dihydroxyphenylalanine and Nerve Degeneration studies

Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

Excerpt	Relevance	Reference
" However, they do little to combat the underlying degeneration of dopaminergic neurones in the substantia nigra pars compacta (SNc) and their long-term use is associated with the appearance of adverse effects such as L-DOPA-induced dyskinesia."	2.46	Therapeutic potential of targeting group III metabotropic glutamate receptors in the treatment of Parkinson's disease. ( Duty, S, 2010)
"With respect to Parkinson's disease PET and later SPECT allowed the number of dopaminergic neurons to be assessed in vivo."	2.46	[Nuclear medicine imaging in patients with Parkinson's syndrome: an update]. ( Schwarz, J, 2010)
"The selective VTA DAergic neuron degeneration results in lower DA outflow in the hippocampus and nucleus accumbens (NAc) shell."	1.46	Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease. ( Aversa, D; Berretta, N; Cavallucci, V; Coccurello, R; Cordella, A; Cutuli, D; D'Amelio, M; De Bartolo, P; Dell'Acqua, MC; Federici, M; Giacovazzo, G; Keller, F; Krashia, P; Latagliata, EC; Marino, R; Mercuri, NB; Nobili, A; Petrosini, L; Puglisi-Allegra, S; Rizzo, FR; Sancandi, M; Viscomi, MT, 2017)
" The long-term use of LD is limited by the development of L-DOPA-induced dyskinesias and dystonia."	1.39	The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and cytological preservation in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia. ( Aley-Medina, P; Anaya-Martínez, V; Avila-Costa, MR; Espinosa-Villanueva, J; García-Ruiz, R; Gutiérrez-Valdez, AL; Montiel-Flores, E; Reynoso-Erazo, L; Sánchez-Betancourt, J; Torres-Esquivel, C; Tron-Alvarez, R, 2013)
" The stronger in vivo effect of (+)-catechin on L-DOPA methylation compared to the other dietary compounds is due to its better bioavailability in vivo."	1.39	Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. ( Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT, 2013)

Timeframe	Studies, this research(%)	All Research%
pre-1990	26 (61.90)	18.7374
1990's	4 (9.52)	18.2507
2000's	6 (14.29)	29.6817
2010's	5 (11.90)	24.3611
2020's	1 (2.38)	2.80

Authors	Studies
Guo, Q	1
Wang, B	1
Wang, X	1
Smith, WW	1
Zhu, Y	1
Liu, Z	1
Nobili, A	1
Latagliata, EC	1
Viscomi, MT	1
Cavallucci, V	1
Cutuli, D	1
Giacovazzo, G	1
Krashia, P	1
Rizzo, FR	1
Marino, R	1
Federici, M	1
De Bartolo, P	1
Aversa, D	1
Dell'Acqua, MC	1
Cordella, A	1
Sancandi, M	1
Keller, F	1
Petrosini, L	1
Puglisi-Allegra, S	1
Mercuri, NB	1
Coccurello, R	1
Berretta, N	1
D'Amelio, M	1
Gutiérrez-Valdez, AL	1
García-Ruiz, R	1
Anaya-Martínez, V	1
Torres-Esquivel, C	1
Espinosa-Villanueva, J	1
Reynoso-Erazo, L	1
Tron-Alvarez, R	1
Aley-Medina, P	1
Sánchez-Betancourt, J	1
Montiel-Flores, E	1
Avila-Costa, MR	1
Duty, S	1
Schwarz, J	1
Kang, KS	1
Yamabe, N	1
Wen, Y	1
Fukui, M	1
Zhu, BT	1
Ruprecht-Dörfler, P	1
Berg, D	1
Tucha, O	1
Benz, P	1
Meier-Meitinger, M	1
Alders, GL	1
Lange, KW	1
Becker, G	1
Skaper, SD	1
Negro, A	1
Facci, L	1
Dal Toso, R	1
Tedroff, J	1
Aquilonius, SM	1
Hartvig, PG	1
Långström, B	1
Nagasawa, H	1
Tanji, H	1
Nomura, H	1
Saito, H	1
Itoyama, Y	1
Kimura, I	1
Tuji, S	1
Fujiwara, T	1
Iwata, R	1
Itoh, M	1
Ido, T	1
Laureys, S	1
Salmon, E	1
Garraux, G	1
