dihydroxyphenylalanine has been researched along with Neuroblastoma in 79 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to accomplish this goal in neuroblastoma, we rationally designed a prodrug of etoposide as substrate for tyrosine hydroxylase, a well established neuroblastoma associated enzyme." | 7.72 | Neuroblastoma directed therapy by a rational prodrug design of etoposide as a substrate for tyrosine hydroxylase. ( Gaedicke, G; Huebener, N; Jikai, J; Lange, B; Lode, HN; Schroeder, U; Shabat, D; Shamis, M; Wenkel, J; Wrasidlo, W, 2003) |
| " In a series of experiments we found that incubation of the neuroblastoma cell line SK-N-SH with ascorbic acid (100-500 microM) for 2 h results in a significantly enhanced synthesis of 3,4-dihydroxyphenylalanine (DOPA) and dopamine." | 7.70 | Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH. ( Beck, JF; Böhm, W; Bruchelt, G; Gebhardt, S; Lode, HN; Niethammer, D; Seitz, G, 1998) |
| "Tyrosine hydroxylation was studied in intact cells of mouse neuroblastoma clone N1E-115 which have high levels of tyrosine 3-monooxygenase (EC 1." | 7.65 | Properties of tyrosine hydroxylation in living mouse neuroblastoma clone N1E-115. ( Richelson, E, 1976) |
| "This retrospective study aimed to determine the prognostic value of imaging parameters derived from midtherapy 18F-fluorodihydroxyphenylalanine (18F-DOPA) and 18F-FDG PET in pediatric patients with stage 3-4 neuroblastoma." | 4.12 | Prognostic Value of Interim 18F-DOPA and 18F-FDG PET/CT Findings in Stage 3-4 Pediatric Neuroblastoma. ( Chang, HH; Chou, SW; Hsu, WM; Jou, ST; Ko, CL; Ko, KY; Lu, MY; Yang, YL; Yen, RF, 2022) |
| "We used dopaminergic human neuroblastoma BE(2)-M17 cell lines stably transfected with WT or A30P mutant alpha-synuclein to characterize the effect of alpha-synuclein on dopamine toxicity." | 3.76 | Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells. ( Bisaglia, M; Bubacco, L; Cookson, MR; Greggio, E; Maric, D; Miller, DW, 2010) |
| " In order to accomplish this goal in neuroblastoma, we rationally designed a prodrug of etoposide as substrate for tyrosine hydroxylase, a well established neuroblastoma associated enzyme." | 3.72 | Neuroblastoma directed therapy by a rational prodrug design of etoposide as a substrate for tyrosine hydroxylase. ( Gaedicke, G; Huebener, N; Jikai, J; Lange, B; Lode, HN; Schroeder, U; Shabat, D; Shamis, M; Wenkel, J; Wrasidlo, W, 2003) |
| " In a series of experiments we found that incubation of the neuroblastoma cell line SK-N-SH with ascorbic acid (100-500 microM) for 2 h results in a significantly enhanced synthesis of 3,4-dihydroxyphenylalanine (DOPA) and dopamine." | 3.70 | Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH. ( Beck, JF; Böhm, W; Bruchelt, G; Gebhardt, S; Lode, HN; Niethammer, D; Seitz, G, 1998) |
| "The inhibitory effect of apomorphine on tyrosine hydroxylase (TH) was tested using enzyme preparations from rat striatum, neuroblastoma clone N1E-115 and pheochromocytoma clone PC-12." | 3.67 | Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine. ( Bräutigam, M; Kittner, B; Laschinski, G, 1984) |
