dimercaprol has been researched along with Hepatolenticular Degeneration in 75 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Hepatolenticular Degeneration: A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Copper overload in patients with Wilson's disease is caused by impairment to the biliary route for excretion of dietary copper A combination of neurological, psychiatric and hepatic symptoms can make the diagnosis of Wilson's disease challenging." | 2.49 | The treatment of Wilson's disease, a rare genetic disorder of copper metabolism. ( Purchase, R, 2013) |
| "In 1951, BAL was used to treat Wilson's disease with striking success." | 1.32 | British anti-Lewisite (dimercaprol): an amazing history. ( Redman, K; Vilensky, JA, 2003) |
| "Wilson's disease is named after Kinnier Wilson (1878-1937), a famous British neurologist." | 1.28 | Wilson's disease, Kayser and Fleischer's sign and Walshe's treatment. ( McIntyre, N, 1991) |
| "Fifty-eight patients with Wilson's disease are reviewed, of whom 25 symptomatic patients experienced liver disease first and 28, brain disease." | 1.26 | Clinical spectrum of Wilson's disease (hepatolenticular degeneration). ( Dobyns, WB; Goldstein, NP; Gordon, H, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 66 (88.00) | 18.7374 |
| 1990's | 4 (5.33) | 18.2507 |
| 2000's | 4 (5.33) | 29.6817 |
| 2010's | 1 (1.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Purchase, R | 1 |
| Walshe, JM | 5 |
| Vilensky, JA | 2 |
| Robertson, WM | 1 |
| Gilman, S | 1 |
| Redman, K | 1 |
| STREIFLER, M | 1 |
| FELDMAN, S | 1 |
| SCHECHTER, MM | 1 |
| JONES, CA | 1 |
| BONDUELLE, M | 1 |
| HARL, JM | 1 |
| ERDMANN-MULLER, GJ | 1 |
| HORNBOSTEL, H | 2 |
| PALMER, JF | 1 |
| DREW, AL | 1 |
| CHENOWETH, MB | 1 |
| WARNOCK, CG | 1 |
| NEILL, DW | 1 |
| DENNY-BROWN, D | 3 |
| BOUDIN, G | 2 |
| PEPIN, B | 2 |
| GILSANZ, V | 1 |
| SEGOVIA, JM | 1 |
| CASTROMENDOZA, HJ | 1 |
| GOYTRE, A | 1 |
| KNUPPEL, H | 1 |
| BOZHINOV, S | 1 |
| MINNITI, G | 2 |
| FERRISS, GS | 1 |
| BERRY, S | 1 |
| OSBORN, SB | 1 |
| CUMINGS, JN | 3 |
| KUZNETSOVA, NE | 1 |
| WENDER, M | 2 |
| NISHI, N | 1 |
| IIZUKA, R | 1 |
| FUJII, H | 1 |
| KAWAMURA, K | 1 |
| TAKAHATA, N | 1 |
| GIRAULT, M | 1 |
| NGUYEN VAN, LE | 1 |
| TU, JB | 1 |
| HUNG, TP | 1 |
| BLACKWELL, RQ | 1 |
| WATTEN, RH | 1 |
| LAURAS, A | 1 |
| BARRAINE, R | 1 |
| TODA, S | 1 |
| SUZUKI, N | 1 |
| WATANABE, I | 1 |
| WATABE, T | 1 |
| SAKUMA, T | 1 |
| HO, K | 1 |
| SOTODA, S | 1 |
| YAMAKI, Y | 1 |
| MIYAKO, M | 1 |
| AKSOY, M | 2 |
| BIYAL, F | 1 |
| SECER, F | 1 |
| CAKIRGOEZ, C | 1 |
| CETINGIL, AI | 1 |
