dihydroxyphenylalanine has been researched along with Melanoma in 261 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Homovanillic acid (HVA) was determined both in 45 patients with different forms of melanoma and those hospitalized on the suspicion of melanoma and in 15 healthy persons." | 8.75 | Clinical evaluation of a method of quantitative determination of homovanillic acid for the estimation of degree of tumor dissemination process in melanoma of the skin. ( Ivanova, VD; Raushenbakh, MO; Trapeznikov, NN; Yavorsky, VV, 1975) |
| "The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro." | 7.69 | Selective incorporation of the prototype melanoma seeker thiourea into nascent melanin: a chemical insight. ( d'Ischia, M; De Martino, L; Larsson, BS; Mårs, U; Napolitano, A; Palumbo, A; Prota, G, 1997) |
| "1) within melanoma cells to form the cellular toxin 2,4,5-trihydroxyphenylalanine (6-hydroxydopa)." | 7.67 | In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells. ( Cohen, G; Morrison, ME; Yagi, MJ, 1985) |
| "To determine whether plasma 5-S-cysteinyldopa levels are useful in following up patients at risk for melanoma, we measured plasma 5-S-cysteinyldopa in patients with dysplastic nevus syndrome and/or malignant melanoma and in control subjects." | 7.67 | Plasma 5-S-cysteinyldopa differentiates patients with primary and metastatic melanoma from patients with dysplastic nevus syndrome and normal subjects. ( Fletcher, WS; Ilias, A; Palmquist, M; Peterson, LL; Tucker, MA; Woodward, WR, 1988) |
| "The concentrations of dopa, cysteinyldopas, 5-S-glutathionyldopa, gamma-glutamyl-5-S-cysteinyldopa and 5-S-cysteinylglycinedopa, were analysed in homogenates of cultured human melanoma cells and in culture media." | 7.67 | Dopaquinone addition products in cultured human melanoma cells. ( Carstam, R; Hansson, C; Lindbladh, C; Rorsman, H; Rosengren, E, 1987) |
| "To develop a biochemical diagnosis for malignant melanomas, 5-S-cysteinyldopa in the tissues of malignant melanomas and other pigmented tumors were quantitatively analysed." | 7.67 | [Biochemical diagnoses of malignant melanomas with determinations of 5-S-cysteinyldopa in lesions]. ( Morishima, T; Sameshima, T, 1989) |
| "The production of 5-S-cysteinyldopa by a newly established melanoma cell line GAK is reported." | 7.67 | [A newly established melanoma cell line (GAK) with 5-S-cysteinyldopa phenotype]. ( Kano, S; Kurihara, S; Nozawa, S; Ohta, H; Tsukazaki, K; Udagawa, Y, 1984) |
| "A tyrosinase purified from cultured human melanoma cells was studied for dopa oxidation and tyrosine oxygenation." | 7.66 | Dopa oxidation and tyrosine oxygenation by human melanoma tyrosinase. ( Jergil, B; Lindbladh, C; Rorsman, H; Rosengren, E, 1983) |
| "The effect of dopa, cysteine, and glutathione on 5-S-cysteinyldopa (5-S-CD) genesis in melanoma cells cultured in normal and tyrosine- and cysteine-free media has been studied." | 7.66 | Effect of DOPA-loading on glutathione-dependent 5-S-cysteinyldopa genesis in melanoma cells in vitro. ( Ichihashi, M; Mishima, Y; Mojamdar, M, 1982) |
| "This study examines 5-S-cysteinyldopa, which is a melanoma-associated marker, and sialic acid whose increase appears to be a common feature of numerous cancers." | 7.66 | Urine excretion of 5-S-cysteinyldopa and serum sialic acid as tumor markers in human melanomas. ( Berthelot, P; Decaux, F; Jardillier, JC; Kalis, B; Marnot, D; Warren, L, 1983) |
| "The distribution of gamma-glutamyl transpeptidase (gamma-GTP), tyrosinase, and 5-S-cysteinyldopa (5-S-CD) within melanoma cells has been studied in vitro as well as in vivo." | 7.66 | gamma-Glutamyl transpeptidase, tyrosinase, and 5-S-cysteinyldopa production in melanoma cells. ( Ichihashi, M; Mishima, Y; Mojamdar, M, 1983) |
| "Free dopa and 5-S-cysteinyldopa were extracted from two human melanomas." | 7.66 | Free and bound 5-S-cysteinyldopa and dopa in human malignant melanomas. ( Agrup, G; Hansson, C; Rorsman, H; Rosengren, AM; Rosengren, E, 1978) |
| "In a total of 1,828 determinations, urinary excretion of 5-S-Cysteinyldopa was studied over a period of three years in 384 patients treated for melanoma or with metastases of malignant melanoma." | 7.66 | [5-S-cysteinyldopa in the urine - a "tumor test" for malignant melanoma? Comparison with the usual laboratory examinations]. ( Graef, V; Paul, E; Ruppel, R, 1980) |
| "Determinations of the urinary excretion of 5-S-cysteinyldopa were performed in 571 patients previously treated by surgery for melanoma or melanoma metastasis." | 7.66 | 5 years' experience of 5-S-cysteinyldopa in melanoma diagnosis. ( Agrup, G; Agrup, P; Andersson, T; Hafström, L; Hansson, C; Jacobsson, S; Jönsson, PE; Rorsman, H; Rosengren, AM; Rosengren, E, 1979) |
| "Determination of urine cysteinyldopa excretion is the most sensitive chemical test for the detection of melanoma metastases and has been successfully applied during the Scandinavian winter, when sun irradiation is low." | 7.66 | The urinary melanogen cysteinyldopa in melanoma and in suntanning: Australian experience. ( Nixon, PF, 1978) |
| "This study analyzed the free and protein-bound forms of dopa, 5-S-cysteinyldopa (5-S-CD), and 5-S-glutathionedopa (5-S-GD) in B16 and Harding-Passey (HP) mouse melanomas to investigate the role of these catechols for melanogenesis and melanosome morphogenesis, inasmuch as these tumors produce melanosomes different in color and ultrastructure, i." | 7.66 | Characterization of structural properties for morphologic differentiation of melanosomes. III. free and protein-bound dopa and 5-S-cysteinyldopa in B16 and Harding-Passey melanomas. ( Fujita, K; Homma, K; Ito, S; Jimbow, K; Kiyota, M, 1983) |
| "The growth inhibitory effect of 6-hydroxydopa, a cytotoxic analog of L-dopa, was studied in melanotic and amelanotic Cloudman melanoma, mouse fibroblast L929 and Chinese hamster ovary cells." | 7.66 | Selective toxicity of 6-hydroxydopa for melanoma cells. ( Byers, L; Ratliff, J; Wick, MM, 1979) |
| "The activities of NADP-linked dehydrogenases in the cytosol of amelanotic, black melanotic and brown melanotic hamster melanoma are presented." | 7.66 | The role of NADP-dependent dehydrogenases in hydroxylation of tyrosine in hamster melanoma. ( Scisłowski, PW; Słominski, A, 1983) |
| "We measured free and total 5-S-cysteinyldopa excretion in 24-h urine specimens from nine patients with malignant melanoma and forty-five controls, and found that the levels of 5-S-cysteinyldopa excretion (measured by a fluorometric method) were greatly increased in the melanoma patients." | 7.66 | Urinary free and conjugated 5-S-cysteinyldopa in normal subjects and in patients with melanoma. ( Graef, V; Paul, E, 1982) |
| "In case of uncharacteristic patient complaints or slightly pathologic BSR or liver enzyme levels in patients, suffering from melanoma, the determination of 5-S-cysteinyldopa in the 24-h-urine may be of great diagnostic value." | 7.66 | [5-S-cysteinyldopa determination in the urine. Its value for monitoring in melanoma patients]. ( Graef, V; Hellwich, M; Paul, E; Ruppel, R, 1983) |
| "The effects of theophylline and melanocyte-stimulating hormone on B16 melanoma cells in culture cells were studied by electron microscopy and dopa cytochemistry." | 7.66 | Electron microscopic and cytochemical observations of theophylline and melanocyte-stimulating hormone effects on melanoma cells in culture. ( Hu, F; Mah, K; Teramura, DJ, 1982) |
| "Cysteinyldopas and Dopa in the urine and tissues of Japanese melanoma patients were investigated quantitatively by means of high-performance liquid chromatography." | 7.66 | Cysteinyldopa isomers and dopa in lesions and urine of Japanese patients with malignant melanoma. ( Fujita, M; Fukada, E; Hanawa, S; Morishima, T; Nagashima, N; Saito, M; Tatsumi, F, 1983) |
| "With the aid of gas chromatography and mass spectrometry a metabolite of dopa, 3-methoxytyrosine, has been demonstrated in the urine of 2 patients with melanoma metastases, the amounts excreted being 4." | 7.65 | Demonstration of 3-methoxytyrosine in the urine of melanoma patients. ( Agrup, G; Bengtsson, M; Falck, B; Persson, K; Rorsman, H; Rosengren, AM; Rosengren, E, 1976) |
| "The concentrations of dopa and 5-S-cysteinyldopa were determined in the various cell fractions of Harding-Passey melanomas." | 7.65 | Intracellular distribution of dopa and 5-S-cysteinyldopa in Harding-Passey melanoma. ( Agrup, G; Falck, B; Rorsman, H; Rosengren, AM; Rosengren, E, 1977) |
| "A newly discovered amino acid, 5-S-cysteinyldopa, present in the urine of healthy subjects is excreted in pathological amounts in many patients suffering from melanoma metastases." | 7.65 | 5-S-cysteinyldopa in the urine of melanoma patients. ( Agrup, G; Agrup, P; Andersson, T; Falck, B; Hansson, JA; Jacobsson, S; Rorsman, H; Rosengren, AM; Rosengren, E, 1977) |
| "Homovanillic acid (HVA) was determined both in 45 patients with different forms of melanoma and those hospitalized on the suspicion of melanoma and in 15 healthy persons." | 4.75 | Clinical evaluation of a method of quantitative determination of homovanillic acid for the estimation of degree of tumor dissemination process in melanoma of the skin. ( Ivanova, VD; Raushenbakh, MO; Trapeznikov, NN; Yavorsky, VV, 1975) |
| "The effects of calcium D-pantetheine-S-sulfonate (PaSSO3Ca) on human pigmentation were examined by in vitro assays using two types of human melanocytes: normal adult melanocytes (HNM) and M4Be melanoma cells." | 3.70 | Depigmenting effects of calcium D-pantetheine-S-sulfonate on human melanocytes. ( Coutadeur, MC; Franchi, J; Kupferberg, A; Marteau, C; Mersel, M, 2000) |
| " To address this issue, the levels of CysH and GSH were varied in normal melanocytes and melanoma cells using buthionine sulfoximine (BSO), an inhibitor of GSH biosynthesis." | 3.70 | Co-regulation of melanin precursors and tyrosinase in human pigment cells: roles of cysteine and glutathione. ( Benathan, M; Furumura, M; Hearing, VJ; Kobayashi, N; Panizzon, RG; Virador, V, 1999) |
| "The mechanism of selective incorporation of thiourea into melanotic melanoma was investigated by model experiments in which the effect of the compound was examined at various stages of melanogenesis in vitro." | 3.69 | Selective incorporation of the prototype melanoma seeker thiourea into nascent melanin: a chemical insight. ( d'Ischia, M; De Martino, L; Larsson, BS; Mårs, U; Napolitano, A; Palumbo, A; Prota, G, 1997) |
| "Tyrosinase isolated from cultured human melanoma cells was studied for tyrosine oxygenation activity." | 3.69 | Enzymatic and non-enzymatic oxygenation of tyrosine. ( Odh, G; Rorsman, H; Rosengren, E; Wittbjer, A, 1996) |
| "2-Thiouracil (TU), an antithyroid drug, is receiving growing interest as a specific tumor marker for malignant melanoma, owing to its capability of being selectively accumulated into active melanin-producing tissues." | 3.68 | Selective uptake of 2-thiouracil into melanin-producing systems depends on chemical binding to enzymically generated dopaquinone. ( d'Ischia, M; Iannone, A; Misuraca, G; Palumbo, A; Prota, G, 1990) |
