dimercaprol has been researched along with Pregnancy in 29 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Congenital lead poisoning is uncommon and there is no consensus on the management of the newborn." | 7.76 | Asymptomatic congenital lead poisoning - case report. ( Chinnakaruppan, NR; Marcus, SM, 2010) |
| "Congenital lead poisoning is uncommon and there is no consensus on the management of the newborn." | 3.76 | Asymptomatic congenital lead poisoning - case report. ( Chinnakaruppan, NR; Marcus, SM, 2010) |
| " The mother was prescribed a single course of oral succimer late in the third trimester of pregnancy, without any appreciable change in her blood lead." | 3.71 | Lead poisoning and chelation in a mother-neonate pair. ( Horowitz, BZ; Mirkin, DB, 2001) |
| "Albino rats of Wistar strain (Tamura 1950) breeded in a closed colony were administered arsenic trioxide orally during pregnancy (from the 0 day to the 20th day)." | 3.65 | [Arsenic metabolism. (17) Studies of placental transfer of arsenic and the effects of antidotes and diet]. ( Tanaka, I, 1976) |
| " BAL given following arsenite was not able to ameliorate the developmentally toxic effects of arsenite seen in mice, whereas treatment with DMPS at 150 and 300 mg/kg showed significant protective effects against arsenite embryotoxicity and teratogenicity." | 1.28 | Amelioration by BAL (2,3-dimercapto-1-propanol) and DMPS (sodium 2,3-dimercapto-1-propanesulfonic acid) of arsenite developmental toxicity in mice. ( Bosque, MA; Corbella, J; Domingo, JL; Llobet, JM, 1992) |
| "The sodium salt of 2,3-dimercaptopropane-1-sulfonic acid (DMPS), a water soluble metal complexing agent, was administered to four groups of pregnant Swiss mice at 0, 70, 210, and 630 mg/kg/day by two dosing schedules: gestation day 14 until birth (prenatal exposure), and gestation day 14 until postnatal day 21 (pre- and postnatal section)." | 1.28 | Evaluation of the developmental effects on mice after prenatal, or pre- and postnatal exposure to 2,3-dimercaptopropane-1-sulfonic acid (DMPS). ( Bosque, MA; Corbella, J; Domingo, JL; Ortega, A, 1990) |
| " There were no maternal toxic effects, and no treatment-related changes were recorded in the number of total implants, resorption, the number of live and dead fetuses, fetal body weight or fetal sex distribution data." | 1.28 | Evaluation of the developmental toxicity of 2,3-dimercapto-1-propanesulfonate (DMPS) in mice. Effect on mineral metabolism. ( Bosque, MA; Corbella, J; Domingo, JL; Llobet, JM; Paternain, JL, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (72.41) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chinnakaruppan, NR | 1 |
| Marcus, SM | 1 |
| CZIKAJLO, G | 1 |
| KERKOVITS, G | 1 |
| Mycyk, MB | 1 |
| Leikin, JB | 1 |
| Houvenaghel, A | 2 |
| Peeters, G | 2 |
| Sensirivatana, R | 1 |
| Supachadhiwong, O | 1 |
| Phancharoen, S | 1 |
| Mitrakul, C | 1 |
| Hood, RD | 3 |
| Vedel-Macrander, GC | 1 |
| Chisolm, JJ | 1 |
| Khayat, A | 1 |
| Dencker, L | 1 |
| Wannag, A | 1 |
| Aaseth, J | 1 |
| Gomez, M | 1 |
| Sanchez, DJ | 1 |
| Colomina, MT | 1 |
| Domingo, JL | 4 |
| Corbella, J | 4 |
| Horowitz, BZ | 1 |
| Mirkin, DB | 1 |
| Karimi, A | 1 |
| Moniri, F | 1 |
| Nasihatkon, A | 1 |
| Zarepoor, MJ | 1 |
| Alborzi, A | 1 |
| Philips, VK | 1 |
| Latour, JG | 1 |
| Groulx, C | 1 |
| Léger-Gauthier, C | 1 |
| Neetens, A | 1 |
| Martin, J | 1 |
| Hendrata, Y | 1 |
| Rubbens, MC | 1 |
| Tanaka, I | 1 |
| Thacker, GT | 1 |
| Patterson, BL | 1 |
| Bosque, MA | 3 |
| Llobet, JM | 2 |
| Ortega, A | 1 |
| Paternain, JL | 1 |
| Heyden, G | 1 |
| From, SH | 1 |
| McCormick, JT | 1 |
| Senior, J | 1 |
| Snyder, RD | 1 |
| Pierce, PE | 1 |
| Thompson, JF | 1 |
| Likosky, WH | 1 |
| Nickey, LN | 1 |
| Barthel, WF | 1 |
| Hinman, AR | 1 |
| Pike, CT | 1 |
| Chard, T | 1 |
| Lugo, G | 1 |
| Cassady, G | 1 |
| Palmisano, P | 1 |
| Dreifuss, FE | 1 |
| McKinney, WM | 1 |
2 reviews available for dimercaprol and Pregnancy
| Article | Year |
|---|---|
Poisoning from heavy metals (mercury, lead, and cadmium).