| BUMBALO, TS | 1 |
| STAUB, RU | 1 |
| VILLANUEVA, OQ | 1 |
| RAVIN, HA | 1 |
| STERNLIEB, I | 2 |
| PETIT, H | 1 |
| OZKAN, E | 1 |
| PRIFTI, J | 1 |
| TAG, T | 1 |
| EKMEKCI, A | 1 |
| RICHMOND, J | 1 |
| ROSENOER, VM | 1 |
| TOMPSETT, SL | 1 |
| DRAPER, I | 1 |
| SIMPSON, JA | 1 |
| WATANABE, H | 1 |
| GOLDSTEIN, NP | 4 |
| RANDALL, RV | 2 |
| GROSS, JB | 2 |
| STEGER, J | 1 |
| STEGER, R | 1 |
| OSETOWSKA-WIECKOWSKA, E | 1 |
| CAROIT, M | 1 |
| HOLLISTER, LE | 1 |
| CULL, VL | 1 |
| GONDA, VA | 1 |
| KOLB, FO | 1 |
| MUELLER, K | 1 |
| PORTER, H | 2 |
| Gellis, SS | 1 |
| Feingold, M | 1 |
| Scheinberg, IH | 1 |
| Munro, NA | 1 |
| Subramanian, I | 1 |
| Vanek, ZF | 1 |
| Bronstein, JM | 1 |
| Belkin, M | 1 |
| Zeimer, R | 1 |
| Chajek, T | 1 |
| Friedman, G | 1 |
| Melamed, E | 1 |
| Dobyns, WB | 1 |
| Gordon, H | 1 |
| McIntyre, N | 1 |
| Liu, DK | 1 |
| Li, NZ | 1 |
| Chen, XZ | 1 |
| Yang, YF | 1 |
| Hoogenraad, TU | 1 |
| Van Hattum, J | 1 |
| Chen, ZR | 1 |
| Mera, A | 1 |
| Gharib, M | 1 |
| Owen, CA | 1 |
| Faur, A | 1 |
| Păsculescu, G | 1 |
| Dörl, F | 1 |
| Blattner, RJ | 1 |
| Bickel, H | 1 |
| Spellberg, MA | 1 |
| Kunath, B | 1 |
| Biesold, D | 1 |
| Tauxe, WN | 1 |
| McCall, JT | 1 |
| Mitchell, AM | 1 |
| Heller, GL | 1 |
| Nath, R | 1 |
| Srivastava, SK | 1 |
| Dreifuss, FE | 1 |
| McKinney, WM | 1 |
| Tavolato, B | 1 |
| De Zanche, L | 1 |
8 reviews available for dimercaprol and Hepatolenticular Degeneration
| Article | Year |
|---|---|
The treatment of Wilson's disease, a rare genetic disorder of copper metabolism.
Topics: Brain; Chelating Agents; Copper; Cornea; Dimercaprol; Drug Discovery; Hepatolenticular Degeneration; | 2013 |
Treatment of Wilson's disease: the historical background.
Topics: Chelating Agents; Dimercaprol; Hepatolenticular Degeneration; History, 20th Century; Humans | 1996 |
Diagnosis and treatment of Wilson's disease.
Topics: Chelating Agents; Copper; Dimercaprol; Enzyme Inhibitors; Female; Hepatolenticular Degeneration; Hum | 2002 |
[Hepatolenticular degeneration: biochemical and therapeutic considerations].
Topics: Adrenal Cortex Hormones; Brain; Ceruloplasmin; Chelating Agents; Copper; Dimercaprol; Edetic Acid; H | 1976 |
[Advances in the study of hepatolenticular degeneration].
Topics: Ceruloplasmin; Copper; Dimercaprol; Hepatolenticular Degeneration; Humans; Liver Transplantation; Pe | 1985 |
Introduction. Symposium on copper metabolism and Wilson's disease.
Topics: Ceruloplasmin; Consanguinity; Copper; Diet Therapy; Dimercaprol; Hepatolenticular Degeneration; Huma | 1974 |
[Wilson's disease (hepatolenticular degeneration)].
