dihydroxyphenylalanine has been researched along with Manganese Poisoning in 32 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Manganese Poisoning: Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human manganese poisoning or manganism results in damage to the substantia nigra of the brain stem, a drop in the level of the inhibitory neurotransmitter dopamine, and symptoms resembling those of Parkinson's disease." | 7.67 | Manganese poisoning and the attack of trivalent manganese upon catecholamines. ( Archibald, FS; Tyree, C, 1987) |
| "Human manganese poisoning or manganism results in damage to the substantia nigra of the brain stem, a drop in the level of the inhibitory neurotransmitter dopamine, and symptoms resembling those of Parkinson's disease." | 3.67 | Manganese poisoning and the attack of trivalent manganese upon catecholamines. ( Archibald, FS; Tyree, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (78.13) | 18.7374 |
| 1990's | 2 (6.25) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Criswell, SR | 2 |
| Nielsen, SS | 1 |
| Warden, M | 1 |
| Perlmutter, JS | 2 |
| Moerlein, SM | 2 |
| Flores, HP | 2 |
| Huang, J | 1 |
| Sheppard, L | 1 |
| Seixas, N | 1 |
| Checkoway, H | 1 |
| Racette, BA | 2 |
| Martin, WR | 1 |
| Videen, TO | 1 |
| Birke, AM | 1 |
| Brenner, SR | 1 |
| Tang, LC | 1 |
| Shinotoh, H | 1 |
| Snow, BJ | 1 |
| Chu, NS | 2 |
| Huang, CC | 2 |
| Lu, CS | 1 |
| Lee, C | 1 |
| Takahashi, H | 1 |
| Calne, DB | 2 |
| Abe, Y | 1 |
| Kachi, T | 1 |
| Kato, T | 1 |
| Ito, K | 1 |
| Yanagisawa, N | 1 |
| Sobue, G | 1 |
| Hirata, Y | 1 |
| Kiuchi, K | 1 |
| Nagatsu, T | 1 |
| Ryzhkova, MN | 1 |
| Tarasova, LA | 1 |
| Wolters, EC | 1 |
| Clark, C | 1 |
| Peppard, RF | 1 |
| Okada, J | 1 |
| Adam, MJ | 1 |
| Ruth, TJ | 1 |
| Li, D | 1 |
| Archibald, FS | 1 |
| Tyree, C | 1 |
| Bonilla, E | 1 |
| Diez-Ewald, M | 1 |
| Cook, DG | 1 |
| Fahn, S | 1 |
| Brait, KA | 1 |
| Curzon, G | 1 |
| Klawans, HL | 2 |
| Papavasiliou, PS | 6 |
| Miller, ST | 1 |
| Cotzias, GC | 10 |
| Goldman, ME | 1 |
| Samoĭlova, ZT | 1 |
| Shavolina, VA | 1 |
| Gellene, R | 1 |
| Aronson, RB | 1 |
| Fehling, C | 1 |
| Kaufman, B | 1 |
| Mena, I | 3 |
| Ginos, J | 1 |
| Steck, A | 1 |
| Düby, S | 1 |
| Barbeau, A | 1 |
| Rosenstock, HA | 1 |
| Simons, DG | 1 |
| Meyer, JS | 1 |
| Greenhouse, AH | 1 |
| Court, J | 2 |
| Fuenzalida, S | 2 |
4 reviews available for dihydroxyphenylalanine and Manganese Poisoning
| Article | Year |
|---|---|
The biochemistry of dyskinesias.
Topics: Acetylcholine; Animals; Catecholamines; Cats; Copper; Dihydroxyphenylalanine; Dogs; Hepatolenticular | 1967 |
The pharmacology of extrapyramidal movement disorders.
Topics: Basal Ganglia Diseases; Chorea; Dihydroxyphenylalanine; Dopamine; Dystonia Musculorum Deformans; Hep | 1973 |
Observations on the range of efficacy of L-dopa.
Topics: Brain Diseases; Brain Stem; Cerebellar Diseases; Dementia; Dihydroxyphenylalanine; Dopamine; Extrapy | 1971 |
Metabolic modification of Parkinson's disease and of chronic manganese poisoning.
Topics: Animals; Brain; Choline; Chronic Disease; Dihydroxyphenylalanine; Drug Synergism; Humans; Manganese | 1971 |
3 trials available for dihydroxyphenylalanine and Manganese Poisoning
| Article | Year |
|---|---|
Parkinsonism and DOPA.
Topics: 5-Hydroxytryptophan; Clinical Trials as Topic; Dihydroxyphenylalanine; Dopamine; Humans; Male; Manga | 1968 |
Similarities between neurologic effects of L-dopa and of apomorphine.
Topics: Adult; Apomorphine; Brain; Child; Clinical Trials as Topic; Cyanides; Dihydroxyphenylalanine; Female | 1970 |
Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophane.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Chronic Disease; Dihydroxyphenylalanine; Humans; Male; Manga | 1970 |
25 other studies available for dihydroxyphenylalanine and Manganese Poisoning
| Article | Year |
|---|---|
[
Topics: Adult; Corpus Striatum; Cross-Sectional Studies; Dihydroxyphenylalanine; Female; Humans; Magnetic Re | 2018 |
Fuming over Parkinson disease: are welders at risk?