Peigneux, P	1
Lemaire, C	1
Degueldre, C	1
Franck, G	1
Liang, SL	1
Pan, JT	1
Kordower, JH	1
Emborg, ME	1
Bloch, J	1
Ma, SY	1
Chu, Y	1
Leventhal, L	1
McBride, J	1
Chen, EY	1
Palfi, S	1
Roitberg, BZ	1
Brown, WD	1
Holden, JE	1
Pyzalski, R	1
Taylor, MD	1
Carvey, P	1
Ling, Z	1
Trono, D	1
Hantraye, P	1
Déglon, N	1
Aebischer, P	1
Arai, N	1
Furukawa, N	1
Miyamae, T	1
Goshima, Y	1
Sasaki, Y	1
Ohshima, E	1
Suzuki, F	1
Fujita, K	1
Misu, Y	1
Thobois, S	1
Guillouet, S	1
Broussolle, E	1
Ishihara, K	1
Nonaka, A	1
Fukui, T	1
Kawamura, M	1
Shiota, J	1
Nakano, I	1
Izumi, K	2
Inoue, N	1
Shirabe, T	1
Miyazaki, T	1
Kuroiwa, Y	1
Javoy, F	1
Agid, Y	1
Bouvet, D	1
Glowinski, J	1
Steg, G	1
Bernheimer, H	1
Birkmayer, W	1
Hornykiewicz, O	2
Jellinger, K	1
Seitelberger, F	1
Ungerstedt, U	2
Ziegler, DK	2
Schimke, RN	2
Kepes, JJ	1
Rose, DL	1
Klinkerfuss, G	2
Chase, TN	1
Giacobini, E	1
Toyama, M	1
Maeda, T	2
Shimizu, N	2
Kehr, W	1
Tohyama, M	1
Kashiba, A	1
Ljungberg, T	1
Steele, JC	1
Imura, H	1
Nakai, Y	1
Matsukura, S	1
Matsuyama, H	1
Jonsson, G	2
Sachs, C	2
Sharpe, JA	1
Rewcastle, NB	1
Lloyd, KG	1
Hill, M	1
Tasker, RR	1
Brait, K	1
Fahn, S	1
Schwarz, GA	1
Powell, HC	1
London, GW	1
Lampert, PW	1
Reger, JF	1
Holbrook, JR	1
Pozos, RS	1
Critchley, E	1
Descarries, L	1
Saucier, G	1
Thoa, NB	1
Eichelman, B	1
Ng, LK	1
Kepes, J	1
Rose, D	1
Poirier, LJ	1
Singh, P	1
Sourkes, TL	1
Boucher, R	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Adenosine A2A Blockade With KW-6002 in Parkinson's Disease[NCT00006337]	Phase 2	16 participants	Interventional	2000-10-31	Completed
Effect of Antiglutamatergic Treatment in Parkinson's Disease[NCT00013624]	Phase 2	20 participants	Interventional	2001-03-31	Completed
Effects of Monoamine Reuptake Inhibitor NS2330 in Parkinson's Disease[NCT00006077]	Phase 2	50 participants	Interventional	2000-08-31	Completed
Effect of Serotoninergic Treatment in Parkinson's Disease[NCT00009048]	Phase 2	30 participants	Interventional	2001-01-31	Completed
Levetiracetam Treatment of L-dopa Induced Dyskinesias[NCT00076674]	Phase 2	40 participants	Interventional	2004-01-31	Completed
AMPA Receptor Blockade With LY300164 in the Treatment of Parkinson's Disease[NCT00004576]	Phase 2	20 participants	Interventional	2000-02-29	Completed
Prognostic Value of FP-CIT-SPECT in Patients With Parkinson´s Disease[NCT01038310]		25 participants (Actual)	Observational	2010-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Therapeutic potential of targeting group III metabotropic glutamate receptors in the treatment of Parkinson's disease. British journal of pharmacology, 2010, Volume: 161, Issue:2 Topics: Animals; Basal Ganglia; Dihydroxyphenylalanine; Humans; Nerve Degeneration; Neuroprotective Agents;	2010
[Nuclear medicine imaging in patients with Parkinson's syndrome: an update]. Der Nervenarzt, 2010, Volume: 81, Issue:10 Topics: Animals; Brain; Dihydroxyphenylalanine; Disease Progression; Dopamine; Energy Metabolism; Fluorodeox	2010
Functional positron emission tomographic studies of striatal dopaminergic activity. Changes induced by drugs and nigrostriatal degeneration. Advances in neurology, 1996, Volume: 69 Topics: Animals; Antiparkinson Agents; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Neostriatum; Nerv	1996
Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson's disease. Neurophysiologie clinique = Clinical neurophysiology, 2001, Volume: 31, Issue:5 Topics: Aging; Animals; Antiparkinson Agents; Basal Ganglia; Brain Tissue Transplantation; Cell Transplantat	2001
Pathological aspects on Parkinson's syndrome. Acta neurologica Scandinavica. Supplementum, 1972, Volume: 51 Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Central Nervous System; Chlorpromazine; Corpus Stria	1972

Article	Year
Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models. Cells, 2021, 07-21, Volume: 10, Issue:8 Topics: Adenine; Animals; Animals, Genetically Modified; Antioxidants; Antiparkinson Agents; Astrocytes; Aut	2021
Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease. Nature communications, 2017, 04-03, Volume: 8 Topics: Alzheimer Disease; Animals; Apoptosis; Cell Death; Dendritic Spines; Dihydroxyphenylalanine; Disease	2017
The combination of oral L-DOPA/rimonabant for effective dyskinesia treatment and cytological preservation in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia. Behavioural pharmacology, 2013, Volume: 24, Issue:8 Topics: Administration, Oral; Animals; Cannabinoid Receptor Antagonists; Corpus Striatum; Dihydroxyphenylala	2013
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. Brain research, 2013, Feb-25, Volume: 1497 Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catech	2013
Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease. NeuroImage, 2003, Volume: 18, Issue:2 Topics: Adult; Dihydroxyphenylalanine; Dominance, Cerebral; Female; Fluorine Radioisotopes; Genetic Predispo	2003
Brain-derived neurotrophic factor selectively rescues mesencephalic dopaminergic neurons from 2,4,5-trihydroxyphenylalanine-induced injury. Journal of neuroscience research, 1993, Mar-01, Volume: 34, Issue:4 Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Dihydroxyphenylalanine;	1993
PET study of cerebral glucose metabolism and fluorodopa uptake in patients with corticobasal degeneration. Journal of the neurological sciences, 1996, Volume: 139, Issue:2 Topics: Aged; Apraxias; Atrophy; Basal Ganglia; Basal Ganglia Diseases; Brain Diseases; Cerebral Cortex; Cer	1996
Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration. Journal of neurology, 1999, Volume: 246, Issue:12 Topics: Aged; Basal Ganglia; Brain Diseases; Cerebral Cortex; Dihydroxyphenylalanine; Female; Fluorodeoxyglu	1999
An endogenous serotonergic rhythm acting on 5-HT(2A) receptors may be involved in the diurnal changes in tuberoinfundibular dopaminergic neuronal activity and prolactin secretion in female rats. Neuroendocrinology, 2000, Volume: 72, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amp	2000
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (New York, N.Y.), 2000, Oct-27, Volume: 290, Issue:5492 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Animals; Antigens, CD; Dihydroxyphenylalanine;	2000
DOPA cyclohexyl ester, a competitive DOPA antagonist, protects glutamate release and resultant delayed neuron death by transient ischemia in hippocampus CA1 of conscious rats. Neuroscience letters, 2001, Feb-23, Volume: 299, Issue:3 Topics: Animals; Brain Ischemia; Cell Death; Dihydroxyphenylalanine; Glutamic Acid; Hippocampus; Levodopa; M	2001
