diltiazem has been researched along with Aging in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (40.00) | 18.7374 |
| 1990's | 15 (42.86) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 2 (5.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berkowitz, BA; Grady, EM; Roberts, R | 1 |
| Colucci, M; D'Ambrosio, A; Giordani, L; Quintieri, F; Vanacore, N | 1 |
| Cipolla, MJ; Mandalà, M; Morales Palomares, S; Osol, G; Pedatella, AL | 1 |
| Fujiwara, H; Hattori, A; Hiei, K; Io, K; Kato, T; Kawasaki, M; Matsuo, H; Minatoguchi, S; Morita, N; Nishigaki, K; Noda, T; Ojio, S; Ono, H; Sato, H; Segawa, T; Takemura, G; Tanaka, T; Ueno, K; Watanabe, S | 1 |
| Artman, M; Boucek, RJ; Mushlin, PS; Olson, RD; Shelton, M; Starnes, VA | 1 |
| Hano, T; Kuchii, M; Kusuyama, Y; Masuyama, Y; Nishio, I; Tsuda, K | 1 |
| Masaki, K; Nakayama, M; Wada, S | 1 |
| Kates, RE | 1 |
| Larsen, A; Midtbø, K; Saevareid, L; Storstein, L | 1 |
| Reams, GP | 1 |
| Cooper, CW; Greeley, GH; Ishizuka, J; Murakami, M; Nichols, GA; Thompson, JC | 1 |
| Horton, JW; White, DJ | 1 |
| Applegate, WB | 1 |
| Ascalone, V; Bianchetti, G; Billy, S; Houin, G; Rosenzweig, P; Saivin, S | 1 |
| Levin, RM; Wein, AJ; Yu, HJ | 1 |
| Abe, K; Gu, H; Momma, K; Nakanishi, T | 1 |
| Aramayona, JJ; Bregante, MA; Fraile, LJ; García, MA; Solans, C | 1 |
| Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C | 1 |
| Dahlöf, B; De Faire, U; Hansson, L; Hedner, T; Karlberg, BE; Kjeldsen, SE; Lanke, J; Lindholm, LH; Lund-Johansen, P; Syvertsen, JO | 1 |
| Howlett, SE; Nicholl, PA | 1 |
| Hunt, CM; Stave, GM; Westerkam, WR | 1 |
| Djian, J; Forette, B; Lekieffre, J; Luccioni, R; Roy, M | 1 |
| Carcone, B; Claudel, S; Elkik, F; Grippon, P | 1 |
| Avkiran, M; Hearse, DJ; Murashita, T | 1 |
| Come, PC; Gervino, EV; Manning, WJ; Parker, JA; Santinga, JA; Shannon, RP; Wei, JY | 1 |
| Maher, KA; Royal, HD; Santinga, JT; Shannon, RP; Wei, JY | 1 |
| Shinkai, M; Takayanagi, I; Yamasawa, K | 1 |
| Abernethy, DR; Montamat, SC | 2 |
| O'Donnell, SR; Wanstall, JC | 1 |
| Lauterburg, BH | 1 |
| Bova, S; Cargnelli, G; Ferrari, M; Moretto, R; Padrini, R; Piovan, D | 1 |
| Hermann, P; Morselli, PL | 1 |
| Barst, RJ; Cato, AE; Frosolono, MF; Hall, JC; Mellins, RB; Stalcup, SA; Steeg, CN | 1 |
| Hatano, K; Ito, E; Noda, S; Sotobata, I; Tsuzuki, M; Yamauchi, K | 1 |
4 review(s) available for diltiazem and Aging
| Article | Year |
|---|---|
Calcium antagonists. Pharmacokinetic properties.
Topics: Administration, Oral; Aging; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Diltiazem; Drug Interactions; Humans; Injections, Intravenous; Kinetics; Nifedipine; Protein Binding; Tissue Distribution; Verapamil | 1983 |
Do calcium channel blockers have renal protective effects?
Topics: Aging; Animals; Calcium Channel Blockers; Clinical Trials as Topic; Cyclosporine; Diabetic Nephropathies; Dihydropyridines; Diltiazem; Disease Models, Animal; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension, Renal; Kidney; Kidney Transplantation; Rats; Rats, Inbred SHR; Verapamil | 1994 |
Managing the older patient with hypertension.
Topics: Aged; Aged, 80 and over; Aging; Antihypertensive Agents; Atenolol; Delayed-Action Preparations; Diltiazem; Enalapril; Forecasting; Humans; Hypertension; Randomized Controlled Trials as Topic; Systole | 1993 |
Pharmacokinetics of diltiazem and other calcium entry blockers.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Benzazepines; Blood Proteins; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Diltiazem; Drug Interactions; Humans; Injections, Intravenous; Kinetics; Middle Aged; Nifedipine; Protein Binding; Verapamil | 1985 |
5 trial(s) available for diltiazem and Aging
| Article | Year |
|---|---|
Pharmacokinetics of calcium blockers in patients with renal insufficiency and in geriatric patients.