| "Urinary excretion of cystathionine and dopa metabolites was analyzed in 61 patients with active neuroblastoma before, and at regular intervals during treatment." | 3.67 | Cystathioninuria in patients with neuroblastoma. ( Abeling, NG; Rajnherc, JR; van der Zee, JM; van Gennip, AH; Voûte, PA, 1984) |
| "The catecholic amino acids, dopa and 5-S-cysteinyldopa, and the dopamine metabolite, homovanillic acid, were determined in 8 neuroblastomas." | 3.66 | Melanogenesis in cultured human neuroblastomas. ( Aubert, C; Hansson, C; Janiaud, P; Rorsman, H; Rosengren, E; Rouge, F, 1980) |
| "The natural catecholic amino acid 5-S-cysteinyl-3,4-dihydroxyphenylalanine (1) was selectively toxic to a variety of human tumor cell lines in culture and exhibited antitumor activity against L1210 leukemia and B-16 melanoma in mice at doses which were not toxic to the host." | 3.66 | Synthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalanines and related compounds. ( Fujita, K; Inoue, S; Ito, S; Yamamoto, Y, 1981) |
| "Tyrosine hydroxylation was studied in intact cells of mouse neuroblastoma clone N1E-115 which have high levels of tyrosine 3-monooxygenase (EC 1." | 3.65 | Properties of tyrosine hydroxylation in living mouse neuroblastoma clone N1E-115. ( Richelson, E, 1976) |
| "Neuroblastoma was the most common cause of elevated dopamine in children's specimens, although other associations are described." | 1.33 | Elevated urinary dopamine in adults and children. ( Davidson, DF, 2005) |
| "In untreated active neuroblastoma DOPA or ALAAD (10 out of 10) or both (six out of 10) were clearly elevated." | 1.28 | Combined measurements of plasma aromatic L-amino acid decarboxylase and DOPA as tumour markers in diagnosis and follow-up of neuroblastoma. ( Ausema, L; Boomsma, F; Hahlen, K; Hakvoort-Cammel, FG; Krenning, EP; Man in't Veld, AJ; Oosterom, R; Schalekamp, MA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (62.03) | 18.7374 |
| 1990's | 6 (7.59) | 18.2507 |
| 2000's | 7 (8.86) | 29.6817 |
| 2010's | 15 (18.99) | 24.3611 |
| 2020's | 2 (2.53) | 2.80 |
| Authors | Studies |
|---|---|
| Ko, KY | 2 |
| Yen, RF | 2 |
| Ko, CL | 2 |
| Chou, SW | 1 |
| Chang, HH | 4 |
| Yang, YL | 4 |
| Jou, ST | 4 |
| Hsu, WM | 4 |
| Lu, MY | 4 |
| O'Brien, SR | 1 |
| States, LJ | 1 |
| Zhuang, H | 1 |
| Piccardo, A | 6 |
| Lopci, E | 7 |
| Conte, M | 5 |
| Foppiani, L | 4 |
| Garaventa, A | 5 |
| Cabria, M | 3 |
| Villavecchia, G | 5 |
| Fanti, S | 5 |
| Cistaro, A | 5 |
| Morana, G | 2 |
| Puntoni, M | 2 |
| Sorrentino, S | 2 |
| Naseri, M | 1 |
| Demirsoy, U | 1 |
| Demir, H | 1 |
| Corapcoğlu, F | 1 |
| Huang, YY | 1 |
| Tzen, KY | 4 |
| Liu, YL | 4 |
| Chiu, CH | 1 |
| Tsai, CL | 1 |
| Wen, HP | 1 |
| Tang, KH | 1 |
| Liu, CC | 1 |
| Shiue, CY | 1 |
| Wartski, M | 1 |
| Jehanno, N | 1 |
| Michon, J | 1 |
| de Labriolle-Vaylet, C | 1 |
| Montravers, F | 1 |
| Lu, CC | 1 |
| Lin, DT | 2 |
| Lee, YL | 2 |
| Huang, SF | 2 |
| Jeng, YM | 1 |
| Lee, H | 2 |
| Miser, JS | 1 |
| Lin, KH | 2 |
| Liao, YF | 2 |
| Liu, CJ | 1 |
| Trapani, A | 1 |
| Tricarico, D | 1 |
| Mele, A | 1 |
| Maqoud, F | 1 |
