco, GS | 1 |
1 review available for dimethadione and Pregnancy
| Article | Year |
|---|---|
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 2007 |
23 other studies available for dimethadione and Pregnancy
| Article | Year |
|---|---|
The dimethadione-exposed rat fetus: an animal model for the prenatal ultrasound characterization of ventricular septal defect.
Topics: Animals; Dimethadione; Female; Fetus; Heart Septal Defects, Ventricular; Models, Animal; Pregnancy; | 2023 |
In utero dimethadione exposure causes postnatal disruption in cardiac structure and function in the rat.
Topics: Animals; Anticonvulsants; Blood Pressure; Dimethadione; Echocardiography; Female; Fetal Development; | 2014 |
Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Biomarkers; Dimethadione; Female; Fetal Weigh | 2014 |
In Utero Exposure to a Cardiac Teratogen Causes Reversible Deficits in Postnatal Cardiovascular Function, But Altered Adaptation to the Burden of Pregnancy.
Topics: Animals; Birth Weight; Cardiotoxins; Cardiovascular System; Dimethadione; Disease Models, Animal; Fe | 2015 |
Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels.
Topics: Animals; Anticonvulsants; Dimethadione; Dose-Response Relationship, Drug; Embryo Culture Techniques; | 2015 |
Alterations in mouse embryo intracellular pH by DMO during culture impair implantation and fetal growth.
Topics: Animals; Dimethadione; Embryo Implantation; Embryonic Development; Female; Hydrogen-Ion Concentratio | 2010 |
Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.
Topics: Animals; Bone and Bones; Cardiovascular Abnormalities; Cesarean Section; Dimethadione; Female; Heart | 2011 |
Noninvasive high-resolution ultrasound reveals structural and functional deficits in dimethadione-exposed fetal rat hearts in utero.
Topics: Animals; Dimethadione; Female; Fetus; Heart; Heart Function Tests; Heart Rate; Heart Septal Defects, | 2012 |
Disruption of bovine oocytes and preimplantation embryos by urea and acidic pH.
Topics: Animals; Cattle; Cleavage Stage, Ovum; Culture Media; Culture Techniques; Dimethadione; Embryonic an | 2003 |
Polytherapy with hERG-blocking antiepileptic drugs: increased risk for embryonic cardiac arrhythmia and teratogenicity.
Topics: Animals; Anticonvulsants; Bradycardia; Dimethadione; Dose-Response Relationship, Drug; Drug Therapy, | 2007 |
Estimation of intracellular pH by computer assisted imaging in the developing mouse forelimb bud exposed to acetazolamide.
Topics: Acetazolamide; Amiloride; Animals; Dimethadione; Drug Interactions; Female; Forelimb; Hydrogen-Ion C | 1993 |
Intracellular pH monkey embryos at various stages of organogenesis estimated by dimethadione distribution.
Topics: Analysis of Variance; Animals; Blood Gas Analysis; Chlorides; Crown-Rump Length; Dimethadione; Embry | 1996 |
Altering intracellular pH disrupts development and cellular organization in preimplantation hamster embryos.
Topics: Actin Cytoskeleton; Animals; Blastomeres; Cell Nucleus; Cricetinae; Culture Media; Culture Technique | 2001 |
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Anticonvulsants; Arrhythmias, Cardiac; Cation Tra | 2002 |
Factors determining human chorion laeve permeability in vitro.
Topics: Cell Membrane Permeability; Chorion; Diazepam; Dimethadione; Extraembryonic Membranes; Female; Gluco | 1977 |
Metabolism and disposition of trimethadione in pregnant rats.
Topics: Abnormalities, Drug-Induced; Animals; Dimethadione; Drug Evaluation, Preclinical; Female; Fetus; Oxa | 1979 |
Dimethadione-induced fetotoxicity in rats.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dimethadione; Female; Fetal Death; Fetal Resorpti | 1978 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
A physiologically based kinetic model of rat and mouse gestation: disposition of a weak acid.
Topics: Animals; Carboxylic Acids; Computer Simulation; Dimethadione; Embryo, Mammalian; Female; Mice; Mice, | 1992 |
The effect of administration time on malformations induced by three anticonvulsant agents in C57BL/6J mice with emphasis on forelimb ectrodactyly.
Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Anticonvulsants; Dimethadione; Facial Bones; Fem | 1991 |
Transplacental distribution of weak acids in mice: accumulation in compartments of high pH.
Topics: Acids; Animals; Dimethadione; Female; Gestational Age; Hydrogen-Ion Concentration; Maternal-Fetal Ex | 1991 |
Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Dimethadione; Female; Fetal Death; Fetal Resorpt | 1990 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Respon | 1989 |