| "The production of 5-S-cysteinyldopa by a newly established melanoma cell line GAK is reported." | 3.67 | [A newly established melanoma cell line (GAK) with 5-S-cysteinyldopa phenotype]. ( Kano, S; Kurihara, S; Nozawa, S; Ohta, H; Tsukazaki, K; Udagawa, Y, 1984) |
| "A tyrosinase obtained from cultured human melanoma cells was found to oxygenate 2,4-dihydroxyphenylalanine to the strongly cytotoxic amino acid 6-hydroxydopa (2,4,5-trihydroxyphenylalanine)." | 3.67 | Production of 6-hydroxydopa by human tyrosinase. ( Hansson, C; Rorsman, H; Rosengren, E; Wittbjer, A, 1985) |
| "The concentrations of dopa, cysteinyldopas, 5-S-glutathionyldopa, gamma-glutamyl-5-S-cysteinyldopa and 5-S-cysteinylglycinedopa, were analysed in homogenates of cultured human melanoma cells and in culture media." | 3.67 | Dopaquinone addition products in cultured human melanoma cells. ( Carstam, R; Hansson, C; Lindbladh, C; Rorsman, H; Rosengren, E, 1987) |
| "To develop a biochemical diagnosis for malignant melanomas, 5-S-cysteinyldopa in the tissues of malignant melanomas and other pigmented tumors were quantitatively analysed." | 3.67 | [Biochemical diagnoses of malignant melanomas with determinations of 5-S-cysteinyldopa in lesions]. ( Morishima, T; Sameshima, T, 1989) |
| "Melanoma tissues produce not only 5-S-cysteinyldopa (5-S-CD), a pheomelanin precursor, but also 5,6-dihydroxyindoles, eumelanin precursors." | 3.67 | Correlation between urinary melanin-related metabolites and tumour weight in melanoma-bearing mice. ( Fujita, K; Inoue, S; Ito, S; Wakamatsu, K, 1989) |
| "Significant levels of intracellular catecholamines were found in a human melanoma cell line and were enhanced by increasing the extracellular tyrosine concentration." | 3.67 | Inhibition of melanization in human melanoma cells by a serotonin uptake inhibitor. ( McEwan, M; Parsons, PG, 1987) |
| "To determine whether plasma 5-S-cysteinyldopa levels are useful in following up patients at risk for melanoma, we measured plasma 5-S-cysteinyldopa in patients with dysplastic nevus syndrome and/or malignant melanoma and in control subjects." | 3.67 | Plasma 5-S-cysteinyldopa differentiates patients with primary and metastatic melanoma from patients with dysplastic nevus syndrome and normal subjects. ( Fletcher, WS; Ilias, A; Palmquist, M; Peterson, LL; Tucker, MA; Woodward, WR, 1988) |
| "1) within melanoma cells to form the cellular toxin 2,4,5-trihydroxyphenylalanine (6-hydroxydopa)." | 3.67 | In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells. ( Cohen, G; Morrison, ME; Yagi, MJ, 1985) |
| "The natural catecholic amino acid 5-S-cysteinyl-3,4-dihydroxyphenylalanine (1) was selectively toxic to a variety of human tumor cell lines in culture and exhibited antitumor activity against L1210 leukemia and B-16 melanoma in mice at doses which were not toxic to the host." | 3.66 | Synthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalanines and related compounds. ( Fujita, K; Inoue, S; Ito, S; Yamamoto, Y, 1981) |
| "The effect of dopa, cysteine, and glutathione on 5-S-cysteinyldopa (5-S-CD) genesis in melanoma cells cultured in normal and tyrosine- and cysteine-free media has been studied." | 3.66 | Effect of DOPA-loading on glutathione-dependent 5-S-cysteinyldopa genesis in melanoma cells in vitro. ( Ichihashi, M; Mishima, Y; Mojamdar, M, 1982) |
| "Previous reports have shown that the tyrosinase activities of melanosomes and soluble tyrosinase isolated from melanoma were diminished when these preparations were incubated with 3,4-dihydroxyphenylalanine (dopa)." | 3.66 | Formation of melanin-tyrosinase complex and its possible significance as a model for control of melanin synthesis. ( Haberman, HF; Menon, IA, 1978) |
| "Free dopa and 5-S-cysteinyldopa were extracted from two human melanomas." | 3.66 | Free and bound 5-S-cysteinyldopa and dopa in human malignant melanomas. ( Agrup, G; Hansson, C; Rorsman, H; Rosengren, AM; Rosengren, E, 1978) |
| "Determinations of the urinary excretion of 5-S-cysteinyldopa were performed in 571 patients previously treated by surgery for melanoma or melanoma metastasis." | 3.66 | 5 years' experience of 5-S-cysteinyldopa in melanoma diagnosis. ( Agrup, G; Agrup, P; Andersson, T; Hafström, L; Hansson, C; Jacobsson, S; Jönsson, PE; Rorsman, H; Rosengren, AM; Rosengren, E, 1979) |
| "Determination of urine cysteinyldopa excretion is the most sensitive chemical test for the detection of melanoma metastases and has been successfully applied during the Scandinavian winter, when sun irradiation is low." | 3.66 | The urinary melanogen cysteinyldopa in melanoma and in suntanning: Australian experience. ( Nixon, PF, 1978) |
| "The growth inhibitory effect of 6-hydroxydopa, a cytotoxic analog of L-dopa, was studied in melanotic and amelanotic Cloudman melanoma, mouse fibroblast L929 and Chinese hamster ovary cells." | 3.66 | Selective toxicity of 6-hydroxydopa for melanoma cells. ( Byers, L; Ratliff, J; Wick, MM, 1979) |
| "The distribution of gamma-glutamyl transpeptidase (gamma-GTP), tyrosinase, and 5-S-cysteinyldopa (5-S-CD) within melanoma cells has been studied in vitro as well as in vivo." | 3.66 | gamma-Glutamyl transpeptidase, tyrosinase, and 5-S-cysteinyldopa production in melanoma cells. ( Ichihashi, M; Mishima, Y; Mojamdar, M, 1983) |
| " Carbidopa and DOPA together elevated 5SCD markedly in a dose-dependent manner to values higher than seen in some patients with metastatic malignant melanoma." | 3.66 | Urinary 5-S-cysteinyldopa in Parkinsonism after DOPA and carbidopa. ( Gunder, M; Miller, S; Stewart, RM, 1983) |
| "The medium of cultured melanoma cells was studied for tyrosine hydroxylation and dopa-oxidizing activity." | 3.66 | Tyrosinase activity in the medium of human melanoma cell cultures. ( Jergil, B; Lindbladh, C; Rorsman, H; Rosengren, E, 1983) |
| "A tyrosinase purified from cultured human melanoma cells was studied for dopa oxidation and tyrosine oxygenation." | 3.66 | Dopa oxidation and tyrosine oxygenation by human melanoma tyrosinase. ( Jergil, B; Lindbladh, C; Rorsman, H; Rosengren, E, 1983) |
| "The effects of theophylline and melanocyte-stimulating hormone on B16 melanoma cells in culture cells were studied by electron microscopy and dopa cytochemistry." | 3.66 | Electron microscopic and cytochemical observations of theophylline and melanocyte-stimulating hormone effects on melanoma cells in culture. ( Hu, F; Mah, K; Teramura, DJ, 1982) |
| "Cysteinyldopas and Dopa in the urine and tissues of Japanese melanoma patients were investigated quantitatively by means of high-performance liquid chromatography." | 3.66 | Cysteinyldopa isomers and dopa in lesions and urine of Japanese patients with malignant melanoma. ( Fujita, M; Fukada, E; Hanawa, S; Morishima, T; Nagashima, N; Saito, M; Tatsumi, F, 1983) |
| "This study analyzed the free and protein-bound forms of dopa, 5-S-cysteinyldopa (5-S-CD), and 5-S-glutathionedopa (5-S-GD) in B16 and Harding-Passey (HP) mouse melanomas to investigate the role of these catechols for melanogenesis and melanosome morphogenesis, inasmuch as these tumors produce melanosomes different in color and ultrastructure, i." | 3.66 | Characterization of structural properties for morphologic differentiation of melanosomes. III. free and protein-bound dopa and 5-S-cysteinyldopa in B16 and Harding-Passey melanomas. ( Fujita, K; Homma, K; Ito, S; Jimbow, K; Kiyota, M, 1983) |
| "The activities of NADP-linked dehydrogenases in the cytosol of amelanotic, black melanotic and brown melanotic hamster melanoma are presented." | 3.66 | The role of NADP-dependent dehydrogenases in hydroxylation of tyrosine in hamster melanoma. ( Scisłowski, PW; Słominski, A, 1983) |
| "In case of uncharacteristic patient complaints or slightly pathologic BSR or liver enzyme levels in patients, suffering from melanoma, the determination of 5-S-cysteinyldopa in the 24-h-urine may be of great diagnostic value." | 3.66 | [5-S-cysteinyldopa determination in the urine. Its value for monitoring in melanoma patients]. ( Graef, V; Hellwich, M; Paul, E; Ruppel, R, 1983) |
| "This study examines 5-S-cysteinyldopa, which is a melanoma-associated marker, and sialic acid whose increase appears to be a common feature of numerous cancers." | 3.66 | Urine excretion of 5-S-cysteinyldopa and serum sialic acid as tumor markers in human melanomas. ( Berthelot, P; Decaux, F; Jardillier, JC; Kalis, B; Marnot, D; Warren, L, 1983) |
| "We measured free and total 5-S-cysteinyldopa excretion in 24-h urine specimens from nine patients with malignant melanoma and forty-five controls, and found that the levels of 5-S-cysteinyldopa excretion (measured by a fluorometric method) were greatly increased in the melanoma patients." | 3.66 | Urinary free and conjugated 5-S-cysteinyldopa in normal subjects and in patients with melanoma. ( Graef, V; Paul, E, 1982) |
| "In a total of 1,828 determinations, urinary excretion of 5-S-Cysteinyldopa was studied over a period of three years in 384 patients treated for melanoma or with metastases of malignant melanoma." | 3.66 | [5-S-cysteinyldopa in the urine - a "tumor test" for malignant melanoma? Comparison with the usual laboratory examinations]. ( Graef, V; Paul, E; Ruppel, R, 1980) |
| "With the aid of gas chromatography and mass spectrometry a metabolite of dopa, 3-methoxytyrosine, has been demonstrated in the urine of 2 patients with melanoma metastases, the amounts excreted being 4." | 3.65 | Demonstration of 3-methoxytyrosine in the urine of melanoma patients. ( Agrup, G; Bengtsson, M; Falck, B; Persson, K; Rorsman, H; Rosengren, AM; Rosengren, E, 1976) |
| "A newly discovered amino acid, 5-S-cysteinyldopa, present in the urine of healthy subjects is excreted in pathological amounts in many patients suffering from melanoma metastases." | 3.65 | 5-S-cysteinyldopa in the urine of melanoma patients. ( Agrup, G; Agrup, P; Andersson, T; Falck, B; Hansson, JA; Jacobsson, S; Rorsman, H; Rosengren, AM; Rosengren, E, 1977) |
| "The concentrations of dopa and 5-S-cysteinyldopa were determined in the various cell fractions of Harding-Passey melanomas." | 3.65 | Intracellular distribution of dopa and 5-S-cysteinyldopa in Harding-Passey melanoma. ( Agrup, G; Falck, B; Rorsman, H; Rosengren, AM; Rosengren, E, 1977) |
| "F-FDOPA PET/CT disconfirmed this recurrence but revealed 2 FDOPA-avid left inguinal lymph nodes, confirmed on a subsequent F-FDG PET/CT." | 1.56 | Incidental Metastatic Melanoma Identified on 18F-FDOPA PET/CT With Confirmation by Histology. ( Aouidad, I; Jublanc, C; Montravers, F; Talbot, JN; Zhang-Yin, J, 2020) |
| "Taking a biopsy of malignant melanoma is generally contraindicated because of the high risk of inducing metastasis." | 1.32 | Rectal malignant melanoma diagnosed by N-isopropyl- p-123I-iodoamphetamine single photon emission computed tomography and 5-S-cysteinyl dopa: report of a case. ( Abe, K; Aoki, T; Hayashi, M; Kitamura, K; Koyanagi, Y; Mori, M; Saito, H; Sato, S; Tsuchida, A; Umezu, K; Yamagishi, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 231 (88.51) | 18.7374 |