| Mandracchia, D | 1 |
| Vitale, P | 1 |
| Capriati, V | 1 |
| Trapani, G | 1 |
| Dimiccoli, V | 1 |
| Tolomeo, A | 1 |
| Scilimati, A | 1 |
| Bisaglia, M | 1 |
| Greggio, E | 1 |
| Maric, D | 1 |
| Miller, DW | 1 |
| Cookson, MR | 1 |
| Bubacco, L | 1 |
| Altrinetti, V | 2 |
| Nanni, C | 3 |
| Bianchi, P | 1 |
| Pession, A | 3 |
| Chiti, A | 2 |
| D'Ambrosio, D | 1 |
| Marengo, M | 1 |
| Wu, PY | 1 |
| Luo, TY | 1 |
| Shen, LH | 1 |
| Richelson, E | 1 |
| Jikai, J | 1 |
| Shamis, M | 1 |
| Huebener, N | 1 |
| Schroeder, U | 1 |
| Wrasidlo, W | 1 |
| Wenkel, J | 1 |
| Lange, B | 1 |
| Gaedicke, G | 1 |
| Shabat, D | 1 |
| Lode, HN | 2 |
| SOURKES, TL | 1 |
| DENTON, RL | 1 |
| MURPHY, GF | 1 |
| CHAVEZ, B | 1 |
| SAINT CYR, S | 1 |
| GJESSING, LR | 3 |
| BOHUON, C | 5 |
| TANIGUCHI, K | 1 |
| KAKIMOTO, Y | 1 |
| ARMSTRONG, MD | 1 |
| BORUD, O | 1 |
| GREER, M | 2 |
| ANTON, AH | 3 |
| WILLIAMS, CM | 2 |
| ECHEVARRIA, RA | 1 |
| Hasegawa, T | 1 |
| Matsuzaki, M | 1 |
| Takeda, A | 1 |
| Kikuchi, A | 1 |
| Furukawa, K | 1 |
| Shibahara, S | 1 |
| Itoyama, Y | 1 |
| Machida, Y | 1 |
| Chiba, T | 1 |
| Takayanagi, A | 1 |
| Tanaka, Y | 1 |
| Asanuma, M | 1 |
| Ogawa, N | 1 |
| Koyama, A | 1 |
| Iwatsubo, T | 1 |
| Ito, S | 3 |
| Jansen, PH | 1 |
| Shimizu, N | 1 |
| Tanaka, K | 1 |
| Mizuno, Y | 1 |
| Hattori, N | 1 |
| Davidson, DF | 1 |
| Yatabe, J | 1 |
| Sanada, H | 1 |
| Sharma, SK | 1 |
| El Refaey, H | 1 |
| Ebadi, M | 1 |
| Sayre, DF | 1 |
| Bräutigam, M | 5 |
| Dreesen, R | 2 |
| Flosbach, CW | 1 |
| Herken, H | 4 |
| Laschinski, G | 2 |
| Kittner, B | 3 |
| Inoue, S | 2 |
| Fujita, K | 2 |
| Rajnherc, JR | 1 |
| van Gennip, AH | 2 |
| Abeling, NG | 2 |
| van der Zee, JM | 1 |
| Voûte, PA | 2 |
| Crumrine, RS | 1 |
| Stern, RC | 1 |
| Izant, RJ | 1 |
| Helson, L | 2 |
| Johnson, GA | 1 |
| Smith, R | 1 |
| Aubert, C | 1 |
| Janiaud, P | 1 |
| Rouge, F | 1 |
| Hansson, C | 1 |
| Rorsman, H | 1 |
| Rosengren, E | 1 |
| Yamamoto, Y | 1 |
| Ikeda, H | 2 |
| Pastuszko, A | 1 |
| Ikegaki, N | 1 |
| Kennett, RH | 1 |
| Wilson, DF | 1 |
| Matsuyama, S | 1 |
| Suzuki, N | 1 |
| Takahashi, A | 1 |
| Kuroiwa, M | 1 |
| Seitz, G | 1 |
| Gebhardt, S | 1 |
| Beck, JF | 1 |
| Böhm, W | 1 |
| Niethammer, D | 1 |
| Bruchelt, G | 1 |
| Lelong, IH | 1 |
| Rebel, G | 1 |
| Eldrup, E | 1 |
| Clausen, N | 1 |
| Scherling, B | 1 |
| Schmiegelow, K | 1 |
| LaBrosse, EH | 3 |
| Comoy, E | 3 |
| Zucker, JM | 1 |
| Schweisguth, O | 1 |
| Muskiet, FA | 1 |
| Fremouw-Ottevangers, DC | 1 |
| van der Meulen, J | 1 |
| Wolthers, BG | 1 |
| de Vries, JA | 1 |
| Fraeyman, NH | 1 |
| De Potter, WP | 1 |
| De Schaepdryver, AF | 1 |
| Wexler, B | 1 |
| Katzman, R | 1 |
| Dy, V | 1 |
| Watson, RC | 1 |
| Exelby, PR | 1 |
| Hajdu, SI | 1 |
| Ponzoni, M | 1 |
| Casalaro, A | 1 |
| Lanciotti, M | 1 |
| Montaldo, PG | 1 |
| Cornaglia-Ferraris, P | 1 |
| Jouve, J | 1 |
| Bakri, D | 1 |
| Herault, J | 1 |
| Muh, JP | 1 |
| Boomsma, F | 1 |
| Ausema, L | 1 |
| Hakvoort-Cammel, FG | 1 |
| Oosterom, R | 1 |
| Man in't Veld, AJ | 1 |
| Krenning, EP | 1 |
| Hahlen, K | 1 |
| Schalekamp, MA | 1 |
| Shigetomi, S | 1 |