Topics: Adolescent; Adult; Biopsy; Brain; Ceruloplasmin; Child; Copper; Dimercaprol; Edetic Acid; Hepatolent | 1966 |
Treatment of hepatolenticular degeneration. (Wilson's disease).
Topics: Acute Disease; Ceruloplasmin; Copper; Diet Therapy; Dimercaprol; Edetic Acid; Ethinyl Estradiol; Hep | 1969 |
1 trial available for dimercaprol and Hepatolenticular Degeneration
| Article | Year |
|---|---|
[Hepatolenticular degeneration or Wilson's disease. Results of treatment].
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Dimercaprol; Hepatolenticular Degeneration; Huma | 1965 |
66 other studies available for dimercaprol and Hepatolenticular Degeneration
| Article | Year |
|---|---|
The conquest of Wilson's disease.
Topics: Chelating Agents; Dimercaprol; Drug Discovery; Hepatolenticular Degeneration; History, 20th Century; | 2009 |
Denny-Brown, Wilson's disease, and BAL (British antilewisite [2,3-dimercaptopropanol]).
Topics: Dimercaprol; Female; Hepatolenticular Degeneration; History, 20th Century; Humans; Male; Motion Pict | 2002 |
British anti-Lewisite (dimercaprol): an amazing history.
Topics: Arsenicals; Chelating Agents; Chemical Warfare Agents; Dimercaprol; England; Heavy Metal Poisoning, | 2003 |
Effect of dimercaprol (BAL) in hepatolenticular degeneration; report of a case, with clinical and electroencephalographic study.
Topics: Dimercaprol; Electroencephalography; Hepatolenticular Degeneration | 1953 |
Hepatolenticular degeneration; review of the literature and report of a case with dimercaprol (BAL) therapy.
Topics: Dimercaprol; Hepatolenticular Degeneration | 1953 |
[Biochemistry of hepatolenticular degeneration; its treatment with BAL].
Topics: Dimercaprol; Hepatolenticular Degeneration | 1953 |
[BAL therapy and copper excretion in hepatolenticular syndrome].
Topics: Biological Transport; Body Fluids; Copper; Dimercaprol; Hepatolenticular Degeneration; Syndrome; Uri | 1953 |
Tissue copper determinations in a case of hepatolenticular degeneration treated with BAL (dimercaprol).
Topics: Copper; Dimercaprol; Hepatolenticular Degeneration; Law Enforcement | 1953 |
Dimercaprol in the pre-neurological stage of Wilson's disease (hepatolenticular degeneration).
Topics: Databases, Genetic; Dimercaprol; Hepatolenticular Degeneration; Humans | 1954 |
Abnormal copper metabolism and hepatolenticular degeneration.
Topics: Body Fluids; Copper; Dimercaprol; Hepatolenticular Degeneration; Humans; Urine | 1953 |
[Hepatolenticular degeneration: a new metabolic disease].
Topics: Amino Acids; Biochemical Phenomena; Copper; Dimercaprol; Hepatolenticular Degeneration; Humans; Meta | 1954 |
[Recent findings on the hepatolenticular syndrome].
Topics: Dimercaprol; Hepatolenticular Degeneration; Syndrome | 1954 |
[Hepatolenticular Degeneration].
Topics: Adrenocorticotropic Hormone; Amino Acids; Copper; Dimercaprol; Hepatolenticular Degeneration; Humans | 1954 |
[On BAL treatment of hepatolenticular degeneration].
Topics: Dimercaprol; Hepatolenticular Degeneration; Humans | 1956 |
[BAL (2, 3-dimercaptopropanol) therapy of hepatolenticular degeneration].
Topics: Dimercaprol; Hepatolenticular Degeneration | 1955 |
[A case of Wilson's disease of Kehrer's abdominal variety].
Topics: Abdomen; Dimercaprol; Hepatolenticular Degeneration; Humans | 1956 |
[A case of Wilson's disease of Kehrer's abdominal variety].
Topics: Abdomen; Dimercaprol; Hepatolenticular Degeneration; Humans | 1956 |
[A case of Wilson's disease of Kehrer's abdominal variety].
