dihydroxyphenylalanine has been researched along with Paraganglioma in 33 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Paraganglioma: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)
Excerpt | Relevance | Reference |
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"(18)F-fluorodihydroxyphenylalanine (FDOPA) is a powerful tool for the diagnosis and detection of neuroendocrine tumors when planning and monitoring surgical and oncologic therapies." | 8.90 | 18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors. ( Forsback, S; Kauhanen, S; Kemppainen, J; Minn, H; Seppänen, M, 2014) |
"The aim of this study was to systematically review and conduct a meta-analysis of published data about the diagnostic performance of (18)F-dihydroxyphenylalanine (DOPA) positron emission tomography (PET) in patients with paraganglioma (PG)." | 8.88 | Diagnostic performance of 18F-dihydroxyphenylalanine positron emission tomography in patients with paraganglioma: a meta-analysis. ( Castaldi, P; Cocciolillo, F; de Waure, C; Di Nardo, F; Giordano, A; Gualano, MR; Rufini, V; Treglia, G, 2012) |
"To evaluate (18)F-fluorodihydroxyphenylalanine-positron emission tomography/ contrast-enhanced computed tomography ((18)F-DOPA PET/CT) for the detection of paragangliomas (PARA) without any patient selection, such as genetic predisposition for the development of these tumors, history of metastatic PARA or hormonal status." | 7.83 | Clinical Value of 18F-fluorodihydroxyphenylalanine Positron Emission Tomography/Contrast-enhanced Computed Tomography (18F-DOPA PET/CT) in Patients with Suspected Paraganglioma. ( Dudczak, R; El-Rabadi, K; Hacker, M; Karanikas, G; Mayerhofer, M; Mitterhauser, M; Nakuz, T; Scherer, T; Weber, M, 2016) |
"Pheochromocytomas (PHEOs) and paragangliomas (PGLs) may be better detected by (18)F-fluorodihydroxyphenylalanine-positron emission tomography (FDOPA-PET) than (123)I-metaiodobenzyl-guanidine (123-I-MIBG) scintigraphy." | 7.76 | 6-18F-fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to 123I-metaiodobenzyl-guanidine scintigraphy in the detection of extraadrenal and hereditary pheochromocytomas and paragangliomas: correlation with vesicular monoamine transpo ( Anlauf, M; Bartenstein, P; Fottner, C; Helisch, A; Klöppel, G; Kreft, A; Lackner, KJ; Musholt, TJ; Rossmann, H; Schadmand-Fischer, S; Schreckenberger, M; Weber, MM, 2010) |
"(18)F-fluorodihydroxyphenylalanine (FDOPA) is a powerful tool for the diagnosis and detection of neuroendocrine tumors when planning and monitoring surgical and oncologic therapies." | 4.90 | 18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors. ( Forsback, S; Kauhanen, S; Kemppainen, J; Minn, H; Seppänen, M, 2014) |
"The aim of this study was to systematically review and conduct a meta-analysis of published data about the diagnostic performance of (18)F-dihydroxyphenylalanine (DOPA) positron emission tomography (PET) in patients with paraganglioma (PG)." | 4.88 | Diagnostic performance of 18F-dihydroxyphenylalanine positron emission tomography in patients with paraganglioma: a meta-analysis. ( Castaldi, P; Cocciolillo, F; de Waure, C; Di Nardo, F; Giordano, A; Gualano, MR; Rufini, V; Treglia, G, 2012) |