Topics: Administration, Oral; Adult; Aged; Aging; Diltiazem; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Nifedipine; Uremia; Verapamil | 1984 |
Multicenter studies on the pharmacokinetic profile of sustained-release oral diltiazem (300 mg) after once a day repeated administration: influence of age.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Female; Humans; Male; Middle Aged | 1996 |
Influence of age, sex and blood pressure on the principal endpoints of the Nordic Diltiazem (NORDIL) Study.
Topics: Adrenergic beta-Antagonists; Aged; Aging; Blood Pressure; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertension; Incidence; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Prospective Studies; Sex Characteristics; Stroke; Survival Analysis | 2002 |
Efficacy and tolerance of sustained-release diltiazem 300 mg and a diuretic in the elderly.
Topics: Aged; Aging; Blood Pressure; Delayed-Action Preparations; Diltiazem; Drug Tolerance; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Triamterene | 1990 |
Demographic factors and the antihypertensive effect of diltiazem.
Topics: Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Body Weight; Diltiazem; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Posture; Sex Characteristics | 1991 |
26 other study(ies) available for diltiazem and Aging
| Article | Year |
|---|---|
Confirming a prediction of the calcium hypothesis of photoreceptor aging in mice.
Topics: Aging; Animals; Calcium Channels, L-Type; Color Vision; Diltiazem; Magnetic Resonance Imaging; Male; Manganese; Mice, Inbred C57BL; Photoreceptor Cells, Vertebrate; Rats; Retina; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells | 2014 |
Modulation of human peripheral blood mononuclear cell proliferative response by diltiazem : in vitro comparison in younger versus older subjects.
Topics: Adult; Age Factors; Aged; Aging; Antibodies, Monoclonal; Antihypertensive Agents; CD3 Complex; Cell Proliferation; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Interleukin-2; Leukocytes, Mononuclear; Male; Middle Aged; Pokeweed Mitogens; Tuberculin; Young Adult | 2009 |
Maturation is associated with changes in rat cerebral artery structure, biomechanical properties and tone.
Topics: Aging; Animals; Biomechanical Phenomena; Blood Pressure; Cerebral Arteries; Collagen; Diltiazem; Elastin; Endothelium, Vascular; Enzyme Inhibitors; Male; Models, Animal; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Papaverine; Rats; Rats, Sprague-Dawley; Vascular Resistance | 2012 |
Effects of benidipine and some other calcium channel blockers on the prognosis of patients with vasospastic angina. Cohort study with evaluation of the ergonovine coronary spasm induction test.
Topics: Adult; Aged; Aging; Amlodipine; Angina Pectoris; Calcium Channel Blockers; Cohort Studies; Coronary Angiography; Coronary Stenosis; Coronary Vasospasm; Diabetes Complications; Dihydropyridines; Diltiazem; Ergonovine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifedipine; Oxytocics; Prognosis; Risk Factors | 2007 |
Comparative effects of verapamil, nifedipine, and diltiazem on contractile function in the isolated immature and adult rabbit heart.
Topics: Aging; Animals; Benzazepines; Calcium; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Perfusion; Rabbits; Verapamil | 1984 |
Alteration of presynaptic alpha 2-mediated inhibition of norepinephrine release in perfused mesenteric arteries of young and adult spontaneously hypertensive rats.
Topics: Aging; Animals; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; Male; Mesenteric Arteries; Neural Inhibition; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Yohimbine | 1984 |
Effects of diltiazem hydrochloride on serum lipids: comparison with beta-blockers.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aging; Benzazepines; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus; Diltiazem; Female; Humans; Hyperlipidemias; Lipid Metabolism; Lipids; Male; Middle Aged; Sex Factors; Triglycerides | 1982 |
Age-related changes in gallbladder contractility and cytoplasmic Ca2+ concentration in the guinea pig.
Topics: Aging; Animals; Calcium; Calcium Channels; Cell Membrane; Cytoplasm; Diltiazem; Gallbladder; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Kinetics; Muscle Development; Muscle, Smooth; Sincalide | 1993 |
Diminished cardiac contractile response to burn injury in aged guinea pigs.
Topics: Aging; Animals; Burns; Calcium Channels; Depression, Chemical; Diltiazem; Guinea Pigs; Isoproterenol; Male; Myocardial Contraction; Ventricular Function, Left | 1993 |
Age-related differential susceptibility to calcium channel blocker and low calcium medium in rat detrusor muscle: response to field stimulation.
