dihydroxyphenylalanine has been researched along with Seizures in 52 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the effect of striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice on kainic acid (KA) evoked seizures." | 7.69 | Motor expression of kainic acid seizures is attenuated by dopamine depletion in mice. ( Bonuccelli, U; Fariello, R; Garant, DS; Maggio, R, 1994) |
| "We studied the effect of striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice on kainic acid (KA) evoked seizures." | 3.69 | Motor expression of kainic acid seizures is attenuated by dopamine depletion in mice. ( Bonuccelli, U; Fariello, R; Garant, DS; Maggio, R, 1994) |
| "This result indicates that while the seizure-suppressant effect of intranigral GVG requires alpha 2-mediated NE neurotransmission, the mechanism of this anticonvulsant action is not by increasing NE neuronal activity." | 1.27 | Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission. ( Bonhaus, DW; McNamara, JO, 1988) |
| "Reserpine enhanced the incidence of seizures, and the effect was reversed by 5-hydroxytryptophan but not by dihydroxyphenylalanine." | 1.25 | Effects of aminergic drugs and glutamic acid on audiogenic seizures induced by early exposure to ethanol. ( Ginsburg, BE; Sze, PY; Yanai, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 51 (98.08) | 18.7374 |
| 1990's | 1 (1.92) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LESSIN, AW | 1 |
| PARKES, MW | 1 |
| TRUITT, EB | 1 |
| EBERSBERGER, EM | 1 |
| HEROLD, M | 1 |
| CAHN, J | 1 |
| HELBECQUE, C | 1 |
| KABACOFF, O | 1 |
| KURIHARA, M | 1 |
| NAGAI, K | 2 |
| Wilimowski, M | 2 |
| Orzechowska-Juzwenko, K | 2 |
| Barczyńska, J | 2 |
| Kedzierska-Goździk, L | 1 |
| Witkowska, M | 2 |
| Wojewódzki, W | 2 |
| Duś, E | 1 |
| Pławiak, T | 1 |
| Gryska, J | 1 |
| Maśka, H | 1 |
| Persson, SA | 1 |
| Wahlström, G | 1 |
| Yoshimura, Y | 1 |
| Bonuccelli, U | 1 |
| Garant, DS | 1 |
| Maggio, R | 1 |
| Fariello, R | 1 |
| Ngai, SH | 1 |
| Levy, A | 1 |
| Finck, AD | 1 |
| Yang, JC | 1 |
| Spector, S | 1 |
| Yanai, J | 1 |
| Sze, PY | 1 |
| Ginsburg, BE | 1 |
| Plotnikoff, NP | 7 |
| Kastin, AJ | 4 |
| Coy, DH | 1 |
| Christensen, CW | 1 |
| Schally, AV | 2 |
| Spirtes, MA | 1 |
| Calderini, G | 1 |
| Carlsson, A | 1 |
| Nordström, CH | 1 |
| Razdan, RK | 2 |
| Terris, BZ | 1 |
| Pars, HG | 1 |
| Dodge, PW | 2 |
| Dren, AT | 2 |
| Kyncl, J | 1 |
| Somani, P | 1 |
| Arushanian, EB | 1 |
| Gerald, MC | 1 |
| Gupta, TK | 2 |
| Handrick, GR | 1 |
| Dalzell, HC | 1 |
| Howes, JF | 1 |
| Winn, M | 1 |
| Kellogg, C | 1 |
| White, WF | 1 |
| Kedzierska, L | 1 |
| Felsztyńska, J | 1 |
| Rogers, ME | 1 |
| Sam, J | 1 |
| Nagarajan, K | 1 |
| David, J | 1 |
| Shah, RK | 1 |
| Lee, CM | 1 |
| Bonhaus, DW | 1 |
| McNamara, JO | 1 |
| Litterst, CL | 1 |
| Mimnaugh, EG | 1 |
| Edelman, S | 1 |
| Peters, E | 1 |
| Miller, E | 1 |
| Van Loon, EJ | 1 |
| Meldrum, BS | 1 |
| Balzamo, E | 1 |
| Wada, JA | 3 |
| Vuillon-Cacciuttolo, G | 1 |
| Bennett, JM | 1 |
| Terao, A | 1 |
| Scholtmeyer, H | 1 |
| Trapp, WG | 1 |
| Kamat, UG | 1 |
