diisopropanolnitrosamine has been researched along with Lung Neoplasms in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (29.73) | 18.7374 |
| 1990's | 13 (17.57) | 18.2507 |
| 2000's | 31 (41.89) | 29.6817 |
| 2010's | 8 (10.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alexander, DB; Fukamachi, K; Futakuchi, M; Hirose, A; Kanno, J; Numano, T; Omori, T; Shimizu, H; Suzui, M; Tsuda, H; Xu, J | 1 |
| Imaida, K; Kinouch, S; Kishi, S; Nakano, Y; Ninomiya, F; Saoo, K; Tanizawa, J; Yamakawa, K; Yokohira, M | 1 |
| Konishi, Y; Nakae, D; Tsujiuchi, T | 1 |
| Hashimoto, N; Imaida, K; Kanie, S; Kishi, S; Nakano, Y; Ninomiya, F; Saoo, K; Yamakawa, K; Yokohira, M | 1 |
| Enguita, AB; Hernández, P; Lázaro, S; Martínez-Palacio, J; Oteo, M; Paramio, JM; Pérez-Crespo, M; Sage, J; Santos, M | 1 |
| Fukushima, N; Furukawa, M; Honoki, K; Hotta, M; Obo, Y; Tsujiuchi, T; Yamada, T; Yamasaki, A | 1 |
| Alexander, DB; Fukamachi, K; Furukawa, F; Futakuchi, M; Hirose, A; Iigo, M; Kanno, J; Nishimura, T; Sakai, Y; Shimizu, H; Tamano, S; Tokunaga, H; Tsuda, H; Uchino, T; Xu, J | 1 |
| Fujii, M; Honoki, K; Okabe, K; Tajiri, M; Tsujino, M; Tsujiuchi, T; Wakabayashi, N | 1 |
| Blyth, BJ; Doi, K; Iwata, K; Kakinuma, S; Morioka, T; Nakata, A; Nishimura, M; Oghiso, Y; Shimada, Y; Tani, S; Yamada, Y | 1 |
| Konishi, Y; Sasaki, Y; Tsujiuchi, T; Tsutsumi, M | 6 |
| Furukawa, F; Hirose, M; Imazawa, T; Natsume, M; Nishikawa, A; Okazaki, K; Osakabe, N; Yamagishi, M | 1 |
| Mimeoka, A; Otani, S; Shiraki, K; Une, K; Watanabe, H; Yano, R | 1 |
| Kuniyasu, H; Oka, Y; Sasaki, Y; Tsujiuchi, T; Tsutsumi, M | 1 |
| Amanuma, T; Mori, T; Tanaka, N; Tsujiuchi, T; Tsutsumi, M | 1 |
| Hanaoka, M; Hinotsume, D; Honoki, K; Kato, A; Shigemura, M; Shimizu, K; Shimoichi, Y; Tsujiuchi, T | 1 |
| Donehower, LA; Hirata, A; Masegi, T; Sakai, H; Tatematsu, M; Tsukamoto, T; Yamamoto, M; Yanai, T | 1 |
| Fujii, H; Honoki, K; Kato, A; Shimizu, K; Shimoichi, Y; Tsujiuchi, T | 1 |
| Fujii, H; Honoki, K; Kato, A; Shigemura, M; Shimizu, K; Tsujiuchi, T | 1 |
| Hirose, M; Ishii, Y; Kanki, K; Kitamura, Y; Kuroiwa, Y; Masegi, T; Nishikawa, A; Umemura, T | 1 |
| Fujii, H; Hinotsume, D; Honoki, K; Itsuzaki, Y; Shimizu, K; Shimoichi, Y; Tsujiuchi, T | 1 |
| Hayama, M; Kamiya, K; Kashimoto, N; Watanabe, H | 1 |
| Fujii, H; Honoki, K; Masaoka, T; Onishi, M; Shimizu, K; Sugata, E; Tsujiuchi, T | 1 |
| Crooks, PA; Nakshatri, H; Neelakantan, S; Ralstin, M; Schmidt, CM; Sweeney, CJ; Vegeler, RC; Wu, H; Yip-Schneider, MT | 1 |
| Mori, C; Nishikawa, T; Onishi, M; Saito, M; Shimizu, K; Sokuza, Y; Sugata, E; Tsujiuchi, T | 1 |
| Imaida, K; Kitahashi, T; Oghiso, Y; Sugimura, T; Takahashi, M; Takasuka, N; Tsutsumi, M; Wakabayashi, K; Yamada, Y; Yokohira, M | 1 |
| Hirose, M; Ikawa, E; Ito, N; Masuda, A; Shirai, T | 1 |
| Rao, MS; Reddy, JK | 1 |
| Emi, Y; Higashiguchi, R; Katada, H; Konishi, Y; Maruyama, H; Mikami, R; Takahashi, S; Yokose, Y | 1 |
| Denda, A; Konishi, Y; Mori, Y; Niwa, T; Takahashi, H; Takahashi, S; Toyoshi, K | 1 |
| Fukushima, S; Ito, N; Kurata, Y; Shirai, T | 1 |
| Knutsen, GL; Kovatch, RM; Lijinsky, W; Saavedra, JE | 1 |
| Denda, A; Konishi, Y; Maruyama, H; Matsui, M; Mori, Y; Takahashi, S; Toyoshi, K; Yokose, Y | 1 |
| Althoff, J; Green, U; Ketkar, MB; Konishi, Y | 1 |
| Higashiguchi, R; Ikeda, T; Katada, H; Kawabata, A; Konishi, Y; Maruyama, H; Yoshimura, H | 1 |
| Hiasa, Y; Kitahori, Y; Konishi, N; Naito, H; Ohnishi, T; Shirai, T | 1 |
| Akagi, K; Hirose, M; Hoshiya, T; Ito, N; Mizoguchi, Y; Shirai, T | 1 |
| Fukuda, T; Kitada, H; Konsihi, Y; Narita, N; Takahama, M; Tsujiuchi, T; Tsutsumi, M | 1 |
| Ichinose, T; Kishino, Y; Kohri, T; Mizunuma, T; Sagai, M; Sakai, K | 1 |
| Mitsumori, K; Onodera, H; Shimo, T; Takahashi, M; Takegawa, K; Yasuhara, K | 1 |
| Hirose, M; Ito, N; Kimura, J; Shirai, T; Takaba, K; Yoshida, Y | 1 |
| Hiura, A; Satake, K; Tsutsumi, M | 1 |
| Ikematsu, S; Iki, K; Kadomatsu, K; Konishi, Y; Muramatsu, T; Sakaki, T; Sakitani, H; Sakuma, S; Takahama, M; Tsujiuchi, T; Tsutsumi, M | 1 |
| Iki, K; Kido, A; Kitamura, S; Konishi, Y; Sakitani, H; Takahama, M; Taniguchi, S; Tsujiuchi, T; Tsutsumi, M | 1 |
| Kitada, H; Konishi, Y; Murakawa, K; Sakitani, H; Sasaki, Y; Shiraiwa, K; Takahama, M; Tsujiuchi, T; Tsutsumi, M; Yoshimoto, M | 1 |
| Denda, A; Kitayama, W; Konishi, Y; Murakawa, K; Sasaki, Y; Takahama, M; Tsujiuchi, T; Tsutsumi, M; Yoshida, J | 1 |
| Konishi, Y; Murata, N; Sasaki, Y; Tsujiuchi, T; Tsutsumi, M | 1 |
| Konishi, Y; Kusuoka, O; Masutani, M; Nakagama, H; Nozaki, T; Sugimura, T; Suzuki, H; Tsujiuchi, T; Tsutsumi, M | 1 |
| Akagi, K; Hirose, M; Hoshiya, T; Mizoguchi, Y; Nakamura, A; Shirai, T | 1 |
| Konishi, Y; Mikasa, K; Murakawa, Y; Murata, N; Narita, N; Sasaki, Y; Tsujiuchi, T; Tsutsumi, M | 1 |
| Konishi, Y; Murata, N; Nakae, D; Sasaki, Y; Tsujiuchi, T; Tsutsumi, M | 2 |
| Fukushima, S; Hirata, K; Kishida, H; Morimura, K; Nakae, D; Nishikawa, T; Seike, N; Wanibuchi, H | 1 |
| Denda, A; Ikeda, T; Inui, S; Kojima, K; Kondo, H; Konishi, Y | 1 |
| Hoshimura, H; Ikeda, T; Kondo, H; Konishi, Y; Yoshimura, Y | 1 |
| Denda, A; Kondo, H; Konishi, Y; Takahashi, S | 1 |
| Hasegawa, R; Imaida, K; Ito, N; Takaba, K; Yoshida, Y | 1 |
| Amanuma, T; Denda, A; Kamino, K; Kondoh, S; Konishi, Y; Tsujiuchi, T; Tsutsumi, M | 1 |
| Takemoto, K; Yoshimura, H | 1 |
| Furukawa, F; Hasegawa, R; Hayashi, Y; Hirose, M; Ito, N; Takahashi, M; Toyoda, K | 1 |
| Ichihara, A; Ito, N; Moore, MA; Sato, K; Thamavit, W; Tsuda, H | 1 |
| Bannasch, P; Hacker, HJ; Ito, N; Moore, MA; Sato, K; Tsuda, H | 1 |
| Eimoto, H; Konishi, Y; Nakajima, A; Shiraiwa, K; Tamura, K; Tsutsumi, M; Yamamoto, K; Yokose, Y | 1 |
| Bannasch, P; Moore, MA; Thornton, M; Weber, E | 1 |
| Yamamoto, H | 1 |
| Imaida, K; Ito, N; Masuda, A; Ogiso, T; Shirai, T | 1 |
| Eimoto, H; Konishi, Y; Maruyama, H; Mori, Y; Nakajima, A; Yamamoto, K; Yokose, Y | 1 |
| Danda, A; Eguchi, T; Ito, S; Kitazawa, S; Konishi, Y; Mizumoto, K; Nakajima, A; Tsutsumi, M | 1 |
| Denda, A; Konishi, Y; Mori, Y; Nakajima, A; Yamamoto, K; Yamazaki, H; Yokose, Y | 1 |
| Hirose, M; Ito, N; Ogiso, T; Shirai, T; Tsuda, H | 1 |
1 review(s) available for diisopropanolnitrosamine and Lung Neoplasms
| Article | Year |
|---|---|
Multi-step lung carcinogenesis model induced by oral administration of N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Administration, Oral; Animals; Biotransformation; Carcinogenesis; Cell Line, Tumor; Environmental Pollutants; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Nitrosamines; Rats | 2014 |
73 other study(ies) available for diisopropanolnitrosamine and Lung Neoplasms
| Article | Year |
|---|---|
Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles.
Topics: Animals; Bronchioles; Carcinogenicity Tests; Chlorides; Epithelial Cells; Female; Gene Expression Regulation; Genes, ras; Humans; Hyperplasia; Lung Diseases, Interstitial; Lung Neoplasms; Nanoparticles; Nitrosamines; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Zinc Compounds; Zinc Oxide | 2014 |
Napsin A is possibly useful marker to predict the tumorigenic potential of lung bronchiolo-alveolar hyperplasia in F344 rats.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenoma; Animals; Aspartic Acid Endopeptidases; Biomarkers, Tumor; Bronchioles; Hyperplasia; Immunohistochemistry; Lung; Lung Neoplasms; Nitrosamines; Prognosis; Pulmonary Alveoli; Rats; Rats, Inbred F344 | 2014 |
Rat strain differences in levels and effects of chronic inflammation due to intratracheal instillation of quartz on lung tumorigenesis induced by DHPN.
Topics: Animals; Carcinogenesis; Carcinogens; Inflammation; Lung; Lung Neoplasms; Male; Nitrosamines; Quartz; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar | 2014 |
Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.
Topics: Animals; Cell Transformation, Neoplastic; Lung Neoplasms; Mice; Mice, Knockout; Neoplasms, Experimental; Neuroendocrine Tumors; Nitrosamines; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; Signal Transduction; Urethane | 2017 |
Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Mutational Analysis; Lung Neoplasms; Male; Mutation; Nitrosamines; Polymorphism, Single-Stranded Conformational; Rats; Rats, Wistar; Receptors, Lysophosphatidic Acid | 2009 |
Involvement of macrophage inflammatory protein 1alpha (MIP1alpha) in promotion of rat lung and mammary carcinogenic activity of nanoscale titanium dioxide particles administered by intra-pulmonary spraying.
Topics: Animals; Cell Proliferation; Chemokine CCL3; Chemokine CXCL1; Female; Interleukin-6; Lung Neoplasms; Mammary Neoplasms, Experimental; Nitrosamines; Oxidative Stress; Proto-Oncogene Mas; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Titanium | 2010 |
Alterations of the LKB1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; AMP-Activated Protein Kinase Kinases; Animals; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Male; Mutation; Nitrosamines; Protein Serine-Threonine Kinases; Rats; Rats, Wistar | 2010 |
Co-operative effects of thoracic X-ray irradiation and N-nitrosobis(2-hydroxypropyl) amine administration on lung tumorigenesis in neonatal, juvenile and adult Wistar rats.