| 1990's | 12 (4.60) | 18.2507 |
| 2000's | 11 (4.21) | 29.6817 |
| 2010's | 5 (1.92) | 24.3611 |
| 2020's | 2 (0.77) | 2.80 |
| Authors | Studies |
|---|---|
| Umemura, H | 2 |
| Kaji, T | 2 |
| Tachibana, K | 1 |
| Morizane, S | 1 |
| Yamasaki, O | 2 |
| Zhang-Yin, J | 1 |
| Jublanc, C | 1 |
| Aouidad, I | 1 |
| Montravers, F | 1 |
| Talbot, JN | 1 |
| Ikeda, Y | 1 |
| Wada, A | 1 |
| Hasegawa, T | 1 |
| Yokota, M | 1 |
| Koike, M | 1 |
| Ikeda, S | 1 |
| Yamada, H | 1 |
| Hakozaki, M | 1 |
| Uemura, A | 1 |
| Yamashita, T | 1 |
| Guo, S | 1 |
| Lin, CM | 1 |
| Xu, Z | 1 |
| Miao, L | 1 |
| Wang, Y | 1 |
| Huang, L | 1 |
| Otsuka, M | 1 |
| Asagoe, K | 1 |
| Takata, M | 1 |
| Iwatsuki, K | 1 |
| LERNER, AB | 1 |
| FITZPATRICK, TB | 3 |
| Gasowska-Bajger, B | 1 |
| Frackowiak-Wojtasek, B | 1 |
| Koj, S | 1 |
| Cichoń, T | 1 |
| Smolarczyk, R | 1 |
| Szala, S | 1 |
| Wojtasek, H | 1 |
| Ichikawa, A | 1 |
| Takagi, H | 1 |
| Suda, K | 1 |
| Yao, T | 1 |
| Konishi, H | 1 |
| Yamanaka, K | 1 |
| Mizutani, H | 1 |
| Leonard, JH | 1 |
| Marks, LH | 1 |
| Chen, W | 1 |
| Cook, AL | 1 |
| Boyle, GM | 1 |
| Smit, DJ | 1 |
| Brown, DL | 1 |
| Stow, JL | 1 |
| Parsons, PG | 3 |
| Sturm, RA | 1 |
| Sato, S | 1 |
| Aoki, T | 1 |
| Umezu, K | 1 |
| Mori, M | 1 |
| Hayashi, M | 1 |
| Saito, H | 1 |
| Kitamura, K | 1 |
| Tsuchida, A | 1 |
| Koyanagi, Y | 1 |
| Yamagishi, T | 1 |
| Abe, K | 1 |
| RILEY, V | 1 |
| HEMPEL, K | 5 |
| ERB, W | 1 |
| DEIMEL, M | 2 |
| SCOTT, JA | 1 |
| SEIJI, M | 8 |
| IWASHITA, S | 1 |
| KAUFMAN, HE | 1 |
| TAKAHASHI, H | 2 |
| IPPEN, H | 1 |
| BLOIS, MS | 5 |
| KALLMAN, RF | 1 |
| HIRSCH, HM | 2 |
| ZELICKSON, AS | 2 |
| HARTMANN, JF | 1 |
| Yamakoshi, J | 1 |
| Otsuka, F | 1 |
| Sano, A | 1 |
| Tokutake, S | 1 |
| Saito, M | 4 |
| Kikuchi, M | 1 |
| Kubota, Y | 1 |
| Yatabe, J | 1 |
| Sanada, H | 1 |
| Seshadri, N | 1 |
| Wat, J | 1 |
| Balan, K | 1 |
| Watabe, H | 1 |
| Valencia, JC | 1 |
| Le Pape, E | 1 |
| Yamaguchi, Y | 1 |
| Nakamura, M | 1 |
| Rouzaud, F | 1 |
| Hoashi, T | 1 |
| Kawa, Y | 1 |
| Mizoguchi, M | 1 |
| Hearing, VJ | 6 |
| Adachi, K | 1 |
| Halprin, KM | 1 |
| Coward, RF | 1 |
| Smith, P | 1 |
| Middleton, JE | 1 |
| Meier, DA | 2 |
| Beierwaltes, WH | 2 |
| Counsell, R | 1 |
| Counsell, RE | 1 |
| Dernalowicz, E | 1 |
| Trojanowski, J | 1 |
| Bomirski, A | 3 |
| Dominiczak, T | 1 |
| Hu, F | 5 |
| Mojamdar, M | 7 |
| Ichihashi, M | 7 |
| Mishima, Y | 12 |
| Jönsson, PE | 3 |
| Agrup, G | 14 |
| Arnbjörnsson, E | 1 |
| Hafström, L | 3 |
| Rorsman, H | 31 |
| Pavel, S | 3 |
| Vyhnálková, V | 1 |
| Matous, B | 2 |
| Duchon, J | 3 |
| Kubíková, M | 1 |
| Stewart, RM | 1 |
| Miller, S | 1 |
| Gunder, M | 1 |
| Jergil, B | 2 |
| Lindbladh, C | 4 |
| Rosengren, E | 26 |
| Ito, S | 11 |
| Jimbow, K | 5 |
| Kato, T | 3 |
| Kiyota, M | 2 |
| Fujita, K | 8 |
| Homma, K | 1 |
| Kågedal, B | 2 |
| Pettersson, A | 1 |
| Miranda, M | 1 |
| Botti, D | 1 |
| Scisłowski, PW | 1 |
| Słominski, A | 1 |
| Paul, E | 4 |
| Graef, V | 3 |
| Ruppel, R | 2 |
| Hellwich, M | 1 |
| Morishima, T | 7 |
| Fukada, E | 5 |
| Nagashima, N | 4 |
| Tatsumi, F | 2 |
| Fujita, M | 3 |
| Hanawa, S | 5 |
| Imokawa, G | 1 |
| White, R | 1 |
| Roman, NA | 1 |
| Marnot, D | 1 |
| Decaux, F | 1 |
| Berthelot, P | 1 |
| Kalis, B | 1 |
| Jardillier, JC | 1 |
| Warren, L | 1 |
| Watanabe, M | 1 |
| Aubert, C | 5 |
| Rougé, F | 3 |
| Galindo, JR | 1 |
| Nozawa, S | 1 |
| Ohta, H | 1 |
| Tsukazaki, K | 1 |
| Udagawa, Y | 1 |
| Kurihara, S | 1 |
| Kano, S | 1 |
| Inoi, T | 2 |
| Townsend, D | 1 |
| Guillery, P | 1 |
| King, RA | 1 |
| Miura, S | 1 |
| Ito, Y | 1 |
| Kasuga, T | 3 |
| Maruta, K | 1 |
| Kurahashi, T | 1 |
| Ekel, TM | 3 |
| Montague, PM | 2 |
| Nicholson, JM | 2 |
| Pawelek, J | 2 |
| Körner, A | 2 |
| Bergstrom, A | 1 |
| Bologna, J | 1 |
| Gavrilenko, IS | 7 |
| Rumjancev, PP | 1 |
| Bulycev, AG | 1 |
| Zarembskij, RA | 1 |
| Ivanov, II | 8 |
| Banda, PW | 3 |
| Tuttle, MS | 1 |
| Selmer, LE | 1 |
| Thatachari, YT | 1 |
| Sherry, AE | 2 |
| Teradaira, R | 1 |
| Inoue, S | 3 |
| Yamamoto, Y | 1 |
| Muskiet, FA | 1 |
| Budesínská, A | 1 |
| Ichihasi, M | 1 |
| Mah, K | 1 |
| Teramura, DJ | 1 |
| Morrison, LE | 1 |
| Orlow, SJ | 1 |
| Sakai, C | 1 |
| Urabe, K | 1 |
| Zhou, BK | 1 |
| Silvers, WK | 1 |
| Mintz, B | 1 |
| Dooley, TP | 1 |
| Gadwood, RC | 1 |
| Kilgore, K | 1 |
| Thomasco, LM | 1 |
| Goodall, T | 1 |
| Buffey, JA | 1 |
| Rennie, IG | 1 |
| Benson, M | 1 |
| Parsons, MA | 1 |
| Faulkner, MK | 1 |
| MacNeil, S | 1 |
| Iwashina, T | 1 |
| Alena, F | 1 |
| Yamada, K | 1 |
| Pankovich, J | 1 |
| Umemura, T | 1 |
| Mårs, U | 2 |
| Larsson, BS | 2 |
| Wittbjer, A | 2 |
| Odh, G | 1 |
| de Vries, TJ | 1 |
| Fourkour, A | 1 |
| Wobbes, T | 1 |
| Verkroost, G | 1 |
| Ruiter, DJ | 1 |
| van Muijen, GN | 1 |
| Palumbo, A | 2 |
| De Martino, L | 1 |
| d'Ischia, M | 2 |
| Napolitano, A | 1 |
| Prota, G | 3 |
| Tsukamoto, K | 1 |
| Furue, M | 1 |
| Sato, Y | 1 |
| Takayama, O | 1 |
| Akasu, R | 1 |
| Ohtake, N | 1 |
| Wakamatsu, K | 2 |
| Tamaki, K | 1 |
| Shimada, S | 1 |
| Bánfalvi, T | 1 |
| Bezzegh, A | 1 |
| Edesné, BM | 1 |
| Fejös, Z | 1 |
| Liszkay, G | 1 |
| Schumann, B | 1 |
| Kremmer, T | 1 |
| Ottó, S | 1 |
| Gilde, K | 1 |
| Benathan, M | 1 |
| Virador, V | 1 |
| Furumura, M | 1 |
| Kobayashi, N | 1 |
| Panizzon, RG | 1 |
| Franchi, J | 1 |
| Coutadeur, MC | 1 |
| Marteau, C | 1 |
| Mersel, M | 1 |
| Kupferberg, A | 1 |
| Dimitrakopoulou-Strauss, A | 1 |
| Strauss, LG | 1 |
| Burger, C | 1 |
| Graham, MM | 1 |
| Falck, B | 10 |
| Kennedy, BM | 1 |
| Rosengren, AM | 15 |
| Andersson, T | 4 |
| Persson, K | 2 |
| Gernand, E | 1 |
| Agrup, P | 3 |
| Jacobsson, S | 5 |
| Bengtsson, M | 1 |
| Hansson, JA | 1 |
| Menon, IA | 4 |
| Haberman, HF | 4 |
| Hansson, C | 8 |
| Drzewiecki, KT | 1 |
| Pawelek, JM | 1 |
| Zarembskiĭ, RA | 1 |
| Bobrova, VN | 7 |
| Rumiantseva, LN | 5 |
| Nixon, PF | 1 |
| Hearing, ED | 1 |
| Wick, MM | 1 |
| Byers, L | 1 |
| Ratliff, J | 1 |
| Berkelhammer, J | 1 |
| Caines, SM | 1 |
| Dexter, DL | 1 |
| Adelstein, EH | 1 |
| Oxenhandler, RW | 1 |
| Hook, RR | 1 |
| Foa, C | 1 |
| Lipcey, C | 1 |
| Steigleder, GK | 1 |
| Hunter, JA | 1 |
| Paterson, WD | 1 |
| Fairley, DJ | 1 |
| Cesarini, JP | 2 |
| Daveau, M | 1 |
| Picard, F | 1 |
| Fournier, E | 1 |
| Rivat, L | 1 |
| Rivat, C | 1 |
| Edholm, LE | 1 |
| Chen, YM | 1 |
| Chavin, W | 1 |
| Wrzolkowa, T | 1 |
| Voulot, C | 1 |
| Ortonne, JP | 1 |
| Prabhakaran, K | 6 |
| Oikawa, A | 2 |
| Hutton, IM | 2 |
| Tebbutt, S | 1 |
| Castro, JE | 1 |
| Lagrange, C | 1 |
| Williams-Smith, DL | 1 |
| Dunne, LJ | 1 |
| Evans, S | 1 |
| Pritchard, RG | 1 |
| Evans, EL | 1 |
| Trapeznikov, NN | 1 |
| Raushenbakh, MO | 1 |
| Ivanova, VD | 1 |
| Yavorsky, VV | 1 |
| Stringer, MJ | 2 |
| Stock, JA | 2 |
| Cobb, LM | 2 |
| Meunier, M | 1 |
| Vdovenko, VM | 6 |
| Rumjanceva, LN | 2 |
| Sestakov, AD | 1 |
| Cernyseva, LF | 1 |
| Pentland, M | 1 |
| Misuraca, G | 1 |
| Iannone, A | 1 |
| Carstam, R | 3 |
| Sjöberg, NO | 1 |
| Wirestrand, LE | 1 |
| Källberg, M | 1 |
| Arstrand, K | 1 |
| Enochs, WS | 1 |
| Hyslop, WB | 1 |
| Bennett, HF | 1 |
| Brown, RD | 1 |
| Koenig, SH | 1 |
| Swartz, HM | 1 |
| Sameshima, T | 1 |
| Kanematsu, S | 1 |
| Friedmann, PS | 1 |
| Gilchrest, BA | 1 |
| Chakraborty, C | 1 |
| Hatta, S | 1 |
| Hayashibe, K | 1 |
| Beyer, C | 1 |
| Fiedler, H | 1 |
| Wohlrab, W | 1 |
| Wozniak, KD | 1 |
| Edner, C | 1 |
| McEwan, M | 1 |
| Imai, Y | 1 |
| Akutsu, Y | 1 |
| Naoi, M | 1 |
| Takahashi, T | 1 |
| Nagatsu, T | 2 |
| Peterson, LL | 1 |
| Woodward, WR | 1 |
| Fletcher, WS | 1 |
| Palmquist, M | 1 |
| Tucker, MA | 1 |
| Ilias, A | 1 |
| Yamada, I | 1 |
| Seki, S | 1 |
| Matsubara, O | 1 |
| Suzuki, S | 1 |
| Croce, AC | 1 |
| Bottiroli, G | 1 |
| Prosperi, E | 1 |
| Supino, R | 1 |
| Stoward, PJ | 1 |
| DiSorbo, DM | 1 |
| Harris, NA | 1 |
| Nathanson, L | 1 |
| Morrison, ME | 1 |
| Yagi, MJ | 1 |
| Cohen, G | 1 |
| Pierson, HF | 1 |
| Meadows, GG | 1 |
| Harris, EB | 3 |
| Wong, CK | 1 |
| Vogel, CL | 1 |
| Dhru, D | 1 |
| Pretlow, TG | 1 |
| Boone, CW | 1 |
| Zawrocka-Wrzolkowa, T | 1 |
| Pautsch, F | 1 |
| Fukuzawa, H | 3 |
| Patel, RP | 2 |
| Okun, MR | 5 |
| Yee, WA | 1 |
| Wilgram, GF | 1 |
| Edelstein, LM | 3 |
| Otaki, N | 3 |
| Miyazaki, K | 3 |
| Miyazaki, N | 1 |
| Akiba, H | 1 |
| Holstein, TJ | 1 |
| Stowell, CP | 1 |
| Quevedo, WC | 1 |
| Zarcaro, RM | 1 |
| Bienieki, TC | 1 |
| Shimao, K | 1 |
| Anghileri, LJ | 1 |
| Miller, ES | 1 |
| Duke, PS | 2 |
| Hourani, BT | 1 |
| Demopoulos, HB | 1 |
| Stellar, S | 1 |
| Cooper, IS | 1 |
| Türler, K | 2 |
| Käser, H | 5 |
| McGinness, J | 1 |
| Corry, P | 1 |
| Proctor, P | 1 |
| Wagner, HP | 1 |
| Zuppinger, K | 1 |
| Zurbrügg, R | 1 |
| Donnellan, B | 3 |
| Pearson, SH | 1 |
| Edelstein, LE | 1 |
| Gan, EV | 1 |
| Swan, GA | 1 |
| Frenk, E | 1 |
| Kocsis, M | 1 |
| Fougère, C | 1 |
| Ruiz, F | 1 |
| Ephrussi, B | 1 |
| Nakayasu, M | 1 |
| Nohara, M | 1 |
| Tchen, TT | 1 |
| Hamada, T | 1 |
| Davidson, RL | 1 |
| Sudo, I | 1 |
| Okada, T | 1 |
| Umezawa, H | 1 |
| Takeuchi, T | 1 |
| Kirchheimer, WF | 2 |
| Kruszczyński, T | 2 |
| Robinson, E | 2 |
| Wajsbort, J | 2 |
| Hirshowitz, B | 1 |
| Mekori, T | 1 |
| Lieberman, AN | 1 |
| Shupack, JL | 1 |
| Shanin, AP | 1 |
| Jacobson, S | 1 |
| Olivecrona, H | 2 |
| Pomerantz, SH | 4 |
| Warner, MC | 2 |
| Morgan, LR | 1 |
| Singh, R | 1 |
| Sylvest, V | 1 |
| Weimorts, D | 1 |
| Adams, JF | 1 |
| Bohuon, C | 1 |
| Comoy, E | 1 |
| Edelstein, L | 1 |
| Niebauer, G | 1 |
| Hamada, G | 2 |
| Stanka, P | 1 |
| Kinzel, V | 1 |
| Mohr, U | 1 |
| Rodriguez, HA | 1 |
| Mcgavran, MH | 1 |
| Sohn, N | 1 |
| Gang, H | 1 |
| Gumport, SL | 1 |
| Goldstein, M | 1 |
| Deppisch, LM | 1 |
| Rost, FW | 1 |
| Polak, JM | 1 |
| Pearse, AG | 1 |
| Saunders, RN | 1 |
| Miya, TS | 1 |
| Bousquet, WF | 1 |
| Or, N | 1 |
| Van Woert, MH | 1 |
| Richterich, R | 1 |
| Cantz, B | 1 |
| Dauwalder, H | 1 |
| Herrmann, WP | 1 |
| Cobb, JP | 1 |
| McGrath, A | 1 |
| Skibba, JL | 1 |
| Pinckley, J | 1 |
| Gilbert, EF | 1 |
| Johnson, RO | 1 |
| Hinterberger, H | 1 |
| Freedman, A | 1 |
| Bartholomew, RJ | 1 |
| Davidson, R | 2 |
| Yamamoto, K | 1 |
| Fischer, R | 1 |
| Schachtschabel, D | 2 |
| Zilliken, F | 2 |
| Greer, M | 1 |
| Anton, AH | 1 |
| Williams, CM | 1 |
| Voorhess, ML | 2 |
| Epstein, WL | 1 |
| Fukuyama, K | 1 |
| Fischer, RD | 1 |
| Volina, VV | 2 |
| Maul, GG | 1 |
| Romsdahl, MM | 1 |
| Delacretaz, J | 1 |
| Emch, M | 1 |
| Schellhorn, JP | 1 |
| Ott, F | 1 |
| Grässmann, A | 1 |
| Grässmann, M | 1 |
| Domopoulos, HB | 1 |
| Tritsch, GL | 1 |
| Takagi, N | 1 |
| Moore, GE | 1 |
| Sandberg, AA | 1 |
| Ivanov, AI | 2 |
| Zarkov, AV | 1 |
| Klimko, MS | 1 |
| Håkanson, R | 1 |
| Möller, H | 1 |
| Stormby, NG | 1 |
| Solov'ev, AL | 1 |
| Männl, HF | 1 |
9 reviews available for dihydroxyphenylalanine and Melanoma
| Article | Year |
|---|---|
THE UVEA.
Topics: Anatomy; Arthritis; Autoantibodies; Betamethasone; Dexamethasone; Dihydroxyphenylalanine; Epidemiolo | 1964 |
[ON THE PROBLEMS OF RESEARCH ON PIGMENTATION].
Topics: Antihypertensive Agents; Biomedical Research; Central Nervous System Stimulants; Dihydroxyphenylalan | 1964 |
[3,4-Dihydroxyphenyl alanine (DOPA)].
Topics: Adrenal Gland Neoplasms; Biomarkers; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; H | 2005 |
Factors regulating growth and pigmentation of melanoma cells.
Topics: Animals; Bone Neoplasms; Bromodeoxyuridine; Catechol Oxidase; Cell Division; Cell Line; Cell Transfo | 1976 |
[Melanocyte and melanin (author's transl)].
Topics: Animals; Carotenoids; Cells, Cultured; Chemical Phenomena; Chemistry; Cricetinae; Decapodiformes; Di | 1976 |
Clinical evaluation of a method of quantitative determination of homovanillic acid for the estimation of degree of tumor dissemination process in melanoma of the skin.
Topics: Animals; Dihydroxyphenylalanine; Homovanillic Acid; Humans; Lymphatic Metastasis; Melanoma; Phenylac | 1975 |
Structure, chemistry, and biosynthesis of the melanins.
Topics: Animals; Birds; Carbon Radioisotopes; Catechol Oxidase; Catechols; Chemical Phenomena; Chemistry; Di | 1974 |
[A review of the literature concerning the etiology, pathogenesis, histogenesis, clinical picture and treatment of skin melanomas during the past 5 years].
Topics: Carbon Isotopes; Dihydroxyphenylalanine; Golgi Apparatus; Humans; Melanoma; Mitochondria; Nevus; Nev | 1971 |
[Melanoma].
Topics: Animals; Carbon Isotopes; Catechol Oxidase; Cytoplasmic Granules; Dihydroxyphenylalanine; Endoplasmi | 1970 |
1 trial available for dihydroxyphenylalanine and Melanoma
| Article | Year |
|---|---|
[Treatment of malignant melanoma with DTIC--therapeutic effects determined by 5-S-cysteinyldopa changes in the urine (proceedings)].
Topics: Clinical Trials as Topic; Cysteinyldopa; Dacarbazine; Dihydroxyphenylalanine; Drug Evaluation; Human | 1978 |
251 other studies available for dihydroxyphenylalanine and Melanoma
| Article | Year |
|---|---|
Serum 5-S-cysteinyl-dopa levels as a predictive marker for the efficacy of nivolumab in advanced malignant melanoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Immunological; Cohort Studies; Dihydroxyphenylalanin | 2019 |
Incidental Metastatic Melanoma Identified on 18F-FDOPA PET/CT With Confirmation by Histology.
Topics: Dihydroxyphenylalanine; Female; Humans; Incidental Findings; Melanoma; Middle Aged; Neoplasm Staging | 2020 |
Melanocyte progenitor cells reside in human subcutaneous adipose tissue.
Topics: Biomarkers; Cell Differentiation; Cell Line, Tumor; Dihydroxyphenylalanine; Down-Regulation; Epiderm | 2021 |
Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells.
Topics: Actins; Animals; Cell Line, Tumor; Cell Proliferation; Dihydroxyphenylalanine; Docosahexaenoic Acids | 2019 |
Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; C | 2014 |
Usefulness of serum 5-S-cysteinyl-dopa as a biomarker for predicting prognosis and detecting relapse in patients with advanced stage malignant melanoma.
Topics: Biomarkers, Tumor; Cysteinyldopa; Dihydroxyphenylalanine; Feasibility Studies; Female; Follow-Up Stu | 2017 |
Enzymatic oxidation of tyrosine and dihydroxyphenylalanine by melanoma extracts.
Topics: Dihydroxyphenylalanine; Humans; Melanoma; Oxidation-Reduction; Tyrosine | 1948 |
Oxidation of carbidopa by tyrosinase and its effect on murine melanoma.
Topics: Animals; Antineoplastic Agents; Carbidopa; Cell Line, Tumor; Cyclization; Dihydroxyphenylalanine; Me | 2009 |
New methodological approach for the rapid and sensitive detection of melanocytes and melanocytic tumours. The DOPA-GA method.
Topics: Diagnosis, Differential; Dihydroxyphenylalanine; Glyoxylates; Humans; Melanocytes; Melanoma; Microsc | 2009 |
Possible case for false-positive reaction in serum 5-S-cysteinyldopa levels in a patient with malignant melanoma by ingestion of Agaricus blazei Murrill extract.
Topics: Agaricus; Aged; Biomarkers, Tumor; Dihydroxyphenylalanine; False Positive Reactions; Female; Humans; | 2010 |
Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: pigmentation marker, ultrastructural and UV-survival studies.
Topics: Alleles; alpha-MSH; Antigens; Arginine; Cell Survival; Cells, Cultured; Cystine; Dihydroxyphenylalan | 2003 |
Rectal malignant melanoma diagnosed by N-isopropyl- p-123I-iodoamphetamine single photon emission computed tomography and 5-S-cysteinyl dopa: report of a case.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Dihydroxyphenylalanine; Female; Humans; Iofetamine; Mela | 2003 |
Synergistic reaction between p-phenylenediamine and melanoma components.
Topics: Aniline Compounds; Coloring Agents; Dihydroxyphenylalanine; Melanoma; Phenylenediamines | 1958 |
[Autoradiographic studies on protein and melanin metabolism in different cell types in melanoma in mice (Harding-Passey type)].
Topics: Animals; Autoradiography; Dihydroxyphenylalanine; Melanins; Melanoma; Mice; Neoplasms; Neoplasms, Ex | 1962 |
[Studies on controlled radiotherapy of melanoma and on the chromaffin system by selective H-3 incorporation after administration of H-3-labelled DOPA].
Topics: Autoradiography; Chromaffin System; Dihydroxyphenylalanine; Melanoma; Radiometry | 1963 |
3,4-dihydroxyphenylalanine (DOPA) excretion in patients with malignant melanoma.
Topics: Dihydroxyphenylalanine; Humans; Melanoma | 1962 |
ON THE SITE OF MELANIN FORMATION IN MELANOCYTES.
Topics: Animals; Carbon Isotopes; Cell Biology; Chromatophores; Dihydroxyphenylalanine; Liver; Melanins; Mel | 1963 |
[EFFECT OF THE DOPA-DECARBOXYLASE INHIBITOR ALPHA-METHYLDOPA ON THE INCORPORATION OF DOPA INTO MELANIN AND PYROCATECHOLAMINE. IN VIVO STUDIES ON MELANOMA MICE WITH TRITIATED DOPA].
Topics: Animals; Antihypertensive Agents; Autoradiography; Catecholamines; Dihydroxyphenylalanine; Dopa Deca | 1963 |
QUANTITATIVE DETERMINATION OF DOPA; ITS APPLICATION TO MEASUREMENT OF DOPA IN URINE AND IN THE ASSAY OF TYROSINASE IN SERUM.
Topics: Animals; Blood Chemical Analysis; Dihydroxyphenylalanine; Melanoma; Mice; Monophenol Monooxygenase; | 1964 |
THE INCORPORATION OF C14 FROM 3,4-DIHYDROXYPHENYLALANINE-2'-C14 INTO THE MELANIN OF MOUSE MELANOMAS.
Topics: Animals; Carbon Isotopes; Dihydroxyphenylalanine; Melanins; Melanoma; Metabolism; Mice; Neoplasms; N | 1964 |
AN ENZYMATIC AND ELECTRON MICROSCOPIC CHARACTERIZATION OF A VARIANT OF THE CLOUDMAN S-91 MELANOMA.
Topics: Animals; Dihydroxyphenylalanine; Electrons; Enzyme Inhibitors; Histocytochemistry; Melanins; Melanom | 1964 |
MELANOGENESIS: AN AUTORADIOGRAPHIC STUDY AT THE ULTRASTRUCTURAL LEVEL.
Topics: Animals; Autoradiography; Dihydroxyphenylalanine; Electrons; Histocytochemistry; Melanins; Melanoma; | 1964 |
Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds.
Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Deoxyadenosines; Dihydroxyphenylalanine; | 2003 |
Bilateral adrenal metastases from malignant melanoma: concordant findings on (18)F-FDG and (18)F-FDOPA PET.
Topics: Adrenal Gland Neoplasms; Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Humans; Male; Melanoma; Mid | 2006 |
Involvement of dynein and spectrin with early melanosome transport and melanosomal protein trafficking.
Topics: Actins; Adaptor Proteins, Signal Transducing; Agouti Signaling Protein; Animals; Biological Transpor | 2008 |
A sensitive fluorometric assay method for mammalian tyrosinase.
Topics: Animals; Dihydroxyphenylalanine; Fluorometry; Hydrogen-Ion Concentration; Melanoma; Mice; Spectrum A | 1967 |
Urinary phenols in melanoma.
Topics: Chromatography; Dihydroxyphenylalanine; Humans; Melanoma; Normetanephrine; Oxidation-Reduction; Phen | 1967 |
Radioactivity from labeled precursors of melanin in mice and hamsters with melanomas.
Topics: Adrenal Glands; Animals; Carbon Isotopes; Cricetinae; Dihydroxyphenylalanine; Enzymes; Iodine Isotop | 1967 |
Radioactivity from labeled precursors of melanin in mice and hamsters with melanomas.
Topics: Adrenal Glands; Animals; Carbon Isotopes; Cricetinae; Dihydroxyphenylalanine; Indoles; Iodine Isotop | 1967 |
Tyrosinase activity in the amelanotic melanoma in golden hamsters.
