dimethadione has been researched along with Abnormalities, Drug-Induced in 10 studies
Dimethadione: An anticonvulsant that is the active metabolite of TRIMETHADIONE.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is evidence that drug-induced embryonic arrhythmia initiates phenytoin (PHT) teratogenicity." | 3.71 | Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? ( Azarbayjani, F; Danielsson, BR, 2002) |
| " Instead, single dosing on specific days is proposed to be a better way to characterize the teratogenic potential of Ikr blocking drugs." | 2.44 | Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs. ( Danielsson, BR; Danielsson, C; Nilsson, MF, 2007) |
| " Dosing pregnant rats with 300mg/kg DMO every 12h from the evening of gestational day (GD) 8 until the morning of GD 11 (six total doses) produces a mean 74% incidence of CHD with inter litter variability ranging from 40 to 100%." | 1.40 | Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung. ( Lam, I; Ozolinš, TR; Purssell, E; Rodger, I; Rutter, A; Thompson, M, 2014) |
| "When acetazolamide-amiloride was administered in C57BL/6NCrlBR mice on day 9, 9." | 1.28 | Abnormalities in ureter and kidney development in mice given acetazolamide-amiloride or dimethadione (DMO) during embryogenesis. ( Miller, TA; Scott, WJ, 1992) |
| "Dimethadione was given similarly on Days 11 and 12, or 12 and 13, in a dose (900 mg/kg ip) that was equimolar to 1000 mg/kg of trimethadione." | 1.28 | Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. ( Greco, GS; Nagai, MK; Wells, PG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodger, I | 1 |
| Lam, I | 1 |
| Purssell, E | 1 |
| Thompson, M | 1 |
| Rutter, A | 1 |
| Ozolinš, TR | 1 |
| Danielsson, BR | 2 |
| Danielsson, C | 1 |
| Nilsson, MF | 1 |
| Azarbayjani, F | 1 |
| Midha, KK | 1 |
| Buttar, HS | 2 |
| Rowe, M | 1 |
| Dupuis, I | 2 |
| Khera, KS | 1 |
| Anderson, RC | 1 |
| Miller, TA | 1 |
| Scott, WJ | 3 |
| Collins, MD | 2 |
| Walling, KM | 1 |
| Resnick, E | 1 |
| Fradkin, R | 1 |
| Wells, PG | 1 |
| Nagai, MK | 1 |
| Greco, GS | 1 |
1 review available for dimethadione and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 2007 |
9 other studies available for dimethadione and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Maternal rat serum concentrations of dimethadione do not explain intra-litter differences in the incidence of dimethadione-induced birth defects, including novel findings in foetal lung.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Biomarkers; Dimethadione; Female; Fetal Weigh | 2014 |
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Anticonvulsants; Arrhythmias, Cardiac; Cation Tra | 2002 |
Metabolism and disposition of trimethadione in pregnant rats.
Topics: Abnormalities, Drug-Induced; Animals; Dimethadione; Drug Evaluation, Preclinical; Female; Fetus; Oxa | 1979 |
Dimethadione-induced fetotoxicity in rats.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dimethadione; Female; Fetal Death; Fetal Resorpti | 1978 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Abnormalities in ureter and kidney development in mice given acetazolamide-amiloride or dimethadione (DMO) during embryogenesis.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Amiloride; Animals; Dimethadione; Drug Combinations; Emb | 1992 |
The effect of administration time on malformations induced by three anticonvulsant agents in C57BL/6J mice with emphasis on forelimb ectrodactyly.
Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Anticonvulsants; Dimethadione; Facial Bones; Fem | 1991 |
Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A/J mice.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Dimethadione; Female; Fetal Death; Fetal Resorpt | 1990 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Respon | 1989 |