dihydroxyphenylalanine has been researched along with Vitiligo in 31 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Vitiligo: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vitiligo is a hypopigmentation disease characterized by melanocyte death in the human epidermis." | 1.72 | Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation. ( Enami, H; Hirobe, T, 2022) |
| "The etiology of vitiligo is still being debated, although neural factors seem to play a pivotal role in its pathogenesis." | 1.31 | Higher plasma catecholamine and metabolite levels in the early phase of nonsegmental vitiligo. ( Cucchi, ML; Frattini, P; Orecchia, G; Santagostino, G, 2000) |
| "Vitiligo is a common pigment disease that is difficult to treat." | 1.28 | Role of hair follicles in the repigmentation of vitiligo. ( Cui, J; Shen, LY; Wang, GC, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (74.19) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Hirobe, T | 2 |
| Enami, H | 2 |
| Chakraborty, C | 2 |
| Chakraborty, AK | 3 |
| Dutta, AK | 1 |
| Chakraborty, DP | 3 |
| Chatterjee, A | 1 |
| Husain, I | 1 |
| Vijayan, E | 1 |
| Ramaiah, A | 1 |
| Pasricha, JS | 1 |
| Madan, NC | 1 |
| Orecchia, G | 2 |
| Frattini, P | 2 |
| Cucchi, ML | 2 |
| Santagostino, G | 2 |
| Arrunátegui, A | 1 |
| Arroyo, C | 1 |
| Garcia, L | 1 |
| Covelli, C | 1 |
| Escobar, C | 1 |
| Carrascal, E | 1 |
| Falabella, R | 1 |
| Roy, S | 1 |
| Schallreuter, KU | 1 |
| Phillips, J | 1 |
| Gawkrodger, DJ | 1 |
| Caddy, CM | 1 |
| Hedley, S | 1 |
| Dawson, RA | 1 |
| Smith-Thomas, L | 1 |
| Freedlander, E | 1 |
| Mac Neil, S | 1 |
| Ortonne, JP | 2 |
| MacDonald, DM | 1 |
| Micoud, A | 1 |
| Thivolet, J | 1 |
| Mishima, Y | 1 |
| Voulot, C | 1 |
| Ito, K | 1 |
| Cui, J | 1 |
| Shen, LY | 1 |
| Wang, GC | 1 |
| Gilhar, A | 1 |
| Pillar, T | 1 |
| Eidelman, S | 1 |
| Etzioni, A | 1 |
| Boissy, RE | 2 |
| Moellmann, G | 1 |
| Trainer, AT | 1 |
| Smyth, JR | 2 |
| Lerner, AB | 1 |
| Iyengar, B | 2 |
| Misra, RS | 1 |
| Gecks, S | 1 |
| Nordlund, JJ | 1 |
| Mendiratta, PC | 1 |
| Woolfson, H | 1 |
| Finn, OA | 1 |
| Goolamali, SK | 1 |
| Riley, PA | 2 |
| Brown, J | 1 |
| Winklemann, RK | 1 |
| Wolff, K | 1 |
| Frenk, E | 1 |
| Kocsis, M | 1 |
| Huriez, C | 1 |
| Brun, R | 1 |
| Gonin, J | 1 |
| Iparraguirre, CE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Catecholamines Level in Urine and Serum in Stable Non-segmental Vitiligo Patients Before and After Excimer Light[NCT04803461] | 21 participants (Anticipated) | Observational | 2021-04-01 | Not yet recruiting | |||
| Fractional Carbon Dioxide Laser Combined With Topical Corticosteroid and Narrow Band Ultraviolet B in Treatment of Stable Vitiligo.[NCT03158675] | 25 participants (Anticipated) | Interventional | 2018-12-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for dihydroxyphenylalanine and Vitiligo
| Article | Year |
|---|---|
Vitiligo, psoralen, and melanogenesis: some observations and understanding.
