dihydroxyphenylalanine has been researched along with Psychotic Disorders in 41 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The probenecid technique was used in study of the central dopamine DA metabolism in patients with depressions, psychotic disorders, and Parkinson's disease." | 3.65 | Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders. ( Korf, J; Praag, HM; Schut, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (56.10) | 18.7374 |
| 1990's | 1 (2.44) | 18.2507 |
| 2000's | 1 (2.44) | 29.6817 |
| 2010's | 12 (29.27) | 24.3611 |
| 2020's | 4 (9.76) | 2.80 |
| Authors | Studies |
|---|---|
| Sabaroedin, K | 1 |
| Razi, A | 1 |
| Chopra, S | 1 |
| Tran, N | 1 |
| Pozaruk, A | 1 |
| Chen, Z | 1 |
| Finlay, A | 1 |
| Nelson, B | 1 |
| Allott, K | 1 |
| Alvarez-Jimenez, M | 1 |
| Graham, J | 1 |
| Yuen, HP | 1 |
| Harrigan, S | 1 |
| Cropley, V | 1 |
| Sharma, S | 1 |
| Saluja, B | 1 |
| Williams, R | 1 |
| Pantelis, C | 1 |
| Wood, SJ | 1 |
| O'Donoghue, B | 1 |
| Francey, S | 1 |
| McGorry, P | 1 |
| Aquino, K | 1 |
| Fornito, A | 1 |
| D'Ambrosio, E | 2 |
| Jauhar, S | 8 |
| Kim, S | 1 |
| Veronese, M | 8 |
| Rogdaki, M | 6 |
| Pepper, F | 2 |
| Bonoldi, I | 4 |
| Kotoula, V | 1 |
| Kempton, MJ | 1 |
| Turkheimer, F | 7 |
| Kwon, JS | 1 |
| Kim, E | 1 |
| Howes, OD | 13 |
| Santangelo, B | 1 |
| Demjaha, A | 1 |
| Salimbeni, H | 1 |
| Huajie, J | 1 |
| McCrone, P | 1 |
| Howes, O | 3 |
| Devroye, C | 1 |
| Ciampoli, M | 1 |
| Ashok, AH | 1 |
| McCutcheon, RA | 1 |
| Gudbrandsen, M | 1 |
| Daly, E | 1 |
| van Amelsvoort, T | 1 |
| Van Den Bree, M | 1 |
| Owen, MJ | 1 |
| Papaleo, F | 1 |
| Nour, MM | 3 |
| Azis, M | 1 |
| McGuire, P | 10 |
| Young, AH | 1 |
| Hathway, P | 2 |
| Turkheimer, FE | 1 |
| Stone, J | 3 |
| Egerton, A | 8 |
| Kapur, S | 2 |
| Dahoun, T | 1 |
| Pardiñas, AF | 1 |
| Bloomfield, MAP | 2 |
| Froudist-Walsh, S | 1 |
| Nosarti, C | 1 |
| Korth, C | 1 |
| Hennah, W | 1 |
| Walters, J | 1 |
| Prata, D | 1 |
| Natesan, S | 1 |
| McCutcheon, R | 1 |
| Borgan, F | 1 |
| Nour, M | 1 |
| Valmaggia, LR | 1 |
| Day, F | 1 |
| Chaddock, CA | 3 |
| Allen, P | 7 |
| Winton-Brown, TT | 2 |
| Bhattacharyya, S | 2 |
| Chilcott, J | 1 |
| Lappin, JM | 1 |
| Murray, RM | 1 |
| Fusar-Poli, P | 3 |
| Valli, I | 4 |
| Broome, M | 3 |
| Grasby, P | 1 |
| Asselin, MC | 1 |
| Grasby, PM | 1 |
| McGuire, PK | 2 |
| Stone, JM | 1 |
| Kambeitz, J | 2 |
| Lythgoe, DJ | 1 |
| O'Gorman, RL | 1 |
| McLean, MA | 1 |
| Barker, GJ | 1 |
| Bose, S | 1 |
| Stahl, D | 1 |
| Valmaggia, L | 1 |
| Murray, R | 1 |
| Luigjes, J | 1 |
| Hirao, K | 1 |
| Roiser, JP | 1 |
| Joyce, EM | 1 |
| Bloomfield, MA | 1 |
| VANDER WENDE, C | 1 |
| SPOERLEIN, MT | 1 |
| SCHULTE, W | 1 |
| TURNER, WJ | 1 |
| MERLIS, S | 2 |
| Danielczyk, W | 1 |
| Reith, J | 1 |
| Benkelfat, C | 1 |
| Sherwin, A | 1 |
| Yasuhara, Y | 1 |
| Kuwabara, H | 1 |
| Andermann, F | 1 |
| Bachneff, S | 1 |
| Cumming, P | 1 |
| Diksic, M | 1 |
| Dyve, SE | 1 |
| Etienne, P | 1 |
| Evans, AC | 1 |
| Lal, S | 1 |
| Shevell, M | 1 |
| Savard, G | 1 |
| Wong, DF | 1 |
| Chouinard, G | 1 |
| Gjedde, A | 1 |
| Mato, M | 1 |
| Uchiyama, Y | 1 |
| Kurihara, K | 1 |
| Karasawa, T | 1 |
| Tissot, R | 1 |
| Campbell, KM | 1 |
| Wade, D | 1 |
| Ross, LW | 1 |
| Meyer, GG | 1 |
| Praag, HM | 1 |
| Korf, J | 1 |
| Schut, T | 1 |
| Hegedus, ZL | 1 |
| Altschule, MD | 1 |
| Kanig, K | 1 |
| Oesterle, W | 1 |
| Angrist, B | 1 |
| Gershon, S | 1 |
| Israelstam, DM | 1 |
| Yaryura-Tobias, JA | 1 |
| Diamond, B | 1 |
| Goodwin, FK | 1 |
| Sack, RL | 1 |
| Mathieu, P | 1 |
| Charvet, JC | 1 |
| Chazot, G | 1 |
| Trouillas, P | 1 |
| Celesia, GG | 1 |