Topics: Animals; Cricetinae; Dihydroxyphenylalanine; Hydroxylamines; Kidney; Liver; Manometry; Melanoma; Neo | 1967 |
Theophylline and melanocyte-stimulating hormone effects on gamma-glutamyl transpeptidase and DOPA reactions in cultured melanoma cells.
Topics: Animals; Cell Line; Dihydroxyphenylalanine; gamma-Glutamyltransferase; Melanocyte-Stimulating Hormon | 1982 |
Tyrosinase and gamma-glutamyl transpeptidase in 5-s-cysteinyldopa genesis within melanotic and amelanotic melanomas.
Topics: Catechol Oxidase; Cysteinyldopa; Dihydroxyphenylalanine; Ditiocarb; gamma-Glutamyltransferase; Human | 1982 |
gamma-Glutamyl transpeptidase, tyrosinase, and 5-S-cysteinyldopa production in melanoma cells.
Topics: Animals; Catechol Oxidase; Cricetinae; Cysteinyldopa; Dihydroxyphenylalanine; gamma-Glutamyltransfer | 1983 |
Treatment of malignant melanoma with dacarbazin (DTIC-DOME) with special reference to urinary excretion of 5-S-cysteinyldopa.
Topics: Adult; Aged; Brain Neoplasms; Cysteinyldopa; Dacarbazine; Digestive System; Dihydroxyphenylalanine; | 1980 |
[Evaluation of the excretion of phenolic and indolic substances in patients with malignant melanoma at the district hospital in Ustí nad Labem].
Topics: Dihydroxyphenylalanine; Humans; Hydroxyindoleacetic Acid; Melanins; Melanoma | 1980 |
Urinary 5-S-cysteinyldopa in Parkinsonism after DOPA and carbidopa.
Topics: Adult; Aged; Carbidopa; Cysteinyldopa; Dihydroxyphenylalanine; Humans; Melanoma; Middle Aged; Parkin | 1983 |
Tyrosinase activity in the medium of human melanoma cell cultures.
Topics: Ascorbic Acid; Catechol Oxidase; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Medi | 1983 |
Protein-bound dopa and 5-S-cysteinyldopa in non-melanogenic tissues.
Topics: Animals; Cysteine; Cysteinyldopa; Dihydroxyphenylalanine; Free Radicals; Indoles; Melanins; Melanoma | 1983 |
Dopa oxidation and tyrosine oxygenation by human melanoma tyrosinase.
Topics: Catechol Oxidase; Cell Line; Cells, Cultured; Dihydroxyphenylalanine; Humans; Hydroxylation; Melanom | 1983 |
Characterization of structural properties for morphologic differentiation of melanosomes. III. free and protein-bound dopa and 5-S-cysteinyldopa in B16 and Harding-Passey melanomas.
Topics: Animals; Cysteinyldopa; Dihydroxyphenylalanine; Hair; Melanocytes; Melanoma; Mice; Neoplasms, Experi | 1983 |
Determination of urinary 5-S-cysteinyldopa by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Cysteinyldopa; Dihydroxyphenylalanine; Electrochemistry; Femal | 1983 |
Harding-passey mouse-melanoma tyrosinase inactivation by reaction products and activation by L-epinephrine.
Topics: Animals; Catechol Oxidase; Dihydroxyphenylalanine; Enzyme Activation; Epinephrine; Melanins; Melanom | 1983 |
The role of NADP-dependent dehydrogenases in hydroxylation of tyrosine in hamster melanoma.
Topics: Animals; Cricetinae; Dihydroxyphenylalanine; Electrophoresis, Polyacrylamide Gel; Hydroxylation; Mel | 1983 |
[5-S-cysteinyldopa determination in the urine. Its value for monitoring in melanoma patients].
Topics: Cysteinyldopa; Dihydroxyphenylalanine; Humans; Isomerism; Melanoma; Neoplasm Metastasis; Skin Neopla | 1983 |
[Diagnosis of amelanotic malignant melanoma by means of the fluorescence method (Falck & Hillarp) and determination of 5-S-cysteinyldopa in the lesions].
Topics: Adult; Aged; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Male; Melanoma; Microscopy, Fluo | 1983 |
Cysteinyldopa isomers and dopa in lesions and urine of Japanese patients with malignant melanoma.
Topics: Cysteinyldopa; Dihydroxyphenylalanine; Humans; Isomerism; Japan; Lymphatic Metastasis; Melanoma; Ski | 1983 |
Selective aberration and pigment loss in melanosomes of malignant melanoma cells in vitro by glycosylation inhibitors: premelanosomes as glycoprotein.
Topics: Animals; Dihydroxyphenylalanine; Glucosamine; Melanins; Melanocytes; Melanoma; Mice; Microscopy, Ele | 1983 |
False dopa reaction in studies of mammalian tyrosinase: some characteristics and precautions.
Topics: Animals; Catechol Oxidase; Cells, Cultured; Dihydroxyphenylalanine; False Positive Reactions; Fibrob | 1983 |
Urine excretion of 5-S-cysteinyldopa and serum sialic acid as tumor markers in human melanomas.
Topics: Adult; Aged; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Male; Melanoma; Middle Aged; Neo | 1983 |
[Excretion of 5-S-cysteinyldopa in the urine of Japanese patients with malignant melanoma--a helpful biochemical marker for assessing the progression of disease].
Topics: Adolescent; Adult; Asian People; Child; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Japan | 1983 |
Studies on amelanotic melanoma with the fluorescence method (Falck and Hillarp) and biochemical analysis of 5-S-cysteinyldopa in the tissues.
Topics: Adult; Aged; Carcinoma, Basal Cell; Cysteinyldopa; Dihydroxyphenylalanine; Humans; Male; Melanoma; M | 1983 |
Differentiation and tumorigenicity of human malignant melanocytes in relation to their culture conditions.
Topics: Animals; Cell Line; Chromosomes, Human; Culture Media; Cysteinyldopa; Cystine; Dihydroxyphenylalanin | 1984 |
[A newly established melanoma cell line (GAK) with 5-S-cysteinyldopa phenotype].
Topics: Aged; Animals; Cell Line; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Isomerism; Lymphati | 1984 |
[Therapeutic evaluation of human malignant melanoma by urinary 5-S-cysteinyldopa dynamics: chemotherapy and surgery].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Cysteinyldopa; Dacarbazin | 1984 |
Optimized assay for mammalian tyrosinase (polyhydroxyl phenyloxidase).
Topics: Animals; Buffers; Catechol Oxidase; Dihydroxyphenylalanine; Hair; Humans; Hydrogen-Ion Concentration | 1984 |
[Utilization of melanin precursors for experimental chemotherapy of malignant melanoma].
Topics: Animals; Catecholamines; Cysteamine; Cysteine; Dihydroxyphenylalanine; Melanins; Melanocytes; Melano | 1984 |
Determination of DOPA, dopamine, and 5-S-cysteinyl-DOPA in plasma, urine, and tissue samples by high-performance liquid chromatography with electrochemical detection.
Topics: Animals; Chromatography, High Pressure Liquid; Cysteinyldopa; Dihydroxyphenylalanine; Dopamine; Elec | 1984 |
Mammalin tyrosinase. Stoichiometry and measurement of reaction products.
Topics: Amino Acids; Animals; Basidiomycota; Catechol Oxidase; Dihydroxyphenylalanine; Melanins; Melanocytes | 1980 |
New regulators of melanin biosynthesis and the autodestruction of melanoma cells.
Topics: Animals; Dihydroxyphenylalanine; Indolequinones; Indoles; Melanins; Melanocyte-Stimulating Hormones; | 1980 |
[Tritiated DOPA: distribution in the subcellular melanoma fractions and perspective of its radiotherapeutical use (author's transl)].
Topics: Animals; Dihydroxyphenylalanine; Melanoma; Mice; Microscopy, Electron; Neoplasms, Experimental; Radi | 1980 |
Data processing of urine chromatograms for the clinical management of melanoma.
Topics: Chromatography, Ion Exchange; Computers; Cysteinyldopa; Data Display; Dihydroxyphenylalanine; Homova | 1980 |
[5-S-cysteinyldopa in the urine - a "tumor test" for malignant melanoma? Comparison with the usual laboratory examinations].
Topics: BCG Vaccine; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Male; Melanoma; Melphalan; Neopl | 1980 |
Distribution and metabolism of tritiumlabelled 5-S-cysteinyldopa in mice.
Topics: Animals; Cysteinyldopa; Dihydroxyphenylalanine; Levodopa; Male; Melanoma; Mice; Mice, Inbred Strains | 1980 |
Synthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalanines and related compounds.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cricetinae; Cysteinyldopa; Dihydroxyphenyl | 1981 |
A qualitative gas chromatographic analysis of substituted 5,6-dihydroxyindoles from the urine of patients with melanoma.
Topics: Chromatography, Gas; Dihydroxyphenylalanine; Humans; Indoles; Melanins; Melanoma; Skin Neoplasms | 1981 |
[Urinary 5-S-cysteinyldopa in malignant melanoma subjects-with special reference to melanoma stages and dopa loading test (author's transl)].
Topics: Adolescent; Adult; Aged; Child; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Male; Melanom | 1981 |
Effect of DOPA-loading on glutathione-dependent 5-S-cysteinyldopa genesis in melanoma cells in vitro.
Topics: Animals; Cells, Cultured; Cricetinae; Culture Media; Cysteine; Cysteinyldopa; Dihydroxyphenylalanine | 1982 |
Urinary free and conjugated 5-S-cysteinyldopa in normal subjects and in patients with melanoma.
Topics: Adult; Aged; Cysteinyldopa; Dihydroxyphenylalanine; Female; Fluorometry; Humans; Male; Melanoma; Mid | 1982 |
[High-performance liquid chromatographic determination of urinary 5-S, 2-S-, 6-S-cysteinyldopa and 2,5-S,S-dicysteinyldopa (author's transl)].
Topics: Chromatography, High Pressure Liquid; Cysteinyldopa; Dihydroxyphenylalanine; Humans; Melanoma | 1982 |
Electron microscopic and cytochemical observations of theophylline and melanocyte-stimulating hormone effects on melanoma cells in culture.
Topics: Animals; Cell Line; Cells, Cultured; Dihydroxyphenylalanine; Melanocyte-Stimulating Hormones; Melano | 1982 |
[Contents of cysteinyldopa isomers and DOPA in lesions of malignant melanoma (author's transl)].
Topics: Aged; Cysteinyldopa; Dihydroxyphenylalanine; Humans; Isomerism; Male; Melanoma; Skin Neoplasms | 1982 |
DNA damage and selective toxicity of dopa and ascorbate:copper in human melanoma cells.
Topics: Ascorbic Acid; Catalase; Cell Line; Cell Survival; Copper; Dihydroxyphenylalanine; DNA Repair; DNA, | 1982 |
Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin.
Topics: Catechol Oxidase; Cells, Cultured; Dihydroxyphenylalanine; Indoles; Kinetics; Melanins; Melanoma; Mo | 1982 |
[Correlation of urinary 5-S-cysteinyldopa with repeated remission of melanoma induced by DTIC combination chemotherapy].
Topics: Cysteinyldopa; Dacarbazine; Dihydroxyphenylalanine; Female; Humans; Lymphoma; Melanoma; Middle Aged; | 1982 |
Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression.
Topics: Animals; Antigens, Neoplasm; Dihydroxyphenylalanine; Humans; Intramolecular Oxidoreductases; Isomera | 1995 |
Development of an in vitro primary screen for skin depigmentation and antimelanoma agents.
Topics: Animals; Antineoplastic Agents; Benzene Derivatives; Benzoquinones; Cell Division; Dihydroxyphenylal | 1994 |
Effect of melanocyte stimulating hormone on human cultured choroidal melanocytes, uveal melanoma cells, and retinal epithelial cells.
Topics: Animals; Cattle; Cells, Cultured; Choroid; Culture Techniques; Dihydroxyphenylalanine; Humans; Melan | 1994 |
Exploitation of pigment biosynthesis pathway as a selective chemotherapeutic approach for malignant melanoma.
Topics: Benzoquinones; Catechols; Cysteinyldopa; Dihydroxyphenylalanine; Dopamine; Humans; Indoles; Melanins | 1993 |
New thioureas and related substances intended for melanoma targeting.
Topics: Animals; Autoradiography; Basidiomycota; Benzoquinones; Dihydroxyphenylalanine; Dopamine Agents; Int | 1995 |
Enzymatic and non-enzymatic oxygenation of tyrosine.
Topics: Animals; Catalase; Cattle; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; H | 1996 |
Heterogeneous expression of immunotherapy candidate proteins gp100, MART-1, and tyrosinase in human melanoma cell lines and in human melanocytic lesions.
Topics: Antigens, Neoplasm; Dihydroxyphenylalanine; gp100 Melanoma Antigen; Humans; Immunohistochemistry; MA | 1997 |
Selective incorporation of the prototype melanoma seeker thiourea into nascent melanin: a chemical insight.
Topics: Antineoplastic Agents; Chemistry, Pharmaceutical; Dihydroxyphenylalanine; Melanins; Melanoma; Monoph | 1997 |
Generalized melanosis in metastatic malignant melanoma: the possible role of DOPAquinone metabolites.
Topics: Aged; Benzoquinones; Dihydroxyphenylalanine; Fatal Outcome; Genital Neoplasms, Male; Humans; Male; M | 1998 |
[Determination of serum S-100 protein and 5-S-cysteinyl-DOPA levels in melanoma patients].
