dimercaprol has been researched along with Cholestasis, Intrahepatic in 1 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a female patient treated for rheumatoid arthritis, who had gold salt overdose, and in whom acute cholestatic hepatitis occurred three weeks after beginning of therapy." | 1.32 | Prolonged cholestasis and ductopenia following gold salt therapy. ( Basset, C; Denis, J; Poupon, J; Vadrot, J; Zafrani, ES, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Basset, C | 1 |
| Vadrot, J | 1 |
| Denis, J | 1 |
| Poupon, J | 1 |
| Zafrani, ES | 1 |
1 other study available for dimercaprol and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Prolonged cholestasis and ductopenia following gold salt therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bile Duct Diseases; Biopsy; Chemical and Drug Induced L | 2003 |