| Wanamaker, WM | 1 |
| Proctor, P | 1 |
| Vaisrub, S | 1 |
| Randrup, A | 1 |
| Munkvad, I | 1 |
| Lipman, IJ | 1 |
| Knopp, W | 1 |
| Paulson, G | 1 |
| Allen, JN | 1 |
| Smeltzer, D | 1 |
| Brown, FD | 1 |
| Kose, W | 1 |
| Rajput, AH | 1 |
| Chornell, G | 1 |
| Rozdilsky, B | 1 |
| Ferraris, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis[NCT05282277] | Phase 4 | 103 participants (Anticipated) | Interventional | 2022-04-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for dihydroxyphenylalanine and Psychotic Disorders
| Article | Year |
|---|---|
The common pathophysiology of monaminergic psychoses: a new hypothesis.
Topics: 5-Hydroxytryptophan; Amino Acids; Biological Transport, Active; Bipolar Disorder; Blood-Brain Barrie | 1975 |
[Biochemical treatment possibilities in psychoses].
Topics: Amino Acids; Ascorbic Acid; Dihydroxyphenylalanine; Humans; Methionine; Niacinamide; Nicotinic Acids | 1969 |
Dopamine and psychotic states: preliminary remarks.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Carbon Radioisotopes; Cats; Cocaine; Dihydroxyp | 1974 |
Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover.
Topics: Adult; Affective Symptoms; Anger; Bipolar Disorder; Central Nervous System; Depression; Diagnosis, D | 1974 |
Pharmacological studies on the brain mechanisms underlying two forms of behavioral excitation: stereotyped hyperactivity and "rage".
Topics: Aggression; Amphetamine; Anger; Animals; Basal Ganglia; Behavior, Animal; Brain; Brain Chemistry; Di | 1969 |
L-dopa therapy in Parkinson's disease.
Topics: Delirium; Depression; Dihydroxyphenylalanine; Gastrointestinal Hemorrhage; Hallucinations; Humans; H | 1971 |
2 trials available for dihydroxyphenylalanine and Psychotic Disorders
| Article | Year |
|---|---|
Psychiatric manifestations of levodopa.
Topics: Adult; Affect; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; Evaluation Studies as T | 1972 |
Parkinson's disease: L-dopa treatment and handwriting area.
Topics: Adult; Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Handwriting; Humans; Middle Aged; Mot | 1970 |
33 other studies available for dihydroxyphenylalanine and Psychotic Disorders
| Article | Year |
|---|---|
Frontostriatothalamic effective connectivity and dopaminergic function in the psychosis continuum.
Topics: Dihydroxyphenylalanine; Dopamine; Humans; Magnetic Resonance Imaging; Neural Pathways; Psychotic Dis | 2023 |
The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal
Topics: Dihydroxyphenylalanine; Dopamine; Gray Matter; Humans; Magnetic Resonance Imaging; Positron-Emission | 2021 |
A potential biomarker for treatment stratification in psychosis: evaluation of an [
Topics: Biomarkers; Dihydroxyphenylalanine; Humans; Positron-Emission Tomography; Psychotic Disorders; Radio | 2021 |
Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study.
Topics: DiGeorge Syndrome; Dihydroxyphenylalanine; DNA Copy Number Variations; Dopamine; Humans; Positron-Em | 2023 |
A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Cross-Sectional Studies; Dihydroxyphenylalanine; Dopa | 2017 |
Determinants of treatment response in first-episode psychosis: an
Topics: Adult; Antipsychotic Agents; Case-Control Studies; Cohort Studies; Corpus Striatum; Dihydroxyphenyla | 2019 |
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.
Topics: Adult; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Genetic Predisposition to Disease; | 2018 |
The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.
Topics: Adult; Antipsychotic Agents; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male | 2019 |
The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study.
