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dimercaprol and Seizures

dimercaprol has been researched along with Seizures in 11 studies

Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
" With the possible exception of dimercaprol, no increase in toxic effects of oxygen was observed after administering these chelate-forming agents in the doses used."1.27Studies on the oxygen toxicity after administration of chelate-forming agents in mice. ( Kramer, HJ; Renner, G, 1983)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19908 (72.73)18.7374
1990's0 (0.00)18.2507
2000's3 (27.27)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
ABDEL-GHAFFAR, Y1
SHERIF, YA1
EL-MASSRY, ZH1
BARSOOM, KA1
VANTASSEL, PV1
Florin, TA1
Brent, RL1
Weitzman, M1
Brito, VB1
Folmer, V1
Puntel, GO1
Fachinetto, R1
Soares, JC1
Zeni, G1
Nogueira, CW2
Rocha, JB2
Paton, WD1
Renner, G1
Kramer, HJ1
Soares, FA1
Bolzan, RC1
Jacques-Silva, MC1
Souza, DO1
Sitarz, AL1
Nogué, S1
Mas, A1
Parés, A1
Nadal, P1
Bertrán, A1
Torra, M1
Bachs, M1
Blesa, R1
TVan Tassel, PV1
Madonia, P1
Palazzoadriano, M1

Other Studies

11 other studies available for dimercaprol and Seizures

ArticleYear
LEAD ENCEPHALOPATHY: CASE REPORT.
    The Journal of the Egyptian Medical Association, 1963, Volume: 46

    Topics: Blood Chemical Analysis; Coma; Delirium; Dimercaprol; Lead Poisoning; Neurologic Examination; Neurot

1963
THE EFFECT OF DIMERCAPTOPROPANOL (BRITISH ANTI-LEWISITE) ON THE TOXICITY OF OXYGEN AT SIX ATMOSPHERES' PRESSURE ON WHITE MALE RATS. SAM-TR-65-11.
    AMD-TR [reports]. United States. Aerospace Medical Division, 1965

    Topics: Atmosphere; Dimercaprol; Hyperbaric Oxygenation; Oxygen; Pharmacology; Rats; Research; Seizures; Tox

1965
The need for vigilance: the persistence of lead poisoning in children.
    Pediatrics, 2005, Volume: 115, Issue:6

    Topics: Cheek; Chelation Therapy; Child, Preschool; Dimercaprol; Drug Therapy, Combination; Edema; Edetic Ac

2005
Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice.
    Brain research bulletin, 2006, Feb-15, Volume: 68, Issue:6

    Topics: Animals; Benzene Derivatives; Brain; Chelating Agents; Convulsants; Dimercaprol; Disease Models, Ani

2006
Experiments on the convulsant and anaesthetic effects of oxygen.
    British journal of pharmacology and chemotherapy, 1967, Volume: 29, Issue:3

    Topics: Anesthesia, Inhalation; Animals; Anticonvulsants; Brain; Bromides; Chlorpromazine; Cobalt; Dimercapr

1967
Studies on the oxygen toxicity after administration of chelate-forming agents in mice.
    International journal of clinical pharmacology, therapy, and toxicology, 1983, Volume: 21, Issue:3

    Topics: Animals; Carbon Dioxide; Chelating Agents; Dimercaprol; Drug Synergism; Female; Hyperbaric Oxygenati

1983
Investigations into the mechanism of 2,3-dimercaptopropanol neurotoxicity.
    Neurochemical research, 2000, Volume: 25, Issue:12

    Topics: Animals; Anticonvulsants; Brain; Cell Membrane; Chelating Agents; Dimercaprol; Dizocilpine Maleate;

2000
Letter: Severe lead poisoning in a 6-month-old infant.
    The Journal of pediatrics, 1975, Volume: 86, Issue:5

    Topics: Anemia; Bone Development; Ceramics; Citrus; Diagnosis, Differential; Dimercaprol; Edetic Acid; Femal

1975
[Myoclonic and convulsive encephalopathy caused by bismuth. Usefulness of dimercaprol treatment].
    Medicina clinica, 1985, Apr-06, Volume: 84, Issue:13

    Topics: Bismuth; Dimercaprol; Humans; Male; Middle Aged; Myoclonus; Seizures

1985
Effect of dimercaprol on oxygen toxicity in rats.
    Journal of applied physiology, 1965, Volume: 20, Issue:3

    Topics: Animals; Antidotes; Benzoates; Dimercaprol; Glycerol; Hyperbaric Oxygenation; Oils; Oxygen; Rats; Se

1965
[Central excitation caused by molecules with thiolic structure].
    Bollettino della Societa italiana di biologia sperimentale, 1965, Mar-31, Volume: 41, Issue:6

    Topics: Animals; Brain Chemistry; Cysteamine; Dimercaprol; Liver; Rats; Seizures; Sulfhydryl Compounds; Trem

1965