Page last updated: 2024-10-26

dimercaprol and Polyarthritis

dimercaprol has been researched along with Polyarthritis in 10 studies

Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.

Research Excerpts

ExcerptRelevanceReference
"Oral gold (auranofin) has been used in 31 patients, 20 with active rheumatoid arthritis and 11 with active psoriatic arthritis."9.05Longterm experience with oral gold in rheumatoid arthritis and psoriatic arthritis. ( Dequeker, J; Gevers, G; Vanschoubroek, K; Verdickt, W, 1984)
"The authors describe the association of gold salt-induced cholestasis and lymphocytic alveolitis proved by liver biopsy and broncho-alveolar lavage."7.67Cholestasis and pneumonitis induced by gold therapy. ( Colombel, JF; Delcambre, B; Duquesnoy, B; Farre, JM; Hautefeuille, P; Perez, T; Tonnel, F, 1989)
"Oral gold (auranofin) has been used in 31 patients, 20 with active rheumatoid arthritis and 11 with active psoriatic arthritis."5.05Longterm experience with oral gold in rheumatoid arthritis and psoriatic arthritis. ( Dequeker, J; Gevers, G; Vanschoubroek, K; Verdickt, W, 1984)
"The authors describe the association of gold salt-induced cholestasis and lymphocytic alveolitis proved by liver biopsy and broncho-alveolar lavage."3.67Cholestasis and pneumonitis induced by gold therapy. ( Colombel, JF; Delcambre, B; Duquesnoy, B; Farre, JM; Hautefeuille, P; Perez, T; Tonnel, F, 1989)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-199010 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
MCMAHON, JM1
WATSON, EM1
THOMPSON, M1
SINCLAIR, RJ1
DUTHIE, JJ1
EDSTROM, G1
GARDNER, GM1
FAIRLEY, DL1
KUZELL, WC1
Dequeker, J1
Verdickt, W1
Gevers, G1
Vanschoubroek, K1
Farre, JM1
Perez, T1
Hautefeuille, P1
Tonnel, F1
Colombel, JF1
Duquesnoy, B1
Delcambre, B1
Fraisse, P1
Sutter, B1
Tritschler, JL1
Niederberger, P1
Kuntz, JL1
Asch, L1
Burdeĭnyĭ, AP1
Sigidin, IaA1
Novoselova, TM1
Maslennikov, EIu1
Perepechaĭ, LD1
Vulkov, GA1

Trials

2 trials available for dimercaprol and Polyarthritis

ArticleYear
Longterm experience with oral gold in rheumatoid arthritis and psoriatic arthritis.
    Clinical rheumatology, 1984, Volume: 3 Suppl 1

    Topics: Adult; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Auranofin; Aurothioglucose; Clini

1984
[Treatment of psoriatic arthritis with gold salts (chrysotherapy)].
    Terapevticheskii arkhiv, 1986, Volume: 58, Issue:7

    Topics: Adult; Arthritis; Clinical Trials as Topic; Dimercaprol; Drug Therapy, Combination; Female; Gold; Hu

1986

Other Studies

8 other studies available for dimercaprol and Polyarthritis

ArticleYear
Toxic reaction from gold appearing during ACTH administration; report of a case.
    The New Orleans medical and surgical journal, 1952, Volume: 104, Issue:16

    Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Dimercaprol; Gold; Postoperative Comp

1952
The haematopathological complications of gold therapy: effects of splenectomy and bal.
    Canadian Medical Association journal, 1953, Volume: 69, Issue:1

    Topics: Anemia; Anemia, Aplastic; Arthritis; Arthritis, Rheumatoid; Dimercaprol; Gold; Humans; Purpura; Purp

1953
Thrombocytopenic purpura after administration of gold; comparison of treatment with dimercaprol, A.C.T.H., and cortisone.
    British medical journal, 1954, Apr-17, Volume: 1, Issue:4867

    Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Cortisone; Dimercaprol; Gold; Purpura

1954
The effects of 2.3-dimercaptopropanol (BAL) on gold reactions.
    Annals of the rheumatic diseases, 1950, Volume: 9, Issue:2

    Topics: Arthritis; Dimercaprol; Gold; Organogold Compounds

1950
Effect of BAL on experimental polyarthritis of rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1949, Volume: 71, Issue:1

    Topics: Animals; Arthritis; Dimercaprol; Rats

1949
Cholestasis and pneumonitis induced by gold therapy.
    Clinical rheumatology, 1989, Volume: 8, Issue:4

    Topics: Aged; Arthritis; Cholestasis; Dimercaprol; Gold; Humans; Male; Metalloproteins; Organogold Compounds

1989
[Morvan's fibrillary chorea after gold therapy].
    Presse medicale (Paris, France : 1983), 1985, May-11, Volume: 14, Issue:19

    Topics: Anti-Inflammatory Agents; Arthritis; Chorea; Dimercaprol; Female; Gold; Humans; Middle Aged; Organog

1985
[Experimental and clinical substantiation of the intra-articular administration of unithiol in reactive traumatic arthritis].
    Ortopediia travmatologiia i protezirovanie, 1985, Issue:9

    Topics: Animals; Arthritis; Dimercaprol; Female; Injections, Intra-Articular; Knee Injuries; Knee Joint; Mal

1985