Lewy body-free nigral degeneration--a case report. Journal of the neurological sciences, 2002, Jun-15, Volume: 198, Issue:1-2 Topics: Aged; Dihydroxyphenylalanine; Fatal Outcome; Female; Humans; Lewy Bodies; Nerve Degeneration; Parkin	2002
Response to levodopa therapy in striatonigral degeneration. Lancet (London, England), 1972, Sep-30, Volume: 2, Issue:7779 Topics: Basal Ganglia; Corpus Striatum; Diagnosis, Differential; Dihydroxyphenylalanine; Humans; Nerve Degen	1972
In vivo estimation of tyrosine hydroxylation in the dopaminergic terminals of the rat neostriatum. The Journal of pharmacy and pharmacology, 1974, Volume: 26, Issue:3 Topics: Animals; Corpus Striatum; Dextroamphetamine; Dihydroxyphenylalanine; Dopamine; Hydroxylation; Male;	1974
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. Journal of the neurological sciences, 1973, Volume: 20, Issue:4 Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D	1973
Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. Acta physiologica Scandinavica. Supplementum, 1971, Volume: 367 Topics: Animals; Apomorphine; Brain Chemistry; Brain Injuries; Carboxy-Lyases; Dihydroxyphenylalanine; Dopam	1971
Late onset ataxia, rigidity, and peripheral neuropathy. A familial syndrome with variable therapeutic response to levodopa. Archives of neurology, 1972, Volume: 27, Issue:1 Topics: Adult; Aged; Brain; Cerebellar Ataxia; Dihydroxyphenylalanine; Electromyography; Female; Genes, Domi	1972
Serotonergic-dopaminergic interactions and extrapyramidal function. Advances in biochemical psychopharmacology, 1974, Volume: 11, Issue:0 Topics: Biogenic Amines; Brain; Dihydroxyphenylalanine; Dopamine; Extrapyramidal Tracts; Humans; Huntington	1974
Biochemistry of synaptic plasticity studied in single neurons. Advances in biochemical psychopharmacology, 1970, Volume: 2 Topics: Acetylcholine; Acetylcholinesterase; Acyltransferases; Animals; Cats; Cattle; Chick Embryo; Chromato	1970
Detailed noradrenaline pathways of locus coeruleus neuron to the cerebral cortex with use of 6-hydroxydopa. Brain research, 1974, Oct-11, Volume: 79, Issue:1 Topics: Animals; Brain Mapping; Cerebral Cortex; Cerebral Ventricles; Corpus Callosum; Corpus Striatum; Dihy	1974
Temporal changes in catecholamine synthesis of rat forebrain structures after axotomy. Journal of neural transmission, 1974, Volume: 35, Issue:4 Topics: Animals; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Feedba	1974
Fluorescence and electron microscopic analysis of axonal change of coerulo-cortical noradrenaline neuron system following destruction of locus coeruleus and administration of 6-hydroxydopa in the rat brain. Medical journal of Osaka University, 1974, Volume: 24, Issue:4 Topics: Animals; Axons; Cerebral Cortex; Cerebral Ventricles; Dihydroxyphenylalanine; Male; Microscopy, Fluo	1974
Central dopamine neurons and sensory processing. Journal of psychiatric research, 1974, Volume: 11 Topics: Animals; Apomorphine; Auditory Perception; Behavior, Animal; Brain; Corpus Striatum; Dihydroxyphenyl	1974
Progressive supranuclear palsy. Brain : a journal of neurology, 1972, Volume: 95, Issue:4 Topics: Aged; Autopsy; Brain; Brain Diseases; Brain Stem; Bulbar Palsy, Progressive; Cerebellar Nuclei; Dien	1972
