dimethadione has been researched along with Chemical and Drug Induced Liver Injury in 4 studies
Dimethadione: An anticonvulsant that is the active metabolite of TRIMETHADIONE.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "6 h and 163 microgram/ml at 8 h and declined with a half-life of 2." | 1.26 | Pharmacokinetic studies of trimethadione and its metabolite in rats with chemical-induced liver injury. ( Kinoshita, H; Kuroiwa, Y; Takabatake, E; Tanaka, E; Yamamoto, T, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Tanaka, E | 3 |
| Nakamura, T | 1 |
| Misawa, S | 1 |
| Yoshida, T | 2 |
| Kuroiwa, Y | 3 |
| Kinoshita, H | 2 |
| Yamamoto, T | 1 |
| Takabatake, E | 1 |
4 other studies available for dimethadione and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Effects of allyl alcohol and bromobenzene on trimethadione metabolism in the rat.
Topics: 1-Propanol; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Dimethadione; Kinetics; | 1984 |
Trimethadione as a model drug for the evaluation of hepatic drug-metabolizing capacity in normal and D-galactosamine intoxicated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Dimethadione; Galactosamine; Kinetics; | 1982 |
Pharmacokinetic studies of trimethadione and its metabolite in rats with chemical-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biotransformation; Carbon Tetrachloride Poi | 1981 |