Topics: Dihydroxyphenylalanine; Female; Humans; Male; Melanoma; Neoplasm Metastasis; S100 Proteins | 1999 |
Co-regulation of melanin precursors and tyrosinase in human pigment cells: roles of cysteine and glutathione.
Topics: Buthionine Sulfoximine; Cells, Cultured; Cysteine; Cysteinyldopa; Dihydroxyphenylalanine; Glutathion | 1999 |
Depigmenting effects of calcium D-pantetheine-S-sulfonate on human melanocytes.
Topics: Blotting, Western; Coenzyme A; Dihydroxyphenylalanine; Glycosylation; Humans; Immunoblotting; Melani | 2000 |
Quantitative PET studies in pretreated melanoma patients: a comparison of 6-[18F]fluoro-L-dopa with 18F-FDG and (15)O-water using compartment and noncompartment analysis.
Topics: Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Humans; Melanoma; Models, Theoretical; Oxygen Radioi | 2001 |
Combined 18F-FDG-FDOPA tumor imaging for assessing response to therapy.
Topics: Dihydroxyphenylalanine; Fluorodeoxyglucose F18; Humans; Melanoma; Neoplasms; Radiopharmaceuticals; T | 2001 |
Formation of cysteinyldopa from glutathionedopa in melanoma.
Topics: Animals; Cysteine; Depression, Chemical; Dihydroxyphenylalanine; Glutathione; Guinea Pigs; Humans; K | 1975 |
5-S-cysteinyldopa in the plasma of melanoma patients and the renal clearance of this amino acid.
Topics: Adult; Breast Neoplasms; Cysteine; Dihydroxyphenylalanine; Humans; Liver Neoplasms; Lung Neoplasms; | 1975 |
Increase of melanocytes around malignant melanoma.
Topics: Adult; Aged; Cell Count; Dihydroxyphenylalanine; Female; Humans; Male; Melanocytes; Melanoma; Middle | 1975 |
Urinary excretion of 5-S-cysteinyldopa in patients with primary melanoma or melanoma metastasis.
Topics: Adult; Aged; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Melanoma; Middle Aged; Neoplasm | 1975 |
Demonstration of 3-methoxytyrosine in the urine of melanoma patients.
Topics: Chromatography, Gas; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Mass Spectrometry; Mela | 1976 |
Intracellular distribution of dopa and 5-S-cysteinyldopa in Harding-Passey melanoma.
Topics: Animals; Cysteinyldopa; Dihydroxyphenylalanine; Melanoma; Mice; Mice, Inbred DBA; Neoplasms, Experim | 1977 |
5-S-cysteinyldopa in the urine of melanoma patients.
Topics: Adult; Aged; Cysteinyldopa; Dihydroxyphenylalanine; Eye Neoplasms; Female; Humans; Male; Melanoma; M | 1977 |
Glutathionedopa in malignant melanoma.
Topics: Cysteinyldopa; Dihydroxyphenylalanine; Glutathione; Humans; Liver Neoplasms; Melanoma | 1977 |
Formation of melanin-tyrosinase complex and its possible significance as a model for control of melanin synthesis.
Topics: Catechol Oxidase; Dihydroxyphenylalanine; Humans; Melanins; Melanocytes; Melanoma; Models, Biologica | 1978 |
Free and bound 5-S-cysteinyldopa and dopa in human malignant melanomas.
Topics: Cysteinyldopa; Dihydroxyphenylalanine; Humans; Melanoma; Skin Neoplasms | 1978 |
5 years' experience of 5-S-cysteinyldopa in melanoma diagnosis.
Topics: Adult; Aged; Cysteinyldopa; Dihydroxyphenylalanine; Female; Hair Color; Humans; Lymphatic Metastasis | 1979 |
Detection and quantitation of 5-S-cysteinyldopa in melanotic and amelanotic melanoma in comparison with nonpigment cell tumors and it's urinary excretion.
Topics: Adult; Aged; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Male; Melanoma; Middle Aged; Ski | 1979 |
The epidermal melanocyte system in patients with malignant melanoma. Quantitative and qualitative investigation of dopa positive melanocytes.
Topics: Cell Count; Cell Transformation, Neoplastic; Dihydroxyphenylalanine; Epidermis; Humans; Melanocytes; | 1979 |
[Regulatory role of DOPA and components of the cyclic adenosine-3',5'-monophosphate system].
Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Dihydroxyphenylalanine; Melanoma; Mice; Neoplasms, Experimen | 1978 |
The urinary melanogen cysteinyldopa in melanoma and in suntanning: Australian experience.
Topics: Adolescent; Adult; Australia; Cysteinyldopa; Dihydroxyphenylalanine; Humans; Melanoma; Neoplasm Meta | 1978 |
Mammalian tyrosinase: isolation by a simple new procedure and characterization of its steric requirements for cofactor activity.
Topics: Animals; Catechol Oxidase; Dihydroxyphenylalanine; Kinetics; Melanins; Melanocytes; Melanoma; Mice; | 1978 |
Selective toxicity of 6-hydroxydopa for melanoma cells.
Topics: Animals; Cells, Cultured; Cricetinae; Dihydroxyphenylalanine; Growth Inhibitors; Melanoma; Mice; Neo | 1979 |
Adaptation of Sinclair swine melanoma cells to long-term growth in vitro.
Topics: Animals; Cell Division; Cell Line; Dihydroxyphenylalanine; Female; Male; Melanoma; Neoplasm Regressi | 1979 |
5-S-cysteinyldopa in diagnosis and treatment of human malignant melanomas and ultrastructural observations.
Topics: Adult; Aged; Cysteinyldopa; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Melanoma; Micros | 1977 |
[Special aspects of basaliomas (pigmentation, stroma, glucosaminoglycan capillary patterns)].
Topics: Capillaries; Carcinoma, Basal Cell; Cell Division; Diagnosis, Differential; Dihydroxyphenylalanine; | 1978 |
Human malignant melanoma. Melanosomal polymorphism and the ultrastructural dopa reaction.
Topics: Dihydroxyphenylalanine; Endoplasmic Reticulum; Golgi Apparatus; Histocytochemistry; Humans; Melanocy | 1978 |
Simple screening test for estimation of some phenolic and indolic compounds in urine application to melanoma.
Topics: 3,4-Dihydroxyphenylacetic Acid; Dihydroxyphenylalanine; Humans; Hydroxyindoleacetic Acid; Indoles; M | 1978 |
[Urinary evaluation of 5-S-cysteinyldopa and seric evaluation of IgG4 subclass during follow-up of 27 primitive malignant melanomas (author's transl)].
Topics: Cysteinyldopa; Dihydroxyphenylalanine; Humans; Immunoglobulin G; Melanoma; Neoplasm Metastasis | 1978 |
The quantitative determination of 5-S-cysteinyldopa and dopa in normal serum and in serum from patients with malignant melanoma by means of high-pressure liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Cysteinyldopa; Dihydroxyphenylalanine; Drug Stability; Electro | 1978 |
[Melanoma metabolites (proceedings)].
Topics: Cysteinyldopa; Dihydroxyphenylalanine; Humans; Melanoma; Neoplasm Metastasis; Skin Neoplasms | 1978 |
Melanogenesis in human melanomas.
Topics: Catechol Oxidase; Cell Fractionation; Cold Temperature; Dihydroxyphenylalanine; Electrophoresis, Dis | 1975 |
Involvement of tyrosinase in melanin formation in murine melanoma.
Topics: Animals; Catechol Oxidase; Cell Line; Chelating Agents; Chromatography, DEAE-Cellulose; Dihydroxyphe | 1975 |
Ultrastructural tyrosine reaction in hamster melanoma.
Topics: Animals; Catechol Oxidase; Cricetinae; Dihydroxyphenylalanine; Endoplasmic Reticulum; Hydroxylation; | 1975 |
The tyrosinases of normal and diseased human skin (naevi, malignant melanoma, vitiligo).
Topics: Adult; Catalase; Catechol Oxidase; Ceruloplasmin; Dihydroxyphenylalanine; Electrophoresis, Polyacryl | 1975 |
5-thio-D-glucose: o-diphenoloxidase inhibition as its mechanism of action.
Topics: Basidiomycota; Catechol Oxidase; Cells, Cultured; Dihydroxyphenylalanine; Glucose; In Vitro Techniqu | 1976 |
Isolation of 2-S-cysteinyldopa and 2,5-S,S-dicysteinyldopa from the urine of patients with melanoma.
Topics: Cysteinyldopa; Dihydroxyphenylalanine; Humans; Melanoma; Neoplasm Metastasis | 1977 |
Dopa uptake by human melanomas maintained in immunosuppressed mice.
Topics: Animals; Colonic Neoplasms; Dihydroxyphenylalanine; Female; Humans; Immunosuppression Therapy; Melan | 1977 |
Catechols in primary and metastatic human malignant melanoma cells in monolayer culture.
Topics: Adult; Clone Cells; Dihydroxyphenylalanine; Female; Humans; Male; Melanocytes; Melanoma; Middle Aged | 1976 |
Detection of occult metastatic melanoma by urine chromatography.
Topics: Chromatography, Ion Exchange; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Male; Melanoma; | 1976 |
X-ray photoelectron spectroscopy and the structure of melanins.
Topics: Animals; Dihydroxyphenylalanine; Dopamine; Electrons; Hair; Horses; Humans; Melanins; Melanoma; Mole | 1976 |
Proceedings: Distribution studies with an aminophosphonic and analogue of DOPA in mice bearing the Harding-Passey melanoma.
Topics: Animals; Dihydroxyphenylalanine; Melanoma; Mice; Neoplasms, Experimental | 1975 |
Differentiation of melanocytes in cultures of primary malignant melanoma indicated by 5-S-cysteinyldopa formation.
Topics: Cell Differentiation; Cells, Cultured; Cysteine; Dihydroxyphenylalanine; Humans; Melanocytes; Melano | 1975 |
[Urinary 5-S-cysteinyldopa levels in patients with malignant melanoma. Preliminary results].
Topics: Creatinine; Cysteine; Dihydroxyphenylalanine; Melanoma; Neoplasm Metastasis; Skin Neoplasms | 1975 |
[Possibilities of using tritium in the intratissue rachiotheraphy of tumors].
Topics: Chemical Phenomena; Chemistry; Cyclophosphamide; Dihydroxyphenylalanine; Humans; Melanoma; Neoplasms | 1975 |
[Chemical diagnosis of melanoma].
Topics: Cysteine; Dihydroxyphenylalanine; Humans; Melanoma; Neoplasm Metastasis; Skin Neoplasms | 1976 |
Uptake of melanin precursors in mouse melanoma.
Topics: Animals; Dihydroxyphenylalanine; Dopamine; Female; Melanins; Melanoma; Mice; Mice, Inbred CBA; Neopl | 1976 |
Selective uptake of 2-thiouracil into melanin-producing systems depends on chemical binding to enzymically generated dopaquinone.
Topics: Animals; Benzoquinones; Biomarkers, Tumor; Chromatography, Gel; Chromatography, High Pressure Liquid | 1990 |
Production of 6-hydroxydopa by human tyrosinase.
Topics: Catalysis; Catechol Oxidase; Cell Line; Culture Media; Dihydroxyphenylalanine; Humans; Melanoma; Mon | 1985 |
Urinary excretion of melanocytic metabolites in fertile women.
Topics: Adult; Contraceptives, Oral; Cysteinyldopa; Dihydroxyphenylalanine; Female; Humans; Indoles; Melanom | 1985 |
Dopaquinone addition products in cultured human melanoma cells.
Topics: Benzoquinones; Cell Line; Cysteinyldopa; Dihydroxyphenylalanine; Humans; Melanoma; Pigmentation | 1987 |
Automated high-performance liquid chromatographic determination of 5-S-cysteinyl-3,4-dihydroxyphenylalanine in urine.
Topics: Catecholamines; Chromatography, High Pressure Liquid; Cysteinyldopa; Dihydroxyphenylalanine; Electro | 1989 |
Sources of the increased longitudinal relaxation rates observed in melanotic melanoma. An in vitro study of synthetic melanins.
Topics: Chemical Phenomena; Chemistry, Physical; Copper; Dihydroxyphenylalanine; Dopamine; Free Radicals; Hu | 1989 |
[Biochemical diagnoses of malignant melanomas with determinations of 5-S-cysteinyldopa in lesions].
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cysteinyldopa; Dihydroxyphenylalanine; Female; Hu | 1989 |
[Definitive diagnosis of early malignant melanoma lesions by the quantitative analysis of 5-S-cysteinyldopa in the tissue and touch fluorescence method].
Topics: Adolescent; Adult; Aged; Cysteinyldopa; Dihydroxyphenylalanine; Female; Fluorescence; Humans; Male; | 1989 |
Correlation between urinary melanin-related metabolites and tumour weight in melanoma-bearing mice.
Topics: Animals; Cysteinyldopa; Dihydroxyphenylalanine; Indoles; Melanins; Melanoma; Mice; Mice, Inbred C57B | 1989 |
Ultraviolet radiation directly induces pigment production by cultured human melanocytes.
Topics: Cells, Cultured; Cyclic AMP; Dihydroxyphenylalanine; Dose-Response Relationship, Radiation; Humans; | 1987 |
Effects of L-glutamine on tyrosinase and gamma-glutamyl transpeptidase of B-16 melanoma cells in culture.