"To evaluate (18)F-fluorodihydroxyphenylalanine-positron emission tomography/ contrast-enhanced computed tomography ((18)F-DOPA PET/CT) for the detection of paragangliomas (PARA) without any patient selection, such as genetic predisposition for the development of these tumors, history of metastatic PARA or hormonal status." | 3.83 | Clinical Value of 18F-fluorodihydroxyphenylalanine Positron Emission Tomography/Contrast-enhanced Computed Tomography (18F-DOPA PET/CT) in Patients with Suspected Paraganglioma. ( Dudczak, R; El-Rabadi, K; Hacker, M; Karanikas, G; Mayerhofer, M; Mitterhauser, M; Nakuz, T; Scherer, T; Weber, M, 2016) |
"To evaluate the clinical value of (18) F-fluorodihydroxyphenylalanine ((18) F-FDOPA) PET in relation to tumour localization and the patient's genetic status in a large series of pheochromocytoma/paraganglioma (PHEO/PGL) patients and to discuss in detail false-negative results." | 3.79 | Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions. ( Barlier, A; Blanchet, EM; Chen, CC; Deveze, A; Fakhry, N; Gabriel, S; Morange, I; Pacak, K; Sebag, F; Taïeb, D, 2013) |
"To define the appropriate scan time for fluorine-18-labeled dihydroxyphenylalanine (F-18 DOPA) PET in oncological imaging of pheochromocytomas and paragangliomas." | 3.78 | Is there an optimal scan time for 6-[F-18]fluoro-L-DOPA PET in pheochromocytomas and paragangliomas? ( Boedeker, CC; Brink, I; Hentschel, M; Neumann, HP; Rottenburger, C, 2012) |
"Pheochromocytomas (PHEOs) and paragangliomas (PGLs) may be better detected by (18)F-fluorodihydroxyphenylalanine-positron emission tomography (FDOPA-PET) than (123)I-metaiodobenzyl-guanidine (123-I-MIBG) scintigraphy." | 3.76 | 6-18F-fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to 123I-metaiodobenzyl-guanidine scintigraphy in the detection of extraadrenal and hereditary pheochromocytomas and paragangliomas: correlation with vesicular monoamine transpo ( Anlauf, M; Bartenstein, P; Fottner, C; Helisch, A; Klöppel, G; Kreft, A; Lackner, KJ; Musholt, TJ; Rossmann, H; Schadmand-Fischer, S; Schreckenberger, M; Weber, MM, 2010) |
"Besides (123)I-metaiodobenzylguanidine (MIBG), positron emission tomography (PET) agents are available for the localization of paraganglioma (PGL), including (18)F-3,4-dihydroxyphenylalanine (DOPA), (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG), and (18)F-fluorodopamine ((18)F-FDA)." | 3.75 | Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma. ( Adams, KT; Carrasquillo, JA; Chen, CC; Eisenhofer, G; Havekes, B; Ling, A; Martiniova, L; Pacak, K; Timmers, HJ; Whatley, M, 2009) |
"Paragangliomas are tumours that arise within the sympathetic nervous system originating from the neural crest." | 2.43 | Imaging of pheochromocytoma and paraganglioma. ( Bley, TA; Brink, I; Hoegerle, S; Klisch, J, 2005) |
"F-FDOPA PET/CT disconfirmed this recurrence but revealed 2 FDOPA-avid left inguinal lymph nodes, confirmed on a subsequent F-FDG PET/CT." | 1.56 | Incidental Metastatic Melanoma Identified on 18F-FDOPA PET/CT With Confirmation by Histology. ( Aouidad, I; Jublanc, C; Montravers, F; Talbot, JN; Zhang-Yin, J, 2020) |
"Paragangliomas and pheochromocytomas are genetically heterogeneous diseases." | 1.38 | Correlation of the genotype of paragangliomas and pheochromocytomas with their metabolic phenotype on 3,4-dihydroxy-6-18F-fluoro-L-phenylalanin PET. ( Benz, MR; Campbell, D; Dumont, RA; Mix, M; Neumann, HP; Rischke, HC; Rössler, J; Seufert, J; Weber, WA; Wiech, T; Wild, D, 2012) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 6 (18.18) | 29.6817 |
2010's | 24 (72.73) | 24.3611 |
2020's | 3 (9.09) | 2.80 |
Authors | Studies |
---|---|