Topics: Abdomen; Dimercaprol; Hepatolenticular Degeneration; Humans | 1956 |
[A case of Wilson's disease of Kehrer's abdominal variety].
Topics: Abdomen; Dimercaprol; Hepatolenticular Degeneration; Humans | 1956 |
Hepatolenticular degeneration; follow-up report of a case treated with dimercaprol (BAL), potassium sulfide, and high-protein diet.
Topics: Diet; Dimercaprol; Follow-Up Studies; Hepatolenticular Degeneration; Humans; Potassium; Sulfides | 1957 |
Effects of penicillamine and dimercaprol on turnover of copper in patients with Wilson's disease.
Topics: Copper; Cysteine; Dimercaprol; Hepatolenticular Degeneration; Humans; Penicillamine | 1958 |
The treatment of hepatolenticular degeneration.
Topics: Cysteine; Dimercaprol; Hepatolenticular Degeneration; Humans | 1959 |
[The content of histamine in the blood of patients with hepatolenticular degeneration (before and after therapy with thio compounds)].
Topics: Dimercaprol; Hepatolenticular Degeneration; Histamine; Maleates | 1960 |
[Results of the treatment of hepatolenticular degeneration with small doses of BAL, potassium sulfide and protein-rich diets].
Topics: Diet; Dimercaprol; Hepatolenticular Degeneration; Nutrition Assessment; Nutritional Status; Potassiu | 1961 |
[Results of BAL therapy of hepatolenticular degeneration].
Topics: Dimercaprol; Hepatolenticular Degeneration | 1959 |
[On 2 family lines with Wilson's pseudosclerosis. Clinical course and therapy, with special reference to combined therapy with BAL, penicillamine and vitamin E].
Topics: Chelating Agents; Dimercaprol; Hepatolenticular Degeneration; Humans; Penicillamine; Psychotherapy, | 1963 |
[Westphal-Strumpell pseudosclerosis. Clinical, biological and chemical study of 3 cases reported for the 1st time in Viet-Nam. Favorable influence of B.A.L].
Topics: Dimercaprol; Hepatolenticular Degeneration; Leadership; Vietnam | 1962 |
STUDY OF WILSON'S DISEASE IN TAIWAN.
Topics: Adolescent; Blood Chemical Analysis; Child; China; Clinical Laboratory Techniques; Dimercaprol; Hepa | 1962 |
[OUR EXPERIENCE IN THE TREATMENT OF WILSON'S DISEASE WITH PENICILLAMINE].
Topics: Adolescent; Copper; Dimercaprol; Edetic Acid; Hepatolenticular Degeneration; Humans; Neurologic Mani | 1963 |
[LONG-TERM USE OF BAL IN WILSON'S DISEASE WITH SPECIAL REFERENCE TO THE OBSERVATION OF CHANGES IN BLOOD COPPER AND LIVER TISSUE].
Topics: Adolescent; Blood Chemical Analysis; Copper; Dimercaprol; Genetics, Medical; Hepatolenticular Degene | 1964 |
[2 CASES OF WILSON'S DISEASE, WITH SPECIAL REFERENCE TO THERAPY AND THE DANGER OF FURTHER PROGRESS OF THE DISEASE].
Topics: Blood Chemical Analysis; Body Fluids; Child; Dimercaprol; Hepatolenticular Degeneration; Pathology; | 1964 |
[HEPATOCEREBRAL OR HEPATOLENTICULAR DEGENERATION].
Topics: Adolescent; Alkaline Phosphatase; Amino Acids; Bilirubin; Blood Coagulation Tests; Ceruloplasmin; Ch | 1964 |
WILSON'S DISEASE.
Topics: Child; Clinical Laboratory Techniques; Dimercaprol; Genetics, Medical; Hepatolenticular Degeneration | 1964 |
WILSON'S DISEASE, AN INBORN ERROR OF METABOLISM AND A MODEL OF DEGENERATIVE CENTRAL NERVOUS SYSTEM DISEASE.