| Overmars, H | 1 |
| Goldstein, DS | 1 |
| Stull, R | 1 |
| Eisenhofer, G | 1 |
| Sisson, JC | 1 |
| Weder, A | 1 |
| Averbuch, SD | 1 |
| Keiser, HR | 1 |
| Alvarado, CS | 1 |
| Faraj, BA | 1 |
| Kim, TH | 1 |
| Camp, VM | 1 |
| Bain, RP | 1 |
| Ragab, AH | 1 |
| Kharchenko, AD | 1 |
| Kniazev, IuA | 1 |
| Bukhny, AE | 2 |
| Kovalev, GP | 1 |
| Kosiakov, GA | 1 |
| Türler, K | 2 |
| Käser, H | 5 |
| Wender, M | 1 |
| Wagner, HP | 1 |
| Zuppinger, K | 1 |
| Zurbrügg, R | 1 |
| Imashuku, S | 2 |
| Johnson, EM | 1 |
| Morgenroth, VH | 1 |
| Zenker, N | 1 |
| Louis, WJ | 1 |
| Doyle, AE | 1 |
| Heath, WC | 1 |
| Robinson, MJ | 1 |
| De Bault, LE | 1 |
| Millard, SA | 1 |
| Dziedzic, SW | 1 |
| Dziedzic, LB | 1 |
| Gitlow, SE | 1 |
| Stepanov, EA | 1 |
| Bol'shakova, TD | 1 |
| Lukicheva, TI | 1 |
| Eichhorn, F | 1 |
| Rutenberg, A | 1 |
| Kott, E | 1 |
| Burri, PH | 1 |
| Bell, M | 1 |
| von Studnitz, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of 18F-Fluciclovine PET-MRI to Differentiate Tumor Progression From Post-treatment Changes in Pediatric High-grade Glioma (HGG)[NCT05553041] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2023-08-07 | Recruiting | ||
| Evaluation of 18F-Fluciclovine PET-MRI as a Biomarker of Response in Pediatric and Young Adult Patients With Low Grade Gliomas (LGG)[NCT05555550] | Early Phase 1 | 30 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for dihydroxyphenylalanine and Neuroblastoma
| Article | Year |
|---|---|
PET/CT imaging in neuroblastoma.
Topics: 3-Iodobenzylguanidine; Adolescent; Adult; Central Nervous System Neoplasms; Child; Child, Preschool; | 2013 |
[RECENT DATA ON THE BIOCHEMISTRY OF NEUROBLASTOMAS].
Topics: Catecholamines; Child; Diarrhea; Dihydroxyphenylalanine; Dopamine; Ganglioneuroma; Humans; Mandelic | 1964 |
[3,4-Dihydroxyphenyl alanine (DOPA)].
Topics: Adrenal Gland Neoplasms; Biomarkers; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; H | 2005 |
2 trials available for dihydroxyphenylalanine and Neuroblastoma
| Article | Year |
|---|---|
18F-DOPA PET/CT in neuroblastoma: comparison of conventional imaging with CT/MR.
Topics: Child; Dihydroxyphenylalanine; Female; Humans; Magnetic Resonance Imaging; Male; Multimodal Imaging; | 2012 |
Feasibility of carbidopa premedication in pediatric patients: a pilot study.
Topics: Carbidopa; Child; Child, Preschool; Dihydroxyphenylalanine; Drug Interactions; Female; Fluorine Radi | 2012 |
74 other studies available for dihydroxyphenylalanine and Neuroblastoma
| Article | Year |
|---|---|
Prognostic Value of Interim 18F-DOPA and 18F-FDG PET/CT Findings in Stage 3-4 Pediatric Neuroblastoma.
Topics: Child; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Humans; Neuroblastoma; Positron Emission Tomo | 2022 |
Neuroblastoma Shown on 18F-DOPA PET/CT Performed to Evaluate Congenital Hyperinsulinism.
Topics: Congenital Hyperinsulinism; Dihydroxyphenylalanine; Humans; Male; Neuroblastoma; Positron Emission T | 2021 |
Bone and lymph node metastases from neuroblastoma detected by 18F-DOPA-PET/CT and confirmed by posttherapy 131I-MIBG but negative on diagnostic 123I-MIBG scan.
