dimaprit has been researched along with Muscle Contraction in 44 studies
Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects." | 7.68 | Mechanism of action of doxepin in the treatment of chronic urticaria. ( Almeida, L; Figueiredo, A; Gonçalo, M; Poiares-Baptista, A; Ribeiro, CA; Teixeira, F, 1990) |
| "The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects." | 3.68 | Mechanism of action of doxepin in the treatment of chronic urticaria. ( Almeida, L; Figueiredo, A; Gonçalo, M; Poiares-Baptista, A; Ribeiro, CA; Teixeira, F, 1990) |
| " Histamine dose-dependently induced the contraction of sections of the guinea-pig small intestine, and the pretreatment of the tissue section with aminoguanidine (100 microM), a diamine oxidase inhibitor, but not with S-[4-(N,N-dimethylamino)butyl]isothiourea (100 microM), an inhibitor of histamine N-methyltransferase, shifted the dose-response curve of histamine-induced contraction to lower concentrations." | 1.31 | Expression of diamine oxidase (histaminase) in guinea-pig tissues. ( Kitanaka, J; Kitanaka, N; Takemura, M; Terada, N; Tsujimura, T, 2002) |
| "Histamine is a vasoactive amine which is endogenously produced in many organs including the penis." | 1.29 | Characterization and function of histamine receptors in corpus cavernosum. ( Carson, CC; Davies, MG; Hagen, PO; Kim, YC; Lee, TH, 1995) |
| " The H1-antagonist chlorpheniramine shifted to the right the dose-response curves to histamine and to 2-aminoethylthiazole with the kinetics of the competitive antagonism." | 1.27 | Histamine receptors in the human ureter. ( Bertaccini, G; Bezzi, E; Potenzoni, D; Zappia, L, 1983) |
| "Histamine has a greater relaxant effect on mesenteric artery strips at 22 degrees than at 38 degrees, normally." | 1.27 | Dibenamine enhancement of histamine-induced relaxation of the rabbit mesenteric artery. ( Christiansen, VJ; Horst, MA; Robinson, C, 1983) |
| " ratios indicate that, relative to ranitidine, the bioavailability of AY-29,315 by the oral route was low, particularly in the dog." | 1.27 | Antisecretory and antiulcer activities of a potent new histamine H2-receptor antagonist with an intermediate duration of action. ( Borella, L; Failli, A; Grimes, D; Mir, GN; Rimele, TJ; Russell, J, 1988) |
| " In an apparently all-or-none manner, both caused a sinistral shift in dose-response curves for the phasic component of the contractile response to histamine at H1 receptors on the ileum." | 1.27 | Metronidazole and 5-aminosalicylic acid enhance the contractile activity of histaminergic agonists on the guinea-pig isolated ileum. ( Barker, LA; Winbery, SL, 1986) |
| " Conversely, following potentiation of the response to histamine with DTT, exposure of the tissue to desensitizing concentrations of histamine resulted in a dextral shift of the dose-response curve (dose ratio = 39." | 1.27 | Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol. ( Donaldson, J; Hill, SJ, 1986) |