Topics: Central Nervous System Diseases; Chelating Agents; Copper; Dimercaprol; Hepatolenticular Degeneratio | 1964 |
WILSON'S DISEASE AS A GASTROENTEROLOGIC PROBLEM.
Topics: Copper; Diet; Diet Therapy; Dimercaprol; Gastroenterology; Genetics, Medical; Hepatolenticular Degen | 1964 |
[CURRENT ASPECTS OF WILSON'S DISEASE].
Topics: Carbamates; Ceruloplasmin; Diagnosis; Diet; Diet Therapy; Dimercaprol; Drug Therapy; Esters; Genetic | 1964 |
[MODE OF ACTION OF CHELATOR AGENTS IN THE TREATMENT OF HEPATOLENTICULAR DEGENERATION].
Topics: Chelating Agents; Dimercaprol; Edetic Acid; Hepatolenticular Degeneration; Humans; Penicillamine | 1964 |
HEPATO-LENTICULAR DEGENERATION (WILSON'S DISEASE) TREATED BY PENICILLAMINE.
Topics: Adolescent; Alkaline Phosphatase; Bilirubin; Blood Chemical Analysis; Blood Protein Electrophoresis; | 1964 |
[WILSON'S DISEASE].
Topics: Chelating Agents; Dimercaprol; Drug Therapy; Hepatolenticular Degeneration; Humans | 1965 |
CHEMICAL THERAPY OF WILSON'S DISEASE.
Topics: Dimercaprol; Drug Therapy; Edetic Acid; Hepatolenticular Degeneration; Humans; Penicillamine | 1965 |
[Disorders of copper and amino acid metabolism in hepato-cerebral degeneration and their treatment with BAL].
Topics: Amino Acids; Biochemical Phenomena; Copper; Dimercaprol; Hepatolenticular Degeneration; Humans; Neur | 1954 |
[New concepts of pathogenesis of hepatolenticular degeneration; attempt of BAL therapy; first report].
Topics: Dimercaprol; Hepatolenticular Degeneration | 1955 |
[BAL therapy of hepatolenticular degeneration].
Topics: Dimercaprol; Hepatolenticular Degeneration | 1955 |
Hepatolenticular degeneration. Clinical, biochemical and pathologic study of a patient with fulminant course aggravated by treatment with BAL and versenate.
Topics: Dimercaprol; Edetic Acid; Hepatolenticular Degeneration; Medical Records | 1960 |
[Side-effects in BAL therapy of hepatolenticular degeneration (Westphal-Strumpell-Wilson)].
Topics: Dimercaprol; Hepatolenticular Degeneration | 1960 |
The effects of B.A.L. in hepatolenticular degeneration.
Topics: Corpus Striatum; Dimercaprol; Hepatolenticular Degeneration | 1951 |
The effect of BAL (2,3-dimercaptopropanol) on hepatolenticular degeneration (Wilson's disease).
Topics: Dimercaprol; Hepatolenticular Degeneration; Humans | 1951 |
DIMERCAPROL for hepatolenticular degeneration.
Topics: Dimercaprol; Hepatolenticular Degeneration | 1952 |
The effect of BAL (2,3-dimercaptopropanol) on hepatolenticular degeneration (Wilson's disease).
Topics: Dimercaprol; Hepatolenticular Degeneration; Humans | 1951 |
Picture of the month. Wilson's disease (hepato-lenticular degeneration).
Topics: Child; Diet; Dimercaprol; Eye Manifestations; Facial Expression; Female; Hepatolenticular Degenerati | 1967 |
Treatment of the neurologic manifestations of Wilson's disease.
Topics: Dimercaprol; Hepatolenticular Degeneration; Humans; Molybdenum; Nervous System Diseases; Penicillami | 1995 |
Zinc-induced deterioration in Wilson's disease aborted by treatment with penicillamine, dimercaprol, and a novel zero copper diet.