Topics: Aging; Animals; Calcium; Calcium Channel Blockers; Culture Media; Diltiazem; Drug Resistance; Electric Stimulation; Intracellular Membranes; Male; Rats; Rats, Sprague-Dawley; Urinary Bladder | 1996 |
Developmental changes in the contractile system of the mesenteric small artery of rabbit.
Topics: Aging; Animals; Arteries; Calcium; Calcium Channel Blockers; Diltiazem; Endoplasmic Reticulum; Female; Mesentery; Muscle Contraction; Muscle Development; Muscle, Smooth, Vascular; Potassium Chloride; Pregnancy; Rabbits; Vascular Resistance | 1997 |
Enhanced diltiazem deacetylase activity in pre-term and full-term rabbits compared with adult rabbits.
Topics: Aging; Animals; Animals, Newborn; Brain; Calcium Channel Blockers; Diltiazem; Esterases; Female; Gestational Age; Intestine, Small; Liver; Lung; Pregnancy; Rabbits; Time Factors | 1997 |
Development of diltiazem deacetylase and demethylase activities during ontogeny in rabbit.
Topics: Age Factors; Aging; Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Female; Hydrolases; Kinetics; Liver; Models, Chemical; Models, Statistical; Oxidoreductases, O-Demethylating; Rabbits; Time Factors; Tissue Distribution | 2001 |
Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters.
Topics: Aging; Allosteric Site; Animals; Calcium Channels; Cricetinae; Dihydropyridines; Diltiazem; In Vitro Techniques; Kinetics; Male; Myocardium; Nifedipine; Verapamil | 1992 |
Effect of age and gender on the activity of human hepatic CYP3A.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking | 1992 |
Effects of diltiazem as an additive to St Thomas's Hospital cardioplegic solution in isolated neonatal and adult rabbit hearts.
Topics: Aging; Animals; Bicarbonates; Calcium Chloride; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Drug Combinations; Heart; Magnesium; Myocardial Contraction; Organ Culture Techniques; Potassium Chloride; Rabbits; Sodium Chloride | 1991 |
Reversal of changes in left ventricular diastolic filling associated with normal aging using diltiazem.
Topics: Adult; Aged; Aging; Blood Flow Velocity; Cardiac Output; Diltiazem; Echocardiography; Echocardiography, Doppler; Female; Humans; Male; Myocardial Contraction; Ventricular Function, Left | 1991 |
Comparison of differences in the hemodynamic response to passive postural stress in healthy subjects greater than 70 years and less than 30 years of age.
Topics: Adult; Aged; Aging; Blood Pressure; Cardiac Volume; Cardiovascular Physiological Phenomena; Diltiazem; Heart Rate; Hemodynamics; Humans; Posture; Stroke Volume | 1991 |
Effects of aging on alpha 1-adrenoceptor mechanisms and the inhibitory effect of diltiazem on noradrenaline maximum response in isolated rat aortic preparation.
Topics: Aging; Animals; Aorta, Thoracic; Diltiazem; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin | 1989 |
Calcium antagonists in geriatric patients: diltiazem in elderly persons with hypertension.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Blood Pressure; Catecholamines; Diltiazem; Female; Heart Rate; Humans; Hypertension; Infusions, Intravenous; Male | 1989 |
Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent.
Topics: Aging; Animals; Aorta; Calcium; Calcium Channel Blockers; Diltiazem; Drug Interactions; Felodipine; Male; Nitrendipine; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Serotonin | 1989 |
[Clinical pharmacology of calcium antagonists].
Topics: Aging; Arrhythmias, Cardiac; Biological Availability; Calcium Channel Blockers; Diltiazem; Drug Interactions; Half-Life; Heart Failure; Humans; Kidney; Liver; Liver Diseases; Nifedipine; Verapamil | 1987 |
N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Diltiazem; Female; Half-Life; Humans; Hypertension; Kinetics; Male | 1987 |
Physiological, pharmacological and pathological factors affecting the pharmacokinetics of calcium entry blockers.
Topics: Aging; Animals; Calcium Channel Blockers; Diltiazem; Drug Administration Schedule; Guinea Pigs; Humans; Isomerism; Liver; Liver Diseases; Monitoring, Physiologic; Nifedipine; Phenotype; Verapamil | 1987 |
Relation of arachidonate metabolites to abnormal control of the pulmonary circulation in a child.
Topics: 6-Ketoprostaglandin F1 alpha; Aging; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Diltiazem; Epoprostenol; Female; Hemodynamics; Humans; Infant; Nifedipine; Pulmonary Artery; Pulmonary Circulation; Thromboxane B2; Vascular Diseases; Vasodilation | 1985 |
[Arrhythmias in the elderly patients: atrial fibrillation].
Topics: Aged; Aging; Atrial Fibrillation; Coronary Disease; Diltiazem; Humans; Hypertension; Mitral Valve Insufficiency; Verapamil | 1985 |