dimercaprol has been researched along with Acute Liver Injury, Drug-Induced in 19 studies
Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gold salts are still a first choice for treatment of rheumatoid arthritis." | 8.78 | [Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts]. ( Beyner, F; Buss, W; Ott, H; Van Linthoudt, D, 1991) |
| "Gold salts are still a first choice for treatment of rheumatoid arthritis." | 4.78 | [Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts]. ( Beyner, F; Buss, W; Ott, H; Van Linthoudt, D, 1991) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "We report the case of a female patient treated for rheumatoid arthritis, who had gold salt overdose, and in whom acute cholestatic hepatitis occurred three weeks after beginning of therapy." | 1.32 | Prolonged cholestasis and ductopenia following gold salt therapy. ( Basset, C; Denis, J; Poupon, J; Vadrot, J; Zafrani, ES, 2003) |
| " The low toxicity of DMPS and DMSA compared to BAL enabled doses of 160 mumol kg-1 on a more prolonged dosing schedule to be used for DMPS and DMSA." | 1.29 | Efficacy of dimercapto chelating agents for the treatment of poisoning by percutaneously applied dichloro(2-chlorovinyl)arsine in rabbits. ( Inns, RH; Rice, P, 1993) |
| "Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC." | 1.26 | Effect of various treatments on toxicity of inhaled vinylidene chloride. ( Lee, CC; Minor, JL; Seifter, J; Short, RD; Winston, JM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (57.89) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Basset, C | 1 |
| Vadrot, J | 1 |
| Denis, J | 1 |
| Poupon, J | 1 |
| Zafrani, ES | 1 |
| YAMAMOTO, S | 1 |
| IGAMI, H | 1 |
| BRAEUNLICH, H | 1 |
| Korneĭchuk, AV | 1 |
| Kushnir, LV | 1 |
| McKinney, PE | 1 |
| Brent, J | 1 |
| Kulig, K | 1 |
| Inns, RH | 1 |
| Rice, P | 1 |
| Hughes, RD | 2 |
| Gazzard, BG | 2 |
| Hanid, MA | 1 |
| Trewby, PN | 1 |
| Murray-Lyon, IM | 2 |
| Davis, M | 1 |
| Williams, R | 2 |
| Bennet, JR | 1 |
| Short, RD | 1 |
| Winston, JM | 1 |
| Minor, JL | 1 |
| Seifter, J | 1 |
| Lee, CC | 1 |
| Frimmer, M | 1 |
| Petzinger, E | 1 |
| Homann, J | 1 |
| Chhibber, AD | 1 |
| Bennett, JR | 1 |
| Dordoni, B | 1 |
| Van Linthoudt, D | 1 |
| Buss, W | 1 |
| Beyner, F | 1 |
| Ott, H | 1 |
| Prescott, LF | 1 |
| Wright, N | 1 |
| Mitchell, JR | 1 |
| Thorgeirsson, SS | 1 |
| Potter, WZ | 1 |
| Jollow, DJ | 1 |
| Keiser, H | 1 |
| Strubelt, O | 1 |
| Siegers, CP | 1 |
| Schütt, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00799578] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00799578)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Number of Improved Subjects | 7 |
2 reviews available for dimercaprol and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dimercaprol; Go | 1991 |
3 trials available for dimercaprol and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Controlled trial of cysteamine and dimercaprol after paracetamol overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Cysteamine; Dimerca | 1977 |
Proceedings: Controlled trial of cysteamine and dimercaprol in the prevention of liver damage after paracetamol overdose.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Cysteamine; Dimerca | 1975 |
Letter: Cysteamine for paracetamol overdosage.
Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Ch | 1974 |
14 other studies available for dimercaprol and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Prolonged cholestasis and ductopenia following gold salt therapy.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bile Duct Diseases; Biopsy; Chemical and Drug Induced L | 2003 |
[DRUG-INDUCED LIVER DAMAGE AND COUNTERMEASURES].
Topics: Adrenocorticotropic Hormone; Anabolic Agents; Androgens; Anesthetics; Anti-Bacterial Agents; Antibio | 1964 |
[THE ALTERATION OF THE HYPERGLYCEMIC EFFECT OF MORPHINE BY OPIATE ANTAGONISTS AND OTHER DRUGS].
Topics: Chemical and Drug Induced Liver Injury; Dimercaprol; Ergotamine; Hepatitis A; Hyperglycemia; Insulin | 1964 |
[Case of drug (krizanol) hepatitis].
Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dimercaprol; Drug Therapy, Com | 1982 |
Acute zinc chloride ingestion in a child: local and systemic effects.
Topics: Acidosis; Acute Disease; Ammonium Chloride; Amylases; Burns, Chemical; Chemical and Drug Induced Liv | 1994 |
Efficacy of dimercapto chelating agents for the treatment of poisoning by percutaneously applied dichloro(2-chlorovinyl)arsine in rabbits.
Topics: Administration, Topical; Animals; Arsenic Poisoning; Arsenicals; Chelating Agents; Chemical and Drug | 1993 |
Effect of various treatments on toxicity of inhaled vinylidene chloride.
Topics: Amino Acids, Sulfur; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Dichloroethylen | 1977 |
[Phalloidin antagonists 4th communication: Thioctic acid, SH-compounds, rifampicin, choleretics, dexamethasone, estradiol, unspecific inhibitors, and ineffective compounds (author's transl)].
Topics: Animals; Chelating Agents; Chemical and Drug Induced Liver Injury; Chloroform; Cholagogues and Chole | 1975 |
Letter: B.A.L. in paracetamol poisoning.
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteamine; Dimercaprol; Drug Evaluation; Hum | 1974 |
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury; | 1974 |
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteami | 1974 |