dimaprit has been researched along with Melanoma in 5 studies
Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A series of analogues of the weak histamine (H2) agonist S-[2-(N,N-dimethylamine)ethyl] isothiourea (nordimaprit) was produced to investigate the possibility that bulky substituents on the tertiary amine of nordimaprit would enhance potency for depigmentation and killing of melanoma cells." | 7.68 | Inhibition of melanogenesis in human melanoma cells by novel analogues of the partial histamine (H2) agonist nordimaprit. ( Fechner, GA; Jacobs, JJ; Parsons, PG, 1993) |
| "Human melanoma cells were treated in culture with the histamine (H2) agonist S-(3-(N-N-dimethylamino)propyl)isothiourea (dimaprit), a partial agonist, S-(2-(N,N-dimethylamino)ethyl)-isothiourea (nordimaprit), and two analogues of nordimaprit, S-(2-(N,N-diethylamino)ethyl)isothiourea (DENOR) and S-(2-(N,N-diisopropylamino)ethyl)isothiourea (DINOR), to investigate the effects on toxicity and tyrosinase activity." | 7.68 | Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells. ( Fechner, GA; Jacobs, JJ; McEwan, MT; Parsons, PG; Takahashi, H, 1992) |
| "Histamine displayed specific and saturable binding to membrane fractions of the human melanoma cell line MM96E (Kd = 72." | 3.69 | Dimaprit analogues inhibit tyrosinase via a disulphide breakdown product independently of the histamine H2 receptor. ( Fechner, GA; Jacobs, JJ; Parsons, PG, 1994) |
| "A series of analogues of the weak histamine (H2) agonist S-[2-(N,N-dimethylamine)ethyl] isothiourea (nordimaprit) was produced to investigate the possibility that bulky substituents on the tertiary amine of nordimaprit would enhance potency for depigmentation and killing of melanoma cells." | 3.68 | Inhibition of melanogenesis in human melanoma cells by novel analogues of the partial histamine (H2) agonist nordimaprit. ( Fechner, GA; Jacobs, JJ; Parsons, PG, 1993) |
| "Human melanoma cells were treated in culture with the histamine (H2) agonist S-(3-(N-N-dimethylamino)propyl)isothiourea (dimaprit), a partial agonist, S-(2-(N,N-dimethylamino)ethyl)-isothiourea (nordimaprit), and two analogues of nordimaprit, S-(2-(N,N-diethylamino)ethyl)isothiourea (DENOR) and S-(2-(N,N-diisopropylamino)ethyl)isothiourea (DINOR), to investigate the effects on toxicity and tyrosinase activity." | 3.68 | Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells. ( Fechner, GA; Jacobs, JJ; McEwan, MT; Parsons, PG; Takahashi, H, 1992) |
| "In cultured human melanoma cells, histamine H1 (mepyramine) and H2 receptor antagonists (cimetidine, ranitidine, impromidine) increased tyrosinase activity, whereas H2 agonists (dimaprit, nordimaprit) decreased activity." | 3.68 | Regulation of tyrosinase expression and activity in human melanoma cells via histamine receptors. ( McEwan, MT; Parsons, PG, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fechner, GA | 4 |
| Jacobs, JJ | 4 |
| Parsons, PG | 5 |
| Michel, J | 1 |
| Sturm, RA | 1 |
| McEwan, MT | 2 |
| Takahashi, H | 1 |
5 other studies available for dimaprit and Melanoma
| Article | Year |
|---|---|
Dimaprit analogues inhibit tyrosinase via a disulphide breakdown product independently of the histamine H2 receptor.
Topics: Biotransformation; Cell Line; Dimaprit; Disulfides; Histamine; Humans; Kinetics; Melanoma; Monopheno | 1994 |
Reduction of DNA synthesis, pigment synthesis, pigmentation gene mRNA and resistance to UVB in human melanoma cells treated with analogues of a histamine (H2) agonist.
Topics: Blotting, Northern; Cell Survival; Dimaprit; DNA, Neoplasm; Histamine Agonists; Humans; Isothiuroniu | 1994 |
Inhibition of melanogenesis in human melanoma cells by novel analogues of the partial histamine (H2) agonist nordimaprit.
Topics: Cell Line; Cell Survival; Dimaprit; Humans; Melanins; Melanoma; Monophenol Monooxygenase; Pigmentati | 1993 |
Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells.
Topics: Cell Division; Cell Survival; Cimetidine; Dimaprit; Humans; Immunoblotting; Melanoma; Microscopy, El | 1992 |
Regulation of tyrosinase expression and activity in human melanoma cells via histamine receptors.
Topics: Dimaprit; Flow Cytometry; Gene Expression Regulation, Enzymologic; Histamine H2 Antagonists; Humans; | 1991 |