Goujon, A | 1 |
Pop, G | 1 |
Hissier, J | 1 |
Moreau, B | 1 |
Palard-Novello, X | 1 |
Zhang-Yin, J | 1 |
Jublanc, C | 1 |
Aouidad, I | 1 |
Montravers, F | 1 |
Talbot, JN | 1 |
Araghi, ZJ | 1 |
Ranjbar, S | 1 |
Paar, M | 1 |
Pirich, C | 1 |
Beheshti, M | 1 |
Berends, AMA | 1 |
Kerstens, MN | 2 |
Bolt, JW | 1 |
Links, TP | 2 |
Korpershoek, E | 1 |
de Krijger, RR | 1 |
Walenkamp, AME | 1 |
Noordzij, W | 1 |
van Etten, B | 1 |
Kats-Ugurlu, G | 1 |
Brouwers, AH | 2 |
van der Horst-Schrivers, ANA | 1 |
Leroy Freschini, B | 1 |
Addeo, P | 1 |
Averous, G | 1 |
Goichot, B | 2 |
Bachellier, P | 1 |
Imperiale, A | 2 |
Calabrò, D | 1 |
Allegri, V | 1 |
Fanti, S | 2 |
Ambrosini, V | 1 |
Blanchet, EM | 3 |
Martucci, V | 2 |
Millo, C | 2 |
Chen, CC | 5 |
Herscovitch, P | 2 |
Pacak, K | 9 |
Maass-Moreno, R | 1 |
Bluemke, DA | 1 |
Taïeb, D | 6 |
Timmers, HJ | 2 |
Shulkin, BL | 1 |
Minn, H | 1 |
Kemppainen, J | 1 |
Kauhanen, S | 1 |
Forsback, S | 1 |
Seppänen, M | 1 |
Santhanam, P | 1 |
Treglia, G | 3 |
Ruberto, T | 1 |
Giovanella, L | 1 |
Shamim, SA | 1 |
Kumar, A | 1 |
Kumar, R | 1 |
Janssen, I | 1 |
Patronas, NJ | 1 |
Millo, CM | 1 |
Adams, KT | 4 |
Nambuba, J | 1 |
Sadowski, SM | 1 |
Fojo, AT | 1 |
Buchmann, I | 1 |
Kebebew, E | 1 |
Archier, A | 1 |
Varoquaux, A | 1 |
Garrigue, P | 1 |
Montava, M | 1 |
Guerin, C | 1 |
Gabriel, S | 2 |
Beschmout, E | 1 |
Morange, I | 2 |
Fakhry, N | 2 |
Castinetti, F | 1 |
Sebag, F | 2 |
Barlier, A | 2 |
Loundou, A | 1 |
Guillet, B | 1 |
Knie, B | 1 |
Plotkin, M | 1 |
Zschieschang, P | 1 |
Prasad, V | 1 |
Moskopp, D | 1 |
El-Rabadi, K | 1 |
Weber, M | 1 |
Mayerhofer, M | 1 |
Nakuz, T | 1 |
Scherer, T | 1 |
Mitterhauser, M | 1 |
Dudczak, R | 1 |
Hacker, M | 1 |
Karanikas, G | 1 |
Fiebrich, HB | 1 |
Pijl, ME | 1 |
Kema, IP | 1 |
de Jong, JR | 1 |
Jager, PL | 1 |
Elsinga, PH | 1 |
Dierckx, RA | 1 |
van der Wal, JE | 1 |
Sluiter, WJ | 1 |
de Vries, EG | 1 |
Carrasquillo, JA | 1 |
Whatley, M | 1 |
Ling, A | 2 |
Havekes, B | 1 |
Eisenhofer, G | 2 |
Martiniova, L | 1 |
Chew, SL | 1 |
Fottner, C | 1 |
Helisch, A | 1 |
Anlauf, M | 1 |
Rossmann, H | 1 |
Musholt, TJ | 1 |
Kreft, A | 1 |
Schadmand-Fischer, S | 1 |
Bartenstein, P | 1 |
Lackner, KJ | 1 |
Klöppel, G | 1 |
Schreckenberger, M | 1 |
Weber, MM | 1 |
Rufini, V | 2 |
Castaldi, P | 2 |
Perotti, G | 1 |
Calcagni, ML | 1 |
Corsello, SM | 1 |
Galli, G | 1 |
Giordano, A | 2 |
Levine, DS | 1 |
Metzger, DL | 1 |
Nadel, HR | 1 |
Oviedo, A | 1 |
Adam, MJ | 1 |
Skarsgard, E | 1 |
King, KS | 1 |
Alexopoulos, DK | 1 |
Whatley, MA | 1 |
Reynolds, JC | 1 |
Patronas, N | 1 |
Xekouki, P | 1 |
Lando, H | 1 |
Stratakis, CA | 1 |
Hentschel, M | 1 |
Rottenburger, C | 1 |
Boedeker, CC | 1 |
Neumann, HP | 4 |
Brink, I | 4 |
Cocciolillo, F | 1 |
de Waure, C | 1 |
Di Nardo, F | 1 |
Gualano, MR | 1 |
Rischke, HC | 1 |
Benz, MR | 1 |
Wild, D | 1 |
Mix, M | 1 |
Dumont, RA | 1 |
Campbell, D | 1 |
Seufert, J | 1 |
Wiech, T | 1 |
Rössler, J | 1 |
Weber, WA | 1 |
Taquet, MC | 1 |
Rust, E | 1 |
Hubele, F | 1 |
Veillon, F | 1 |
Deveze, A | 1 |
Hoegerle, S | 2 |
Ghanem, N | 1 |
Altehoefer, C | 1 |
Schipper, J | 1 |
Moser, E | 1 |
Goldstein, DS | 1 |
Sullivan, P | 1 |
Csako, G | 1 |
Brouwers, FM | 1 |
Lai, EW | 1 |
Klisch, J | 1 |
Bley, TA | 1 |
Schaefer, O | 1 |
Walz, M | 1 |
5 reviews available for dihydroxyphenylalanine and Paraganglioma
Article | Year |
---|---|
18F-fluorodihydroxyphenylalanine in the diagnosis of neuroendocrine tumors.
