dimethadione has been researched along with Abnormality, Heart in 4 studies
Dimethadione: An anticonvulsant that is the active metabolite of TRIMETHADIONE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dosing pregnant rats with 300mg/kg DMO every 12h from the evening of gestational day (GD) 8 until the morning of GD 11 (six total doses) produces a mean 74% incidence of CHD with inter litter variability ranging from 40 to 100%." | 1.40 | Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung. ( Lam, I; Ozolinš, TR; Purssell, E; Rodger, I; Rutter, A; Thompson, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aasa, KL | 2 |
| Purssell, E | 2 |
| Adams, MA | 2 |
| Ozolinš, TR | 3 |
| Rodger, I | 1 |
| Lam, I | 1 |
| Thompson, M | 1 |
| Rutter, A | 1 |
| Maciver, RD | 1 |
| Ramchandani, S | 1 |
| Anderson, RC | 1 |
4 other studies available for dimethadione and Abnormality, Heart
| Article | Year |
|---|---|
In utero dimethadione exposure causes postnatal disruption in cardiac structure and function in the rat.
Topics: Animals; Anticonvulsants; Blood Pressure; Dimethadione; Echocardiography; Female; Fetal Development; | 2014 |
Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Biomarkers; Dimethadione; Female; Fetal Weigh | 2014 |
In Utero Exposure to a Cardiac Teratogen Causes Reversible Deficits in Postnatal Cardiovascular Function, But Altered Adaptation to the Burden of Pregnancy.
Topics: Animals; Birth Weight; Cardiotoxins; Cardiovascular System; Dimethadione; Disease Models, Animal; Fe | 2015 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |