diisononyl-adipate and Cell-Transformation--Neoplastic

Di-isononyl adipate (DINA) is one of a group of adipates used primarily as plasticizers. Concern over the mutagenic and carcinogenic potential of these materials was stimulated by the finding that one member of this class, di-(2-ethylhexyl) adipate (DEHA), induced liver tumors in female mice in a chronic feeding study. Accordingly, the genotoxic potential of DINA was evaluated in a battery of in vitro tests including the Salmonella/mammalian microsome mutagenicity assay, the mouse lymphoma TK +/-assay, and two tests of morphologic transforming ability, the BALB 3T3 and the Syrian hamster embryo in vitro transformation assays. DINA did not exhibit any evidence of mutagenic or transforming potential in any of the assays utilized.

Topics: Adipates; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Cricetinae; In Vitro Techniques; Mesocricetus; Mutagenicity Tests; Mutagens; Plasticizers; Salmonella