Topics: Animals; Carbohydrates; Catechol Oxidase; Cattle; Culture Media; Dihydroxyphenylalanine; Fibroblasts | 1988 |
[Comparative studies between excretion of 5-S-cysteinyldopa and indole melanogens in urine].
Topics: Cysteinyldopa; Dihydroxyphenylalanine; Humans; Indoles; Melanoma; Skin Neoplasms | 1986 |
Metabolism of 5-S-glutathionyldopa.
Topics: Basidiomycota; Cell Line; Ceruloplasmin; Cysteinyldopa; Dihydroxyphenylalanine; Humans; Hydroxydopam | 1986 |
Inhibition of melanization in human melanoma cells by a serotonin uptake inhibitor.
Topics: Catecholamines; Cell Line; Dihydroxyphenylalanine; Humans; Melanins; Melanoma; Quinolines; Quipazine | 1987 |
Growth inhibition of melanoma cells by N-protected dopa derivatives.
Topics: Animals; Catalase; Cell Survival; Dihydroxyphenylalanine; Humans; Hydrogen Peroxide; Melanoma; Mice; | 1987 |
Immunoelectron microscopic demonstration of human melanosome associated antigens (HMSA) on melanoma cells: comparison with tyrosinase distribution.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Catechol Oxidase; Dihydroxyphenylalanine; Endoplasmic Re | 1988 |
Accumulation of N-methyl-4-phenylpyridinium ion (MPP+) in human melanoma cell line, HMV-I and -II.
Topics: 1-Methyl-4-phenylpyridinium; beta-Galactosidase; Cell Line; Dihydroxyphenylalanine; Dopamine; Humans | 1988 |
Plasma 5-S-cysteinyldopa differentiates patients with primary and metastatic melanoma from patients with dysplastic nevus syndrome and normal subjects.
Topics: Adult; Aged; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Cysteinyldopa; Diagnosis, Diff | 1988 |
The killing effects of 4-S-cysteinylcatechol and analogues on human melanoma cells.
Topics: Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry; Cysteine; Dihydroxyphenylalanin | 1988 |
Limitations of the quantitative cytochemical assay of catechol oxidase in melanoma cells.
Topics: Catechol Oxidase; Cell Line; Dihydroxyphenylalanine; Fixatives; Formaldehyde; Histocytochemistry; Hu | 1988 |
Suppression of DNA synthesis in NEL-M1 human melanoma cells by triamcinolone acetonide.
Topics: Cells, Cultured; Dihydroxyphenylalanine; DNA, Neoplasm; Humans; Melanoma; Receptors, Glucocorticoid; | 1985 |
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
Topics: Animals; Cell Survival; Cells, Cultured; Dihydroxyphenylalanine; Leukemia L1210; Mammary Neoplasms, | 1985 |
Influence of supplemental ascorbate on the antitumor activity of 5-hydroxydopa, a purported cytotoxic metabolite.
Topics: Animals; Ascorbic Acid; Dihydroxyphenylalanine; Drug Interactions; Female; Leukemia L1210; Leukemia | 1985 |
A possible metabolic role for o-diphenoloxidase in Mycobacterium leprae.
Topics: Animals; Armadillos; Bacterial Proteins; Basidiomycota; Catechol Oxidase; Dihydroxyphenylalanine; Hu | 1985 |
A study of melanocytes in the normal skin surrounding malignant melanomata.
Topics: Adult; Aged; Cell Count; Chromatophores; Dihydroxyphenylalanine; Female; Humans; Male; Melanins; Mel | 1970 |
Fluorometry of a DOPA peptide and its thioether.
Topics: Carbon Isotopes; Catechol Oxidase; Catechols; Chromatography, Paper; Cysteine; Dihydroxyphenylalanin | 1971 |
Presence and properties of tyrosinase in sera of melanoma-bearing animals.
Topics: Animals; Blood; Catechol Oxidase; Centrifugation, Density Gradient; Chromatography; Cricetinae; Dihy | 1971 |
Dopa and 5-S-cysteinyldopa in malignant melanoma in Ugandan Africans.
Topics: Adult; Aged; Black People; Cysteine; Dihydroxyphenylalanine; Female; Humans; Male; Melanoma; Middle | 1974 |
5-S-cysteinyldopa in melanomas of Caucasians.
Topics: Adult; Aged; Chromatography; Cysteine; Dihydroxyphenylalanine; Female; Fluorometry; Hair; Humans; Me | 1974 |
Enzymic differentiation of melanin phagocytosis and synthesis. A combined dopa-acid phosphatase reaction.
Topics: Acid Phosphatase; Dihydroxyphenylalanine; Histocytochemistry; Humans; In Vitro Techniques; Melanins; | 1966 |
Separation of malignant cells from transplantable rodent tumors.
Topics: Animals; Cell Count; Centrifugation, Density Gradient; Centrifugation, Zonal; Clone Cells; Culture T | 1970 |
Levodopa and melanoma.
Topics: Catechol Oxidase; Dihydroxyphenylalanine; Humans; Male; Melanocytes; Melanoma; Parkinson Disease; Sk | 1973 |
Electron microscopic studies on transplantable melanotic and amelanotic melanomas in hamsters.
Topics: Animals; Catechol Oxidase; Chromatophores; Cricetinae; Cytoplasm; Cytoplasmic Granules; Dihydroxyphe | 1973 |
Tyrosinase in melanized melanosomes.
Topics: Acid Phosphatase; Animals; Catechol Oxidase; Chick Embryo; Deoxycholic Acid; Dihydroxyphenylalanine; | 1972 |
Inability of murine melanoma "tyrosinase" (dopa ozidase) to oxidize tyrosine in the presence or absence of dopa or dihydroxyfumarate cofactor.
Topics: Animals; Catechol Oxidase; Chromatography; Dihydroxyphenylalanine; Fumarates; Hydrogen-Ion Concentra | 1973 |
Immunologic homogeneity and electrophoretic heterogeneity of mouse melanoma tyrosinases.
Topics: Animals; Catechol Oxidase; Chromatography, Gel; Cross Reactions; Dihydroxyphenylalanine; Immune Sera | 1973 |
Regulatory mechanisms of tyrosinase activity in melanocyte. I.
Topics: Allosteric Regulation; Animals; Carbon Radioisotopes; Catechol Oxidase; Cell Fractionation; Cell Lin | 1973 |
Peroxidase, "protyrosinase," and the multiple forms of tyrosinase in mice.
Topics: Animals; Biphenyl Compounds; Catalase; Catechol Oxidase; Dihydroxyphenylalanine; Electrophoresis, Po | 1973 |
The synthesis of a DOPA analogue, 1-amino-2-(3, 4-dihydroxyphenyl)-ethylphosphonic acid and distribution studies in mice bearing the Harding-Passey melanoma.
Topics: Adrenal Glands; Animals; Basidiomycota; Catechol Oxidase; Chromatography, Thin Layer; Dihydroxypheny | 1974 |
Inactivation mechanism of tyrosinase.
Topics: Animals; Catechol Oxidase; Dihydroxyphenylalanine; Kinetics; Mathematics; Melanins; Melanoma; Mice; | 1974 |
The incorporation of 51Cr-3, 4-dihydroxyphenylalanine (DOPA) complex into melanoma B 16.
Topics: Adrenal Glands; Animals; Chromium Isotopes; Dihydroxyphenylalanine; Disease Models, Animal; Kidney; | 1970 |
The influence of certain hormones and chemicals on mammalian pigment cells.
Topics: Adrenocorticotropic Hormone; Animals; Ascorbic Acid; Chromatophores; Colchicine; Copper; Culture Tec | 1966 |
Study of S91 mouse melanomas by electron paramagnetic resonance (EPR) spectroscopy and tissue culture. II. Effects of penicillamine on EPR signals and on growth in vitro.
Topics: Animals; Chromatography, Paper; Copper; Culture Techniques; Dihydroxyphenylalanine; Electron Spin Re | 1967 |
Recent advances in neurosurgical treatment for the elderly.
Topics: Aged; Animals; Brain Neoplasms; Cats; Central Nervous System Diseases; Cerebral Angiography; Cryosur | 1970 |
Quantitative fluorimetric determination of urinary dopa and its significance for the diagnosis of neural crest tumours.
Topics: Adult; Child; Chromatography, Ion Exchange; Dihydroxyphenylalanine; Fluorometry; Ganglioneuroma; Hum | 1971 |
Circular thin-layer chromatography for diagnosis and follow-up of neural crest tumours.
Topics: Catecholamines; Catechols; Chromatography, Gas; Chromatography, Thin Layer; Diagnosis, Differential; | 1973 |
Amorphous semiconductor switching in melanins.
Topics: Cytochrome c Group; Dihydroxyphenylalanine; Electric Conductivity; Humans; Melanins; Melanocytes; Me | 1974 |
[Biochemical tumor diagnosis in childhood].
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Carcinoma, Hepatocellular; Child; Cushing Syndrome; De | 1974 |
Melanin: a normal component of human eosinophils.
Topics: Adolescent; Adult; Aged; Animals; Basophils; Catecholamines; Child; Child, Preschool; Color; Dihydro | 1974 |
Oxidation of NADH by melanin and melanoproteins.
Topics: Amino Acids; Animals; Catechol Oxidase; Cattle; Chymotrypsin; Dihydroxyphenylalanine; Kinetics; Mela | 1974 |
[On the biosynthesis and structure of animal melanin. In vivo studies with tritium and 14C-labelled dopa on the mouse Harding-Passey melanoma].
Topics: Animals; Autoradiography; Carbon Isotopes; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Me | 1967 |
An automatic analyzer for the detection of dihydroxyphenylalanine metabolites and other reducing componds in urine.
Topics: Absorption; Autoanalysis; Chromatography, Ion Exchange; Colorimetry; Dihydroxyphenylalanine; Humans; | 1974 |
[Adhesive tape induced depigmentation. An ultrastructural study and comparison with vitiligo and vitiliginous depigmentation associated with melanoma (author's transl)].
Topics: Adhesiveness; Bandages; Basement Membrane; Biopsy; Diagnosis, Differential; Dihydroxyphenylalanine; | 1974 |
Melanocytic neoplasms.
Topics: Dihydroxyphenylalanine; Epinephrine; Humans; Melanins; Melanocytes; Melanoma; Mustard Compounds; Neo | 1974 |
The melanocyte illuminated.
Topics: Animals; Cysteine; Dihydroxyphenylalanine; Histocytochemistry; Humans; Melanocytes; Melanoma | 1974 |
Gene dosage dependence of pigment synthesis in melanoma x fibroblast hybrids (hamster cells-mouse fibroblast-DOPA-oxidase-irradiation).
Topics: Animals; Catechol Oxidase; Cell Line; Chromosomes; Cricetinae; Crosses, Genetic; Dihydroxyphenylalan | 1972 |
Fate of L-(3,5- 3H) tyrosine in cell-free extracts and tissue cultures of melanoma cells: a new assay method for tyrosinase in living cells.
Topics: Animals; Catechol Oxidase; Cell Line; Cell-Free System; Cells, Cultured; Chromatography, Paper; Cult | 1972 |
Intracellular localization of tyrosinase inhibitor in amelanotic and melanotic malignant melanoma.
Topics: Animals; Catechol Oxidase; Cricetinae; Cytoplasm; Dihydroxyphenylalanine; Golgi Apparatus; Melanins; | 1972 |
Regulation of malanin synthesis in mammalian cells: effect of gene dosage on the expression of differentiation.
Topics: Animals; Catechol Oxidase; Cell Differentiation; Cell Fusion; Cell Line; Clone Cells; Connective Tis | 1972 |
Inhibition of melanoma tyrosinase by fusaric acid.
Topics: Animals; Catechol Oxidase; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; In Vitro Techniques; M | 1972 |
The nature of the phenolase enzyme in Mycobacterium leprae: structure-activity relationships of substrates and comparison with other copper proteins and enzymes.
Topics: Animals; Basidiomycota; Catalase; Catechol Oxidase; Cattle; Cell-Free System; Ceruloplasmin; Dihydro | 1972 |
[The combined action of 2,5,6-H3-DOPA and alkylating agents on Harding-Passy melanoma].
Topics: Animals; Cyclophosphamide; Dihydroxyphenylalanine; Melanoma; Melphalan; Mice; Mice, Inbred BALB C; N | 1972 |
3,4-Dihydroxyphenylalanine in the urine of patients with ocular malignant melanoma.
Topics: Centrifugation; Chromatography, Paper; Dihydroxyphenylalanine; Eye Neoplasms; Filtration; Humans; Hy | 1972 |
[Biochemical diagnosis of pheochromocytoma, neuroblastoma and other neuro-ectodermal neoplasms].
Topics: Adolescent; Adult; Catecholamines; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Electr | 1972 |
Levodopa and malignant melanoma.
Topics: Dihydroxyphenylalanine; Humans; Male; Melanoma; Middle Aged; Parkinson Disease; Skin Neoplasms | 1973 |
Subcellular demonstration of peroxidatic oxidation of tyrosine to melanin using dihydroxyfumarate as cofactor in mouse melanoma cells.
Topics: Amines; Animals; Biphenyl Compounds; Carbamates; Dihydroxyphenylalanine; Endoplasmic Reticulum; Fuma | 1973 |
Effect of L-DOPA on transplanted malignant melanomas in mice.
Topics: Animals; Dihydroxyphenylalanine; Female; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Transplantatio | 1973 |
Determination of 5-S-cysteinyldopa in melanomas with a fluorimetric method.
