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dimercaprol and Abnormalities, Drug-Induced

dimercaprol has been researched along with Abnormalities, Drug-Induced in 4 studies

Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
dimercaprol : A dithiol that is propane-1,2-dithiol in which one of the methyl hydrogens is replaced by a hydroxy group. a chelating agent originally developed during World War II as an experimental antidote against the arsenic-based poison gas Lewisite, it has been used clinically since 1949 for the treatment of poisoning by arsenic, mercury and gold. It can also be used for treatment of poisoning by antimony, bismuth and possibly thallium, and (with sodium calcium edetate) in cases of acute leaad poisoning. Administration is by (painful) intramuscular injection of a suspension of dimercaprol in peanut oil, typically every 4 hours for 2-10 days depending on the toxicity. In the past, dimercaprol was also used for the treatment of Wilson's disease, a severely debilitating genetic disorder in which the body tends to retain copper, with resultant liver and brain injury.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
" There were no maternal toxic effects, and no treatment-related changes were recorded in the number of total implants, resorption, the number of live and dead fetuses, fetal body weight or fetal sex distribution data."1.28Evaluation of the developmental toxicity of 2,3-dimercapto-1-propanesulfonate (DMPS) in mice. Effect on mineral metabolism. ( Bosque, MA; Corbella, J; Domingo, JL; Llobet, JM; Paternain, JL, 1990)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gomez, M1
Sanchez, DJ1
Colomina, MT1
Domingo, JL2
Corbella, J2
Hood, RD2
Thacker, GT1
Patterson, BL1
Bosque, MA1
Paternain, JL1
Llobet, JM1
Pike, CT1

Other Studies

4 other studies available for dimercaprol and Abnormalities, Drug-Induced

ArticleYear
Evaluation of the protective activity of 2,3-dimercaptopropanol and sodium 2,3-dimercaptopropane-1-sulfonate on methylmercury-induced developmental toxicity in mice.
    Archives of environmental contamination and toxicology, 1994, Volume: 26, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Dimercaprol; Female; Fetus; Methylmercury Compounds; Mice; Pre

1994
Effects in the mouse and rat of prenatal exposure to arsenic.
    Environmental health perspectives, 1977, Volume: 19

    Topics: Abnormalities, Drug-Induced; Animals; Arsenic; Dimercaprol; Dose-Response Relationship, Drug; Female

1977
Evaluation of the developmental toxicity of 2,3-dimercapto-1-propanesulfonate (DMPS) in mice. Effect on mineral metabolism.
    Toxicology, 1990, Volume: 62, Issue:3

    Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Body Weight; Dimercaprol; Embryonic and

1990
BAL alleviation of arsenate-induced teratogenesis in mice.
    Teratology, 1972, Volume: 6, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Arsenic; Body Weight; Dimercaprol; Female; Fetal Death; Fetus;

1972