dimercaprol has been researched along with Brain Diseases in 27 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three patients with myoclonic encephalopathy caused by bismuth salts are reported, one with the severe and another with the mild form; dimercaprol was effective for the rapid improvement of the symptoms in both." | 1.28 | [Myoclonic encephalopathy caused by bismuth salts. Efficacy of treatment with dimercaprol]. ( Bermejo, F; Calandre, L; Fernández-Ortega, JD; Molina, JA; Posadas, F, 1989) |
| "Treatment with dimercaprol produced a clinical improvement on the fourth day with a fall in blood mercury from 3." | 1.26 | [Encephalopathy due to organomercuric compounds]. ( Gil, R; Lefèvre, JP, 1977) |
| "Fifty-eight patients with Wilson's disease are reviewed, of whom 25 symptomatic patients experienced liver disease first and 28, brain disease." | 1.26 | Clinical spectrum of Wilson's disease (hepatolenticular degeneration). ( Dobyns, WB; Goldstein, NP; Gordon, H, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (92.59) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Fox, ER | 1 |
| Johnson-Arbor, K | 1 |
| Mazer-Amirshahi, M | 1 |
| MASTERS, JB | 1 |
| DANBY, CW | 1 |
| GIANNATTASIO, RC | 1 |
| PIROZZI, MJ | 1 |
| DAS GUPTA, A | 1 |
| PRASAD, B | 1 |
| BRADLEY, JE | 1 |
| BAUMGARTNER, RJ | 1 |
| KONAR, NR | 1 |
| DASS, AK | 1 |
| MONTERO, R | 1 |
| BEATO, J | 1 |
| KEIZER, DP | 1 |
| Gościńska, Z | 1 |
| Bartoszewicz, B | 1 |
| Piasecka, M | 1 |
| Shaltout, A | 1 |
| Yaish, SA | 1 |
| Fernando, N | 1 |
| Piomelli, S | 1 |
| Rosen, JF | 1 |
| Chisolm, JJ | 3 |
| Graef, JW | 1 |
| Kurt, TL | 1 |
| McAnalley, BH | 1 |
| Garriott, JC | 1 |
| Gordon, RA | 1 |
| Roberts, G | 1 |
| Amin, Z | 1 |
| Williams, RH | 1 |
| Paloucek, FP | 1 |
| Barltrop, D | 1 |
| Lefèvre, JP | 1 |
| Gil, R | 1 |
| Feldman, RG | 1 |
| Baker, EL | 1 |
| Dobyns, WB | 1 |
| Goldstein, NP | 1 |
| Gordon, H | 1 |
| Kurliandchikov, VN | 1 |
| Molina, JA | 1 |
| Calandre, L | 1 |
| Bermejo, F | 1 |
| Posadas, F | 1 |
| Fernández-Ortega, JD | 1 |
| Schergna, E | 1 |
| Greenberg, JO | 1 |
| Buge, A | 1 |
| Poisson, M | 1 |
| Philippon, J | 1 |
| Rancurel, G | 1 |
| Cortot, A | 1 |
| Bricaire, F | 1 |
| Haenggeli, CA | 1 |
| Katakalidis, G | 1 |
| Stoll, E | 1 |
| Sundaravalli, N | 1 |
| Sundaram, VM | 1 |
| Raju, VB | 1 |
| Coffin, R | 1 |
| Phillips, JL | 1 |
| Staples, WI | 1 |
| Spector, S | 1 |
3 reviews available for dimercaprol and Brain Diseases
| Article | Year |
|---|---|
Aggressive approach in the treatment of acute lead encephalopathy with an extraordinarily high concentration of lead.
Topics: Brain Diseases; Child, Preschool; Dimercaprol; Edetic Acid; Environmental Exposure; Female; Humans; | 1998 |
Recognition and management of children with increased lead absorption.
Topics: Absorption; Acute Disease; Behavior; Bone and Bones; Bone Marrow; Brain Diseases; Child; Dimercaprol | 1979 |
The use of chelating agents in the treatment of acute and chronic lead intoxication in childhood.
Topics: Acute Disease; Amino Acids; Animals; Brain Diseases; Child; Child, Preschool; Chronic Disease; Creat | 1968 |
24 other studies available for dimercaprol and Brain Diseases
| Article | Year |
|---|---|
Will There Ever be an Antidote for Drug Shortages?
Topics: Antidotes; Brain Diseases; Dimercaprol; Humans; Lead; Pharmaceutical Preparations; United States | 2021 |
A case of arsenic encephalopathy successfully treated with BAL.
Topics: Arsenic; Arsenic Poisoning; Brain Diseases; Dimercaprol | 1948 |
The use of BAL (2,3 dimercaptopropanol) in arsenical encephalopathy.