| " Pretreatment of parenchymal strips with cimetidine or YM-11170, H2-receptor antagonists, resulted in a parallel shift of the dimaprit dose-response curve to the right." | 1.26 | Effects of histamine H2-receptor agonists and antagonists on isolated guinea-pig airway muscles. ( Tomioka, K; Yamada, T, 1982) |
| " dose-response curves were generated for the initial response; for isolated ileal segments the EC50 was 5." | 1.26 | Histamine H2-receptors on guinea-pig ileum myenteric plexus neurons mediate the release of contractile agents. ( Barker, LA; Ebersole, BJ, 1982) |
| "7 Cimetidine was without effect on histamine sensitivity in young guinea-pigs after propranolol treatment but significantly reduced airway sensitivity to histamine in old guinea-pigs." | 1.26 | Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development. ( Brink, C; Douglas, JS; Duncan, PG, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (54.55) | 18.7374 |
| 1990's | 16 (36.36) | 18.2507 |
| 2000's | 4 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eriks, JC | 1 |
| van der Goot, H | 1 |
| Sterk, GJ | 1 |
| Timmerman, H | 3 |
| Lampe, JW | 1 |
| Hanna, RG | 1 |
| Piscitelli, TA | 1 |
| Chou, YL | 1 |
| Erhardt, PW | 1 |
| Lumma, WC | 1 |
| Greenberg, SS | 1 |
| Ingebretsen, WR | 1 |
| Marshall, DC | 1 |
| Wiggins, J | 1 |
| Linney, ID | 1 |
| Buck, IM | 1 |
| Harper, EA | 1 |
| Kalindjian, SB | 1 |
| Pether, MJ | 1 |
| Shankley, NP | 1 |
| Watt, GF | 1 |
| Wright, PT | 1 |
| Bozarov, A | 1 |
| Wang, YZ | 2 |
| Yu, JG | 1 |
| Wunderlich, J | 1 |
| Hassanain, HH | 1 |
| Alhaj, M | 1 |
| Cooke, HJ | 2 |
| Grants, I | 1 |
| Ren, T | 1 |
| Christofi, FL | 1 |
| Fox, JL | 1 |
| von der Weid, PY | 1 |
| Oriowo, MA | 1 |
| Tomioka, K | 1 |
| Yamada, T | 1 |
| Wieczorek, WJ | 1 |
| D'Mello, A | 1 |
| Bielkiewicz, B | 1 |
| Cook, D | 1 |
| Barker, LA | 3 |
| Ebersole, BJ | 1 |
| Wise, WE | 2 |
| LaMorte, WW | 1 |
| Gaca, JM | 1 |
| Schoetz, DJ | 1 |
| Birkett, DH | 1 |
| Williams, LF | 1 |
| Mirbahar, KB | 1 |
| Eyre, P | 1 |
| Bertaccini, G | 5 |
| Zappia, L | 1 |
| Bezzi, E | 1 |
| Potenzoni, D | 1 |
| Hough, LB | 1 |
| Mikkelsen, E | 1 |
| Sakr, AM | 1 |
| Jespersen, LT | 1 |
| Robinson, C | 1 |
| Christiansen, VJ | 1 |
| Horst, MA | 1 |
| La Morte, WW | 1 |
| Hingston, SJ | 1 |
| Tenner, TE | 1 |
| Mantovani, P | 1 |
| Santicioli, P | 1 |
| Di Donato, M | 1 |
| Ercan, ZS | 1 |
| Brink, C | 2 |
| Douglas, JS | 1 |
| Duncan, PG | 1 |
| Kim, YC | 1 |
| Davies, MG | 1 |
| Lee, TH | 1 |
| Hagen, PO | 1 |
| Carson, CC | 1 |
| Luo, XX | 1 |
| Tan, YH | 1 |
| Rogers, R | 1 |
| Jennings, LJ | 1 |
| Salido, GM | 1 |
| Pozo, MJ | 1 |
| Davison, JS | 1 |
| Sharkey, KA | 1 |
| Lea, RW | 1 |
| Singh, J | 1 |
| Malmberg-Aiello, P | 1 |
| Lamberti, C | 1 |
| Ipponi, A | 1 |
| Hänninen, J | 1 |
| Ghelardini, C | 1 |
| Bartolini, A | 1 |
| Morini, G | 2 |
| Coruzzi, G | 4 |
| Poli, E | 2 |
| Pozzoli, C | 1 |
| Izzo, AA | 1 |
| Costa, M | 1 |
| Mascolo, N | 1 |
| Capasso, F | 1 |
| Kitanaka, J | 1 |
| Kitanaka, N | 1 |
| Tsujimura, T | 1 |
| Terada, N | 1 |
| Takemura, M | 2 |