Topics: Adrenal Gland Neoplasms; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Humans; Intestinal Neopl | 2014 |
Role of (18) F-FDOPA PET/CT imaging in endocrinology.
Topics: Adrenal Gland Neoplasms; Carbidopa; Carcinoid Tumor; Carcinoma, Neuroendocrine; Dihydroxyphenylalani | 2014 |
PET/Computed Tomography in Neuroendocrine Tumor: Value to Patient Management and Survival Outcomes.
Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Gallium Radioisotopes; Gast | 2015 |
Diagnostic performance of 18F-dihydroxyphenylalanine positron emission tomography in patients with paraganglioma: a meta-analysis.
Topics: Dihydroxyphenylalanine; Humans; Multimodal Imaging; Paraganglioma; Positron-Emission Tomography; Rad | 2012 |
Imaging of pheochromocytoma and paraganglioma.
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Huma | 2005 |
3 trials available for dihydroxyphenylalanine and Paraganglioma
Article | Year |
---|---|
Integrated whole-body PET/MRI with 18F-FDG, 18F-FDOPA, and 18F-FDA in paragangliomas in comparison with PET/CT: NIH first clinical experience with a single-injection, dual-modality imaging protocol.
Topics: Adult; Dihydroxyphenylalanine; Dopamine; Female; Fluorodeoxyglucose F18; Humans; Injections; Magneti | 2014 |
Prospective comparison of (68)Ga-DOTATATE and (18)F-FDOPA PET/CT in patients with various pheochromocytomas and paragangliomas with emphasis on sporadic cases.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Dihydroxyphenylalanine; False Positive Reac | 2016 |
18F-DOPA positron emission tomography for the detection of glomus tumours.
Topics: Adult; Aged; Carotid Body Tumor; Dihydroxyphenylalanine; Female; Glomus Tumor; Humans; Male; Middle | 2003 |
25 other studies available for dihydroxyphenylalanine and Paraganglioma
Article | Year |
---|---|
18 F-FDOPA PET/CT of Paraganglioma in the Spermatic Cord.
Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Humans; Male; Middle Aged; Paraganglioma; Positron | 2023 |
Incidental Metastatic Melanoma Identified on 18F-FDOPA PET/CT With Confirmation by Histology.
Topics: Dihydroxyphenylalanine; Female; Humans; Incidental Findings; Melanoma; Middle Aged; Neoplasm Staging | 2020 |
Accurate detection of intracranial extension of jugulotympanic paraganglioma by [
Topics: Dihydroxyphenylalanine; Humans; Magnetic Resonance Imaging; Paraganglioma; Positron Emission Tomogra | 2021 |
False-positive findings on 6-[18F]fluor-l-3,4-dihydroxyphenylalanine PET (
Topics: Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; False Positive Reactions; Female; Huma | 2018 |
18F-FDOPA PET/CT of Nonfunctioning Paraganglioma of the Gastroepiploic Pedicle.
Topics: Diagnosis, Differential; Dihydroxyphenylalanine; Female; Gastrointestinal Neoplasms; Humans; Mesente | 2018 |
Topics: Abdominal Neoplasms; Dihydroxyphenylalanine; Head and Neck Neoplasms; Humans; Hypertension; Image Pr | 2019 |
Multitracer PET imaging of bone metastases from paraganglioma: peripheral halo of uptake on 18F-FLT PET mismatching with central uptake of 18F-FDOPA, 18F-fluorodopamine, and 18F-FDG.
