dimercaprol has been researched along with Fetal Death in 4 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " BAL given following arsenite was not able to ameliorate the developmentally toxic effects of arsenite seen in mice, whereas treatment with DMPS at 150 and 300 mg/kg showed significant protective effects against arsenite embryotoxicity and teratogenicity." | 1.28 | Amelioration by BAL (2,3-dimercapto-1-propanol) and DMPS (sodium 2,3-dimercapto-1-propanesulfonic acid) of arsenite developmental toxicity in mice. ( Bosque, MA; Corbella, J; Domingo, JL; Llobet, JM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hood, RD | 3 |
| Vedel-Macrander, GC | 1 |
| Thacker, GT | 1 |
| Patterson, BL | 1 |
| Domingo, JL | 1 |
| Bosque, MA | 1 |
| Llobet, JM | 1 |
| Corbella, J | 1 |
| Pike, CT | 1 |
4 other studies available for dimercaprol and Fetal Death
| Article | Year |
|---|---|
Evaluation of the effect of BAL (2,3-dimercaptopropanol) on arsenite-induced teratogenesis in mice.
Topics: Animals; Arsenic; Arsenites; Dimercaprol; Dose-Response Relationship, Drug; Female; Fetal Death; Ges | 1984 |
Effects in the mouse and rat of prenatal exposure to arsenic.
Topics: Abnormalities, Drug-Induced; Animals; Arsenic; Dimercaprol; Dose-Response Relationship, Drug; Female | 1977 |
Amelioration by BAL (2,3-dimercapto-1-propanol) and DMPS (sodium 2,3-dimercapto-1-propanesulfonic acid) of arsenite developmental toxicity in mice.
Topics: Animals; Arsenic; Arsenites; Dimercaprol; Drug Interactions; Female; Fetal Death; Fetal Resorption; | 1992 |
BAL alleviation of arsenate-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Animals; Arsenic; Body Weight; Dimercaprol; Female; Fetal Death; Fetus; | 1972 |