Effect of intravenous infusion of L-DOPA on plasma growth hormone levels in man. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1973, Volume: 5, Issue:1 Topics: Adult; Aged; Anorexia Nervosa; Blood Glucose; Central Nervous System Diseases; Dihydroxyphenylalanin	1973
Pharmacological modifications of the 6-hydroxy-dopa induced degeneration of central noradrenaline neurons. Biochemical pharmacology, 1973, Jul-15, Volume: 22, Issue:14 Topics: Amphetamine; Animals; Brain; Caudate Nucleus; Cerebral Cortex; Chromatography; Dihydroxyphenylalanin	1973
Striatonigral degeneration. Response to levodopa therapy with pathological and neurochemical correlation. Journal of the neurological sciences, 1973, Volume: 19, Issue:3 Topics: Basal Ganglia; Carboxy-Lyases; Cerebellum; Cerebral Cortex; Corpus Striatum; Diencephalon; Dihydroxy	1973
Sporadic and familial parkinsonism and motor neuron disease. Neurology, 1973, Volume: 23, Issue:9 Topics: Aged; Amantadine; Amyotrophic Lateral Sclerosis; Cerebellar Diseases; Corpus Striatum; Dihydroxyphen	1973
Neurofibrillary tangles in progressive supranuclear palsy. Electron microscopic observations. Journal of neuropathology and experimental neurology, 1974, Volume: 33, Issue:1 Topics: Aged; Amantadine; Brain; Brain Diseases; Bulbar Palsy, Progressive; Dementia; Dihydroxyphenylalanine	1974
Selective 6-hydroxy-DOPA induced degeneration of central and peripheral noradrenaline neurons. Brain research, 1972, May-26, Volume: 40, Issue:2 Topics: Animals; Cerebellar Cortex; Cerebral Cortex; Dihydroxyphenylalanine; Hydroxylation; Male; Mice; Micr	1972
The fine structure of cerebellar lesions after L-dopa administration in the dog. Experimental neurology, 1972, Volume: 35, Issue:3 Topics: Animals; Caudate Nucleus; Cerebellar Cortex; Cerebral Cortex; Corpus Callosum; Corpus Striatum; Dihy	1972
Clinical manifestations of essential tremor. Journal of neurology, neurosurgery, and psychiatry, 1972, Volume: 35, Issue:3 Topics: Adult; Aged; Amantadine; Ataxia; Chlordiazepoxide; Dihydroxyphenylalanine; Female; Humans; Male; Mep	1972
Disappearance of the locus coeruleus in the rat after intraventricular 6-hydroxdopamine. Brain research, 1972, Feb-25, Volume: 37, Issue:2 Topics: Animals; Brain Stem; Cerebral Ventricles; Dihydroxyphenylalanine; Dopamine; Male; Microscopy, Fluore	1972
Shock-induced aggression: effects of 6-hydroxydopamine and other pharmacological agents. Brain research, 1972, Aug-25, Volume: 43, Issue:2 Topics: Aggression; Amphetamine; Animals; Apomorphine; Brain; Catecholamines; Desipramine; Dihydroxyphenylal	1972
A familial neurological disease with symptomatic response to levodopa. Transactions of the American Neurological Association, 1971, Volume: 96 Topics: Adult; Amyotrophic Lateral Sclerosis; Diagnosis, Differential; Dihydroxyphenylalanine; Female; Human	1971
Effect of amine precursors on the concentration of striatal dopamine and serotonin in cats with and without unilateral brain stem lesions. Brain research, 1967, Volume: 6, Issue:4 Topics: 5-Hydroxytryptophan; Animals; Basal Ganglia; Brain Stem; Cats; Dihydroxyphenylalanine; Dopamine; Ner	1967

dihydroxyphenylalanine and Nerve Degeneration

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