dihydroxyphenylalanine has been researched along with Supranuclear Palsy, Progressive in 14 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Supranuclear Palsy, Progressive: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "When all three categories of Parkinson's disease, MSA, and SRO were considered together, clinical and 18F-dopa PET findings correlated in 64% of patients assigned a diagnosis of Parkinson's disease and 70% of those given a diagnosis of SRO; MSA was less readily discriminated, patients with MSA being assigned to MSA, Parkinson's disease, and SRO groups with equal frequency." | 1.29 | Differential diagnosis of Parkinson's disease, multiple system atrophy, and Steele-Richardson-Olszewski syndrome: discriminant analysis of striatal 18F-dopa PET data. ( Brooks, DJ; Burn, DJ; Sawle, GV, 1994) |
| "21 patients who had Parkinson's disease (PD), PD plus dementia of Alzheimer type (PDAT) or progressive supranuclear palsy (PSP), were studied with positron emission tomography (PET) using (18F)-2-fluoro-2-deoxy-D-glucose (FDG)." | 1.28 | Positron emission tomography in degenerative disorders of the dopaminergic system. ( Heiss, WD; Herholz, K; Holthoff, V; Huber, M; Karbe, H; Wagner, R; Wienhard, K, 1992) |
| "While the Parkinson's disease patients had a decreased uptake of [18F]fluorodopa in the striatum but no abnormality in the glucose metabolism." | 1.28 | Positron emission tomography (PET) in "pure akinesia". ( Fujii, N; Goto, I; Hasuo, K; Hosokawa, S; Ichiya, Y; Kato, M; Kuwabara, Y; Otsuka, M; Taniwaki, T, 1992) |
| "As a group, the patients with progressive supranuclear palsy had reduced 6-FD uptake constants." | 1.28 | Positron emission tomography in progressive supranuclear palsy. ( Bhatt, MH; Calne, DB; Martin, WR; Peppard, R; Snow, BJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ros, R | 2 |
| Gómez Garre, P | 1 |
| Hirano, M | 1 |
| Tai, YF | 2 |
| Ampuero, I | 1 |
| Vidal, L | 1 |
| Rojo, A | 1 |
| Fontan, A | 1 |
| Vazquez, A | 1 |
| Fanjul, S | 1 |
| Hernandez, J | 1 |
| Cantarero, S | 1 |
| Hoenicka, J | 2 |
| Jones, A | 1 |
| Ahsan, RL | 2 |
| Pavese, N | 2 |
| Piccini, P | 3 |
| Brooks, DJ | 6 |
| Perez-Tur, J | 1 |
| Nyggard, T | 1 |
| de Yébenes, JG | 3 |
| Thobois, S | 1 |
| Streichenberger, N | 1 |
| Kopp, N | 1 |
| Sánchez, MP | 1 |
| Pérez, M | 1 |
| Avila, J | 1 |
| Honnorat, J | 1 |
| Eckert, T | 1 |
| Feigin, A | 1 |
| Lewis, DE | 1 |
| Dhawan, V | 1 |
| Frucht, S | 1 |
| Eidelberg, D | 1 |
| Burn, DJ | 1 |
| Sawle, GV | 3 |
| Cordes, M | 1 |
| Snow, BJ | 2 |
| Morrison, S | 1 |
| Sossi, V | 1 |
| Ruth, TJ | 1 |
| Calne, DB | 2 |
| Otsuka, M | 2 |
| Ichiya, Y | 2 |
| Kuwabara, Y | 2 |
| Sasaki, M | 1 |
| Yoshida, T | 1 |
| Fukumura, T | 1 |
| Masuda, K | 1 |
| de Yebenez, J | 1 |
| Lees, AJ | 3 |
| Ceravolo, R | 1 |
| Turjanski, N | 1 |
| Pramstaller, P | 1 |
| Karbe, H | 1 |
| Holthoff, V | 1 |
| Huber, M | 1 |
| Herholz, K | 1 |
| Wienhard, K | 1 |
| Wagner, R | 1 |
| Heiss, WD | 1 |
| Taniwaki, T | 1 |
| Hosokawa, S | 1 |
| Goto, I | 1 |
| Fujii, N | 1 |
| Hasuo, K | 1 |
| Kato, M | 1 |
| Marsden, CD | 2 |
| Frackowiak, RS | 3 |
| Bhatt, MH | 1 |
| Martin, WR | 1 |
| Peppard, R | 1 |
| Ibanez, V | 1 |
| Quinn, N | 1 |
| Mathias, CJ | 1 |
| Bannister, R | 1 |
| Leenders, KL | 1 |
14 other studies available for dihydroxyphenylalanine and Supranuclear Palsy, Progressive
| Article | Year |
|---|---|
Genetic linkage of autosomal dominant progressive supranuclear palsy to 1q31.1.