| Sheth, UK | 1 |
| McKenzie, GM | 1 |
| Soroko, FE | 1 |
| Birkmayer, W | 1 |
| Neumayer, E | 1 |
| Prakh'e, IB | 1 |
| Jobe, PC | 1 |
| Stull, RE | 1 |
| Geiger, PF | 1 |
| McLean, JR | 1 |
| Ensor, CR | 1 |
| McCarthy, DA | 1 |
| Bohner, B | 1 |
| Potoczak, D | 1 |
| Wada, J | 1 |
| Ikeda, H | 2 |
| Boggan, WO | 1 |
| Seiden, LS | 1 |
| Ferrini, R | 1 |
| Glässer, A | 1 |
| Weissman, A | 1 |
| Koe, BK | 1 |
| McGeer, EG | 1 |
| Yamamoto, I | 2 |
| Inoki, R | 2 |
| Tamari, Y | 1 |
| Iwatsubo, K | 1 |
| Kohli, RP | 1 |
| Parmar, SS | 1 |
| Arora, RC | 1 |
| De Ropp, RS | 2 |
| Kastl, L | 2 |
| Furst, A | 2 |
| Wood, CD | 1 |
| Perkins, GF | 1 |
| McPherson, A | 2 |
| Gray, WD | 1 |
| Rauh, CE | 1 |
| Cuparencu, B | 1 |
| Safta, L | 1 |
| Cojocaru, Z | 1 |
| Pitea, M | 1 |
| Barzu, T | 1 |
| Ghiran, D | 1 |
| Ticsla, I | 1 |
| Rudzik, AD | 1 |
| Mennear, JH | 1 |
2 reviews available for dihydroxyphenylalanine and Seizures
| Article | Year |
|---|---|
[Central monoaminergic mechanisms and generalized convulsions (review)].
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Biogenic Amines; Brain; Cerebral Cortex; | 1976 |
Phenomenological and pharmacological identity of audiogenic-sensitive state in animals treated with methionine sulfoximine and in genetically audiogenic-seizure-susceptible animals.
Topics: Animals; Atropine; Cats; Dihydroxyphenylalanine; Electroencephalography; Escape Reaction; Female; Ip | 1966 |
50 other studies available for dihydroxyphenylalanine and Seizures
| Article | Year |
|---|---|
The effects of reserpine and other agents upon leptazol convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Dihydroxyphenylalanine; Iproniazid; Mice; Pentylenetetrazole; R | 1959 |
Decarboxylase inhibitors affect convulsion thresholds to hexafluorodiethyl ether.
Topics: Amines; Animals; Brain; Carboxy-Lyases; Dihydroxyphenylalanine; Ether; Lyases; Mental Disorders; Mic | 1962 |
[Action of some DOPA decarboxylase inhibitors with reference to different types of convulsions].
Topics: Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Dopa Decarboxylase; Humans; Hy | 1962 |
[SOME PHARMACOLOGICAL EXPERIMENTS ON ANTIDEPRESSANTS--IN REFERENCE TO CEREBRAL MONOAMINES].
Topics: 5-Hydroxytryptophan; Antidepressive Agents; Bemegride; Dihydroxyphenylalanine; Eyelids; Fever; Imipr | 1963 |
[STUDIES ON NICOTINE. CHANGES IN CATECHLOAMINES IN RATS WITH NICOTINE-INDUCED CONVULSIONS].
Topics: Adrenal Glands; Adrenalectomy; Brain; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Epinephr | 1963 |
Pharmacological properties of new heterocyclic derivatives of 1,5-benzodiazepine.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Dihydroxyphenylalanine; Drug Interactions; Female; He | 1983 |
Studies on interactions between striatal dopaminergic and cholinergic mechanisms in the early abstinence after chronic treatment with barbital in the rat.
Topics: Acetylcholine; Animals; Barbital; Barbiturates; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; H | 1984 |
[Mechanisms of local anesthetic-induced convulsions. The relation to brain catecholamines].