Topics: Adrenal Gland Neoplasms; Aged; Biological Transport; Bone Neoplasms; Dideoxynucleosides; Dihydroxyph | 2013 |
Renaissance of (18)F-FDG positron emission tomography in the imaging of pheochromocytoma/paraganglioma.
Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; History, 20th Century; Hist | 2014 |
Trimodal (18)F-DOPA PET/CT/MR fusion imaging for optimal restaging of head and neck paragangliomas in a SDHD mutation carrier.
Topics: Adult; Dihydroxyphenylalanine; Female; Head and Neck Neoplasms; Humans; Magnetic Resonance Imaging; | 2016 |
68Ga-DOTATATE PET/CT in the Localization of Head and Neck Paragangliomas Compared with Other Functional Imaging Modalities and CT/MRI.
Topics: Adult; Aged; Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans | 2016 |
A family with pheochromocytoma-paraganglioma inherited tumour syndrome. Serial 18F-DOPA PET/CT investigations.
Topics: Adult; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Neoplastic Syndromes, Hereditary; | 2016 |
Clinical Value of 18F-fluorodihydroxyphenylalanine Positron Emission Tomography/Contrast-enhanced Computed Tomography (18F-DOPA PET/CT) in Patients with Suspected Paraganglioma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; False Negative Reactions; Female; Huma | 2016 |
6-[F-18]Fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to conventional imaging with (123)I-metaiodobenzylguanidine scintigraphy, computer tomography, and magnetic resonance imaging in localizing tumors causing catecholamine exces
Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Biomarkers; | 2009 |
Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma.
Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; Dop | 2009 |
Diagnosis: imaging of pheochromocytomas and paragangliomas.
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Contrast Media; Diagnostic Imaging; Dihydroxyphenyla | 2010 |
6-18F-fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to 123I-metaiodobenzyl-guanidine scintigraphy in the detection of extraadrenal and hereditary pheochromocytomas and paragangliomas: correlation with vesicular monoamine transpo
Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Biomarkers; Data Interpreta | 2010 |
Comparison of 123I-MIBG SPECT-CT and 18F-DOPA PET-CT in the evaluation of patients with known or suspected recurrent paraganglioma.
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adult; Aged; Dihydroxyphenylalanine; Female; Humans; | 2011 |
Novel use of F-DOPA PET/CT imaging in a child with paraganglioma/pheochromocytoma syndrome.
Topics: Adolescent; Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Female; Humans; Kidney Neoplasms; Multi | 2011 |
Functional imaging of SDHx-related head and neck paragangliomas: comparison of 18F-fluorodihydroxyphenylalanine, 18F-fluorodopamine, 18F-fluoro-2-deoxy-D-glucose PET, 123I-metaiodobenzylguanidine scintigraphy, and 111In-pentetreotide scintigraphy.
Topics: 3-Iodobenzylguanidine; Adult; Brain Mapping; Dihydroxyphenylalanine; Dopamine; Female; Fluorodeoxygl | 2011 |
Is there an optimal scan time for 6-[F-18]fluoro-L-DOPA PET in pheochromocytomas and paragangliomas?
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Dihydroxyphenylalanine; Female; | 2012 |
Correlation of the genotype of paragangliomas and pheochromocytomas with their metabolic phenotype on 3,4-dihydroxy-6-18F-fluoro-L-phenylalanin PET.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Biological Transport; Child; Di | 2012 |
Head-to-head comparison between SRS, (18)F-FDG and (18)F-FDOPA PET/CT in a patient with recurrent SDHC-related jugular paraganglioma.
Topics: Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Membrane Pr | 2012 |
Functional characterization of nonmetastatic paraganglioma and pheochromocytoma by (18) F-FDOPA PET: focus on missed lesions.
Topics: Abdominal Neoplasms; Adrenal Gland Neoplasms; Dihydroxyphenylalanine; False Negative Reactions; Head | 2013 |
Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine.
Topics: Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Middle Aged; | 2005 |
Fluorine-18 DOPA PET imaging of paraganglioma syndrome.
Topics: Abdominal Neoplasms; Child; Dihydroxyphenylalanine; Head and Neck Neoplasms; Humans; Male; Paragangl | 2006 |