dihydroxyphenylalanine has been researched along with Muscle Spasticity in 2 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lal, S | 1 |
| Bernheimer, H | 1 |
| Birkmayer, W | 1 |
| Hornykiewicz, O | 1 |
| Jellinger, K | 1 |
| Seitelberger, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adenosine A2A Blockade With KW-6002 in Parkinson's Disease[NCT00006337] | Phase 2 | 16 participants | Interventional | 2000-10-31 | Completed | ||
| Effect of Antiglutamatergic Treatment in Parkinson's Disease[NCT00013624] | Phase 2 | 20 participants | Interventional | 2001-03-31 | Completed | ||
| Effects of Monoamine Reuptake Inhibitor NS2330 in Parkinson's Disease[NCT00006077] | Phase 2 | 50 participants | Interventional | 2000-08-31 | Completed | ||
| Effect of Serotoninergic Treatment in Parkinson's Disease[NCT00009048] | Phase 2 | 30 participants | Interventional | 2001-01-31 | Completed | ||
| Levetiracetam Treatment of L-dopa Induced Dyskinesias[NCT00076674] | Phase 2 | 40 participants | Interventional | 2004-01-31 | Completed | ||
| AMPA Receptor Blockade With LY300164 in the Treatment of Parkinson's Disease[NCT00004576] | Phase 2 | 20 participants | Interventional | 2000-02-29 | Completed | ||
| Prognostic Value of FP-CIT-SPECT in Patients With Parkinson´s Disease[NCT01038310] | 25 participants (Actual) | Observational | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for dihydroxyphenylalanine and Muscle Spasticity
| Article | Year |
|---|---|
Pathophysiology and pharmacotherapy of spasmodic torticollis: a review.
Topics: 5-Hydroxytryptophan; Animals; Antipsychotic Agents; Callitrichinae; Deanol; Dihydroxyphenylalanine; | 1979 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |
Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.
Topics: Aged; Autopsy; Basal Ganglia; Benzoates; Caudate Nucleus; Corpus Striatum; Dihydroxyphenylalanine; D | 1973 |