Topics: Animals; Body Burden; Cadmium Poisoning; Chelating Agents; Child, Preschool; Dimercaprol; Disease Ou | 1980 |
Intramuscular gold for rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Dimercaprol; Drug Administration Schedule; Drug Eruptions; Female; Gold; Huma | 1977 |
27 other studies available for dimercaprol and Pregnancy
| Article | Year |
|---|---|
Asymptomatic congenital lead poisoning - case report.
Topics: Adult; Dimercaprol; Exchange Transfusion, Whole Blood; Female; Humans; Infant, Newborn; Lead; Lead P | 2010 |
[Dicaptol treated and cured mercury poisoning; uneventful pregnancy in two cases after poisoning].
Topics: Dimercaprol; Humans; Mercury; Mercury Poisoning; Pregnancy | 1953 |
Combined exchange transfusion and chelation therapy for neonatal lead poisoning.
Topics: Adult; Ceramics; Chelating Agents; Chelation Therapy; Combined Modality Therapy; Dimercaprol; Edetic | 2004 |
[Influence of bradykinin on the ejection of milk in the sheep and the goat].
Topics: Animals; Bradykinin; Dimercaprol; Female; Goats; Lactation; Pregnancy; Sheep | 1967 |
Neonatal lead poisoning. An unusual clinical manifestation.
Topics: Adult; Bone and Bones; Diagnosis, Differential; Dimercaprol; Drug Therapy, Combination; Edetic Acid; | 1983 |
Evaluation of the effect of BAL (2,3-dimercaptopropanol) on arsenite-induced teratogenesis in mice.
Topics: Animals; Arsenic; Arsenites; Dimercaprol; Dose-Response Relationship, Drug; Female; Fetal Death; Ges | 1984 |
Fetal uptake and distribution of metallic mercury vapor in the mouse: influence of ethanol and aminotriazole.
Topics: Amitrole; Animals; Dimercaprol; Ethanol; Female; Fetus; Gestational Age; Mercury; Mice; Mice, Inbred | 1982 |
The effect of immediate and delayed treatment with 2,3-dimercaptopropane-1-sulphonate on the distribution and toxicity of inorganic mercury in mice and in foetal and adult rats.
Topics: Animals; Brain; Chelating Agents; Dimercaprol; Extraembryonic Membranes; Feces; Female; Fetus; Kidne | 1980 |
Evaluation of the protective activity of 2,3-dimercaptopropanol and sodium 2,3-dimercaptopropane-1-sulfonate on methylmercury-induced developmental toxicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Dimercaprol; Female; Fetus; Methylmercury Compounds; Mice; Pre | 1994 |
Lead poisoning and chelation in a mother-neonate pair.
Topics: Adult; Chelating Agents; Chelation Therapy; Dimercaprol; Edetic Acid; Female; Fetal Blood; Humans; I | 2001 |
Mercury exposure among residents of a building block in Shiraz, Iran.