Topics: Adult; Copper; Dimercaprol; Female; Hepatolenticular Degeneration; Humans; Penicillamine; Sulfates; | 1995 |
Non-invasive quantitation of corneal copper in hepatolenticular degeneration (Wilson's disease).
Topics: Adolescent; Adult; Copper; Cornea; Dimercaprol; Hepatolenticular Degeneration; Humans; Middle Aged; | 1976 |
Clinical spectrum of Wilson's disease (hepatolenticular degeneration).
Topics: Adolescent; Adult; Brain Diseases; Child; Copper; Cornea; Dimercaprol; Female; Hepatolenticular Dege | 1979 |
Wilson's disease, Kayser and Fleischer's sign and Walshe's treatment.
Topics: Ceruloplasmin; Corneal Diseases; Dimercaprol; Hepatolenticular Degeneration; History, 20th Century; | 1991 |
Unithiol in Wilson's disease.
Topics: Adolescent; Copper; Dimercaprol; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Unithio | 1985 |
Unithiol in Wilson's disease.
Topics: Dimercaprol; Hepatolenticular Degeneration; Humans; Male; Unithiol; Zinc | 1985 |
[Early diagnosis and treatment of hepatolenticular degeneration: clinical analysis of 92 cases].
Topics: Adolescent; Adult; Child; Diagnosis, Differential; Dimercaprol; Female; Hepatolenticular Degeneratio | 1985 |
Inborn errors of metabolism in neurology (Wilson's disease, Refsum's disease and lipidoses).
Topics: Adolescent; Adult; Cerebral Cortex; Ceruloplasmin; Cholesterol; Copper; Dimercaprol; Fatty Acids; Fe | 1971 |
Uncommon EEG findings in hepato-lenticular degeneration.
Topics: Cerebral Cortex; Child; Dimercaprol; Electroencephalography; Epilepsy; Female; Hepatolenticular Dege | 1969 |
Unusual problems tend to appear in crops.
Topics: Adult; Biopsy; Ceruloplasmin; Child; Diagnosis, Differential; Diet; Dimercaprol; Eye Manifestations; | 1971 |
[Current treatment of hepatolenticular degenerescence].
Topics: Adrenal Cortex Hormones; Cysteine; Diet Therapy; Dimercaprol; Edetic Acid; Folic Acid; Hepatolenticu | 1972 |
Hemolytic anemia associated with Wilson's disease.
Topics: Adult; Anemia, Hemolytic; Ascites; Child; Copper; Cornea; Diet Therapy; Dimercaprol; Edetic Acid; Fe | 1967 |
[Wilson's disease: hepatocerebral degeneration. 2. Clinical findings and therapy].
Topics: Adult; Dimercaprol; Female; Hepatolenticular Degeneration; Humans; Male; Penicillamine; Prognosis | 1969 |
Wilson's disease (hepatolenticular degeneration). Treatment with penicillamine and changes in hepatic trapping of radioactive copper.
Topics: Adolescent; Adult; Child; Child, Preschool; Copper; Diet Therapy; Dimercaprol; Female; Hepatolenticu | 1971 |
Changes in Kayser-Fleischer ring during treatment of hepatolenticular degeneration.
Topics: Adult; Copper; Cornea; Diet Therapy; Dimercaprol; Female; Hepatolenticular Degeneration; Humans; Mal | 1968 |
Role of citrate in abnormal copper metabolism.
Topics: Aniline Compounds; Blood; Ceruloplasmin; Citrates; Copper; Dimercaprol; Hepatolenticular Degeneratio | 1965 |
Wilson's disease (hepatolenticular degeneration) and pregnancy.
Topics: Adult; Ceruloplasmin; Dimercaprol; Female; Hepatolenticular Degeneration; Humans; Pregnancy; Pregnan | 1966 |
[Therapeutic considerations on Wilson's disease].
Topics: Adult; Dimercaprol; Hepatolenticular Degeneration; Humans; Male; Mental Disorders; Movement Disorder | 1966 |