Topics: 3-Iodobenzylguanidine; Bone Neoplasms; Child; Dihydroxyphenylalanine; Humans; Lymphatic Metastasis; | 2014 |
(18)F-DOPA PET/CT for assessment of response to induction chemotherapy in a child with high-risk neuroblastoma.
Topics: Bone Marrow Neoplasms; Child, Preschool; Dihydroxyphenylalanine; Female; Humans; Induction Chemother | 2014 |
Prognostic value of ¹⁸F-DOPA PET/CT at the time of recurrence in patients affected by neuroblastoma.
Topics: 3-Iodobenzylguanidine; Abdominal Neoplasms; Adolescent; Adult; Child; Child, Preschool; Dihydroxyphe | 2014 |
Bone and lymph node metastases from neuroblastoma detected by (18)F-DOPA-PET/CT and confirmed by posttherapy (131)I-MIBG but negative on diagnostic (123)I-MIBG scan.
Topics: 3-Iodobenzylguanidine; Bone Neoplasms; Dihydroxyphenylalanine; Humans; Male; Multimodal Imaging; Neu | 2014 |
Impact of residual (18)F-fluoride in (18)F-FDOPA for the diagnosis of neuroblastoma.
Topics: Bone Neoplasms; Child; Child, Preschool; Chromatography; Dihydroxyphenylalanine; Female; Fluorine Ra | 2015 |
Weak uptake of 123I-MIBG and 18F-FDOPA contrasting with high 18F-FDG uptake in stage I neuroblastoma.
Topics: 3-Iodobenzylguanidine; Brain Neoplasms; Child; Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F1 | 2015 |
Diagnostic FDG and FDOPA positron emission tomography scans distinguish the genomic type and treatment outcome of neuroblastoma.
Topics: Cohort Studies; Dihydroxyphenylalanine; Disease-Free Survival; Female; Fluorodeoxyglucose F18; Genom | 2016 |
Risk Stratification of Pediatric Patients With Neuroblastoma Using Volumetric Parameters of 18F-FDG and 18F-DOPA PET/CT.
Topics: Adolescent; Child; Child, Preschool; Cone-Beam Computed Tomography; Dihydroxyphenylalanine; Female; | 2017 |
Risk Stratification of Pediatric Patients With Neuroblastoma Using Volumetric Parameters of 18F-FDG and 18F-DOPA PET/CT.
Topics: Adolescent; Child; Child, Preschool; Cone-Beam Computed Tomography; Dihydroxyphenylalanine; Female; | 2017 |
Risk Stratification of Pediatric Patients With Neuroblastoma Using Volumetric Parameters of 18F-FDG and 18F-DOPA PET/CT.
Topics: Adolescent; Child; Child, Preschool; Cone-Beam Computed Tomography; Dihydroxyphenylalanine; Female; | 2017 |
Risk Stratification of Pediatric Patients With Neuroblastoma Using Volumetric Parameters of 18F-FDG and 18F-DOPA PET/CT.
Topics: Adolescent; Child; Child, Preschool; Cone-Beam Computed Tomography; Dihydroxyphenylalanine; Female; | 2017 |
A novel injectable formulation of 6-fluoro-l-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson's disease.
Topics: Animals; beta-Cyclodextrins; Cell Line, Tumor; Chemistry, Pharmaceutical; Cysteine; Dihydroxyphenyla | 2017 |
Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells.
Topics: alpha-Synuclein; Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Dihydroxyphenylalanine; Dop | 2010 |
Comparison of 18F-dopa PET/CT and 123I-MIBG scintigraphy in stage 3 and 4 neuroblastoma: a pilot study.
Topics: 3-Iodobenzylguanidine; Adult; Child; Child, Preschool; Dihydroxyphenylalanine; Female; Humans; Infan | 2012 |
Characterization of neuroblastic tumors using 18F-FDOPA PET.
Topics: 3-Iodobenzylguanidine; Biological Transport; Carboxy-Lyases; Catecholamines; Dihydroxyphenylalanine; | 2013 |
Properties of tyrosine hydroxylation in living mouse neuroblastoma clone N1E-115.
Topics: Animals; Biological Assay; Cell Count; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, | 1976 |
Neuroblastoma directed therapy by a rational prodrug design of etoposide as a substrate for tyrosine hydroxylase.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biotransformation; Blotting, Western; Cell Survival; Chr | 2003 |
The excretion of dihydroxyphenylalanine, dopamine, and dihydroxyphenylacetic acid in neuroblastoma.