Topics: Adenocarcinoma; Adenoma; Aging; Animals; Animals, Newborn; Carcinogens; Cell Transformation, Neoplastic; Female; Lung Neoplasms; Neoplasms, Radiation-Induced; Nitrosamines; Rats; Rats, Wistar; Thorax | 2013 |
Alterations of the retinoblastoma-related gene RB2/p130 in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Animals; Blotting, Northern; Blotting, Western; DNA Mutational Analysis; DNA Primers; Genes, Retinoblastoma; Lung Neoplasms; Male; Mutagens; Nitrosamines; Phosphoproteins; Polymorphism, Single-Stranded Conformational; Proteins; Rats; Rats, Wistar; Retinoblastoma Protein; Retinoblastoma-Like Protein p130; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
Alterations of the M6p/Igf2 receptor gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Animals; Base Sequence; Carcinogens; DNA Primers; Lung Neoplasms; Male; Nitrosamines; Rats; Rats, Wistar; Receptor, IGF Type 2; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Cacao; Carcinoma; Catechin; Diethylnitrosamine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Flavonoids; Gastrointestinal Neoplasms; Injections, Intraperitoneal; Injections, Subcutaneous; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Phenols; Phytotherapy; Pituitary Neoplasms; Plant Extracts; Polymers; Proanthocyanidins; Rats; Rats, Inbred F344; Thyroid Neoplasms; Urogenital Neoplasms | 2003 |
Inhibition by long-term fermented miso of induction of pulmonary adenocarcinoma by diisopropanolnitrosamine in Wistar rats.
Topics: Adenocarcinoma; Animals; Diet; Fermentation; Glycine max; Lung Neoplasms; Male; Nitrosamines; Organ Size; Rats; Rats, Wistar | 2003 |
Alterations of the Dutt1/Robo1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Carcinogens; Cell Transformation, Neoplastic; Lung Neoplasms; Male; Molecular Sequence Data; Nerve Tissue Proteins; Nitrosamines; Rats; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Roundabout Proteins; Tumor Suppressor Proteins | 2004 |
Establishment and characterization of a rat lung adenocarcinoma cell line with low malignant potential.
Topics: Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Genes, p16; Genes, ras; Lung Neoplasms; Male; Mutation; Neoplasm Invasiveness; Nitrosamines; Polymorphism, Single-Stranded Conformational; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
Reduced expressions of Foxp1 and Rassf1a genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Animals; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Down-Regulation; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Male; Nitrosamines; Rats; Rats, Wistar; Repressor Proteins; RNA, Messenger; Tumor Suppressor Proteins | 2006 |
Organ-specific susceptibility of p53 knockout mice to N-bis(2-hydroxypropyl)nitrosamine carcinogenesis.
Topics: Animals; Female; Genes, p53; Hemangioma; Hemangiosarcoma; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nitrosamines; Organ Specificity; Tumor Suppressor Protein p53 | 2006 |
Aberrant DNA methylation of E-cadherin and p16 genes in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine.
Topics: Adenocarcinoma; Animals; Cadherins; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, p16; Lung; Lung Neoplasms; Male; Nitrosamines; Rats; Rats, Wistar; Reference Values; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Aberrant methylation patterns of the Rassf1a gene in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine.
Topics: Adenocarcinoma; Animals; Base Sequence; DNA Methylation; Lung; Lung Neoplasms; Male; Molecular Sequence Data; Mutation; Nitrosamines; Rats; Reference Values; Tumor Suppressor Proteins | 2006 |
Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis: results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Bromodeoxyuridine; Carcinogens; Cell Proliferation; Disease Models, Animal; DNA; DNA Damage; Guanine; Lipid Peroxidation; Lung; Lung Neoplasms; Male; Nitrosamines; Oxidative Stress; Quinolines; Rats; Thiobarbituric Acid Reactive Substances | 2006 |
Reduced expression of the Connexin26 gene and its aberrant DNA methylation in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine.
Topics: Adenocarcinoma; Animals; Carcinoma, Non-Small-Cell Lung; Connexin 26; Connexins; DNA Methylation; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Male; Nitrosamines; Rats; Rats, Wistar | 2006 |
Inhibitory effect of a water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi) mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis (2-hydroxypropyl) amine in Wistar rats.
Topics: Adenocarcinoma; Animals; Carcinogens; Culture Media; Diet; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Immunohistochemistry; Lung Neoplasms; Male; Mycelium; Nitrosamines; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Reishi | 2006 |
Hypermethylation of the Dal-1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: 5' Flanking Region; Adenocarcinoma; Animals; DNA Methylation; Lung Neoplasms; Male; Membrane Proteins; Nitrosamines; Rats; Rats, Wistar; RNA, Messenger; Tumor Suppressor Proteins | 2007 |
Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Celecoxib; Cricetinae; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lung; Lung Neoplasms; Mesocricetus; NF-kappa B; Nitrosamines; Pyrazoles; Random Allocation; Sesquiterpenes; Sulfonamides | 2007 |
Numerical changes in the mitochondrial DNA displacement loop in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Adenoma; Animals; DNA, Mitochondrial; Hyperplasia; Lung; Lung Neoplasms; Male; Mutagens; Mutation; Nitrosamines; Rats; Rats, Wistar | 2008 |
Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.
