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dimercaprol and Acute Liver Injury, Drug-Induced

dimercaprol has been researched along with Acute Liver Injury, Drug-Induced in 19 studies

Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.

Research Excerpts

ExcerptRelevanceReference
"Gold salts are still a first choice for treatment of rheumatoid arthritis."8.78[Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts]. ( Beyner, F; Buss, W; Ott, H; Van Linthoudt, D, 1991)
"Gold salts are still a first choice for treatment of rheumatoid arthritis."4.78[Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts]. ( Beyner, F; Buss, W; Ott, H; Van Linthoudt, D, 1991)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
"We report the case of a female patient treated for rheumatoid arthritis, who had gold salt overdose, and in whom acute cholestatic hepatitis occurred three weeks after beginning of therapy."1.32Prolonged cholestasis and ductopenia following gold salt therapy. ( Basset, C; Denis, J; Poupon, J; Vadrot, J; Zafrani, ES, 2003)
" The low toxicity of DMPS and DMSA compared to BAL enabled doses of 160 mumol kg-1 on a more prolonged dosing schedule to be used for DMPS and DMSA."1.29Efficacy of dimercapto chelating agents for the treatment of poisoning by percutaneously applied dichloro(2-chlorovinyl)arsine in rabbits. ( Inns, RH; Rice, P, 1993)
"Disulfiram treatment reduced the acute lethal and hepatotoxic effects of inhaled VDC and reduced the levels of covalent bound radioactivity in the liver and kidney after the intraperitoneal administration of 14C-VDC."1.26Effect of various treatments on toxicity of inhaled vinylidene chloride. ( Lee, CC; Minor, JL; Seifter, J; Short, RD; Winston, JM, 1977)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199011 (57.89)18.7374
1990's3 (15.79)18.2507
2000's1 (5.26)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Ekins, S1
Williams, AJ1
Xu, JJ1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W2
Chen, M1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Basset, C1
Vadrot, J1
Denis, J1
Poupon, J1
Zafrani, ES1
YAMAMOTO, S1
IGAMI, H1
BRAEUNLICH, H1
Korneĭchuk, AV1
Kushnir, LV1
McKinney, PE1
Brent, J1
Kulig, K1
Inns, RH1
Rice, P1
Hughes, RD2
Gazzard, BG2
Hanid, MA1
Trewby, PN1
Murray-Lyon, IM2
Davis, M1
Williams, R2
Bennet, JR1
Short, RD1
Winston, JM1
Minor, JL1
Seifter, J1
Lee, CC1
Frimmer, M1
Petzinger, E1
Homann, J1
Chhibber, AD1
Bennett, JR1
Dordoni, B1
Van Linthoudt, D1
Buss, W1
Beyner, F1
Ott, H1
Prescott, LF1
Wright, N1
Mitchell, JR1
Thorgeirsson, SS1
Potter, WZ1
Jollow, DJ1
Keiser, H1
Strubelt, O1
Siegers, CP1
Schütt, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00799578]Phase 1/Phase 213 participants (Actual)Interventional2008-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Normalization or >50% of Serum ALT Levels From Baseline

(NCT00799578)
Timeframe: 6 months

Interventionparticipants (Number)
Number of Improved Subjects7

Reviews

2 reviews available for dimercaprol and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
[Fatal hepatic necrosis due to a treatment course of rheumatoid arthritis with gold salts].
    Schweizerische medizinische Wochenschrift, 1991, Jul-27, Volume: 121, Issue:30

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dimercaprol; Go

1991

Trials

3 trials available for dimercaprol and Acute Liver Injury, Drug-Induced

ArticleYear
Controlled trial of cysteamine and dimercaprol after paracetamol overdose.
    British medical journal, 1977, Nov-26, Volume: 2, Issue:6099

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Cysteamine; Dimerca

1977
Proceedings: Controlled trial of cysteamine and dimercaprol in the prevention of liver damage after paracetamol overdose.
    Gut, 1975, Volume: 16, Issue:10

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Cysteamine; Dimerca

1975
Letter: Cysteamine for paracetamol overdosage.
    Lancet (London, England), 1974, May-18, Volume: 1, Issue:7864

    Topics: Acetaminophen; Acetylcysteine; Blood Specimen Collection; Chemical and Drug Induced Liver Injury; Ch

1974

Other Studies

14 other studies available for dimercaprol and Acute Liver Injury, Drug-Induced

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Prolonged cholestasis and ductopenia following gold salt therapy.
    Liver international : official journal of the International Association for the Study of the Liver, 2003, Volume: 23, Issue:2

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bile Duct Diseases; Biopsy; Chemical and Drug Induced L

2003
[DRUG-INDUCED LIVER DAMAGE AND COUNTERMEASURES].
    [Chiryo] [Therapy], 1964, Volume: 46

    Topics: Adrenocorticotropic Hormone; Anabolic Agents; Androgens; Anesthetics; Anti-Bacterial Agents; Antibio

1964
[THE ALTERATION OF THE HYPERGLYCEMIC EFFECT OF MORPHINE BY OPIATE ANTAGONISTS AND OTHER DRUGS].
    Acta biologica et medica Germanica, 1964, Volume: 12

    Topics: Chemical and Drug Induced Liver Injury; Dimercaprol; Ergotamine; Hepatitis A; Hyperglycemia; Insulin

1964
[Case of drug (krizanol) hepatitis].
    Vrachebnoe delo, 1982, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Dimercaprol; Drug Therapy, Com

1982
Acute zinc chloride ingestion in a child: local and systemic effects.
    Annals of emergency medicine, 1994, Volume: 23, Issue:6

    Topics: Acidosis; Acute Disease; Ammonium Chloride; Amylases; Burns, Chemical; Chemical and Drug Induced Liv

1994
Efficacy of dimercapto chelating agents for the treatment of poisoning by percutaneously applied dichloro(2-chlorovinyl)arsine in rabbits.
    Human & experimental toxicology, 1993, Volume: 12, Issue:3

    Topics: Administration, Topical; Animals; Arsenic Poisoning; Arsenicals; Chelating Agents; Chemical and Drug

1993
Effect of various treatments on toxicity of inhaled vinylidene chloride.
    Environmental health perspectives, 1977, Volume: 21

    Topics: Amino Acids, Sulfur; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Dichloroethylen

1977
[Phalloidin antagonists 4th communication: Thioctic acid, SH-compounds, rifampicin, choleretics, dexamethasone, estradiol, unspecific inhibitors, and ineffective compounds (author's transl)].
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:12

    Topics: Animals; Chelating Agents; Chemical and Drug Induced Liver Injury; Chloroform; Cholagogues and Chole

1975
Letter: B.A.L. in paracetamol poisoning.
    Lancet (London, England), 1974, Oct-05, Volume: 2, Issue:7884

    Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Cysteamine; Dimercaprol; Drug Evaluation; Hum

1974
Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy.
    Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:4

    Topics: Acetaminophen; Acetylcysteine; Adult; Amobarbital; Animals; Chemical and Drug Induced Liver Injury;

1974
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
    Archives of toxicology, 1974, Volume: 33, Issue:1

    Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteami

1974