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; Dihydroxypheny | 1984 |
Motor expression of kainic acid seizures is attenuated by dopamine depletion in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Dihydroxyphenylalanine; Dopa | 1994 |
Central nervous system toxicity of hyperbaric oxygen--effects of light, norepinephrine depletion and beta-adrenergic blockade.
Topics: Adrenergic beta-Antagonists; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Blindnes | 1977 |
Effects of aminergic drugs and glutamic acid on audiogenic seizures induced by early exposure to ethanol.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug I | 1975 |
Neuropharmacological actions of enkephalin after systemic administration.
Topics: Aggression; Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug Synergism; Humans; Mice; Nerve T | 1976 |
Monoamine metabolism during bicuculline-induced epileptic seizures in the rat.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Bicuculline; Brain; Catecholamines; Cerebellum; Corpus St | 1978 |
Neuropharmacological review of hypothalamic releasing factors.
Topics: Animals; Apomorphine; Behavior, Animal; Central Nervous System; Dihydroxyphenylalanine; Electroencep | 1977 |
Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs.
Topics: Acoustic Stimulation; Aggression; Analgesics; Animals; Ataxia; Behavior, Animal; Cannabis; Cats; Dih | 1976 |
Catecholaminergic involvement in the effects of amphetamine isomers on seizure susceptibility.
Topics: Amphetamine; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Catecholamines; D | 1977 |
Neuropharmacological tests with alpha-melanocyte stimulating hormone.
Topics: Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug Synergism; Electroshock; Male; Melanocyte-St | 1976 |
Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs.
Topics: Acoustic Stimulation; Aggression; Analgesics; Animals; Ataxia; Cannabis; Cats; Cyclohexanes; Cyclope | 1976 |
Audiogenic seizures: relation to age and mechanisms of monoamine neurotransmission.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Aging; Animals; Benserazide; Brain; Catecholamines; Dihyd | 1976 |
Gonadotropin releasing hormone (GnRH): neuropharmacological studies.
Topics: Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug Synergism; Gonadotropin-Releasing Hormone; M | 1975 |
Central action of 2-amino- and 2-amino-5-aryltetrahydropyrimidinediones-4,6.
Topics: Amphetamine; Analgesia; Animals; Central Nervous System; Dihydroxyphenylalanine; Drug Synergism; Fem | 1975 |
3-Arylquinolizidines, potential antidepressant agents.
Topics: Acoustic Stimulation; Animals; Antidepressive Agents; Dihydroxyphenylalanine; Lethal Dose 50; Mice; | 1975 |
Central nervous system active 5-oxo-1,4,5,6,7,8-hexahydrocinnolines.
Topics: Animals; Body Temperature; Central Nervous System; Depression, Chemical; Dihydroxyphenylalanine; Ele | 1976 |
Antidepressant and anticonvulsant activity of 1-(5-phenyl-4-oxazolin-2-yl)-4-substituted piperazines.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Dihydroxyph | 1976 |
Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission.
Topics: Aminocaproates; Animals; Anticonvulsants; Dihydroxyphenylalanine; Dioxanes; Dioxins; Idazoxan; Musci | 1988 |
Distribution and biochemical effects of pentylenetetrazol in brains of swine treated with a polychlorinated biphenyl.
Topics: Aminobutyrates; Animals; Body Weight; Brain; Caudate Nucleus; Cerebellum; Chromatography, Gas; Dihyd | 1974 |
Effects of L-tryptophan, L-3, 4, dihydroxyphenylalanine and tranylcypromine on the electroencephalogram and on photically induced epilepsy in the baboon, Papio papio.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Dihydroxyphenylalanine; Dose-Response R | 1972 |
Relation of dopa and 5-HTP to convulsions induced by strychnine and leptazol.
Topics: 5-Hydroxytryptophan; Animals; Anura; Dihydroxyphenylalanine; Injections, Subcutaneous; Muscle Contra | 1970 |
Susceptibility to audiogenic stimuli induced by hyperbaric oxygenation and various neuroactive agents.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Brain; Dihydroxyphenylalanine; Fenclonine; Hyperbaric Oxygen | 1971 |
The role of central monoamines in decapitation convulsions of mice.