Topics: Corpus Striatum; Dihydroxyphenylalanine; Fluorine Radioisotopes; Globus Pallidus; Humans; Magnetic R | 2011 |
Reduced uptake of [¹⁸F]FDOPA PET in asymptomatic welders with occupational manganese exposure.
Topics: Adult; Aged; Corpus Striatum; Dihydroxyphenylalanine; Female; Fluorine Radioisotopes; Humans; Linear | 2011 |
Reduced uptake of [18F]FDOPA PET in asymptomatic welders with occupational manganese exposure.
Topics: Dihydroxyphenylalanine; Female; Humans; Male; Manganese Poisoning; Occupational Exposure; Positron-E | 2011 |
A personal and scientific biography of Dr. George C. Cotzias.
Topics: Brain Chemistry; Dihydroxyphenylalanine; Dopamine; History, 20th Century; Humans; Levodopa; Manganes | 1984 |
Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: a positron emission tomography study.
Topics: Adult; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Fluorine Radioisotop | 1997 |
[Diagnostic utility of positron emission tomography for parkinsonism after chronic manganese exposure].
Topics: Diagnosis, Differential; Dihydroxyphenylalanine; Fluorine Radioisotopes; Humans; Male; Manganese Poi | 1999 |
Manganese mimics the action of 1-methyl-4-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dihydroxyphenylalanine; Dopamine; Dose-Respon | 2001 |
[Pathogenesis and treatment of manganese induced Parkinsonism].
Topics: Adult; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Manganese Poisoning; Norepinephrine; | 1975 |
Positron emission tomography in manganese intoxication.
Topics: Adult; Brain; Chronic Disease; Dihydroxyphenylalanine; Humans; Magnetic Resonance Imaging; Manganese | 1989 |
Manganese poisoning and the attack of trivalent manganese upon catecholamines.
Topics: Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Kinetics; Manganese; Manganese Poison | 1987 |
Effect of L-DOPA on brain concentration of dopamine and homovanillic acid in rats after chronic manganese chloride administration.
Topics: Administration, Oral; Animals; Brain; Chlorides; Dihydroxyphenylalanine; Dopamine; Female; Homovanil | 1974 |
L-dopa in chronic manganese poisoning.
Topics: Chronic Disease; Dihydroxyphenylalanine; Humans; Manganese Poisoning | 1970 |
Chronic manganese intoxication.
Topics: Adult; Diagnosis, Differential; Dihydroxyphenylalanine; Edetic Acid; Environmental Exposure; Evaluat | 1974 |
Functional interactions between biogenic amines, 3',5'-cyclic AMP and manganese.
Topics: Adenine Nucleotides; Animals; Bile; Cyclic AMP; Dihydroxyphenylalanine; Dopamine; Epinephrine; Gluca | 1968 |
Levo-dihydroxyphenylalanine--Parkinson's disease and manganese poisoning.
Topics: Basal Ganglia Diseases; Catecholamines; Dihydroxyphenylalanine; Humans; Manganese Poisoning; Parkins | 1972 |
[Changes of catecholamine metabolism and symptoms of parkinsonism in rats with manganotoxicosis].
Topics: Animals; Brain; Catecholamines; Chlorides; Dihydroxyphenylalanine; Dopamine; Epinephrine; Male; Mang | 1974 |
Rationale for the use of L-dopa in the torsion dystonias.
Topics: Animals; Basal Ganglia; Dihydroxyphenylalanine; Dopamine; Dystonia Musculorum Deformans; Haplorhini; | 1970 |
Chronic manganism. Neurologic and laboratory studies during treatment with levodopa.
Topics: Administration, Oral; Adult; Chronic Disease; Dihydroxyphenylalanine; Edetic Acid; Facial Expression | 1971 |
Manganese intoxication in the United States.
Topics: Dihydroxyphenylalanine; Humans; Male; Manganese Poisoning; Movement Disorders; Psychoses, Substance- | 1971 |
Levodopa in the treatment of Parkinsonism.
Topics: Animals; Apomorphine; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Dihydroxyphenylalanine; D | 1971 |
Parkinsoism anDopa.
Topics: Dihydroxyphenylalanine; Dopamine; Humans; Manganese; Manganese Poisoning; Parkinson Disease | 1969 |
[L-Dopa in the management of chronic manganese poisoning].
Topics: Adult; Aged; Dihydroxyphenylalanine; Extrapyramidal Tracts; Humans; Male; Manganese Poisoning; Middl | 1969 |
Metabolic modification of some neurologic disorders.
Topics: Dihydroxyphenylalanine; Dopamine; Humans; Male; Manganese; Manganese Poisoning; Parkinson Disease; P | 1969 |
"Catecholamines" in the brain.
Topics: Animals; Apomorphine; Brain; Dihydroxyphenylalanine; Dopamine; Humans; Manganese Poisoning; Parkinso | 1970 |