| Ortiz, JL | 2 |
| Labat, C | 1 |
| Norel, X | 1 |
| Gorenne, I | 1 |
| Verley, J | 1 |
| Ohrui, T | 1 |
| Yamauchi, K | 1 |
| Sekizawa, K | 1 |
| Ohkawara, Y | 1 |
| Maeyama, K | 1 |
| Sasaki, M | 1 |
| Wada, H | 1 |
| Watanabe, T | 1 |
| Sasaki, H | 1 |
| Leurs, R | 1 |
| Brozius, MM | 1 |
| Smit, MJ | 1 |
| Bast, A | 1 |
| Obi, T | 1 |
| Matsumoto, M | 1 |
| Nishio, A | 1 |
| Vassilev, P | 1 |
| Mutafova-Yambolieva, V | 1 |
| Staneva-Stoytcheva, D | 1 |
| Todorov, S | 1 |
| Figueiredo, A | 1 |
| Ribeiro, CA | 1 |
| Gonçalo, M | 1 |
| Almeida, L | 1 |
| Poiares-Baptista, A | 1 |
| Teixeira, F | 1 |
| Cortijo, J | 1 |
| Sanz, C | 1 |
| Perpiñá, M | 1 |
| Orón, JD | 1 |
| Esplugues, J | 1 |
| Morcillo, EJ | 1 |
| DiJoseph, JF | 1 |
| Eash, JR | 1 |
| Mir, GN | 2 |
| Borella, L | 1 |
| Russell, J | 1 |
| Rimele, TJ | 1 |
| Grimes, D | 1 |
| Failli, A | 1 |
| Winbery, SL | 1 |
| Donaldson, J | 1 |
| Hill, SJ | 1 |
| de Castiglione, R | 1 |
| Perseo, G | 1 |
| Impicciatore, M | 1 |
| Chiavarini, M | 1 |
| Plazzi, PV | 1 |
| Bordi, F | 1 |
| Vitali, F | 1 |
44 other studies available for dimaprit and Muscle Contraction
| Article | Year |
|---|---|
Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazoles.
Topics: Animals; Atrial Function; Chemical Phenomena; Chemistry, Physical; Electrochemistry; Guinea Pigs; He | 1992 |
Cardiotonic agents. 6. Histamine analogues as potential cardiovascular selective H2 agonists.
Topics: Animals; Cardiotonic Agents; Drug Design; Ferrets; Gastric Acid; Guinea Pigs; Heart Rate; Histamine; | 1990 |
Design, synthesis, and structure-activity relationships of novel non-imidazole histamine H(3) receptor antagonists.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Dimaprit; Drug Design; Guanidines; Guinea Pigs; Hist | 2000 |
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relation | 2009 |
Effects of histamine on the contractile and electrical activity in isolated lymphatic vessels of the guinea-pig mesentery.
Topics: Animals; Dimaprit; Dose-Response Relationship, Drug; Endothelium, Lymphatic; Female; Guinea Pigs; Hi | 2002 |
An inhibitory effect of histamine on the rat anococcygeus muscle.
Topics: Acetylcholine; Animals; Carbachol; Cimetidine; Dimaprit; Drug Interactions; Guanidines; Histamine; I | 1982 |
Effects of histamine H2-receptor agonists and antagonists on isolated guinea-pig airway muscles.
Topics: Airway Resistance; Animals; Cimetidine; Dimaprit; Drug Interactions; Guinea Pigs; Histamine H2 Antag | 1982 |
Effect of drug-induced tone on the ability of histamine H2 receptor agonists to relax guinea-pig tracheal chain.
Topics: Animals; Dimaprit; Guanidines; Guinea Pigs; Imidazoles; Impromidine; In Vitro Techniques; Isoprotere | 1982 |
Are there excitatory H2 receptors in guinea-pig ileum?
Topics: Animals; Dimaprit; Guinea Pigs; Histamine H2 Antagonists; Ileum; Imidazoles; Impromidine; In Vitro T | 1983 |
Histamine H2-receptors on guinea-pig ileum myenteric plexus neurons mediate the release of contractile agents.