Topics: Dihydroxyphenylalanine; Dopamine; Ganglioneuroma; Humans; Neuroblastoma; Phenylacetates | 1963 |
STUDIES OF FUNCTIONAL NEURAL TUMORS. V. URINARY EXCRETION OF 3-METHOXY-4HYDROXYPHENYL-LACTIC ACID.
Topics: Acetates; Adrenal Gland Neoplasms; Butyrates; Carcinoid Tumor; Child; Chromatography; Dihydroxypheny | 1963 |
QUANTITATIVE DETERMINATION OF METANEPHRINE AND NORMETANEPHRINE IN URINE.
Topics: Amines; Chromatography; Dihydroxyphenylalanine; Epinephrine; Fluorescence; Fluorometry; Humans; Indi | 1964 |
STUDIES OF FUNCTIONAL NEURAL TUMORS. VI. BIOCHEMICAL DIAGNOSIS.
Topics: Abdominal Neoplasms; Adolescent; Adrenal Gland Neoplasms; Amino Acids; Child; Dihydroxyphenylalanine | 1964 |
STUDIES OF FUNCTIONAL NEURAL TUMORS. VII. URINARY EXCRETION OF PHENOLIC PYRUVIC ACIDS.
Topics: Alkylation; Child; Chromatography; Dihydroxyphenylalanine; Humans; Metabolism; Neoplasm Metastasis; | 1965 |
TUMORS OF NEURAL CREST ORIGIN; BIOCHEMICAL AND PATHOLOGICAL CORRELATION.
Topics: Biochemical Phenomena; Biochemistry; Catecholamines; Child; Dihydroxyphenylalanine; Dopamine; Epinep | 1965 |
Increased dopamine and its metabolites in SH-SY5Y neuroblastoma cells that express tyrosinase.
Topics: Clone Cells; Dihydroxyphenylalanine; Dopamine; Gene Expression; Humans; Melanins; Monophenol Monooxy | 2003 |
Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells.
Topics: alpha-Synuclein; Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Dihydroxyphenylalanine; Dopam | 2005 |
Elevated urinary dopamine in adults and children.
Topics: Adrenal Gland Neoplasms; Adult; Antidepressive Agents; Catecholamines; Child; Dihydroxyphenylalanine | 2005 |
Complex-1 activity and 18F-DOPA uptake in genetically engineered mouse model of Parkinson's disease and the neuroprotective role of coenzyme Q10.
Topics: Analysis of Variance; Animals; Brain; Cell Line, Tumor; Chromatography, High Pressure Liquid; Coenzy | 2006 |
Dihydroxyphenylalanine secretion in a malignant pheochromocytoma.
Topics: Adult; Diagnosis, Differential; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Fluorometry; | 1967 |
Mouse neuroblastoma clone N1E-115: a suitable model for studying the action of dopamine agonists of tyrosine hydroxylase activity.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Catecholamines; Cells, Cultured; Clone Cells; Dihydro | 1982 |
Dopa-release from mouse neuroblastoma clone N 1 E-115 into the culture medium. A test for tyrosine hydroxylase activity.
Topics: Animals; Apomorphine; Catecholamines; Cells, Cultured; Clone Cells; Culture Media; Dihydroxyphenylal | 1982 |
Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine.
Topics: Animals; Apomorphine; Biopterins; Cells, Cultured; Corpus Striatum; Dihydroxyphenylalanine; In Vitro | 1984 |
The mechanism of toxicity of 5-S-cysteinyldopa to tumour cells. Hydrogen peroxide as a mediator of cytotoxicity.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cysteinyldopa; Dihydroxyphenylalanine; Dop | 1983 |
Cystathioninuria in patients with neuroblastoma.
Topics: Adolescent; Child; Child, Preschool; Cystathionine; Dihydroxyphenylalanine; Female; Homovanillic Aci | 1984 |
Inhibition of catecholamine biosynthesis by carbidopa and metyrosine in neuroblastoma.
Topics: alpha-Methyltyrosine; Carbidopa; Catecholamines; Child, Preschool; Dihydroxyphenylalanine; Dopamine; | 1983 |
DOPA metabolism in neuroblastoma.
Topics: Adolescent; Bone Neoplasms; Brain Neoplasms; Child; Dihydroxyphenylalanine; False Negative Reactions | 1980 |
Melanogenesis in cultured human neuroblastomas.