Topics: Animals; Black People; Cysteine; Dihydroxyphenylalanine; Dopamine; Fluorometry; Guinea Pigs; Hair; H | 1973 |
Levodopa and melanoma.
Topics: Aged; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Humans; Male; Melanoma; Middle Aged; | 1974 |
Fluorescent dopa reaction of nevi and melanomas.
Topics: Dihydroxyphenylalanine; Fluorescence; Humans; Lymphatic Metastasis; Melanoma; Microscopy, Fluorescen | 1966 |
Identification of 3,4-dihydroxyphenylalanine as tyrosinase cofactor in melanoma.
Topics: Animals; Coenzymes; Cricetinae; Dihydroxyphenylalanine; Electrophoresis; Enterococcus faecalis; In V | 1966 |
3,4-dihydroxy-L-phenylalanine as the tyrosinase cofactor. Occurrence in melanoma and binding constant.
Topics: Animals; Binding Sites; Carbon Isotopes; Catechol Oxidase; Chromatography, Paper; Cricetinae; Dihydr | 1967 |
Oxidation of o-aminophenols by mouse and human melanoma dihydroxyphenylalanine oxidase and dihydroxyphenylalanine.
Topics: Animals; Antibiotics, Antineoplastic; Catechol Oxidase; Culture Techniques; Dihydroxyphenylalanine; | 1967 |
Tyrosinase activity in serum from normal and melanoma-bearing mice.
Topics: Animals; Ascorbic Acid; Catechol Oxidase; Dihydroxyphenylalanine; Hot Temperature; Melanoma; Mice; N | 1968 |
Properties of phenoloxidase in Mycobacterium leprae.
Topics: Animals; Basidiomycota; Benzoates; Catechol Oxidase; Cinnamates; Dihydroxyphenylalanine; Melanoma; M | 1968 |
Non-premelanosomal and premelanosomal tyrosinase activity in Greene's amelanotic and melanotic malignant melanoma.
Topics: Animals; Catechol Oxidase; Dihydroxyphenylalanine; Fluorescence; Histocytochemistry; In Vitro Techni | 1969 |
[Urinary excretion of 3,4-dihydroxyphenylalanine (DOPA) and dopamine in hamsters with induced or transplanted melanomas].
Topics: Animals; Cricetinae; Dihydroxyphenylalanine; Dopamine; Melanoma; Neoplasm Transplantation; Neoplasms | 1969 |
The histochemical tyrosine-dopa reaction for tyrosinase and its use in localizing tyrosinase activity in mast cells.
Topics: Animals; Catechol Oxidase; Dihydroxyphenylalanine; Histocytochemistry; Humans; Mast Cells; Melanoma; | 1969 |
[Electron microscope study of the origin of premelanosomes in melanoma cells in vitro].
Topics: Animals; Catechol Oxidase; Cricetinae; Culture Techniques; Dihydroxyphenylalanine; Endoplasmic Retic | 1969 |
A modified DOPA reaction for the diagnosis and investigation of pigment cells.
Topics: Catechol Oxidase; Chromatophores; Dihydroxyphenylalanine; Histocytochemistry; Histological Technique | 1969 |
Generalized melanosis secondary to malignant melanoma. Report of a case with serum and tissue tyrosinase studies.
Topics: Catechol Oxidase; Dihydroxyphenylalanine; Female; Humans; Lung Neoplasms; Melanins; Melanoma; Melano | 1969 |
Effect of inhibitors on phenoloxidase of Mycobacterium leprae.
Topics: Antimetabolites; Basidiomycota; Carbamates; Catechol Oxidase; Dihydroxyphenylalanine; Enzyme Repress | 1969 |
The melanocyte: its cytochemical and immunological relationship to cells of the endocrine polypeptide (APUD) series.
Topics: Animals; Cholinesterases; Cricetinae; Dihydroxyphenylalanine; Fluorescent Antibody Technique; Gastri | 1969 |
Stimulation of DOPA14C incorporation into melanoma tissue by chlorpromazine and reserpine.
Topics: Animals; Carbon Isotopes; Catechol Oxidase; Chlorpromazine; Dihydroxyphenylalanine; In Vitro Techniq | 1970 |
The role of peroxidase vs. the role of tyrosinase in enzymatic conversion of tyrosine to melanin in melanocytes, mast cells and eosinophils.
Topics: Animals; Carbon Isotopes; Catechol Oxidase; Chromatophores; Dihydroxyphenylalanine; Dogs; Eosinophil | 1970 |
Effect of phenothiazines on melanoma tyrosinase activity.
Topics: Adrenal Glands; Animals; Basidiomycota; Carbon Isotopes; Catechol Oxidase; Cell Membrane Permeabilit | 1970 |
Increased urinary dihydroxyphenylalanine oxidase activity in patients suffering from malignant melanoma.
Topics: Catechol Oxidase; Chromatography, Gel; Dialysis; Dihydroxyphenylalanine; Hot Temperature; Humans; Hy | 1970 |
[Immunologic analysis of tyrosinase in malignant melanoma, nevi and clinically normal skin].
Topics: Adolescent; Adult; Agar; Aged; Catechol Oxidase; Child; Child, Preschool; Dihydroxyphenylalanine; El | 1971 |
Unusual effects of reducing agents on 0-diphenoloxidase of Mycobacterium leprae.
Topics: Animals; Ascorbic Acid; Azides; Basidiomycota; Catechol Oxidase; Cell-Free System; Cyanides; Cystein | 1971 |
Tyrosinase isolated from mouse melanoma melanosome.
Topics: Animals; Catechol Oxidase; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatogr | 1971 |
Melanization and tyrosinase activity.
Topics: Animals; Binding Sites; Catechol Oxidase; Copper; Dihydroxyphenylalanine; Melanins; Melanocytes; Mel | 1971 |
[Excretion of 3-4-dihydroxyphenyloalanin (DOPA) in the urine of patients with malignant melanoma of the organ of vision].
Topics: Dihydroxyphenylalanine; Eye Neoplasms; False Negative Reactions; False Positive Reactions; Female; H | 1972 |
S91 mouse melanoma sublines following total in vitro versus alternate in vivo passages.
Topics: Animals; Autoradiography; Cell Line; Cells, Cultured; Dihydroxyphenylalanine; DNA, Neoplasm; Histocy | 1972 |
Multiple primary melanoma following administration of levodopa.
Topics: Administration, Oral; Dihydroxyphenylalanine; Humans; Male; Melanoma; Middle Aged; Neoplasm Recurren | 1972 |
Precursors of melanin in the blood and urine in malignant melanoma.
Topics: Adult; Aged; Catechols; Chromatography; Chromatography, Thin Layer; Dihydroxyphenylalanine; Dopamine | 1972 |
Regulation of melanin synthesis in mammalian cells, as studied by somatic hybridization. II. The level of regulation of 3,4-dihydroxyphenylalanine oxidase.
Topics: Animals; Cricetinae; Dihydroxyphenylalanine; Enzyme Repression; Hybridization, Genetic; Melanins; Me | 1968 |
Melanosome and lysosome. II. Digestion of melanosome with mouse liver lysosome.
Topics: Amino Acids; Animals; Carbon Isotopes; Chromatophores; Cytoplasmic Granules; Dihydroxyphenylalanine; | 1970 |
The tyrosine hydroxylase activity of mammalian tyrosinase.
Topics: 5-Hydroxytryptophan; Animals; Ascorbic Acid; Carbamates; Cricetinae; Cyanides; Dihydroxyphenylalanin | 1966 |
[Biochemical studies on the influencing of melanin formation in cell cultures of the Harding-Passey melanoma].
Topics: Animals; Culture Techniques; Depression, Chemical; Dihydroxyphenylalanine; Melanins; Melanoma; Mice; | 1969 |
[A historadiographic study of the incorporation of 3-(3,4-dioxyphenyl)-alanine-2,5,6 3H3 into Harding-Passy melanoma cells].
Topics: Animals; Autoradiography; Dihydroxyphenylalanine; Melanoma; Mice; Tritium | 1969 |
Failure of enzyme inhibition therapy for malignant melanoma.
Topics: Adult; Brain Neoplasms; Dihydroxyphenylalanine; Dopamine; Enzyme Repression; Epinephrine; Humans; Ma | 1969 |
Interactions between genomes in somatic cell hybrids: studies on the regulation of differentiation.
Topics: Animals; Catechol Oxidase; Cell Differentiation; Cell Fractionation; Cell Line; Chromosomes; Clone C | 1969 |
Dopa in melanin producing cells.
Topics: Animals; Chromatophores; Dihydroxyphenylalanine; Humans; Melanins; Melanocytes; Melanoma; Microscopy | 1969 |
Urinary excreion of DOPA and metabolites by patients with melanoma.
Topics: Adolescent; Adult; Aged; Chromatography, Ion Exchange; Chromatography, Paper; Dihydroxyphenylalanine | 1970 |
Light and electron microscopic studies of a transplantable melanoma associated with virus-like particles.
Topics: Acid Phosphatase; Animals; Cricetinae; Cytoplasmic Granules; Dihydroxyphenylalanine; Endoplasmic Ret | 1970 |
[Specific cell functions of cell and tissue cultures. II. Control of melanin synthesis in cell cultures of the Harding-Passey melanoma].
Topics: Animals; Carbon Isotopes; Culture Techniques; Depression, Chemical; Dihydroxyphenylalanine; Leucine; | 1970 |
[Distribution of pyrocatechol-3,4,5,6-3H4 and 3-(3,4-dihydroxyphenyl)-alanine-2,5,6-3H3 in tissues of mice with Garding-Passy melanoma after single and fractional injections].
Topics: Animals; Catechols; Dihydroxyphenylalanine; Melanoma; Methods; Mice; Neoplasms, Experimental; Tritiu | 1970 |
Ultrastructural comparison of two human malignant melanoma cell lines.
Topics: Acid Phosphatase; Back; Cell Line; Chromatophores; Clone Cells; Culture Techniques; Dihydroxyphenyla | 1970 |
[Distribution of DL-3 (3,4-dihydroxyphenyl)-alanine-2 C14 in the organism of mice with Cloudmann's S91 melanoma].
Topics: Adrenal Gland Neoplasms; Animals; Carbon Isotopes; Computers; Dihydroxyphenylalanine; Isocarboxazid; | 1970 |
[Biochemical studies of malignant melanoma].
Topics: Adult; Chemical Phenomena; Chemistry; Dihydroxyphenylalanine; Flavoring Agents; Humans; Lactates; Me | 1970 |
Degradation of melanosomes by lysosomes.
Topics: Acid Phosphatase; Amino Acids; Animals; Carbon Isotopes; Cathepsins; Culture Techniques; Dihydroxyph | 1971 |
[The formation of melanin in muscle cells after the direct transfer of RNA from Harding-Passey melanoma cells].
Topics: Animals; Autoradiography; Cell Transformation, Neoplastic; Culture Techniques; Cycloheximide; Deoxyr | 1971 |
One-dimensional paper chromatographic method for determination of urinary homovanillic acid.
Topics: Adolescent; Adult; Aged; Chromatography, Paper; Dihydroxyphenylalanine; Female; Humans; Male; Melani | 1968 |
Effect of alpha-methyl-p-tyrosine on 3,4-dihydroxyphenylalanine (DOPA) excretion of hamsters with melanotic melanoma.
Topics: Animals; Cricetinae; Dihydroxyphenylalanine; Female; Injections, Intraperitoneal; Melanoma; Methylty | 1968 |
Variability of karyotypes and pigment-producing enzymes in a hamster melanoma.
Topics: Animals; Cricetinae; Culture Techniques; Cytogenetics; Dihydroxyphenylalanine; Hydrogen-Ion Concentr | 1968 |
[On the possibilities of using labelled 3-(3,4-dioxyphenyl)-alanine (DOPA) in the radioisotope therapy of melanomas].
Topics: Animals; Carbon Isotopes; Dihydroxyphenylalanine; Melanoma; Mice | 1968 |
The developmental cycle of B16 melanoma cell in culture.
Topics: Animals; Chromatophores; Culture Techniques; Dihydroxyphenylalanine; Melanoma; Mice; Neoplasm Transp | 1965 |
DOPA decarboxylase activity in a transplantable hamster melanoma.
Topics: Animals; Carbon Isotopes; Cricetinae; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; In Vitro | 1965 |
Tyrosine hydroxylation catalyzed by mammalian tyrosinase: an improved method of assay.
Topics: Animals; Cricetinae; Dihydroxyphenylalanine; In Vitro Techniques; Kinetics; Melanoma; Neoplasms, Exp | 1964 |
[On the possibility of using 3-(3,4-dihydroxyphenyl)-alanine (DOPA) as a mediator of radioisotopes in a melanoma].
Topics: Animals; Carbon Isotopes; Dihydroxyphenylalanine; Electrophoresis; Melanins; Melanoma; Mice; Neoplas | 1965 |
Large amounts of deoxyphenylalanine in the hydrolysate of melanosomes from Harding-Passey mouse melanoma.
Topics: Animals; Chromatography, Paper; Dihydroxyphenylalanine; Fluorometry; Melanoma; Mice; Neoplasm Protei | 1966 |
The conversion of [3H]tyrosine to [3H]DOPA in mouse melanoma in vivo.
Topics: Animals; Asparagine; Aspartic Acid; Chromatography, Paper; Dihydroxyphenylalanine; Electrophoresis; | 1966 |