Topics: Animals; Dihydroxyphenylalanine; Disease Models, Animal; Furocoumarins; Humans; Indoles; Lead; Melan | 1996 |
A review of recent advances on the regulation of pigmentation in the human epidermis.
Topics: Albinism, Oculocutaneous; alpha-MSH; Biopterins; Dihydroxyphenylalanine; Enzyme Activation; Epidermi | 1999 |
2 trials available for dihydroxyphenylalanine and Vitiligo
| Article | Year |
|---|---|
Keratinocytes suppress TRP-1 expression and reduce cell number of co-cultured melanocytes - implications for grafting of patients with vitiligo.
Topics: Adult; Aged; Animals; Cell Division; Cell Transplantation; Coculture Techniques; Dihydroxyphenylalan | 2001 |
[Copper metabolism disorders in vitiligo].
Topics: Albinism; Autoimmune Diseases; Catechol Oxidase; Ceruloplasmin; Clinical Trials as Topic; Copper; Di | 1972 |
27 other studies available for dihydroxyphenylalanine and Vitiligo
| Article | Year |
|---|---|
Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation.
Topics: Dihydroxyphenylalanine; Humans; Hypopigmentation; Melanocytes; Skin; Skin Pigmentation; Skin Transpl | 2022 |
Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation.
Topics: Dihydroxyphenylalanine; Humans; Hypopigmentation; Melanocytes; Skin; Skin Pigmentation; Skin Transpl | 2022 |
Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation.
Topics: Dihydroxyphenylalanine; Humans; Hypopigmentation; Melanocytes; Skin; Skin Pigmentation; Skin Transpl | 2022 |
Reduced Elastin Fibers and Melanocyte Loss in Vitiliginous Skin Are Restored after Repigmentation by Phototherapy and/or Autologous Minigraft Transplantation.
Topics: Dihydroxyphenylalanine; Humans; Hypopigmentation; Melanocytes; Skin; Skin Pigmentation; Skin Transpl | 2022 |
Abnormal tryptophan pyrrolase and amino acids related to melanogenesis in vitiligo.
Topics: Adolescent; Adult; Amino Acids; Dihydroxyphenylalanine; Humans; Melanins; Monophenol Monooxygenase; | 1983 |
Effect of tryptophan on tyrosinase in relation to vitiligo.
Topics: Animals; Bufonidae; Catechol Oxidase; Dihydroxyphenylalanine; Mice; Monophenol Monooxygenase; Trypto | 1980 |
Demonstration of tyrosinase in the vitiligo skin of human beings by a sensitive fluorometric method as well as by 14C(U)-L-tyrosine incorporation into melanin.
Topics: Cadaver; Carbon Radioisotopes; Catechol Oxidase; Culture Techniques; Dihydroxyphenylalanine; Humans; | 1982 |
Normal-range plasma catecholamines in patients with generalized and acrofacial vitiligo: preliminary report.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Aged; Case-Control Studies; Catecholamines; Dihydroxyp | 1994 |
Melanocyte reservoir in vitiligo.
Topics: Adult; Aged; Dihydroxyphenylalanine; Epidermis; Female; Follow-Up Studies; Graft Survival; Hair; Hum | 1994 |
Higher plasma catecholamine and metabolite levels in the early phase of nonsegmental vitiligo.
Topics: Adolescent; Adult; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Homovanill | 2000 |
PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural study.
Topics: Adult; Cell Count; Dihydroxyphenylalanine; Female; Histocytochemistry; Humans; Male; Melanocytes; Me | 1979 |
Histopathology of functional pigmentary disorders.
Topics: Albinism; Animals; Cricetinae; Dihydroxyphenylalanine; Female; Humans; Infant; Melanocytes; Melanosi | 1978 |
The tyrosinases of normal and diseased human skin (naevi, malignant melanoma, vitiligo).
Topics: Adult; Catalase; Catechol Oxidase; Ceruloplasmin; Dihydroxyphenylalanine; Electrophoresis, Polyacryl | 1975 |
[Ultrastructual observations of dendritic cells in the repigmented area of vitiligo: electron microscopic studies on dopa oxidase in melanocytes which are present between the epidermal basal cells in the repigmented area of vitiligo (author's transl)].