Topics: Aged; Brain Chemistry; Caudate Nucleus; Chromosomes, Human, Pair 1; Dihydroxyphenylalanine; DNA; Fem | 2005 |
A new mutation of the tau gene, G303V, in early-onset familial progressive supranuclear palsy.
Topics: Amino Acid Substitution; Blotting, Northern; Blotting, Western; Brain; Dihydroxyphenylalanine; DNA M | 2005 |
Characterization of dopaminergic dysfunction in familial progressive supranuclear palsy: an 18F-dopa PET study.
Topics: Aged; Amygdala; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Disease Progression; Dopam | 2007 |
Regional metabolic changes in parkinsonian patients with normal dopaminergic imaging.
Topics: Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Ganglia; Humans; Male; Middle Aged | 2007 |
Differential diagnosis of Parkinson's disease, multiple system atrophy, and Steele-Richardson-Olszewski syndrome: discriminant analysis of striatal 18F-dopa PET data.
Topics: Adult; Aged; Analysis of Variance; Caudate Nucleus; Corpus Striatum; Diagnosis, Differential; Dihydr | 1994 |
Parametric imaging of the rate constant Ki using [18Fluoro]-L-dopa positron emission tomography in progressive supranuclear palsy.
Topics: Aged; Brain Mapping; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Radioisotop | 1993 |
Nigrofrontal dopaminergic function as assessed by 18F-dopa PET.
Topics: Adult; Aged; Cerebellum; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Radiois | 1995 |
Familial progressive supranuclear palsy: detection of subclinical cases using 18F-dopa and 18fluorodeoxyglucose positron emission tomography.
Topics: Adult; Aged; Caudate Nucleus; Dihydroxyphenylalanine; Dopamine Agents; Female; Fluorine Radioisotope | 2001 |
Positron emission tomography in degenerative disorders of the dopaminergic system.
Topics: Adult; Aged; Alzheimer Disease; Basal Ganglia; Brain; Brain Stem; Deoxyglucose; Dihydroxyphenylalani | 1992 |
Positron emission tomography (PET) in "pure akinesia".
Topics: Adult; Aged; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Female; Glucose; Humans; Magnetic Re | 1992 |
Corticobasal degeneration. A unique pattern of regional cortical oxygen hypometabolism and striatal fluorodopa uptake demonstrated by positron emission tomography.
Topics: Aged; Animals; Apraxias; Brain Diseases; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; E | 1991 |
Positron emission tomography in progressive supranuclear palsy.
Topics: Aged; Dihydroxyphenylalanine; Dopamine; Humans; Male; Middle Aged; Substantia Nigra; Supranuclear Pa | 1991 |
Differing patterns of striatal 18F-dopa uptake in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Topics: Adult; Aged; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; Female; Fluorine Radioisotope | 1990 |
Steele-Richardson-Olszewski syndrome. Brain energy metabolism, blood flow and fluorodopa uptake measured by positron emission tomography.
Topics: Adult; Brain; Cerebrovascular Circulation; Dihydroxyphenylalanine; Energy Metabolism; Fluorine Radio | 1988 |