dimercaprol has been researched along with Cadmium Poisoning in 19 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Cadmium Poisoning: Poisoning occurring after exposure to cadmium compounds or fumes. It may cause gastrointestinal syndromes, anemia, or pneumonitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although cadmium poisoning in humans is uncommon, there are reports of chronic cadmium poisoning in workmen and also in others in certain polluted areas." | 1.26 | Chelation of cadmium with BAL and DTPA in rats. ( Cherian, MG, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GILMAN, A | 2 |
| PHILIPS, FS | 1 |
| TOBIAS, JM | 1 |
| LUSHBAUGH, CC | 1 |
| GINZLER, AM | 1 |
| DALHAMN, T | 1 |
| FRIBERG, L | 1 |
| MACFARLAND, HN | 1 |
| ELSKAMP, DM | 1 |
| Aposhian, HV | 2 |
| Mancinella, A | 1 |
| Chisolm, JJ | 2 |
| Cherian, MG | 2 |
| Rodgers, K | 1 |
| Hornbostel, H | 1 |
| Kaufmann, W | 1 |
| Siegenthaler, W | 1 |
| Jones, MM | 1 |
| Basinger, MA | 1 |
| Peele, DB | 1 |
| Farmer, JD | 1 |
| MacPhail, RC | 1 |
| Verich, GE | 1 |
| Eybl, V | 2 |
| Sýkora, J | 2 |
| Mertl, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Transdermal Absorption of DMPS and Its Effect on Urinary Mercury Excretion[NCT01059474] | Phase 1 | 9 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dimercaprol and Cadmium Poisoning
| Article | Year |
|---|---|
DMSA and DMPS--water soluble antidotes for heavy metal poisoning.
Topics: Animals; Antidotes; Arsenic Poisoning; Biotransformation; Cadmium Poisoning; Dimercaprol; Forecastin | 1983 |
[Current levels of cadmium in living organisma: physiopathological, clinical and therapeutic considerations].
Topics: Aspirin; Cadmium; Cadmium Poisoning; Chronic Disease; Dimercaprol; Edetic Acid; Environmental Pollut | 1981 |
Poisoning from heavy metals (mercury, lead, and cadmium).
Topics: Animals; Body Burden; Cadmium Poisoning; Chelating Agents; Child, Preschool; Dimercaprol; Disease Ou | 1980 |
16 other studies available for dimercaprol and Cadmium Poisoning
| Article | Year |
|---|---|
The treatment of acute cadmium intoxication in rabbits with 2,3-dimercaptopropanol (BAL) and other mercaptans.
Topics: Animals; Cadmium; Cadmium Poisoning; Dimercaprol; Psychoses, Substance-Induced; Rabbits; Sulfhydryl | 1946 |
The pathology and therapy with 2,3-dimercaptopropanol (BAL) of experimental Cd poisoning.
Topics: Cadmium; Cadmium Poisoning; Dimercaprol; Humans | 1946 |
The effect of BAL therapy on the pathology of systemic cadmium poisoning.
Topics: Cadmium; Cadmium Poisoning; Dimercaprol; Humans | 1946 |
Dimercaprol (2, 3-dimercaptopropanol) in chronic cadmium poisoning.
Topics: Cadmium; Cadmium Poisoning; Dimercaprol; Poisoning | 1955 |
The use of dimercaprol (BAL) in the treatment of cadmium oxide fume poisoning.
Topics: Cadmium; Cadmium Compounds; Cadmium Poisoning; Dimercaprol; Oxides | 1960 |
[THERAPY OF CADMIUM POISONING].
Topics: Cadmium; Cadmium Poisoning; Dimercaprol; Edetic Acid; Toxicology | 1964 |
Biological chelation: 2,3-dimercapto-propanesulfonic acid and meso-dimercaptosuccinic acid.
Topics: Animals; Arsenic Poisoning; Arsenites; Cadmium Poisoning; Chelating Agents; Dimercaprol; Lethal Dose | 1982 |
Chelation of cadmium from metallothionein in vivo and its excretion in rats repeatedly injected with cadmium chloride.
Topics: Animals; Cadmium; Cadmium Chloride; Cadmium Poisoning; Copper; Dimercaprol; Kidney; Male; Metallopro | 1982 |
Chelation of cadmium with BAL and DTPA in rats.
Topics: Animals; Cadmium Poisoning; Dimercaprol; Disease Models, Animal; Drug Therapy, Combination; Feces; K | 1980 |
[Therapy of poisoning with heavy metals].
Topics: Aminolevulinic Acid; Cadmium Poisoning; Chromium; Deferoxamine; Dimercaprol; Edetic Acid; Ferrocyani | 1975 |
Restrictions on the applicability of mixed ligand chelate therapy (MLC) in acute cadmium intoxication.
Topics: Acute Disease; Animals; Cadmium Poisoning; Chelating Agents; Dimercaprol; Drug Therapy, Combination; | 1979 |
Behavioral consequences of chelator administration in acute cadmium toxicity.
Topics: Animals; Behavior, Animal; Body Weight; Cadmium Poisoning; Chelating Agents; Conditioning, Operant; | 1988 |
[Effect of unithiol and lipamide on the cardiovascular function of animals administered cadmium and copper compounds].
Topics: Animals; Antidotes; Cadmium Poisoning; Cardiovascular System; Copper; Dimercaprol; Drug Evaluation, | 1987 |
[Effects of chelating agents on the excretion of cadmium in cadmium poisoning].
Topics: Animals; Cadmium; Cadmium Poisoning; Chelating Agents; Dimercaprol; Penicillamine; Rats; Urine | 1965 |
Poisoning due to heavy metals.
Topics: Arsenic Poisoning; Cadmium Poisoning; Chelating Agents; Child; Child, Preschool; Copper; Deferoxamin | 1970 |
[Protective effect of chelating agents in acute cadmium chloride poisoning].
Topics: Animals; Cadmium Poisoning; Chelating Agents; Dimercaprol; Mice; Pentetic Acid | 1966 |