dihydroxyphenylalanine has been researched along with Lewy Body Disease in 5 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
Lewy Body Disease: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Braak's staging concept of Lewy body disease pathogenesis is based on a spatiotemporal sequence of alpha-synuclein deposition, with autonomic nervous system involvement before synucleinopathy in substantia nigra neurons." | 3.78 | Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy. ( Goldstein, DS; Holmes, C; Park, MY; Sewell, L; Sharabi, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klein, JC | 1 |
| Eggers, C | 1 |
| Kalbe, E | 1 |
| Weisenbach, S | 1 |
| Hohmann, C | 1 |
| Vollmar, S | 1 |
| Baudrexel, S | 1 |
| Diederich, NJ | 1 |
| Heiss, WD | 1 |
| Hilker, R | 1 |
| Salazar, G | 1 |
| Cuello, D | 1 |
| Fragoso, M | 1 |
| Benlloc, L | 1 |
| Goldstein, DS | 1 |
| Holmes, C | 1 |
| Sewell, L | 1 |
| Park, MY | 1 |
| Sharabi, Y | 1 |
| Hu, XS | 1 |
| Okamura, N | 1 |
| Arai, H | 1 |
| Higuchi, M | 1 |
| Matsui, T | 1 |
| Tashiro, M | 1 |
| Shinkawa, M | 1 |
| Itoh, M | 1 |
| Ido, T | 1 |
| Sasaki, H | 1 |
| Hisanaga, K | 1 |
| Suzuki, H | 1 |
| Tanji, H | 1 |
| Mochizuki, H | 1 |
| Iwasaki, Y | 1 |
| Sato, N | 1 |
| Jin, K | 1 |
5 other studies available for dihydroxyphenylalanine and Lewy Body Disease
| Article | Year |
|---|---|
Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo.
Topics: Acetylcholine; Aged; Brain; Brain Mapping; Dihydroxyphenylalanine; Dopamine; Fluorodeoxyglucose F18; | 2010 |
Neuropsychiatric symptoms in Lewy body diffuse disease: a case report.
Topics: Aged; Antidepressive Agents; Cognition Disorders; Depressive Disorder, Major; Dihydroxyphenylalanine | 2011 |
Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy.
Topics: Aged; alpha-Synuclein; Autonomic Denervation; Dementia; Dihydroxyphenylalanine; Disease Progression; | 2012 |
18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Humans; Kinetics; Lewy B | 2000 |
Fluoro-DOPA and FDG positron emission tomography in a case of pathologically verified pure diffuse Lewy body disease.
Topics: Dihydroxyphenylalanine; Female; Fluorodeoxyglucose F18; Humans; Lewy Body Disease; Magnetic Resonanc | 2001 |