Topics: Animals; Dimaprit; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth | 1982 |
Reciprocal H1- and H2-histamine receptors in guinea pig gallbladder.
Topics: Animals; Dimaprit; Female; Gallbladder; Guinea Pigs; Histamine; Male; Muscle Contraction; Muscle, Sm | 1982 |
Autacoid and autonomic reactivity of bovine and ovine bronchus: modifications by antigenic sensitization.
Topics: Animals; Bronchi; Carbachol; Cattle; Dimaprit; Dose-Response Relationship, Drug; Epinephrine; Histam | 1982 |
Histamine receptors in the human ureter.
Topics: Chlorpheniramine; Dimaprit; Histamine; Humans; In Vitro Techniques; Metiamide; Muscle Contraction; M | 1983 |
Selectivity of 4-methylhistamine at H1- and H2-receptors in the guinea-pig isolated ileum.
Topics: Animals; Dibenzylchlorethamine; Dimaprit; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Te | 1983 |
Studies on the effect of histamine in isolated human pulmonary arteries and veins.
Topics: Aged; Dimaprit; Female; Histamine; Humans; In Vitro Techniques; Male; Methylhistamines; Middle Aged; | 1984 |
Dibenamine enhancement of histamine-induced relaxation of the rabbit mesenteric artery.
Topics: Animals; Cold Temperature; Dibenzylchlorethamine; Dimaprit; Drug Synergism; Histamine; Mesenteric Ar | 1983 |
pH-dependent activity of H1- and H2-histamine receptors in guinea-pig gallbladder.
Topics: Acetylcholine; Animals; Dimaprit; Female; Gallbladder; Guinea Pigs; Histamine; Hydrogen-Ion Concentr | 1981 |
Comparison of H2 receptor agonists in rabbit atria and aorta.
Topics: Animals; Aorta; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Female; Guanidines; Heart At | 1981 |
Further experiments on the pharmacological actions of ergometrine.
Topics: Animals; Cattle; Cimetidine; Coronary Vessels; Dimaprit; Ergonovine; Gastric Acid; Guinea Pigs; Hist | 1981 |
Prostaglandin-mediated contractile effect of impromidine and dimaprit in the isolated rat stomach fundus.
Topics: Animals; Dimaprit; Female; Guanidines; Imidazoles; Impromidine; In Vitro Techniques; Male; Muscle Co | 1981 |
Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development.
Topics: Aging; Airway Resistance; Animals; Bronchi; Cimetidine; Dimaprit; Female; Guanidines; Guinea Pigs; H | 1982 |
Characterization and function of histamine receptors in corpus cavernosum.
Topics: Acetylcholine; Animals; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Electric Stimulation | 1995 |
Presynaptic histamine H1- and H3-receptors modulate sympathetic neurotransmission in isolated guinea pig vas deferens.
Topics: Animals; Chlorpheniramine; Dimaprit; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Agonis | 1994 |
Coordination of Cl- secretion and contraction by a histamine H2-receptor agonist in guinea pig distal colon.
Topics: Animals; Chlorides; Cimetidine; Colon; Dimaprit; Electric Conductivity; Guinea Pigs; In Vitro Techni | 1993 |
The source and action of histamine in the isolated guinea-pig gallbladder.
Topics: Animals; Dimaprit; Electric Stimulation; Female; Gallbladder; Guinea Pigs; Histamine; Histamine Agon | 1995 |
Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301 U, in rodent antinociception.
Topics: Analgesics; Animals; Dimaprit; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid Antag | 1997 |
Contractile and relaxant effects of dimaprit on guinea pig isolated intestinal cells.
Topics: Animals; Cells, Cultured; Dimaprit; Guinea Pigs; Histamine Agonists; Intestines; Male; Muscle Contra | 1997 |
Histamine receptor-independent muscle relaxation elicited by a series of histamine H2-receptor agonists on the isolated guinea pig duodenum: a study into the mechanism of action.