Topics: Animals; Base Sequence; Carcinogens; Exons; Female; Genes, erbB-1; Genes, ras; Lung Neoplasms; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Neoplasms, Radiation-Induced; Nitrosamines; Rats; Urethane; X-Rays | 2008 |
Enhancement of N-bis(2-hydroxypropyl)nitrosamine-initiated lung tumor development in rats by bleomycin and N-methyl-N-nitrosourethane.
Topics: Adenocarcinoma; Animals; Bleomycin; Carcinogens; Drug Synergism; Hyperplasia; Lung; Lung Neoplasms; Male; Nitrosamines; Nitrosomethylurethane; Rats; Rats, Inbred F344; Time Factors; Urethane | 1984 |
Carcinogenicity of 2,2'-dihydroxy-di-n-propylnitrosamine in the tree shrew (Tupaia glis): light and electron microscopic features of pulmonary adenomas.
Topics: Adenoma; Animals; Carcinogens; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Female; Liver Neoplasms; Lung Neoplasms; Male; Microscopy, Electron; Neoplasms, Experimental; Nitrosamines; Skin Neoplasms; Time Factors; Tupaiidae | 1980 |
Effects of chrysotile asbestos on lung and pleural carcinogenesis of N-bis(2-hydroxypropyl)nitrosamine in rats.
Topics: Animals; Asbestos; Asbestos, Serpentine; Carcinogens; Drug Interactions; Lung; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Pleura; Pleural Neoplasms; Rats; Rats, Inbred Strains | 1983 |
Mutagenicity of N-nitrosobis(2-hydroxypropyl)amine and its related compounds in the presence of rat lung and liver S9.
Topics: Aniline Hydroxylase; Animals; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Liver; Lung; Lung Neoplasms; Male; Mutagenicity Tests; Neoplasms, Experimental; Nitrosamines; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains | 1983 |
Dose-related induction of lung, thyroid and kidney tumors by N-bis(2-hydroxypropyl)nitrosamine given orally to F344 rats.
Topics: Administration, Oral; Animals; Carcinogens; Dose-Response Relationship, Drug; Kidney Neoplasms; Lung Neoplasms; Male; Nitrosamines; Rats; Thyroid Neoplasms; Time Factors; Urinary Bladder Neoplasms | 1984 |
Comparison of the carcinogenic effectiveness of N-nitrosobis(2-hydroxypropyl)amine, N-nitrosobis(2-oxopropyl)amine, N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine, and N-nitroso-2,6-dimethylmorpholine in Syrian hamsters.
Topics: Animals; Carcinogens; Cricetinae; Female; Liver Neoplasms; Lung Neoplasms; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Pancreatic Neoplasms; Structure-Activity Relationship | 1984 |
Organotropic effect of N-nitroso-bis-(2-hydroxypropyl)-amine: production of lung adenocarcinoma in rats by a single intraperitoneal injection.
Topics: Adenocarcinoma; Animals; Autoradiography; Carcinogens; Injections, Intraperitoneal; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred Strains | 1982 |
Comparative study of the carcinogenic effect of BHP and BAP on NMRI mice.
Topics: Animals; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrosamines; Propylamines | 1980 |
Carcinogenic effect of N-bis-(2-hydroxypropyl)nitrosamine in newborn rats.
Topics: Animals; Animals, Newborn; Body Weight; Carcinogens; Female; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms; Nitrosamines; Ovarian Neoplasms; Pancreatic Neoplasms; Rats; Thyroid Neoplasms | 1980 |
Frequent mutations of Ki-ras codon 12 in N-bis (2-hydroxypropyl)-nitrosamine-initiated thyroid, kidney and lung tumors in Wistar rats.
