dimercaprol has been researched along with Body Weight in 14 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dimercaprol treatment did not restore the normal enzyme activity of the liver after the 25% inhibition caused by 4." | 1.29 | Effect of mercuric chloride intoxication and dimercaprol treatment on delta-aminolevulinate dehydratase from brain, liver and kidney of adult mice. ( Emanuelli, T; Martins, AF; Morsch, VM; Pereira, ME; Porciuncula, LO; Rocha, JB; Souza, DO, 1996) |
| " Equimolar dosing schedules were used based upon realistic doses for the most toxic agent, BAL." | 1.28 | Evaluation of the efficacy of dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits. ( Bright, JE; Inns, RH; Marrs, TC; Rice, P, 1990) |
| " There were no maternal toxic effects, and no treatment-related changes were recorded in the number of total implants, resorption, the number of live and dead fetuses, fetal body weight or fetal sex distribution data." | 1.28 | Evaluation of the developmental toxicity of 2,3-dimercapto-1-propanesulfonate (DMPS) in mice. Effect on mineral metabolism. ( Bosque, MA; Corbella, J; Domingo, JL; Llobet, JM; Paternain, JL, 1990) |
| " Conversely, unitiol potentiated the acute toxic effect of 5-fluorouracil, bleomycetin and vincristine which was matched by body weight loss following treatment with cytostatic drugs." | 1.27 | [Action of unithiol on the toxic effect of antitumor preparations]. ( Donenko, FV, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tian, R | 1 |
| Shi, R | 1 |
| Szinicz, L | 1 |
| Wiedemann, P | 1 |
| Häring, H | 1 |
| Weger, N | 1 |
| Schäfer, SG | 1 |
| Storp, M | 1 |
| Richter, E | 1 |
| Planas-Bohne, F | 1 |
| Gabard, B | 1 |
| Schäffer, EH | 1 |
| Emanuelli, T | 1 |
| Rocha, JB | 1 |
| Pereira, ME | 1 |
| Porciuncula, LO | 1 |
| Morsch, VM | 1 |
| Martins, AF | 1 |
| Souza, DO | 1 |
| Zimmer, L | 1 |
| Carter, DE | 2 |
| Zimmer, LJ | 1 |
| Hofmann, U | 1 |
| Segewitz, G | 1 |
| Inns, RH | 1 |
| Rice, P | 1 |
| Bright, JE | 1 |
| Marrs, TC | 1 |
| Bosque, MA | 1 |
| Domingo, JL | 1 |
| Paternain, JL | 1 |
| Llobet, JM | 1 |
| Corbella, J | 1 |
| Peele, DB | 1 |
| Farmer, JD | 1 |
| MacPhail, RC | 1 |
| Donenko, FV | 1 |
| Hood, RD | 1 |
| Pike, CT | 1 |
| Teitelbaum, DT | 1 |
| Kier, LC | 1 |
14 other studies available for dimercaprol and Body Weight
| Article | Year |
|---|---|
Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury.
Topics: Acrolein; Animals; Body Weight; Cell Death; Dimercaprol; Disease Models, Animal; Dose-Response Relat | 2017 |
Effects of repeated treatment with sodium 2,3-dimercaptopropane-1-sulfonate in beagle dogs.
Topics: Animals; Body Weight; Cadmium; Copper; Dimercaprol; Dogs; Electrolytes; Female; Hemoglobins; Iron; M | 1983 |
Subchronic treatment with sodium 2,3-dimercaptopropane-1-sulfonate in methylmercury poisoning.
Topics: Animals; Body Weight; Dimercaprol; Feces; Half-Life; Male; Mercury; Mercury Radioisotopes; Methylmer | 1982 |
Toxicological studies on sodium 2,3-dimercaptopropane-1-sulfonate in the rat.
Topics: Animals; Body Weight; Chelating Agents; Copper; Dimercaprol; Female; Fertility; Growth; Lethal Dose | 1980 |
Effect of mercuric chloride intoxication and dimercaprol treatment on delta-aminolevulinate dehydratase from brain, liver and kidney of adult mice.
Topics: Analysis of Variance; Animals; Antidotes; Body Weight; Brain; Dimercaprol; Injections, Subcutaneous; | 1996 |
Effects of complexing treatment administered with the onset of methyl mercury neurotoxic signs.
Topics: Animals; Body Weight; Chelating Agents; Dimercaprol; Female; Glucuronidase; Mercury; Methylmercury C | 1979 |
The efficacy of 2,3-dimercaptopropanol and D-penicillamine on methyl mercury induced neurological signs and weight loss.
Topics: Animals; Body Weight; Dimercaprol; Female; Methylmercury Compounds; Nervous System Diseases; Penicil | 1978 |
Influence of chelation therapy on acute lead intoxication in rats.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Body Weight; Bone and Bones; Chelating Agents; Dimercap | 1975 |
Evaluation of the efficacy of dimercapto chelating agents for the treatment of systemic organic arsenic poisoning in rabbits.
Topics: Animals; Arsenic; Arsenic Poisoning; Arsenicals; Body Weight; Chelating Agents; Dimercaprol; Gallbla | 1990 |
Evaluation of the developmental toxicity of 2,3-dimercapto-1-propanesulfonate (DMPS) in mice. Effect on mineral metabolism.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Dimercaprol; Embryonic and | 1990 |
Behavioral consequences of chelator administration in acute cadmium toxicity.
Topics: Animals; Behavior, Animal; Body Weight; Cadmium Poisoning; Chelating Agents; Conditioning, Operant; | 1988 |
[Action of unithiol on the toxic effect of antitumor preparations].
Topics: Animals; Antineoplastic Agents; Body Weight; Dimercaprol; Drug Interactions; Leukocyte Count; Male; | 1985 |
BAL alleviation of arsenate-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Animals; Arsenic; Body Weight; Dimercaprol; Female; Fetal Death; Fetus; | 1972 |
Arsine poisoning. Report of five cases in the petroleum industry and a discussion of the indications for exchange transfusion and hemodialysis.
Topics: Acute Kidney Injury; Arsenic; Arsenic Poisoning; Arsenicals; Body Weight; Dimercaprol; Environmental | 1969 |