Topics: Animals; Cell Line; Cysteinyldopa; Dihydroxyphenylalanine; Female; Homovanillic Acid; Humans; Male; | 1980 |
Synthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalanines and related compounds.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cricetinae; Cysteinyldopa; Dihydroxyphenyl | 1981 |
3,4-dihydroxyphenylalanine (dopa) metabolism and retinoic acid induced differentiation in human neuroblastoma.
Topics: Cell Differentiation; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Humans; Neuroblastoma; T | 1994 |
3,4-dihydroxyphenylalanine (DOPA) decarboxylase deficiency and resultant high levels of plasma DOPA and dopamine in unfavorable neuroblastoma.
Topics: Biomarkers, Tumor; Brain Neoplasms; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Humans; Ne | 1995 |
Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH.
Topics: Ascorbic Acid; Catecholamines; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamin | 1998 |
pH drift of "physiological buffers" and culture media used for cell incubation during in vitro studies.
Topics: Bicarbonates; Brain Neoplasms; Buffers; Cell Line; Cell Survival; Cells, Cultured; Culture Media; Di | 1998 |
Evaluation of plasma 3,4-dihydroxyphenylacetic acid (DOPAC) and plasma 3,4-dihydroxyphenylalanine (DOPA) as tumor markers in children with neuroblastoma.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Biomarkers, Tumor; Case-Control Studies; Child; C | 2001 |
Catecholamine metabolism in neuroblastoma.
Topics: Catecholamines; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Humans; Metho | 1976 |
Determination of some L-3,4-dihydroxyphenylalanine and dopamine metabolites in urine by means of mass fragmentography.
Topics: 3-Methoxy-4-hydroxyphenylethanol; 3,4-Dihydroxyphenylacetic Acid; Adult; Aging; Child; Child, Presch | 1978 |
Biosynthesis of noradrenaline in C1300 mouse neuroblastoma [proceedings].
Topics: Animals; Dihydroxyphenylalanine; Mice; Neoplasms, Experimental; Neuroblastoma; Norepinephrine; Pheny | 1978 |
Effects of dibutyryl cyclic AMP on tyrosine uptake and metabolism in neuroblastoma cultures.
Topics: Animals; Bucladesine; Cell Line; Dihydroxyphenylalanine; Dopamine; Homovanillic Acid; Hydroxylation; | 1975 |
Improved management of stage III neuroblastoma.
Topics: Age Factors; Antineoplastic Agents; Dihydroxyphenylalanine; Drug Therapy, Combination; Female; Human | 1979 |
The combination of gamma-interferon and tumor necrosis factor causes a rapid and extensive differentiation of human neuroblastoma cells.
Topics: Acetylcholinesterase; Antigens, Surface; Cell Differentiation; Cytoskeletal Proteins; Dihydroxypheny | 1992 |
Determination of urinary vanillactic acid and plasma dihydroxyphenylalanine as markers of non-secreting neuroblastoma by high-performance liquid chromatography with electrochemical detection.
Topics: Adolescent; Biomarkers, Tumor; Child; Child, Preschool; Chromatography, High Pressure Liquid; Diet; | 1991 |
Combined measurements of plasma aromatic L-amino acid decarboxylase and DOPA as tumour markers in diagnosis and follow-up of neuroblastoma.
Topics: Aromatic-L-Amino-Acid Decarboxylases; Biomarkers, Tumor; Child; Child, Preschool; Dihydroxyphenylala | 1989 |
[Clinical significance of 3,4-dihydroxyphenylalanine analysis in endocrine tests of the adrenal medulla and sympathetic nervous system].
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenal Medulla; Adult; Aged; Child; Child, Preschool; Chromato | 1989 |
Evaluation of neurotropic drug actions on tyrosine hydroxylase activity and dopamine metabolism in clonal cell lines.
Topics: Animals; Biopterins; Catechols; Cell Line; Clone Cells; Dihydroxyphenylalanine; Dopamine; Glioma; Mi | 1985 |
Biochemical monitoring of children with neuroblastoma.
Topics: Aminoisobutyric Acids; Child; Cystathionine; Dihydroxyphenylalanine; Homovanillic Acid; Humans; Levo | 1986 |
Plasma 3,4-dihydroxyphenylalanine (dopa) and catecholamines in neuroblastoma or pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Catecholamines; Chromatography, High Pressure Liquid; Dihydroxyphenylalanin | 1986 |
Effect of apomorphine, alpha-methylparatyrosine, haloperidol and reserpine on DOPA production in clonal cell lines (PC-12 and N1E-115).
