dimercaprol has been researched along with Seizures in 11 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
Excerpt | Relevance | Reference |
---|---|---|
" With the possible exception of dimercaprol, no increase in toxic effects of oxygen was observed after administering these chelate-forming agents in the doses used." | 1.27 | Studies on the oxygen toxicity after administration of chelate-forming agents in mice. ( Kramer, HJ; Renner, G, 1983) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (72.73) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (27.27) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
ABDEL-GHAFFAR, Y | 1 |
SHERIF, YA | 1 |
EL-MASSRY, ZH | 1 |
BARSOOM, KA | 1 |
VANTASSEL, PV | 1 |
Florin, TA | 1 |
Brent, RL | 1 |
Weitzman, M | 1 |
Brito, VB | 1 |
Folmer, V | 1 |
Puntel, GO | 1 |
Fachinetto, R | 1 |
Soares, JC | 1 |
Zeni, G | 1 |
Nogueira, CW | 2 |
Rocha, JB | 2 |
Paton, WD | 1 |
Renner, G | 1 |
Kramer, HJ | 1 |
Soares, FA | 1 |
Bolzan, RC | 1 |
Jacques-Silva, MC | 1 |
Souza, DO | 1 |
Sitarz, AL | 1 |
Nogué, S | 1 |
Mas, A | 1 |
Parés, A | 1 |
Nadal, P | 1 |
Bertrán, A | 1 |
Torra, M | 1 |
Bachs, M | 1 |
Blesa, R | 1 |
TVan Tassel, PV | 1 |
Madonia, P | 1 |
Palazzoadriano, M | 1 |
11 other studies available for dimercaprol and Seizures
Article | Year |
---|---|
LEAD ENCEPHALOPATHY: CASE REPORT.
Topics: Blood Chemical Analysis; Coma; Delirium; Dimercaprol; Lead Poisoning; Neurologic Examination; Neurot | 1963 |
THE EFFECT OF DIMERCAPTOPROPANOL (BRITISH ANTI-LEWISITE) ON THE TOXICITY OF OXYGEN AT SIX ATMOSPHERES' PRESSURE ON WHITE MALE RATS. SAM-TR-65-11.
Topics: Atmosphere; Dimercaprol; Hyperbaric Oxygenation; Oxygen; Pharmacology; Rats; Research; Seizures; Tox | 1965 |
The need for vigilance: the persistence of lead poisoning in children.
Topics: Cheek; Chelation Therapy; Child, Preschool; Dimercaprol; Drug Therapy, Combination; Edema; Edetic Ac | 2005 |
Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice.
Topics: Animals; Benzene Derivatives; Brain; Chelating Agents; Convulsants; Dimercaprol; Disease Models, Ani | 2006 |
Experiments on the convulsant and anaesthetic effects of oxygen.
Topics: Anesthesia, Inhalation; Animals; Anticonvulsants; Brain; Bromides; Chlorpromazine; Cobalt; Dimercapr | 1967 |
Studies on the oxygen toxicity after administration of chelate-forming agents in mice.
Topics: Animals; Carbon Dioxide; Chelating Agents; Dimercaprol; Drug Synergism; Female; Hyperbaric Oxygenati | 1983 |
Investigations into the mechanism of 2,3-dimercaptopropanol neurotoxicity.
Topics: Animals; Anticonvulsants; Brain; Cell Membrane; Chelating Agents; Dimercaprol; Dizocilpine Maleate; | 2000 |
Letter: Severe lead poisoning in a 6-month-old infant.
Topics: Anemia; Bone Development; Ceramics; Citrus; Diagnosis, Differential; Dimercaprol; Edetic Acid; Femal | 1975 |
[Myoclonic and convulsive encephalopathy caused by bismuth. Usefulness of dimercaprol treatment].
Topics: Bismuth; Dimercaprol; Humans; Male; Middle Aged; Myoclonus; Seizures | 1985 |
Effect of dimercaprol on oxygen toxicity in rats.
Topics: Animals; Antidotes; Benzoates; Dimercaprol; Glycerol; Hyperbaric Oxygenation; Oils; Oxygen; Rats; Se | 1965 |
[Central excitation caused by molecules with thiolic structure].
Topics: Animals; Brain Chemistry; Cysteamine; Dimercaprol; Liver; Rats; Seizures; Sulfhydryl Compounds; Trem | 1965 |