Topics: Animals; Base Sequence; Carcinogens; Codon; Deoxyribonucleases, Type II Site-Specific; DNA Primers; Genes, ras; Kidney Neoplasms; Lung Neoplasms; Male; Molecular Sequence Data; Mutagenesis; Mutagens; Nitrosamines; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Rats; Rats, Wistar; Thyroid Neoplasms | 1995 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylhydrazines; Drug Screening Assays, Antitumor; Ellagic Acid; Gastrointestinal Neoplasms; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Multiple Primary; Nitrosamines; Quercetin; Random Allocation; Rats; Rats, Inbred F344 | 1995 |
Frequent mutations of Ki-ras but no mutations of Ha-ras and p53 in lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Animals; Base Sequence; Carcinoma, Squamous Cell; DNA Primers; Genes, p53; Genes, ras; Lung Neoplasms; Male; Molecular Sequence Data; Mutagens; Mutation; Nitrosamines; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins p21(ras); Rats; Rats, Wistar; Tumor Suppressor Protein p53 | 1996 |
Immunohistochemical localization of surfactant protein A in N-bis (2-hydroxypropyl) nitrosamine-induced lung tumors in rats.
Topics: Animals; Carcinogens; Hyperplasia; Immunohistochemistry; Lung; Lung Neoplasms; Male; Nitrosamines; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Rats; Rats, Wistar | 1996 |
[Modifying effects of goitrogens on the tumor development in the liver and lung of rats].
Topics: Animals; Antithyroid Agents; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Nitrosamines; Phenobarbital; Propylthiouracil; Rats; Rats, Inbred F344; Sulfadimethoxine; Thiocyanates | 1996 |
Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model.
Topics: Aminobiphenyl Compounds; Animals; Antimutagenic Agents; Antineoplastic Agents; Antioxidants; Carcinogens; Chlorophyllides; Curcumin; Diethylnitrosamine; Guaiacol; Hydrolyzable Tannins; Lignans; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Paraffin; Phytic Acid; Precancerous Conditions; Rats; Rats, Inbred F344 | 1997 |
Inhibitory effect of green tea extract on the process of pancreatic carcinogenesis induced by N-nitrosobis-(2-oxypropyl)amine (BOP) and on tumor promotion after transplantation of N-nitrosobis-(2-hydroxypropyl)amine (BHP)-induced pancreatic cancer in Syri
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma; Carcinoma in Situ; Cricetinae; Lung Neoplasms; Lymphatic Metastasis; Mesocricetus; Neoplasm Invasiveness; Neoplasm Transplantation; Nitrosamines; Pancreatic Neoplasms; Tea | 1997 |
Overexpression of midkine in lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats and its increase with progression.
Topics: Adenocarcinoma; Animals; Base Sequence; Blotting, Northern; Carcinogens; Carcinoma, Squamous Cell; Carrier Proteins; Cytokines; DNA Primers; Female; Immunohistochemistry; Lung Neoplasms; Male; Midkine; Nitrosamines; Pregnancy; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Expression of vascular endothelial growth factor and its receptors during lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Adenoma; Animals; Blotting, Northern; Carcinogens; Carcinoma, Squamous Cell; Disease Progression; Endothelial Growth Factors; Gene Expression Regulation, Neoplastic; Genes, ras; Hyperplasia; Lung Diseases; Lung Neoplasms; Lymphokines; Male; Neoplasm Proteins; Neovascularization, Pathologic; Nitrosamines; Precancerous Conditions; Proto-Oncogene Proteins; Pulmonary Alveoli; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; RNA, Messenger; RNA, Neoplasm; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors | 1999 |
Inhibitory effects of combined administration of antibiotics and anti-inflammatory drugs on lung tumor development initiated by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Carcinogens; Carcinoma, Adenosquamous; Carcinoma, Squamous Cell; Cocarcinogenesis; Disease Progression; Drug Evaluation, Preclinical; Drug Synergism; Drugs, Chinese Herbal; Erythromycin; Gene Expression Regulation; Inflammation; Lung Neoplasms; Macrophages; Male; Neutrophils; Nitrosamines; Penicillins; Piroxicam; Plant Extracts; Pneumonia, Bacterial; Rats; Rats, Sprague-Dawley; Scutellaria baicalensis; Specific Pathogen-Free Organisms | 2000 |
Increased expression of cyclooxygenase-2 protein in rat lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase 1; Cyclooxygenase 2; Enzyme Induction; Growth Disorders; Isoenzymes; Lung Neoplasms; Male; Membrane Proteins; Mice; Nitrosamines; Precancerous Conditions; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar | 2000 |
Elevated expression of interleukins in lung adenocarcinomas induced by N-Nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Disease Progression; Interleukins; Lung Neoplasms; Male; Nitrosamines; Rats; Rats, Wistar | 2000 |
Mutations of the Smad2 and Smad4 genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Animals; Carcinogens; DNA-Binding Proteins; Lung Neoplasms; Male; Mutation; Nitrosamines; Polymorphism, Single-Stranded Conformational; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Smad2 Protein; Smad4 Protein; Trans-Activators | 2000 |
Mutations and reduced expression of the transforming growth factor-beta receptor II gene in rat lung adenocarcinomas induced by N-nitrosobis-(2-hydroxypropyl)amine.
