dimercaprol and Hepatocellular Carcinoma
dimercaprol has been researched along with Hepatocellular Carcinoma in 2 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Pretreatment with diamide and PAO rapidly prevented the inducer-dependent formation of the Ah receptor/xenobiotic response element complex detected by electrophoretic mobility shift assays and suppressed Ah receptor-mediated transcription." | 1.30 | DNA binding activity of the aryl hydrocarbon receptor is sensitive to redox changes in intact cells. ( Pasco, DS; Siu, CS; Xu, C, 1998) |
Research
Studies (2)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (50.00) | 18.7374 |
1990's | 1 (50.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Xu, C | 1 |
Siu, CS | 1 |
Pasco, DS | 1 |
Schultz, A | 1 |
Sasaki, M | 1 |
Natelson, S | 1 |
Other Studies
2 other studies available for dimercaprol and Hepatocellular Carcinoma
Article | Year |
---|---|
DNA binding activity of the aryl hydrocarbon receptor is sensitive to redox changes in intact cells.
Topics: Animals; Arsenicals; Biological Transport; Carcinoma, Hepatocellular; Cytochrome P-450 CYP1A1; Diami | 1998 |
Comparison of the ribonucleotide with the canavanine reductase system.
Topics: Amino Acid Oxidoreductases; Animals; Canavanine; Carcinoma, Hepatocellular; Cell Division; Cells, Cu | 1974 |