Topics: Arsenicals; Brain; Brain Diseases; Brain Injuries; Dimercaprol | 1948 |
BAL therapy in acute lead encephalopathy.
Topics: Brain; Brain Diseases; Dimercaprol; Humans; Lead Poisoning; Neurotoxicity Syndromes | 1953 |
Treatment of arsenic and gold encephalopathy with BAL.
Topics: Arsenic; Arsenic Poisoning; Brain; Brain Diseases; Dimercaprol; Gold; Humans; Poisoning | 1954 |
Subsequent mental development of children with lead encephalopathy, as related to type of treatment.
Topics: Brain; Brain Diseases; Child; Dimercaprol; Edetic Acid; Humans; Infant; Lead Poisoning | 1958 |
Arsenical encephalopathy treated with B. A. L.
Topics: Arsenic; Arsenicals; Brain Diseases; Dimercaprol; Humans | 1950 |
[Arsenical encephalopathy; clinical case cured with BAL, similar case without treatment with fatal outcome].
Topics: Arsenic Poisoning; Brain; Brain Diseases; Dimercaprol; Fatal Outcome; Humans | 1952 |
[Brain disease due to mercurial poisoning in an infant].
Topics: Brain Diseases; Dimercaprol; Mercury; Mercury Compounds; Poisoning; Poisons | 1950 |
[Neurological symptomatology in cases of chronic mercury poisoning in children].
Topics: Acrodynia; Antifungal Agents; Brain Diseases; Child, Preschool; Dimercaprol; Female; Humans; Male; M | 1967 |
Lead encephalopathy in infants in Kuwait. A study of 20 infants with particular reference to clinical presentation and source of lead poisoning.
Topics: Brain Diseases; Dimercaprol; Edetic Acid; Female; Humans; Infant; Lead; Lead Poisoning; Male; Sulfid | 1981 |
Management of childhood lead poisoning.
Topics: Brain Diseases; Chelating Agents; Child; Dimercaprol; Environmental Exposure; Glucosephosphate Dehyd | 1984 |
Lead encephalopathy from gasoline sniffing: successful treatment with chelation.
Topics: Adolescent; Brain Diseases; Chelating Agents; Dexamethasone; Dimercaprol; Edetic Acid; Gasoline; Hum | 1982 |
[Encephalopathy due to organomercuric compounds].
Topics: Adult; Agricultural Workers' Diseases; Brain Diseases; Dimercaprol; Humans; Male; Mercury Poisoning; | 1977 |
Therapy of arsenical encephalopathy.
Topics: Arsenic Poisoning; Brain Diseases; Dimercaprol; Humans | 1979 |
Clinical spectrum of Wilson's disease (hepatolenticular degeneration).
Topics: Adolescent; Adult; Brain Diseases; Child; Copper; Cornea; Dimercaprol; Female; Hepatolenticular Dege | 1979 |
[Treatment of patients with cerebral forms of hypertensive disease by combination of decamevit with unithiol in conditions of biotron].
Topics: Adult; Brain Diseases; Climate; Dimercaprol; Drug Combinations; Environment, Controlled; Humans; Hyp | 1976 |
[Myoclonic encephalopathy caused by bismuth salts. Efficacy of treatment with dimercaprol].
Topics: Adult; Aged; Antacids; Bismuth; Brain Diseases; Dimercaprol; Drug Evaluation; Female; Gallic Acid; H | 1989 |
[Recent therapeutic conquests in extrapyramidal syndromes].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Amantadine; Athetosis; Brain Diseases; Central | 1970 |
The neurological effects of methyl bromide poisoning.
Topics: Adult; Amobarbital; Brain Diseases; Bromine; Cerebellar Ataxia; Diazepam; Dimercaprol; Electroenceph | 1971 |
[Progressive hydrocephalus due to cysticercosis of the fourth ventricle in a young patient from Reunion Island].
Topics: Adult; Brain Diseases; Cerebral Angiography; Cerebral Ventricles; Cerebral Ventriculography; Cystice | 1973 |
[Lead encephalopathy in two infants].
Topics: Brain Diseases; Dimercaprol; Edetic Acid; Female; Humans; Infant; Knee; Lead Poisoning; Male; Penici | 1972 |
Lead encephalopathy: report of a case.
Topics: Brain Diseases; Dimercaprol; Humans; Infant; Lead Poisoning; Male | 1972 |
Treatment of lead encephalopathy in children.
Topics: Brain Diseases; Calcium; Child, Preschool; Dimercaprol; Edetic Acid; Female; Humans; Infant; Lead Po | 1966 |