Topics: Adenocarcinoma; Animals; Carcinogens; Gene Expression; Lung Neoplasms; Male; Mutation; Nitrosamines; Polymorphism, Single-Stranded Conformational; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transforming Growth Factor beta | 2000 |
Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Adenoma; Animals; beta Catenin; Carcinogens; Cytoskeletal Proteins; Disease Progression; DNA Mutational Analysis; Genes, APC; Immunohistochemistry; Lung Neoplasms; Male; Mutagens; Mutation, Missense; Nitrosamines; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Rats; Rats, Wistar; Signal Transduction; Trans-Activators; Transcription Factors | 2000 |
Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Animals; Carcinogens; Lung Neoplasms; Male; Mutation; Nitrosamines; Phosphoric Monoester Hydrolases; Polymorphism, Single-Stranded Conformational; PTEN Phosphohydrolase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Proteins | 2001 |
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenicity Tests; Carcinogens; Disease Susceptibility; Hemangioma; Hemangiosarcoma; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Nitrosamines; Poly(ADP-ribose) Polymerases | 2001 |
Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2'-dihydroxy-di-n-propylnitrosamine in male F344 rats.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Body Weight; Carcinogens; Carcinoma; Catechin; Colonic Neoplasms; Lung Neoplasms; Male; Nitrosamines; Organ Size; Phytotherapy; Rats; Rats, Inbred F344; Tea; Thyroid Neoplasms | 2001 |
[Suppressive efffects of clarithromycin and cyclooxygenase-2 inhibitor, etodolac on N-nitrosobis(2-hydroxypropyl)amine(BHP)- induced experimental lung neoplasm in rats].
Topics: Animals; Anti-Bacterial Agents; Carcinoma, Non-Small-Cell Lung; Chronic Disease; Clarithromycin; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Etodolac; Lung Neoplasms; Male; Nitrosamines; Pneumonia; Rats; Rats, Wistar | 2001 |
Elevated expression of transforming growth factor betas and the tumor necrosis factor family in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Adenocarcinoma; Administration, Oral; Animals; Carcinogens; Disease Models, Animal; Drinking; Lung Neoplasms; Male; Nitrosamines; Rats; Rats, Wistar; RNA, Messenger; RNA, Neoplasm; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2001 |
Lack of promoting effect due to oral administration of dimethylarsinic acid on rat lung carcinogenesis initiated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Arsenicals; Carcinogens; Cell Survival; Deoxyguanosine; Lung; Lung Neoplasms; Male; Mutagens; Nitrosamines; Pulmonary Alveoli; Rats; Rats, Inbred F344 | 2002 |
FHIT alterations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats.
Topics: Acid Anhydride Hydrolases; Adenocarcinoma; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Carcinogens; Exons; Lung Neoplasms; Male; Molecular Sequence Data; Mutagenesis; Mutagens; Neoplasm Proteins; Nitrosamines; Point Mutation; Polymorphism, Single-Stranded Conformational; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2001 |
Organotropic effect of N-bis (2-hydroxypropyl)nitrosamine: production of lung and liver tumors by its oral administration in mice.
Topics: Administration, Oral; Animals; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Nitrosamines | 1978 |
Carcinogenic effect of N-nitrosobis(2-hydroxypropyl)-amine in rabbits.
Topics: Administration, Oral; Animals; Carcinogens; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Propylamines; Rabbits | 1978 |
Lung carcinomas induced by oral administration of N-bis(2-hydroxypropyl)nitrosamine in rats.
Topics: Adenocarcinoma; Adenoma; Administration, Oral; Animals; Body Weight; Carcinoma, Squamous Cell; Kidney; Liver; Lung; Lung Neoplasms; Male; Nitrosamines; Organ Size; Rats | 1976 |
N-nitrosoheptamethyleneimine-induced pulmonary and esophageal carcinogenesis and effects of concomitant treatment with bleomycin in rats.
Topics: Adenoma; Animals; Bleomycin; Carcinoma, Squamous Cell; Drug Antagonism; Esophageal Neoplasms; Hyperplasia; Lung Neoplasms; Male; Nitrosamines; Papilloma; Pulmonary Fibrosis; Rats; Rats, Inbred F344 | 1992 |
Effects of 3-aminobenzamide on induction of multiorgan carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine in hamsters.