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Apomorphine; Cell Line; Dihydroxyphenylalani | 1985 |
Plasma dopa and catecholamines in the diagnosis and follow-up of children with neuroblastoma.
Topics: Analysis of Variance; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female | 1985 |
[Diurnal urine excretion of catecholamines and DOPA in tumors of the sympathetic nervous system in children].
Topics: Adolescent; Catecholamines; Child; Child, Preschool; Dihydroxyphenylalanine; Female; Humans; Lymphom | 1969 |
Quantitative fluorimetric determination of urinary dopa and its significance for the diagnosis of neural crest tumours.
Topics: Adult; Child; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Fluorometry; Ganglioneuroma; Hum | 1971 |
[Biochemical diagnosis of tumors of the autonomic nervous system].
Topics: Autonomic Nervous System; Catecholamines; Dihydroxyphenylalanine; Dopamine; Ganglioneuroma; Neoplasm | 1971 |
Circular thin-layer chromatography for diagnosis and follow-up of neural crest tumours.
Topics: Catecholamines; Catechols; Chromatography, Gas; Chromatography, Thin Layer; Diagnosis, Differential; | 1973 |
[Biochemical tumor diagnosis in childhood].
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Carcinoma, Hepatocellular; Child; Cushing Syndrome; De | 1974 |
Tyrosine hydroxylase in neuroblastoma.
Topics: Adrenal Glands; Alanine; Animals; Benzimidazoles; Cattle; Child, Preschool; Dihydroxyphenylalanine; | 1971 |
Secretion of dopa in phaeochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; H | 1972 |
[Biochemical diagnosis of pheochromocytoma, neuroblastoma and other neuro-ectodermal neoplasms].
Topics: Adolescent; Adult; Catecholamines; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Electr | 1972 |
Inhibition of growth by 6-hydroxydopamine in cultured cells of neuronal and nonneuronal origin.
Topics: Alcohol Oxidoreductases; Animals; Astrocytoma; Carbon Isotopes; Cell Division; Cell Line; Cell Membr | 1973 |
Separation and determination of urinary homovanillic acid and iso-homovanillic acid by gas-liquid chromatography and electron capture detection.
Topics: Adolescent; Adult; Child; Chromatography, Gas; Creatine; Dihydroxyphenylalanine; Homovanillic Acid; | 1973 |
[Determination of homoprotocatechic acid in urine by a radioisotopic method].
Topics: Adult; Carbon Isotopes; Catechols; Child; Chromatography, Paper; Dihydroxyphenylalanine; Humans; Met | 1972 |
[Catecholamine excretion in children with neurogenic tumors of the mediastinum].
Topics: Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Epinephrine; Female; Ganglioneuroma; Huma | 1972 |
Iso-homovanillic acid determination in human urine.
Topics: Chromatography, Paper; Dihydroxyphenylalanine; Humans; Hydrogen-Ion Concentration; Isomerism; Method | 1971 |
Metabolism of L-3,4-dihydroxyphenylalanine-2,5,6-3H and 3,4-dihydroxyphenylethylamine-2-14C in a patient with neuroblastoma.
Topics: Carbon Isotopes; Chromatography, Paper; Creatinine; Dihydroxyphenylalanine; Dopamine; Female; Humans | 1971 |
Fluorometric method for quantitatively estimating urinary dihydroxyphenylethylamine (dopamine), dihydroxyphenylalanine (dopa), and dihydroxyphenylacetic acid (dopac).
Topics: Aluminum; Bone Neoplasms; Dihydroxyphenylalanine; Dopamine; Electrophoresis; Ethylenediamines; Fluor | 1971 |
[Catecholamine metabolism in the tissue of malignant and benign tumors of the sympathetic nervous system].
Topics: Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Microscopy, Electron; Neurobl | 1971 |
Catecholamine metabolism in neuroblastoma.
Topics: Adolescent; Adult; Catecholamines; Child; Child, Preschool; Chromatography, Paper; Dihydroxyphenylal | 1968 |
Neuroblastoma. Newer chemical diagnostic tests.
Topics: Catecholamines; Chemical Phenomena; Chemistry; Child; Diagnosis, Differential; Dihydroxyphenylalanin | 1968 |
Tyrosine hydroxylase activity in human adrenals and tumours of the neural crest.
Topics: Adrenal Glands; Animals; Dihydroxyphenylalanine; Guinea Pigs; Humans; In Vitro Techniques; Mixed Fun | 1965 |