Topics: Adult; Corpus Striatum; Cross-Sectional Studies; Dihydroxyphenylalanine; Dopamine; Female; Glutamic | 2018 |
Adversity in childhood linked to elevated striatal dopamine function in adulthood.
Topics: Adult Survivors of Child Abuse; Brain Mapping; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Do | 2016 |
Multimodal functional imaging investigation before and after the onset of psychosis.
Topics: Brain; Diagnostic Imaging; Dihydroxyphenylalanine; Humans; Magnetic Resonance Imaging; Male; Positro | 2009 |
Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study.
Topics: Adult; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Frontal Lobe; Functional Laterality; Human | 2010 |
Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis.
Topics: Brain Mapping; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Glutamic Acid; Hippocampus; Humans | 2010 |
Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study.
Topics: Adult; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Radioisotopes; Functional | 2011 |
Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals.
Topics: Adult; Brain; Brain Mapping; Case-Control Studies; Dihydroxyphenylalanine; Disease Progression; Fema | 2012 |
Neural and behavioral correlates of aberrant salience in individuals at risk for psychosis.
Topics: Adult; Basal Ganglia; Cerebrum; Delusions; Dihydroxyphenylalanine; Dopamine; Female; Functional Neur | 2013 |
Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort.
Topics: Adult; Basal Ganglia; Cohort Studies; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Hum | 2013 |
Psychotic symptoms induced in mice by the intravenous administration of solutions of 3,4-dihydroxyphenylalanine (DOPA).
Topics: Administration, Intravenous; Animals; Dihydroxyphenylalanine; Mice; Psychopharmacology; Psychotic Di | 1962 |
[PSYCHIATRIC UNIVERSITY CLINIC AND PSYCHIATRIC STATE HOSPITAL].
Topics: Aging; Brain Diseases; Dihydroxyphenylalanine; Germany; Germany, West; Hospitals, Psychiatric; Hospi | 1964 |
A CLINICAL TRIAL OF PARGYLINE AND DOPA IN PSYCHOTIC SUBJECTS.
Topics: Adolescent; Biomedical Research; Brain; Brain Damage, Chronic; Depression; Depressive Disorder, Majo | 1964 |
[3 crises in Parkinson disease].
Topics: Aged; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Parkinson Disease; Psychotic Disord | 1982 |
Elevated dopa decarboxylase activity in living brain of patients with psychosis.
Topics: Adult; Animals; Brain; Dihydroxyphenylalanine; Dopa Decarboxylase; Epilepsy, Complex Partial; Female | 1994 |
Fluorescent substance in leukocytes and platelets of psychiatric patients.
Topics: Bipolar Disorder; Blood Platelets; Depression; Dihydroxyphenylalanine; Dopamine; Histocytochemistry; | 1977 |
Pigmentation and musculoskeletal abnormalities in an aged state hospital population.
Topics: Adult; Aged; Bone Diseases; Dihydroxyphenylalanine; Female; Humans; Male; Melanins; Melatonin; Menta | 1977 |
Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders.
Topics: Adjustment Disorders; Bipolar Disorder; Brain; Carboxy-Lyases; Depression; Dihydroxyphenylalanine; D | 1975 |
Studies on rheomelanins. I. The formation of rheomelanins in human blood plasma from catecholamines, from L-dopa and from some of their derivatives.
Topics: Chromatography, Paper; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Melanins; Methyldopa; | 1970 |
From medical physicist to psychopharmacologist: a neo-renaissance interdisciplinary evolution of.
Topics: Dihydroxyphenylalanine; Disulfiram; Electroconvulsive Therapy; Enzyme Induction; History, 20th Centu | 1972 |
[4-O-Methylated catecholamines: 3-hydroxy, 4-methoxyphenylacetic acid (homo-isovanillic acid, iso-HVA) in biological media: urine, cerebrospinal fluid, and brain tissue].
Topics: Animals; Azo Compounds; Brain Chemistry; Caudate Nucleus; Cerebral Cortex; Chromatography, Paper; Di | 1972 |
Psychiatric disturbances in Parkinson's disease.
Topics: Adult; Aged; Barbiturates; Cognition Disorders; Depression; Dihydroxyphenylalanine; Female; Follow-U | 1972 |
Electron-transfer factors in psychosis and dyskinesia.
Topics: Blood Proteins; Bromides; Dihydroxyphenylalanine; Electron Transport; Epinephrine; Humans; Iron; Lip | 1972 |
Dementia dialytica.
Topics: Autopsy; Brain; Brain Chemistry; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Electroenceph | 1973 |
Progressive external ophthalmoplegia with Parkinsonism and Dementia. Treatment with L-dopa. Report of an autopsied case.
Topics: Brain; Dihydroxyphenylalanine; Follow-Up Studies; Humans; Male; Middle Aged; Ophthalmoplegia; Parkin | 1972 |
[Psychological status of patients with Parkinsonism during treatment with amantadine hydrochloride and L-Dopa].
Topics: Affective Symptoms; Amantadine; Dihydroxyphenylalanine; Humans; Parkinson Disease; Psychotic Disorde | 1971 |