Topics: Animals; Benzamides; Body Weight; Carcinogens; Cricetinae; Liver; Liver Neoplasms, Experimental; Lung; Lung Neoplasms; Male; Mesocricetus; Nitrosamines; Organ Size; Pancreas; Pancreatic Neoplasms; Poly(ADP-ribose) Polymerase Inhibitors | 1991 |
[Effect of cigarette smoking and/or N-bis(2-hydroxypropyl)nitrosamine (DHPN) on the development of lung and pleural tumors in rats induced by administration of asbestos].
Topics: Adenocarcinoma; Animals; Asbestosis; Carcinogens; Cocarcinogenesis; Lung Neoplasms; Male; Mesothelioma; Nitrosamines; Pleural Neoplasms; Rats; Rats, Inbred Strains; Smoking | 1991 |
Inhibitory effects of antioxidants on N-bis(2-hydroxypropyl)nitrosamine-induced lung carcinogenesis in rats.
Topics: Adenoma; Animals; Antioxidants; Ascorbic Acid; Body Weight; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinoma; Catechols; Ethoxyquin; Hydroquinones; Kidney Neoplasms; Lung Neoplasms; Male; Nitrosamines; Organ Size; Rats; Rats, Inbred F344; Resorcinols; Thyroid Neoplasms; Urinary Bladder Neoplasms; Vitamin E | 1990 |
Modifying influence of dehydroepiandrosterone on the development of dihydroxy-di-n-propylnitrosamine-initiated lesions in the thyroid, lung and liver of F344 rats.
Topics: Animals; Body Weight; Carcinogens; Dehydroepiandrosterone; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Glutathione Transferase; Kupffer Cells; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Nitrosamines; Precancerous Conditions; Rats; Rats, Inbred F344; Thyroid Neoplasms; Urinary Bladder Neoplasms | 1986 |
Altered enzyme expression in propylnitrosamine-induced Syrian hamster lung lesions.
Topics: Adenocarcinoma; Adenoma; Animals; Autoradiography; Carcinogens; Cricetinae; Cystadenoma; Immunoenzyme Techniques; Lung Diseases; Lung Neoplasms; Mesocricetus; Microscopy, Electron; Nitrosamines | 1987 |
Comparative histochemical investigation of the glutathione S-transferase placental form and gamma-glutamyltranspeptidase during N-nitrosobis(2-hydroxypropyl)amine-induced lung carcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; gamma-Glutamyltransferase; Glutathione Transferase; Hyperplasia; Immunohistochemistry; Lung; Lung Neoplasms; Male; Metaplasia; Nitrosamines; Placenta; Precancerous Conditions; Rats; Rats, Inbred Strains | 1988 |
Sex-dependent, tissue-specific opposing effects of dehydroepiandrosterone on initiation and modulation stages of liver and lung carcinogenesis induced by dihydroxy-di-n-propylnitrosamine in F344 rats.
Topics: Animals; Dehydroepiandrosterone; Female; Glucosephosphate Dehydrogenase; Glutathione Transferase; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Nitrosamines; Organ Specificity; Rats; Rats, Inbred F344; Sex Factors | 1988 |
Tumorigenesis and cystic lesion of the liver by N-bis(2-hydroxypropyl)nitrosamine in ddY mice.
Topics: Adenocarcinoma; Adenoma; Adenoma, Bile Duct; Animals; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Chemical and Drug Induced Liver Injury; Cysts; Hemangioma; Liver Neoplasms; Lung Neoplasms; Male; Mice; Nitrosamines | 1985 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Inbred F344; Thyroid Neoplasms; Urinary Bladder Neoplasms | 1988 |
Carcinogenic potency of N-nitrosomethyl(2-hydroxypropyl)amine and other metabolic relatives of N-nitrosobis(2-hydroxypropyl)amine by single intraperitoneal injection on the lung of rats.
Topics: Animals; Biotransformation; Body Weight; Carcinogens; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Lung Neoplasms; Male; Nitrosamines; Organ Size; Rats; Rats, Inbred Strains | 1988 |
Modulation of N-nitrosobis(2-hydroxypropyl)amine-induced carcinogenesis by clofibrate in hamsters.
Topics: Animals; Bile; Carcinogens; Clofibrate; Cricetinae; Gallbladder Neoplasms; Hydrogen Peroxide; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Pancreatic Neoplasms | 1988 |
Lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine-related compounds and their formation in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Lung Neoplasms; Male; Nitrosamines; Rats; Rats, Inbred Strains | 1987 |
Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Topics: 2-Acetylaminofluorene; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Drug Interactions; Esophageal Neoplasms; Ethinyl Estradiol; Glutathione Transferase; Isoenzymes; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Thyroid Neoplasms; Urinary Bladder Neoplasms | 1987 |