dimercaprol has been researched along with Chronic Disease in 23 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the German Federal Republic it has recently become known that generalised disorders of chronic mercury poisoning (loss of weight, stomatitis, hearing and sensory loss, emotional disturbances) have accompanied the cardinal signs of nail discolouration and loss of hair." | 7.65 | [Nail changes and loss of hair: cardinal signs of mercury poisoning from hair bleaches (author's transl)]. ( Herpers, H; Käferstein, H; Orfanos, CE; Steinbach, H; Wüstner, H, 1975) |
| "In the German Federal Republic it has recently become known that generalised disorders of chronic mercury poisoning (loss of weight, stomatitis, hearing and sensory loss, emotional disturbances) have accompanied the cardinal signs of nail discolouration and loss of hair." | 3.65 | [Nail changes and loss of hair: cardinal signs of mercury poisoning from hair bleaches (author's transl)]. ( Herpers, H; Käferstein, H; Orfanos, CE; Steinbach, H; Wüstner, H, 1975) |
| "Treatment with dimercaprol remains the mainstay of therapy, and early treatment is necessary to prevent irreversible complications." | 1.26 | Arsenic poisoning. ( Schoolmeester, WL; White, DR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (82.61) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GIANNATTASIO, RC | 1 |
| PIROZZI, MJ | 1 |
| BEDO, AV | 1 |
| JENNINGS, KG | 1 |
| COLE, HN | 1 |
| DOBRINA, D | 1 |
| VOTAVA, Z | 1 |
| VEJVODOVA, L | 1 |
| Mancinella, A | 1 |
| Schoolmeester, WL | 1 |
| White, DR | 1 |
| Sarukhanian, ZhG | 1 |
| Babaian, EA | 1 |
| Nazaretian, RA | 1 |
| Oganesian, RD | 1 |
| Darbinian, GV | 1 |
| Tsyganok, SS | 1 |
| Dubinskiĭ, AA | 1 |
| Guĭda, PP | 1 |
| Wüstner, H | 1 |
| Orfanos, CE | 1 |
| Steinbach, H | 1 |
| Käferstein, H | 1 |
| Herpers, H | 1 |
| Ornat, SIa | 1 |
| Kovalev, IuN | 1 |
| Il'in, II | 1 |
| Makarchuk, OS | 1 |
| Berezhnitskiĭ, MN | 1 |
| Virstiuk, NG | 1 |
| Hall, JC | 1 |
| Harruff, R | 1 |
| Gitter, E | 1 |
| Bonitz, G | 1 |
| Fomicheva, LV | 1 |
| Gmyria, AI | 1 |
| Chisolm, JJ | 1 |
| Kettner, W | 1 |
| Vogel, K | 1 |
| Krüger, G | 1 |
| Barltrop, D | 1 |
| Kośmider, S | 1 |
| Klopotowski, J | 1 |
| Lüders, G | 1 |
| Fischer, H | 1 |
| Hensel, U | 1 |
| Lange, J | 1 |
3 reviews available for dimercaprol and Chronic Disease
| Article | Year |
|---|---|
[Current levels of cadmium in living organisma: physiopathological, clinical and therapeutic considerations].
Topics: Aspirin; Cadmium; Cadmium Poisoning; Chronic Disease; Dimercaprol; Edetic Acid; Environmental Pollut | 1981 |
The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood.
Topics: Acute Disease; Amino Acids; Animals; Brain Diseases; Child; Child, Preschool; Chronic Disease; Creat | 1968 |
Lead poisoning.
Topics: Air Pollution; Bone and Bones; Child, Preschool; Chronic Disease; Dexamethasone; Dimercaprol; Edetic | 1971 |
1 trial available for dimercaprol and Chronic Disease
| Article | Year |
|---|---|
[Unithiol in the treatment of dermatoses].
Topics: Adolescent; Adult; Chronic Disease; Clinical Trials as Topic; Dimercaprol; Drug Evaluation; Eczema; | 1978 |
19 other studies available for dimercaprol and Chronic Disease
| Article | Year |
|---|---|
BAL therapy in chronic lead poisoning.
