dihydroxyphenylalanine has been researched along with Leukemia L 1210 in 4 studies
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.
dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1) within melanoma cells to form the cellular toxin 2,4,5-trihydroxyphenylalanine (6-hydroxydopa)." | 7.67 | In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells. ( Cohen, G; Morrison, ME; Yagi, MJ, 1985) |
| "1) within melanoma cells to form the cellular toxin 2,4,5-trihydroxyphenylalanine (6-hydroxydopa)." | 3.67 | In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells. ( Cohen, G; Morrison, ME; Yagi, MJ, 1985) |
| "The natural catecholic amino acid 5-S-cysteinyl-3,4-dihydroxyphenylalanine (1) was selectively toxic to a variety of human tumor cell lines in culture and exhibited antitumor activity against L1210 leukemia and B-16 melanoma in mice at doses which were not toxic to the host." | 3.66 | Synthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalanines and related compounds. ( Fujita, K; Inoue, S; Ito, S; Yamamoto, Y, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujita, K | 2 |
| Ito, S | 2 |
| Inoue, S | 2 |
| Yamamoto, Y | 2 |
| Takeuchi, J | 1 |
| Shamoto, M | 1 |
| Nagatsu, T | 1 |
| Morrison, ME | 1 |
| Yagi, MJ | 1 |
| Cohen, G | 1 |
| Pierson, HF | 1 |
| Meadows, GG | 1 |
4 other studies available for dihydroxyphenylalanine and Leukemia L 1210
| Article | Year |
|---|---|
Selective toxicity of 5-S-cysteinyldopa, a melanin precursor, to tumor cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line; Cysteinyldopa; Dihydroxyphenylalanine; DNA; Dose-Response | 1980 |
Synthesis and antitumor activity of cysteinyl-3,4-dihydroxyphenylalanines and related compounds.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cricetinae; Cysteinyldopa; Dihydroxyphenyl | 1981 |
In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells.
Topics: Animals; Cell Survival; Cells, Cultured; Dihydroxyphenylalanine; Leukemia L1210; Mammary Neoplasms, | 1985 |
Influence of supplemental ascorbate on the antitumor activity of 5-hydroxydopa, a purported cytotoxic metabolite.
Topics: Animals; Ascorbic Acid; Dihydroxyphenylalanine; Drug Interactions; Female; Leukemia L1210; Leukemia | 1985 |