dimaprit has been researched along with Parkinson Disease in 1 studies
Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, the safety of long-term use of these ATP-competitive LRRK2 kinase inhibitors has been challenged by several studies." | 2.66 | Allosteric inhibition of LRRK2, where are we now. ( Cankara, FN; Kortholt, A; Soliman, A, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soliman, A | 1 |
| Cankara, FN | 1 |
| Kortholt, A | 1 |
1 review available for dimaprit and Parkinson Disease
| Article | Year |
|---|---|
Allosteric inhibition of LRRK2, where are we now.
Topics: Adenosine Triphosphate; Allosteric Site; Animals; Crystallography, X-Ray; Cytosol; Dimaprit; Dimeriz | 2020 |