Topics: Chronic Disease; Dimercaprol; Humans; Lead; Lead Poisoning | 1952 |
Use of dimercaprol (BAL) ointment in chronic chrome dermatitis.
Topics: Chromium; Chromium Radioisotopes; Chronic Disease; Dermatitis; Dermatitis, Contact; Dimercaprol; Hum | 1953 |
[IMMUNITARY MODIFICATIONS INDUCED BY 2-3 DIMERCAPTOPROPANOL IN CHRONIC DISEASES OF THE NERVOUS SYSTEM].
Topics: Central Nervous System Depressants; Chronic Disease; Dimercaprol; Immunity; Nervous System Diseases; | 1964 |
[Effect of BAL on acute and chronic poisoning with arsenic and mercury].
Topics: Arsenic; Arsenicals; Chronic Disease; Dimercaprol; Humans; Mercury; Mercury Compounds; Poisoning; Po | 1950 |
Arsenic poisoning.
Topics: Acute Disease; Adolescent; Adult; Arsenates; Arsenic; Arsenic Poisoning; Child, Preschool; Chronic D | 1980 |
[Possible unithiol and methionine treatment of chronic molybdenum poisoning in white rats].
Topics: Aerosols; Animals; Chronic Disease; Dimercaprol; Drug Evaluation, Preclinical; Methionine; Molybdenu | 1980 |
[Side-effects of the donator of sulfhydryl groups, unithiol].
Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Dimercaprol; Drug Hypersensitivity; Female; Humans; | 1979 |
[Nail changes and loss of hair: cardinal signs of mercury poisoning from hair bleaches (author's transl)].
Topics: Alopecia; Chronic Disease; Cosmetics; Dimercaprol; Female; Humans; Mercury; Mercury Poisoning; Middl | 1975 |
[A method of continuous aurotherapy for rheumatoid arthritis patients under the control of gold excretion].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chronic Disease; Dimercaprol; Feces; Female; Gold; Huma | 1991 |
[The chrysotherapy of patients with Reiter's disease].
Topics: Adolescent; Adult; Antirheumatic Agents; Arthritis, Reactive; Chronic Disease; Dimercaprol; Drug Eva | 1991 |
[The effect of combined drug treatment using gold preparations on indices of lipid peroxidation in patients with rheumatoid arthritis].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Antirheumatic Agents; Arthritis, Rheum | 1990 |
[Changes in the level of unsaturated fatty acids in rheumatoid arthritis patients during treatment].
Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthr | 1990 |
Fatal cardiac arrhythmia in a patient with interstitial myocarditis related to chronic arsenic poisoning.
Topics: Adult; Agricultural Workers' Diseases; Arsenic; Arsenic Poisoning; Chronic Disease; Dimercaprol; Ele | 1989 |
[Chronic arsenic intoxication with atypical involvement of the nervous system].
Topics: Adult; Arsenic; Arsenic Poisoning; Cerebrospinal Fluid Proteins; Chronic Disease; Dimercaprol; Hair; | 1972 |
[Organ of vision in chronic experimental mercury intoxication].
Topics: Animals; Antidotes; Chronic Disease; Dimercaprol; Humans; Hydrogen Sulfide; Mercury Poisoning; Occup | 1973 |
[Clinical picture of argyria].
Topics: Adult; Argyria; Chronic Disease; Dimercaprol; Edetic Acid; Female; Gastritis; Humans; Long-Term Care | 1970 |
[The use of methycillin in cases of chronic mercurialism].
Topics: Adult; Chronic Disease; Dimercaprol; Female; Humans; Male; Mercury; Mercury Poisoning; Methicillin; | 1970 |
[Hydrargyrism of the skin and generalized mercuralism--a side-effect of external treatment with mercury].
Topics: Chronic Disease; Cosmetics; Dimercaprol; Humans; Lentigo; Mercury; Mercury Poisoning | 1968 |
[Chemica damage to the eye in industrial medicine].
Topics: Argyria; Burns, Chemical; Caustics; Chelating Agents; Chronic Disease; Copper; Deferoxamine; Dimerca | 1969 |