Topics: Amines; Amphetamine; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Fenclonine; Guanethidine; Mal | 1971 |
The effects of apomorphine, (+)-amphetamine and L-dopa on maximal electroshock convulsions--a comparative study in the rat and mouse.
Topics: Amphetamine; Animals; Apomorphine; Dextroamphetamine; Dihydroxyphenylalanine; Electroshock; Lethal D | 1972 |
[L-tryptophan therapy of DOPA psychoses].
Topics: Aged; Athetosis; Cardiovascular Diseases; Chorea; Constipation; Dihydroxyphenylalanine; Feeding and | 1972 |
[Effect of agents, changing the monoamine level, on audiogenic epileptic seizures in rats].
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Brain; Depression, Chemical; Di | 1973 |
The relative significance of norepinephrine, dopamine and 5-hydroxytryptamine in electroshock seizure in the rat.
Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Electr | 1974 |
Effects of L-dopa and L-3-methoxytyrosine on D-methamphetamine-induced motor activity and seizures induced by electroshock.
Topics: Animals; Brain; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Electroshock; Male; Methamphetami | 1973 |
Dopa reversal of reserpine enhancement of audiogenic seizure susceptibility in mice.
Topics: Animals; Behavior, Animal; Benzyl Compounds; Brain Chemistry; Dihydroxyphenylalanine; Dopa Decarboxy | 1971 |
Antagonism of central effects of tryptamine and 5-hydroxytryptophan by 1,6-dimethyl-8beta-carbobenzyloxy-aminomethyl-10alpha-ergoline. Interference with amphetamine and DOPA.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Central Nervous System; Dihydroxyphenylalanine; Fever; Mi | 1965 |
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxid | 1967 |
The susceptibility to audiogenic stimuli of rats treated with methionine sulfoximine and various psychoactive agents.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug Antagonism; Drug Synerg | 1967 |
The contents of DOPA and catecholamines in several rat tissues and nicotine-induced convulsions.
Topics: Adrenal Glands; Animals; Brain Chemistry; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Epin | 1966 |
Effect of reserpine on brain levels of 14C-nicotine in relation to nicotine-induced convulsions.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Carbon Isotopes; Chlorpromazine; Dihydroxyphen | 1967 |
Anticonvulsant properties of some newer monoamine oxidase inhibitors.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Drug Synergism; Fem | 1967 |
Biochemical and behavioral effects of some substituted catechols.
Topics: Aldehydes; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Brain; Carbon Is | 1969 |
Factors influencing hypertension and pulmonary edema produced by hyperbaric O2.
Topics: Animals; Capillaries; Carbon Dioxide; Dextroamphetamine; Dihydroxyphenylalanine; Hyperbaric Oxygenat | 1970 |
Convulsive seizures and electroencephalogram changes in three patients during levodopa therapy.
Topics: Aged; Dihydroxyphenylalanine; Electroencephalography; Female; Humans; Male; Middle Aged; Parkinson D | 1970 |
Convulsive seizures and electroencephalogram changes in three patients during levodopa therapy.
Topics: Aged; Brain; Dihydroxyphenylalanine; Electroencephalography; Female; Humans; Male; Middle Aged; Neur | 1970 |
The anticonvulsant action of carbon dioxide: interaction with reserpine and inhibitors of carbonic anhydrase.
Topics: Acid-Base Equilibrium; Animals; Anticonvulsants; Azoles; Bicarbonates; Buffers; Carbon Dioxide; Carb | 1968 |
[Pharmacologic study of certain sulfhydrazide and diacylhydrazine derivatives].
Topics: Animals; Barbiturates; Dihydroxyphenylalanine; Drug Antagonism; Drug Synergism; Hexobarbital; Hydraz | 1968 |
Substituted catechols as convulsant and relaxant agents.
Topics: Animals; Benzoates; Cinnamates; Cornea; Dihydroxyphenylalanine; Drug Antagonism; Male; Mice; Motor A | 1969 |
The mechanism of action of anticonvulsants. II. Acetazolamide.
Topics: Acetazolamide; Animals; Dextroamphetamine; Dihydroxyphenylalanine; Electric Stimulation; Electroshoc | 1966 |