Topics: Animals; Dimaprit; Duodenum; Electric Stimulation; Guinea Pigs; Histamine Agonists; Impromidine; In | 1998 |
The role of histamine H1, H2 and H3 receptors on enteric ascending synaptic transmission in the guinea pig ileum.
Topics: Animals; Cimetidine; Dimaprit; Electric Stimulation; Guinea Pigs; Histamine; Histamine Agonists; His | 1998 |
Expression of diamine oxidase (histaminase) in guinea-pig tissues.
Topics: Amine Oxidase (Copper-Containing); Animals; Brain; Dimaprit; Dose-Response Relationship, Drug; Gastr | 2002 |
Histamine receptors on human isolated pulmonary arterial muscle preparations: effects of endothelial cell removal and nitric oxide inhibitors.
Topics: Arginine; Burimamide; Chlorpheniramine; Cimetidine; Dimaprit; Endothelium, Vascular; Histamine; Huma | 1992 |
Histamine N-methyltransferase controls the contractile response of guinea pig trachea to histamine.
Topics: Animals; Dimaprit; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Histamine; Histamine N | 1992 |
Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine.
Topics: Animals; Atropine; Dimaprit; Electric Stimulation; Guanidines; Guinea Pigs; Histamine; In Vitro Tech | 1991 |
Vasomotor effect of histamine on pig and cattle coronary artery in vitro.
Topics: Animals; Cattle; Cimetidine; Coronary Vessels; Dimaprit; Diphenhydramine; Endothelium, Vascular; His | 1991 |
Involvement of calcium ions in the modulation of electrically-induced rat vas deferens contractions by histaminergic drugs.
Topics: Animals; Calcium; Cimetidine; Dimaprit; Diphenhydramine; Electric Stimulation; Histamine; In Vitro T | 1991 |
Mechanism of action of doxepin in the treatment of chronic urticaria.
Topics: Adult; Aged; Animals; Atropine; Carbachol; Chronic Disease; Dimaprit; Doxepin; Female; Gastric Juice | 1990 |
Responses to histamine and selective H2-receptor agonists in lung parenchymal strips from normal and sensitized guinea-pigs.
Topics: Animals; Benzimidazoles; Cimetidine; Dimaprit; Dose-Response Relationship, Drug; Guanidines; Guinea | 1989 |
Histamine H2 receptor antagonists may modify dog intestinal motility independently of their primary action on the H2 receptors.
Topics: Acetylcholine; Animals; Blood Pressure; Ceruletide; Cimetidine; Dimaprit; Dogs; Female; Gastrointest | 1985 |
Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Ulcer Agents; Aspirin; Carbachol; Clonidine; Cysteamine; Di | 1987 |
Antisecretory and antiulcer activities of a potent new histamine H2-receptor antagonist with an intermediate duration of action.
Topics: Anesthesia; Animals; Anti-Ulcer Agents; Aspirin; Dimaprit; Dogs; Gastric Acid; Gastric Mucosa; Guine | 1988 |
Metronidazole and 5-aminosalicylic acid enhance the contractile activity of histaminergic agonists on the guinea-pig isolated ileum.
Topics: Aminosalicylic Acids; Animals; Cimetidine; Computers; Dimaprit; Dose-Response Relationship, Drug; Dr | 1986 |
Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol.
Topics: Acetylcholine; Animals; Dimaprit; Dithionitrobenzoic Acid; Dithiothreitol; Dose-Response Relationshi | 1986 |
Stimulatory action of (beta-Asp9) ceruletide on dog pancreatic exocrine secretion.
Topics: Amino Acid Sequence; Animals; Ceruletide; Dimaprit; Dogs; Gallbladder; Imidazoles; Impromidine; Musc | 1985 |
Pharmacological activities of two new histamine analogs.
Topics: Animals; Cats; Dimaprit; Dose-Response Relationship, Drug; Gastric Acid; Guinea Pigs; Histamine; Ile | 1986 |