Topics: Adolescent; Adult; Chelating Agents; Child; Child, Preschool; Dimercaprol; Environmental Exposure; F | 2002 |
Activation of the Hageman factor-prekallikrein system in the pathogenesis of the generalized Shwartzman reaction and of the hepatic vein thrombosis phenomenon in the rat.
Topics: Animals; Arginine; Bradykinin; Dexamethasone; Dimercaprol; Endotoxins; Esterases; Factor XII; Female | 1979 |
Iatrogenic breakdown of the corneal epithelium.
Topics: Adult; Anesthetics, Local; Bismuth; Colon; Cornea; Dimercaprol; Female; Humans; Pregnancy | 1977 |
[Arsenic metabolism. (17) Studies of placental transfer of arsenic and the effects of antidotes and diet].
Topics: Animals; Antidotes; Arsenic; Ascorbic Acid; Diet; Dimercaprol; Female; Fetus; Male; Maternal-Fetal E | 1976 |
Effects in the mouse and rat of prenatal exposure to arsenic.
Topics: Abnormalities, Drug-Induced; Animals; Arsenic; Dimercaprol; Dose-Response Relationship, Drug; Female | 1977 |
Amelioration by BAL (2,3-dimercapto-1-propanol) and DMPS (sodium 2,3-dimercapto-1-propanesulfonic acid) of arsenite developmental toxicity in mice.
Topics: Animals; Arsenic; Arsenites; Dimercaprol; Drug Interactions; Female; Fetal Death; Fetal Resorption; | 1992 |
Evaluation of the developmental effects on mice after prenatal, or pre- and postnatal exposure to 2,3-dimercaptopropane-1-sulfonic acid (DMPS).
Topics: Animals; Animals, Newborn; Dimercaprol; Female; Labor, Obstetric; Lactation; Litter Size; Mice; Preg | 1990 |
Evaluation of the developmental toxicity of 2,3-dimercapto-1-propanesulfonate (DMPS) in mice. Effect on mineral metabolism.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Dimercaprol; Embryonic and | 1990 |
[Effect of bradykinin on the secretion of milk by sheep and horses].
Topics: Animals; Bradykinin; Dimercaprol; Drug Synergism; Female; Horses; Kymography; Lactation; Mammary Gla | 1968 |
A histochemical demonstration of ATPase activity druing tooth ontogeny in the mouse.
Topics: Adenosine Triphosphatases; Ameloblasts; Animals; Chloromercuribenzoates; Dimercaprol; Female; Histoc | 1969 |
Plasma kinin and kininogen levels in the female rat during the oestrous cycle, pregnancy, parturition and the puerperium.
Topics: Animals; Biological Assay; Blood Volume; Bradykinin; Chymotrypsin; Dimercaprol; Estrus; Female; In V | 1974 |
The involuntary movements of chronic mercury poisoning.
Topics: Adolescent; Adult; Ataxia; Child; Dimercaprol; Female; Fetal Diseases; Humans; Infant, Newborn; Infa | 1972 |
Alkyl mercury poisoning in humans. Report of an outbreak.
Topics: Adolescent; Adult; Amniocentesis; Animal Feed; Ataxia; Cerebellum; Child; Child, Preschool; Coma; Di | 1972 |
BAL alleviation of arsenate-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Animals; Arsenic; Body Weight; Dimercaprol; Female; Fetal Death; Fetus; | 1972 |
Application of the radioimmunoassay technique for determining plasma levels of oxytocinase.
Topics: Aminopeptidases; Dimercaprol; Female; Humans; Methods; Oxytocin; Pregnancy; Radioimmunoassay | 1969 |
Acute maternal arsenic intoxication with neonatal death.
Topics: Acute Kidney Injury; Adolescent; Arsenic; Arsenic Poisoning; Brain; Dimercaprol; Female; Humans; Hya | 1969 |
Wilson's disease (hepatolenticular degeneration) and pregnancy.
Topics: Adult; Ceruloplasmin; Dimercaprol; Female; Hepatolenticular Degeneration; Humans; Pregnancy; Pregnan | 1966 |