dimaprit has been researched along with Malignant Melanoma in 5 studies
Dimaprit: A histamine H2 receptor agonist that is often used to study the activity of histamine and its receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A series of analogues of the weak histamine (H2) agonist S-[2-(N,N-dimethylamine)ethyl] isothiourea (nordimaprit) was produced to investigate the possibility that bulky substituents on the tertiary amine of nordimaprit would enhance potency for depigmentation and killing of melanoma cells." | 7.68 | Inhibition of melanogenesis in human melanoma cells by novel analogues of the partial histamine (H2) agonist nordimaprit. ( Fechner, GA; Jacobs, JJ; Parsons, PG, 1993) |
| "Human melanoma cells were treated in culture with the histamine (H2) agonist S-(3-(N-N-dimethylamino)propyl)isothiourea (dimaprit), a partial agonist, S-(2-(N,N-dimethylamino)ethyl)-isothiourea (nordimaprit), and two analogues of nordimaprit, S-(2-(N,N-diethylamino)ethyl)isothiourea (DENOR) and S-(2-(N,N-diisopropylamino)ethyl)isothiourea (DINOR), to investigate the effects on toxicity and tyrosinase activity." | 7.68 | Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells. ( Fechner, GA; Jacobs, JJ; McEwan, MT; Parsons, PG; Takahashi, H, 1992) |
| "Histamine displayed specific and saturable binding to membrane fractions of the human melanoma cell line MM96E (Kd = 72." | 3.69 | Dimaprit analogues inhibit tyrosinase via a disulphide breakdown product independently of the histamine H2 receptor. ( Fechner, GA; Jacobs, JJ; Parsons, PG, 1994) |
| "A series of analogues of the weak histamine (H2) agonist S-[2-(N,N-dimethylamine)ethyl] isothiourea (nordimaprit) was produced to investigate the possibility that bulky substituents on the tertiary amine of nordimaprit would enhance potency for depigmentation and killing of melanoma cells." | 3.68 | Inhibition of melanogenesis in human melanoma cells by novel analogues of the partial histamine (H2) agonist nordimaprit. ( Fechner, GA; Jacobs, JJ; Parsons, PG, 1993) |
| "Human melanoma cells were treated in culture with the histamine (H2) agonist S-(3-(N-N-dimethylamino)propyl)isothiourea (dimaprit), a partial agonist, S-(2-(N,N-dimethylamino)ethyl)-isothiourea (nordimaprit), and two analogues of nordimaprit, S-(2-(N,N-diethylamino)ethyl)isothiourea (DENOR) and S-(2-(N,N-diisopropylamino)ethyl)isothiourea (DINOR), to investigate the effects on toxicity and tyrosinase activity." | 3.68 | Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells. ( Fechner, GA; Jacobs, JJ; McEwan, MT; Parsons, PG; Takahashi, H, 1992) |
| "In cultured human melanoma cells, histamine H1 (mepyramine) and H2 receptor antagonists (cimetidine, ranitidine, impromidine) increased tyrosinase activity, whereas H2 agonists (dimaprit, nordimaprit) decreased activity." | 3.68 | Regulation of tyrosinase expression and activity in human melanoma cells via histamine receptors. ( McEwan, MT; Parsons, PG, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fechner, GA | 4 |
| Jacobs, JJ | 4 |
| Parsons, PG | 5 |
| Michel, J | 1 |
| Sturm, RA | 1 |
| McEwan, MT | 2 |
| Takahashi, H | 1 |
5 other studies available for dimaprit and Malignant Melanoma
| Article | Year |
|---|---|
Dimaprit analogues inhibit tyrosinase via a disulphide breakdown product independently of the histamine H2 receptor.
Topics: Biotransformation; Cell Line; Dimaprit; Disulfides; Histamine; Humans; Kinetics; Melanoma; Monopheno | 1994 |
Reduction of DNA synthesis, pigment synthesis, pigmentation gene mRNA and resistance to UVB in human melanoma cells treated with analogues of a histamine (H2) agonist.
Topics: Blotting, Northern; Cell Survival; Dimaprit; DNA, Neoplasm; Histamine Agonists; Humans; Isothiuroniu | 1994 |
Inhibition of melanogenesis in human melanoma cells by novel analogues of the partial histamine (H2) agonist nordimaprit.
Topics: Cell Line; Cell Survival; Dimaprit; Humans; Melanins; Melanoma; Monophenol Monooxygenase; Pigmentati | 1993 |
Antiproliferative and depigmenting effects of the histamine (H2) agonist dimaprit and its derivatives on human melanoma cells.
Topics: Cell Division; Cell Survival; Cimetidine; Dimaprit; Humans; Immunoblotting; Melanoma; Microscopy, El | 1992 |
Regulation of tyrosinase expression and activity in human melanoma cells via histamine receptors.
Topics: Dimaprit; Flow Cytometry; Gene Expression Regulation, Enzymologic; Histamine H2 Antagonists; Humans; | 1991 |