dimercaprol has been researched along with Alzheimer Disease in 3 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Payton, S | 1 |
| Cahill, CM | 1 |
| Randall, JD | 1 |
| Gullans, SR | 1 |
| Rogers, JT | 2 |
| Morse, LJ | 1 |
| Payton, SM | 1 |
| Cuny, GD | 1 |
| Roberge, RJ | 1 |
| Martin, TG | 1 |
1 review available for dimercaprol and Alzheimer Disease
| Article | Year |
|---|---|
Whole bowel irrigation in an acute oral lead intoxication.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Chelation Therapy; Dimercaprol; Hu | 1992 |
2 other studies available for dimercaprol and Alzheimer Disease
| Article | Year |
|---|---|
Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol.
Topics: 5' Untranslated Regions; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A | 2003 |
FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein.
Topics: 5' Untranslated Regions; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; A | 2004 |