Topics: Adult; Aged; Child; Dendrites; Dihydroxyphenylalanine; Female; Humans; In Vitro Techniques; Male; Me | 1975 |
Role of hair follicles in the repigmentation of vitiligo.
Topics: Biopsy; Dihydroxyphenylalanine; Hair; Humans; Melanocytes; Microscopy, Electron, Scanning; Skin; Ski | 1991 |
Vitiligo and idiopathic guttate hypomelanosis. Repigmentation of skin following engraftment onto nude mice.
Topics: Adult; Albinism; Animals; Dihydroxyphenylalanine; Humans; Melanocytes; Mice; Mice, Inbred BALB C; Mi | 1989 |
Delayed-amelanotic (DAM or Smyth) chicken: melanocyte dysfunction in vivo and in vitro.
Topics: Animals; Autoimmune Diseases; Cells, Cultured; Chick Embryo; Chickens; Dihydroxyphenylalanine; Disea | 1986 |
Reaction of dendritic melanocytes in vitiligo to the substrates of tyrosine metabolism.
Topics: Copper; Copper Sulfate; Dendritic Cells; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Mela | 1987 |
Ocular pathology in the minimally depigmented subline of the vitiliginous Smyth chicken.
Topics: Animals; Chickens; Choroid; Dihydroxyphenylalanine; Eye Diseases; Melanocytes; Pigment Epithelium of | 1988 |
Cupric ions and DOPA oxidase activity in melanocytes.
Topics: Catechol Oxidase; Copper; Copper Sulfate; Dihydroxyphenylalanine; Humans; Kinetics; Melanocytes; Mon | 1988 |
Topical levodopa in vitiligo.
Topics: Dihydroxyphenylalanine; Humans; Pigmentation; Time Factors; Vitiligo | 1972 |
Levodopa in vitiligo.
Topics: Adolescent; Adult; Dihydroxyphenylalanine; Female; Humans; Middle Aged; Ultraviolet Therapy; Vitilig | 1973 |
A study of the distribution of epidermal dendritic cells in pigmented and unpigmented skin.
Topics: Adenosine Triphosphatases; Albinism; Animals; Dendrites; Dihydroxyphenylalanine; Guinea Pigs; Histoc | 1967 |
Langerhans cells in vitiligo: a qualitative study.
Topics: Adenosine Triphosphatases; Adult; Aged; Chromatophores; Dihydroxyphenylalanine; Female; Histocytoche | 1967 |
Hydroxyanisole depigmentation: in-vivo studies.
Topics: Adenosine Triphosphatases; Animals; Antioxidants; Ascorbic Acid; Dihydroxyphenylalanine; Guaiacol; G | 1969 |
[Adhesive tape induced depigmentation. An ultrastructural study and comparison with vitiligo and vitiliginous depigmentation associated with melanoma (author's transl)].
Topics: Adhesiveness; Bandages; Basement Membrane; Biopsy; Diagnosis, Differential; Dihydroxyphenylalanine; | 1974 |
Editorial: Leprous leukoderma.
Topics: Animals; Dihydroxyphenylalanine; Humans; Leprosy; Melanins; Mice; Mycobacterium leprae; Vitiligo | 1973 |
[Etiology of vitiligo].
Topics: Animals; Cinnamates; Dihydroxyphenylalanine; Guinea Pigs; In Vitro Techniques; Male; Melanins; Melan | 1972 |
[Letter: Treatment of vitiligo by L Dopa].
Topics: Dihydroxyphenylalanine; Humans; Vitiligo | 1974 |
[Parkinsonism, vitiligo and L-dopa. Contribution to the study of the embryological and functional correlation between nervous system and skin].
Topics: Dihydroxyphenylalanine; Humans; Injections, Intravenous; Male; Middle Aged; Parkinson Disease; Vitil | 1971 |